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The map label for this gene is yhcA [H]

Identifier: 94310335

GI number: 94310335

Start: 1502155

End: 1503681

Strand: Direct

Name: yhcA [H]

Synonym: Rmet_1393

Alternate gene names: 94310335

Gene position: 1502155-1503681 (Clockwise)

Preceding gene: 94310334

Following gene: 94310337

Centisome position: 38.24

GC content: 67.19

Gene sequence:

>1527_bases
GTGAAGCGCGAATCCACCGCGCCGGCAGGTACTGGCAGCGGGGAATCCGGAGGCGGCAACCACGGCGGTGGCGGCGGAGG
GCCGCGCCGCGGTGGGCCCACGCGCGCGCAACTGCGCGCCCGCTATGGCGATCGCCTGCGCTGGCTGATCCTGTTGACGC
TGATGCTTGGCACGGTGTCCTCCATCGTGTCATCGACCATTGTCAATGTCGCCATTCCGGACCTGAGCCGGCATTTCCTG
CTCGGCCAGGAGCGCGCCCAATGGGTGGCGGCCAGCTTCATGATCGCCATGACGCTGTCGATGCTGCTCACCCCCTGGCT
GCTGAACCGATATGGCCTGCGCAGGACCTTCATTGGTGCGCTGGCGCTGCTTGGTGCGGGTGGCCTGATAGGTGGTGTCG
CGCCCACCTTCGGCGTGATGCTGGCGATGCGTGTGGCCGAAGGCGTCGCGGCGGGCATCATGCAGCCGCTGCCCAATATT
TTCATCCTGCGCGTGTTTGACGAACGTGAGCAGGGCAAGGCCCTGTCGCTGTTCGGCTTCGGCGTGGTGCTGGCGCCGGC
CGTCGGGCCCAGCGTGGGCGGCTTTCTCGTCGAGACATTCGGCTGGCGCTCGATTTTCTTCGTGGTGGTGCCGCTGACGC
TGATCGCCCTGGCGATGGCGCGCCGCTTCATGGCGGTGGACTCCGCGATGATGGGTGAGCGCAAGCCGCTGGACTGGCGC
GGCCTGATGCTGGTCGGCGTGGCTACTGTCAGCCTGCTCAACGGGCTGGTGGAGATGCGCGGCGACGTGCATTCCGGGAT
TGGACTGGTCGCCCTGGGCGTGGTCATGCTCGCTGGATTCGTGTTCTGGCAACTGCGCGCGCCGTATCCGCTGATGAACA
TGCGGCTGTACAGCTACCAGCAGTTCTCGGCCGGCGCCATTGTGGCGTTCATTTACGGGGCGGGGCTGTTCGGCTCCACG
TACCTGCTGCCGGTCTATATGCAGATGGCGCTGTCCTATACGCCGTCGGCCGCGGGCATCGTGCTGATGCCGGCTGGCGT
TGCGCTGGCGGTGACGATTGCCGTTGCCGGGCGCCTGACCAGCCGGGTCCCGCCGCACCGGCAGGTGTCGTTCGGGCTGG
CACTGCTTGCGGGGTCGTTCCTGCTCATGGCCACCGGGTCGACGGCTACGCCATACCTGCTGCTGGTCTTATATGCGGTG
ATCGGCCGGATCGGCCTGGGCTGCGTCCTGCCCTCGCTGACAATGGGCTCGATGCGCGGGGTGGATTTCTCCATGATCGC
GCAGGGCTCGAGCTGCATCAACTTCGTGCGGCAACTGGGCGGGGCGATCGGCGTGAGTCTGGCTGGTGTGGGGCTGCAAT
GGCGCCTTGCCGAACACGGTGCCGTGCTCGGCAAGGGCGGTGACGTGGCGGCCCAAGCCGCGCGCATCCAGGCTTTCGAT
GAGACTTTCCTGGCCGTTGGCGTGGTGATTGCCACGGCCATCCTGGCCGCCTGGCGCATCCGCCCGCGGCCAGTGCCGGC
TGATTGA

Upstream 100 bases:

>100_bases
GCGATGACCGTTATGCCGAGATCGTCAAATCCGCCTACCACGAGGCCGACCTCGACACCGTGCGCAAGATCCGGGAGATC
GCCGCGACGGGGCAGCTCGG

Downstream 100 bases:

>100_bases
TCAGCTGGCCTTGCCTTCGAGCAGGTCGGTCACGAGTTCAATGTACTTCTGCATCGCTTCCTCGCGGCCGGTGCCTTTGA
GGGCTTCCCAGGCCTCGAAC

Product: MFS transporter, DHA2 family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKRESTAPAGTGSGESGGGNHGGGGGGPRRGGPTRAQLRARYGDRLRWLILLTLMLGTVSSIVSSTIVNVAIPDLSRHFL
LGQERAQWVAASFMIAMTLSMLLTPWLLNRYGLRRTFIGALALLGAGGLIGGVAPTFGVMLAMRVAEGVAAGIMQPLPNI
FILRVFDEREQGKALSLFGFGVVLAPAVGPSVGGFLVETFGWRSIFFVVVPLTLIALAMARRFMAVDSAMMGERKPLDWR
GLMLVGVATVSLLNGLVEMRGDVHSGIGLVALGVVMLAGFVFWQLRAPYPLMNMRLYSYQQFSAGAIVAFIYGAGLFGST
YLLPVYMQMALSYTPSAAGIVLMPAGVALAVTIAVAGRLTSRVPPHRQVSFGLALLAGSFLLMATGSTATPYLLLVLYAV
IGRIGLGCVLPSLTMGSMRGVDFSMIAQGSSCINFVRQLGGAIGVSLAGVGLQWRLAEHGAVLGKGGDVAAQAARIQAFD
ETFLAVGVVIATAILAAWRIRPRPVPAD

Sequences:

>Translated_508_residues
MKRESTAPAGTGSGESGGGNHGGGGGGPRRGGPTRAQLRARYGDRLRWLILLTLMLGTVSSIVSSTIVNVAIPDLSRHFL
LGQERAQWVAASFMIAMTLSMLLTPWLLNRYGLRRTFIGALALLGAGGLIGGVAPTFGVMLAMRVAEGVAAGIMQPLPNI
FILRVFDEREQGKALSLFGFGVVLAPAVGPSVGGFLVETFGWRSIFFVVVPLTLIALAMARRFMAVDSAMMGERKPLDWR
GLMLVGVATVSLLNGLVEMRGDVHSGIGLVALGVVMLAGFVFWQLRAPYPLMNMRLYSYQQFSAGAIVAFIYGAGLFGST
YLLPVYMQMALSYTPSAAGIVLMPAGVALAVTIAVAGRLTSRVPPHRQVSFGLALLAGSFLLMATGSTATPYLLLVLYAV
IGRIGLGCVLPSLTMGSMRGVDFSMIAQGSSCINFVRQLGGAIGVSLAGVGLQWRLAEHGAVLGKGGDVAAQAARIQAFD
ETFLAVGVVIATAILAAWRIRPRPVPAD
>Mature_508_residues
MKRESTAPAGTGSGESGGGNHGGGGGGPRRGGPTRAQLRARYGDRLRWLILLTLMLGTVSSIVSSTIVNVAIPDLSRHFL
LGQERAQWVAASFMIAMTLSMLLTPWLLNRYGLRRTFIGALALLGAGGLIGGVAPTFGVMLAMRVAEGVAAGIMQPLPNI
FILRVFDEREQGKALSLFGFGVVLAPAVGPSVGGFLVETFGWRSIFFVVVPLTLIALAMARRFMAVDSAMMGERKPLDWR
GLMLVGVATVSLLNGLVEMRGDVHSGIGLVALGVVMLAGFVFWQLRAPYPLMNMRLYSYQQFSAGAIVAFIYGAGLFGST
YLLPVYMQMALSYTPSAAGIVLMPAGVALAVTIAVAGRLTSRVPPHRQVSFGLALLAGSFLLMATGSTATPYLLLVLYAV
IGRIGLGCVLPSLTMGSMRGVDFSMIAQGSSCINFVRQLGGAIGVSLAGVGLQWRLAEHGAVLGKGGDVAAQAARIQAFD
ETFLAVGVVIATAILAAWRIRPRPVPAD

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=432, Percent_Identity=26.6203703703704, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788710, Length=408, Percent_Identity=26.2254901960784, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790195, Length=440, Percent_Identity=23.6363636363636, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081983, Length=329, Percent_Identity=23.4042553191489, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788392, Length=458, Percent_Identity=23.5807860262009, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323735, Length=320, Percent_Identity=24.6875, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53341; Mature: 53341

Theoretical pI: Translated: 11.24; Mature: 11.24

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRESTAPAGTGSGESGGGNHGGGGGGPRRGGPTRAQLRARYGDRLRWLILLTLMLGTVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVSSTIVNVAIPDLSRHFLLGQERAQWVAASFMIAMTLSMLLTPWLLNRYGLRRTFIGA
HHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALLGAGGLIGGVAPTFGVMLAMRVAEGVAAGIMQPLPNIFILRVFDEREQGKALSLFGF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEHH
GVVLAPAVGPSVGGFLVETFGWRSIFFVVVPLTLIALAMARRFMAVDSAMMGERKPLDWR
HHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GLMLVGVATVSLLNGLVEMRGDVHSGIGLVALGVVMLAGFVFWQLRAPYPLMNMRLYSYQ
HHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCEEHHHH
QFSAGAIVAFIYGAGLFGSTYLLPVYMQMALSYTPSAAGIVLMPAGVALAVTIAVAGRLT
HCCCCHHHHHHHHCCHHCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
SRVPPHRQVSFGLALLAGSFLLMATGSTATPYLLLVLYAVIGRIGLGCVLPSLTMGSMRG
HCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDFSMIAQGSSCINFVRQLGGAIGVSLAGVGLQWRLAEHGAVLGKGGDVAAQAARIQAFD
CCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHH
ETFLAVGVVIATAILAAWRIRPRPVPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKRESTAPAGTGSGESGGGNHGGGGGGPRRGGPTRAQLRARYGDRLRWLILLTLMLGTVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVSSTIVNVAIPDLSRHFLLGQERAQWVAASFMIAMTLSMLLTPWLLNRYGLRRTFIGA
HHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALLGAGGLIGGVAPTFGVMLAMRVAEGVAAGIMQPLPNIFILRVFDEREQGKALSLFGF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEHH
GVVLAPAVGPSVGGFLVETFGWRSIFFVVVPLTLIALAMARRFMAVDSAMMGERKPLDWR
HHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GLMLVGVATVSLLNGLVEMRGDVHSGIGLVALGVVMLAGFVFWQLRAPYPLMNMRLYSYQ
HHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCEEHHHH
QFSAGAIVAFIYGAGLFGSTYLLPVYMQMALSYTPSAAGIVLMPAGVALAVTIAVAGRLT
HCCCCHHHHHHHHCCHHCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
SRVPPHRQVSFGLALLAGSFLLMATGSTATPYLLLVLYAVIGRIGLGCVLPSLTMGSMRG
HCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDFSMIAQGSSCINFVRQLGGAIGVSLAGVGLQWRLAEHGAVLGKGGDVAAQAARIQAFD
CCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHH
ETFLAVGVVIATAILAAWRIRPRPVPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]