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The map label for this gene is guaB [H]

Identifier: 94310403

GI number: 94310403

Start: 1581506

End: 1582969

Strand: Direct

Name: guaB [H]

Synonym: Rmet_1461

Alternate gene names: 94310403

Gene position: 1581506-1582969 (Clockwise)

Preceding gene: 94310400

Following gene: 94310404

Centisome position: 40.26

GC content: 62.43

Gene sequence:

>1464_bases
ATGCGTCTTGTCCAGAAAGCACTCACATTCGATGATGTGCTGCTCGTCCCGGCCTATTCGGCCGTCCTGCCCCGGGATGT
TTCCCTCCGCACCCGCCTGACCCGTTCCATCGACTTGAACATTCCGCTGGTTTCCGCCGCCATGGATACCGTGACGGAAG
CTCGCCTTGCCATTTCCATGGCACAGGCCGGTGGTATCGGCATCGTCCACAAAAACCTGAAGCCAGCCGACCAGGCGCGC
GAAGTGCAGCGTGTGAAGCGCTACGAATCGGGCGTGCTGCGTGATCCGATCACCATTTCTCCGGAAATGAAGGTCCGCGA
TGTGATCGCCTTGTCGCAGCAGCATGGCATTTCGGGCTTCCCGGTGCTGGAAGGCAAGACCGTAGTCGGCATTATCACCA
ATCGCGACTTGCGCTTCGAGGAAGAACTCGACGCCCCGGTGCGCGCGAAGATGACGCCGCGAGAAAAGCTCGTGACCGTC
GCCGAAGGCGCACCGCTGGAAGAAGCCAAGCGCCTGATGAACCGCCATCGTCTGGAGCGTGTGCTCGTAGTCAACGGCGC
GTTCGAACTGCGCGGCCTGATTACCGTGAAGGATATCCAGAAGGCCGTGGAAAACCCGCTGGCCAATAAGGATGCGCACG
GCCAACTGCGCGTAGGTGCCGCAGTGGGCGTGGGTCCGGACAACGACGAGCGTGTGGAGTTGCTGGTCAAGGCCGGCGTG
GATGTGATCGTGGTCGATACTGCGCACGGCCACAGCCAGGGCGTGCTGGATCGCGTGCGCTGGGTCAAGCAGAACTTCCC
GCAAGTGCAGGTCGTGGGTGGCAACATCGCCACTGGCGCGGCTGCGCTGGCACTGGTCGAACATGGCGCCGATGGCGTCA
AGGTCGGTATCGGTCCGGGCTCGATCTGTACGACGCGTATCGTTGCTGGCGTCGGCGTGCCGCAGATCACCGCCGTGTCG
AACGTGGCGGAAGCGCTCAAGGGCACAGACGTGCCGCTGATCGCCGATGGCGGCGTGCGCTATTCGGGTGACGTTGCCAA
GGCACTGGCCGCTGGCGCCCACACCGTGATGATGGGCGGCATGTTCTCGGGTACCGAGGAAGCGCCGGGTGAAGTGTTCC
TGTATCAGGGGCGTTCGTTCAAGAGCTACCGTGGCATGGGTTCGGTTGGCGCGATGAAGGACGGTGCCGCTGACCGCTAC
TTCCAGGAAGACAACACGGCCAACGTCGACAAACTCGTGCCCGAAGGCATCGAAGGCCGCGTACCTTACAAGGGCTCGGT
GCAGGCGATCATCCACCAACTGACCGGTGGCATTCGTGCGTCGATGGGCTACTGCGGCGCAAGCTCGATTGCCCAATGGC
ACGAGACCGCCGAGTTCGTGCAGATCACCGCCGCGGGGATGCGCGAGTCGCATGTCCACGATGTGCAGATCACCAAGGAA
GCGCCGAACTACCATATCGATTGA

Upstream 100 bases:

>100_bases
GCGTCTAAAAAGGAGGCCGAGATTAGCAAACGCCATGCGATAACGCATCAGCAAATCCTGCATTCCTGTATAATCTGCTT
TTGCGCCTAGAGGATTCGCT

Downstream 100 bases:

>100_bases
TTTCGATCTGGTGCCTCCCACCACGGCCGCGCTGGTTTCGTCGATGCTGACGGGGCCGCGCGGCCGCGCTGCAAAAAAGG
AGCGCTCATGAAGGTATTGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAISMAQAGGIGIVHKNLKPADQAR
EVQRVKRYESGVLRDPITISPEMKVRDVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNGAFELRGLITVKDIQKAVENPLANKDAHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGAAALALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTDVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVQAIIHQLTGGIRASMGYCGASSIAQWHETAEFVQITAAGMRESHVHDVQITKE
APNYHID

Sequences:

>Translated_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAISMAQAGGIGIVHKNLKPADQAR
EVQRVKRYESGVLRDPITISPEMKVRDVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNGAFELRGLITVKDIQKAVENPLANKDAHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGAAALALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTDVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVQAIIHQLTGGIRASMGYCGASSIAQWHETAEFVQITAAGMRESHVHDVQITKE
APNYHID
>Mature_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAISMAQAGGIGIVHKNLKPADQAR
EVQRVKRYESGVLRDPITISPEMKVRDVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNGAFELRGLITVKDIQKAVENPLANKDAHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGAAALALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTDVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVQAIIHQLTGGIRASMGYCGASSIAQWHETAEFVQITAAGMRESHVHDVQITKE
APNYHID

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=42.0289855072464, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=41.7536534446764, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.7536534446764, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.7536534446764, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.7536534446764, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=41.6842105263158, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=41.1273486430063, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=39.0396659707724, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI156104880, Length=344, Percent_Identity=32.8488372093023, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=38.3064516129032, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=38.3064516129032, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=38.3064516129032, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=38.3064516129032, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=59.958932238193, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1786293, Length=271, Percent_Identity=32.4723247232472, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=37.1069182389937, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.6255924170616, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=242, Percent_Identity=36.7768595041322, Blast_Score=162, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=40.8997955010225, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=40, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=40.6185567010309, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=41.5204678362573, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=39.1666666666667, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.7515527950311, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.7515527950311, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.9092970521542, Blast_Score=311, Evalue=9e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52021; Mature: 52021

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAISM
CCHHHHHCCCCCEEECCCHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
AQAGGIGIVHKNLKPADQAREVQRVKRYESGVLRDPITISPEMKVRDVIALSQQHGISGF
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTVAEGAPLEEAKRLMNRHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEECCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
VLVVNGAFELRGLITVKDIQKAVENPLANKDAHGQLRVGAAVGVGPDNDERVELLVKAGV
EEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHEEEECCC
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGAAALALVEHGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQITAVSNVAEALKGTDVPLIADGGVRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEECC
MFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
CCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVQAIIHQLTGGIRASMGYCGASSIAQWHETAEFVQITAAGMRESHVHDVQITKE
CCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHEEEHHCCCCCCCEEEEEEEC
APNYHID
CCCCCCC
>Mature Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAISM
CCHHHHHCCCCCEEECCCHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
AQAGGIGIVHKNLKPADQAREVQRVKRYESGVLRDPITISPEMKVRDVIALSQQHGISGF
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTVAEGAPLEEAKRLMNRHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEECCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
VLVVNGAFELRGLITVKDIQKAVENPLANKDAHGQLRVGAAVGVGPDNDERVELLVKAGV
EEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHEEEECCC
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGAAALALVEHGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQITAVSNVAEALKGTDVPLIADGGVRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEECC
MFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
CCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVQAIIHQLTGGIRASMGYCGASSIAQWHETAEFVQITAAGMRESHVHDVQITKE
CCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHEEEHHCCCCCCCEEEEEEEC
APNYHID
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA