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The map label for this gene is ethA [H]

Identifier: 94310507

GI number: 94310507

Start: 1685944

End: 1687476

Strand: Reverse

Name: ethA [H]

Synonym: Rmet_1565

Alternate gene names: 94310507

Gene position: 1687476-1685944 (Counterclockwise)

Preceding gene: 94310508

Following gene: 94310487

Centisome position: 42.96

GC content: 59.36

Gene sequence:

>1533_bases
ATGAATGCCAACATCTTGTCCGGGCGCCAGCCTGCCCGACCCGTAGCCACGGAGCATTTCGACGTGATCATCGTCGGTGC
GGGCATCTCGGGTGTAGGCTCGGCCTATCACATGCGGACACAATGCCCCGGCAAGCGTTTCGTCGTGCTCGAAAGCAAGG
ACAGCTTCGGAGGCACCTGGCACACACACCGCTATCCCGGTGTGCGCTCGGATAGTGACCTCTACACCTTCGGCTACCGC
TTCAAGCCATGGATGGGAAAACCCATTGCGACTGCAGAGGAAATCCTCAGCTACATGGCCGAAGTAATCGAAGAAAACGA
CCTCGCTCAGCACATCCGCTATCGCCATCGCATCGACGCGGCCTCCTGGTCTTCCGCCGAAGGACTTTGGACCCTTGATA
CCACACGCCTGGAATCGGGAGAGCGCGTACGATTCACCACCAATTTCCTGTGGATGTGCCAGGGGTACTATCGCCACGAT
CAGGGCTATCTGCCCGAGTGGACGGGCATGGACAATTTCAAAGGCCCGTTGATTCACGCGCAGACCTGGCCCGAGGAACT
GGACGTCCAGGGCAAGCGTGTGGTCGTCATCGGCTCGGGCGCTACCGCTGCCACCGTCGTGCCGGGACTGGCCCGCCTGG
GTGCCAAGGTCACCATGCTGCAACGCTCGCCCACATACTTCATCTCGGGACGCAACGCCAACGATCTCGCAAACGAGCTA
CGCCGGCTCGAAATCGACCCAATGTGGATCCACGCGATCATCCGGAAGAAAGTCCTGATGGATGGCGCCATCTTCGCCCG
CCGCTCACGTGAAGAACCAGAGGAGGTGCGCAAGGAACTGCTTGCAGGGGTTCGCGCGCAGCTTGGCGAGGACTTCGAAC
TCGAACCGCATTTTTCACCACGCTACCGGCCTTGGCAGCAGCGGGTGGCGTTCATTCCCGATGGCGACATGTTCGCGGAA
ATTCGCGAGGGCAACGCCATCGTGGTCACTGACGAGATCGACCGGTTCGTCGAGGACGGCGTCGTGCTCAAGTCCAACGA
GAAGCTAGACGCCGACATCGTTGTGGCCGCTACGGGCTTTCAGCTCAGTGTGCTGGGCGACATTCCGTTTAGCGTCGACG
GCCAATCGCTGGATTTCTCGAAAACCGTGACCTATCGCGGCATGATGTTCACTGGCGTGCCTAACATGGTCTGGGTGTTC
GGCTACTTCCGCGCCAGCTGGACGCTACGGGTTGACATGGTCGCCGACTTCGTCTGCCGCCTGCTGAAGCACATGGATGC
CACAGGAGCAAAGCAAGTCACCCCACAACTCCGTGAAGACGAGAAAGACATGCCTCTATCCGAGTGGATAGACGCCGACA
ACTTCAACCCCGGCTATCTCATGCGCGACATCCAACTCATGCCCAGGAGCGGCAACACGCGCGAGTGGCAACACACGCAA
GACTACTGGGGAGAGAAGGATGAGTTTCCCGAGATTGACCTAACGGATGGGGTATTCCGTTACGACGCAAATCGTCCGTC
AGGTAATGCCTGA

Upstream 100 bases:

>100_bases
CAGGACATTGCCACGAAGAACGACACGGTGGCGCATGACGTCATCGGCGTTCTTCACGTGAGTGGCCAGGGCCACATACG
ATATCTCAGGAGACAACCCC

Downstream 100 bases:

>100_bases
GCCAGGCCGTGGTCGACAGACCGGTGCCGGAAAAATGGCACAAAAAAGCCCGCAGTTATGAACTGACCCCAAGAAGTTGG
ACAGTTAAGGCGGTAGGCTA

Product: Flavin-containing monooxygenase FMO:IMP dehydrogenase/GMP reductase:FAD dependent oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNANILSGRQPARPVATEHFDVIIVGAGISGVGSAYHMRTQCPGKRFVVLESKDSFGGTWHTHRYPGVRSDSDLYTFGYR
FKPWMGKPIATAEEILSYMAEVIEENDLAQHIRYRHRIDAASWSSAEGLWTLDTTRLESGERVRFTTNFLWMCQGYYRHD
QGYLPEWTGMDNFKGPLIHAQTWPEELDVQGKRVVVIGSGATAATVVPGLARLGAKVTMLQRSPTYFISGRNANDLANEL
RRLEIDPMWIHAIIRKKVLMDGAIFARRSREEPEEVRKELLAGVRAQLGEDFELEPHFSPRYRPWQQRVAFIPDGDMFAE
IREGNAIVVTDEIDRFVEDGVVLKSNEKLDADIVVAATGFQLSVLGDIPFSVDGQSLDFSKTVTYRGMMFTGVPNMVWVF
GYFRASWTLRVDMVADFVCRLLKHMDATGAKQVTPQLREDEKDMPLSEWIDADNFNPGYLMRDIQLMPRSGNTREWQHTQ
DYWGEKDEFPEIDLTDGVFRYDANRPSGNA

Sequences:

>Translated_510_residues
MNANILSGRQPARPVATEHFDVIIVGAGISGVGSAYHMRTQCPGKRFVVLESKDSFGGTWHTHRYPGVRSDSDLYTFGYR
FKPWMGKPIATAEEILSYMAEVIEENDLAQHIRYRHRIDAASWSSAEGLWTLDTTRLESGERVRFTTNFLWMCQGYYRHD
QGYLPEWTGMDNFKGPLIHAQTWPEELDVQGKRVVVIGSGATAATVVPGLARLGAKVTMLQRSPTYFISGRNANDLANEL
RRLEIDPMWIHAIIRKKVLMDGAIFARRSREEPEEVRKELLAGVRAQLGEDFELEPHFSPRYRPWQQRVAFIPDGDMFAE
IREGNAIVVTDEIDRFVEDGVVLKSNEKLDADIVVAATGFQLSVLGDIPFSVDGQSLDFSKTVTYRGMMFTGVPNMVWVF
GYFRASWTLRVDMVADFVCRLLKHMDATGAKQVTPQLREDEKDMPLSEWIDADNFNPGYLMRDIQLMPRSGNTREWQHTQ
DYWGEKDEFPEIDLTDGVFRYDANRPSGNA
>Mature_510_residues
MNANILSGRQPARPVATEHFDVIIVGAGISGVGSAYHMRTQCPGKRFVVLESKDSFGGTWHTHRYPGVRSDSDLYTFGYR
FKPWMGKPIATAEEILSYMAEVIEENDLAQHIRYRHRIDAASWSSAEGLWTLDTTRLESGERVRFTTNFLWMCQGYYRHD
QGYLPEWTGMDNFKGPLIHAQTWPEELDVQGKRVVVIGSGATAATVVPGLARLGAKVTMLQRSPTYFISGRNANDLANEL
RRLEIDPMWIHAIIRKKVLMDGAIFARRSREEPEEVRKELLAGVRAQLGEDFELEPHFSPRYRPWQQRVAFIPDGDMFAE
IREGNAIVVTDEIDRFVEDGVVLKSNEKLDADIVVAATGFQLSVLGDIPFSVDGQSLDFSKTVTYRGMMFTGVPNMVWVF
GYFRASWTLRVDMVADFVCRLLKHMDATGAKQVTPQLREDEKDMPLSEWIDADNFNPGYLMRDIQLMPRSGNTREWQHTQ
DYWGEKDEFPEIDLTDGVFRYDANRPSGNA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 58070; Mature: 58070

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANILSGRQPARPVATEHFDVIIVGAGISGVGSAYHMRTQCPGKRFVVLESKDSFGGTW
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCE
HTHRYPGVRSDSDLYTFGYRFKPWMGKPIATAEEILSYMAEVIEENDLAQHIRYRHRIDA
ECCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ASWSSAEGLWTLDTTRLESGERVRFTTNFLWMCQGYYRHDQGYLPEWTGMDNFKGPLIHA
CCCCCCCCEEEEEHHCCCCCCEEEEEECEEEEECCCEECCCCCCCCCCCCCCCCCCEEEC
QTWPEELDVQGKRVVVIGSGATAATVVPGLARLGAKVTMLQRSPTYFISGRNANDLANEL
CCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHH
RRLEIDPMWIHAIIRKKVLMDGAIFARRSREEPEEVRKELLAGVRAQLGEDFELEPHFSP
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RYRPWQQRVAFIPDGDMFAEIREGNAIVVTDEIDRFVEDGVVLKSNEKLDADIVVAATGF
CCCCHHHCEEECCCCCHHHEEECCCEEEEEHHHHHHHHCCEEEECCCCCCCEEEEEECCE
QLSVLGDIPFSVDGQSLDFSKTVTYRGMMFTGVPNMVWVFGYFRASWTLRVDMVADFVCR
EEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCHHHHEEEEEEEEEEEHHHHHHHHHH
LLKHMDATGAKQVTPQLREDEKDMPLSEWIDADNFNPGYLMRDIQLMPRSGNTREWQHTQ
HHHHCCCCCCHHCCCHHHCCCCCCCHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCH
DYWGEKDEFPEIDLTDGVFRYDANRPSGNA
HHCCCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MNANILSGRQPARPVATEHFDVIIVGAGISGVGSAYHMRTQCPGKRFVVLESKDSFGGTW
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCE
HTHRYPGVRSDSDLYTFGYRFKPWMGKPIATAEEILSYMAEVIEENDLAQHIRYRHRIDA
ECCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ASWSSAEGLWTLDTTRLESGERVRFTTNFLWMCQGYYRHDQGYLPEWTGMDNFKGPLIHA
CCCCCCCCEEEEEHHCCCCCCEEEEEECEEEEECCCEECCCCCCCCCCCCCCCCCCEEEC
QTWPEELDVQGKRVVVIGSGATAATVVPGLARLGAKVTMLQRSPTYFISGRNANDLANEL
CCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHH
RRLEIDPMWIHAIIRKKVLMDGAIFARRSREEPEEVRKELLAGVRAQLGEDFELEPHFSP
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RYRPWQQRVAFIPDGDMFAEIREGNAIVVTDEIDRFVEDGVVLKSNEKLDADIVVAATGF
CCCCHHHCEEECCCCCHHHEEECCCEEEEEHHHHHHHHCCEEEECCCCCCCEEEEEECCE
QLSVLGDIPFSVDGQSLDFSKTVTYRGMMFTGVPNMVWVFGYFRASWTLRVDMVADFVCR
EEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCHHHHEEEEEEEEEEEHHHHHHHHHH
LLKHMDATGAKQVTPQLREDEKDMPLSEWIDADNFNPGYLMRDIQLMPRSGNTREWQHTQ
HHHHCCCCCCHHCCCHHHCCCCCCCHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCH
DYWGEKDEFPEIDLTDGVFRYDANRPSGNA
HHCCCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA