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The map label for this gene is metC [H]

Identifier: 94310306

GI number: 94310306

Start: 1473497

End: 1474699

Strand: Direct

Name: metC [H]

Synonym: Rmet_1364

Alternate gene names: 94310306

Gene position: 1473497-1474699 (Clockwise)

Preceding gene: 94310305

Following gene: 94310311

Centisome position: 37.51

GC content: 64.42

Gene sequence:

>1203_bases
GTGTCCGCTTCCGACTCGTCCCGTTACATCAAGACCATTGCCGTCCAGCCAGAACTGGACATCGCGCCGGGCTTCGATTC
GTTCTCCACGCCGACCTACCGCGGCTCCACTGTCGTCTTCCGCAACCTTGCCGAACTGCGCGCCTATGGCGACCGCAGCA
AGACCTACTGGCGCTATGGCCTGCACGCCACGCCGACCAGCGAGGCGCTTTGCCAGCAACTGGCGCAGATCGAAGGTGGC
CGTCACACGCTGCTGTTCCCGTCGGGCCTGGGCGCCATTTCGCTGGTCTATTTCGGCCTGCTGCGTACCGGTGACGATGT
CCTCGTCCCAGAAAACGTCTACGGACCCAATCGCGATCATGGCGACTGGATGGCGCGGGAGTTCGGTATTACCGTGCGCC
CGTATCATCCGTCGGTCGGCGCTGGAATCGCCTCGATGATCCAGCCGAACACGCGTCTGATCTGGATGGAATCGCCGGGC
TCGGTCACGATGGAAGTGCCTGACACCGAGGCGATCGTGGCCGCCGCGAAGGCACGTGGTGTGCTGACCGCGATCGACAA
CACCTGGTCTGCCGGCGTCTACTATCGGCCGTTCGAGAAGGGCATCGATATCTCCGTGCAGGCGCTGACCAAGTACCAAT
CCGGTGGCAGCGATGTACTGATGGGCGCCGTGATCACGCGGGATGACCATCTCCACGACCGCCTCAAGCGCACCCGCATG
CTGATGGGCTGGGGTGTCTCCGCCGACGATTGCTACCTGGTCCTGCGTGGGCTGGCGAGCATGCCGGTGCGCCTGGCCGC
TCACGACCGCGCAGCGCGCGAGGTGGCCGAATGGCTGACGAAACGTCCGGAGGTCGCGCGTGTGCTGCATCCGGCATTGC
CCGATTGCCCCGGCCATGCCGAATGGCTGCGGGATTTCAGCGGGGCGAGTGGTCTGTTCTCGATCATTCTGCACAGCCGC
TATACGCGCGAGCAGGTCGATGCGTTCGTCGAGGCGCTAAAGCTGTTCGCGATTGGCTGGTCGTGGGGCGGTGCGCACAG
TCTGGCTGTGCCCTATCACGTCGACACAATGCGCCCGGCTGGCACGTGGCCGCCCGCTGGATGGGAGAACGCCGGCGAAC
TGGTGCGGCTGTATATTGGTCTGGAAGACACCCGCGACCTGATCGCCGATCTGAAGCAGGCGCTGGAGTCTCAGCTGCGC
TGA

Upstream 100 bases:

>100_bases
CCGTCCTGACCTGACGTGTTTTCGCCGGCCTCGCACGTGGCCTGACTGGCATTTGCTGGTAAGCTCGAACGCCTGATTCG
ACTCCTCCAGGGAAATCGCC

Downstream 100 bases:

>100_bases
CGAGCCAGAATGCGCCCGGACGCGCTAGACGCGTTCGAGCGCCGCGGGTTCTTCTGTCTTTTGGGTATTGGGTGATGCGC
TACGCAGCGCCCATACCGAT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSASDSSRYIKTIAVQPELDIAPGFDSFSTPTYRGSTVVFRNLAELRAYGDRSKTYWRYGLHATPTSEALCQQLAQIEGG
RHTLLFPSGLGAISLVYFGLLRTGDDVLVPENVYGPNRDHGDWMAREFGITVRPYHPSVGAGIASMIQPNTRLIWMESPG
SVTMEVPDTEAIVAAAKARGVLTAIDNTWSAGVYYRPFEKGIDISVQALTKYQSGGSDVLMGAVITRDDHLHDRLKRTRM
LMGWGVSADDCYLVLRGLASMPVRLAAHDRAAREVAEWLTKRPEVARVLHPALPDCPGHAEWLRDFSGASGLFSIILHSR
YTREQVDAFVEALKLFAIGWSWGGAHSLAVPYHVDTMRPAGTWPPAGWENAGELVRLYIGLEDTRDLIADLKQALESQLR

Sequences:

>Translated_400_residues
MSASDSSRYIKTIAVQPELDIAPGFDSFSTPTYRGSTVVFRNLAELRAYGDRSKTYWRYGLHATPTSEALCQQLAQIEGG
RHTLLFPSGLGAISLVYFGLLRTGDDVLVPENVYGPNRDHGDWMAREFGITVRPYHPSVGAGIASMIQPNTRLIWMESPG
SVTMEVPDTEAIVAAAKARGVLTAIDNTWSAGVYYRPFEKGIDISVQALTKYQSGGSDVLMGAVITRDDHLHDRLKRTRM
LMGWGVSADDCYLVLRGLASMPVRLAAHDRAAREVAEWLTKRPEVARVLHPALPDCPGHAEWLRDFSGASGLFSIILHSR
YTREQVDAFVEALKLFAIGWSWGGAHSLAVPYHVDTMRPAGTWPPAGWENAGELVRLYIGLEDTRDLIADLKQALESQLR
>Mature_399_residues
SASDSSRYIKTIAVQPELDIAPGFDSFSTPTYRGSTVVFRNLAELRAYGDRSKTYWRYGLHATPTSEALCQQLAQIEGGR
HTLLFPSGLGAISLVYFGLLRTGDDVLVPENVYGPNRDHGDWMAREFGITVRPYHPSVGAGIASMIQPNTRLIWMESPGS
VTMEVPDTEAIVAAAKARGVLTAIDNTWSAGVYYRPFEKGIDISVQALTKYQSGGSDVLMGAVITRDDHLHDRLKRTRML
MGWGVSADDCYLVLRGLASMPVRLAAHDRAAREVAEWLTKRPEVARVLHPALPDCPGHAEWLRDFSGASGLFSIILHSRY
TREQVDAFVEALKLFAIGWSWGGAHSLAVPYHVDTMRPAGTWPPAGWENAGELVRLYIGLEDTRDLIADLKQALESQLR

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=32.9931972789116, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI299473759, Length=237, Percent_Identity=34.1772151898734, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=29.0102389078498, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789383, Length=364, Percent_Identity=40.1098901098901, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1790375, Length=394, Percent_Identity=30.2030456852792, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=346, Percent_Identity=34.6820809248555, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17538055, Length=343, Percent_Identity=34.9854227405248, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=383, Percent_Identity=29.5039164490862, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=41.4012738853503, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=348, Percent_Identity=28.735632183908, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.1207729468599, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=23.6641221374046, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=367, Percent_Identity=23.433242506812, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922554, Length=345, Percent_Identity=34.7826086956522, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44156; Mature: 44024

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDSSRYIKTIAVQPELDIAPGFDSFSTPTYRGSTVVFRNLAELRAYGDRSKTYWRYG
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
LHATPTSEALCQQLAQIEGGRHTLLFPSGLGAISLVYFGLLRTGDDVLVPENVYGPNRDH
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
GDWMAREFGITVRPYHPSVGAGIASMIQPNTRLIWMESPGSVTMEVPDTEAIVAAAKARG
CHHHHHHHCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCC
VLTAIDNTWSAGVYYRPFEKGIDISVQALTKYQSGGSDVLMGAVITRDDHLHDRLKRTRM
EEEEECCCCCCCEEECCHHCCCCEEEEHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHH
LMGWGVSADDCYLVLRGLASMPVRLAAHDRAAREVAEWLTKRPEVARVLHPALPDCPGHA
HHCCCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHH
EWLRDFSGASGLFSIILHSRYTREQVDAFVEALKLFAIGWSWGGAHSLAVPYHVDTMRPA
HHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEECCCCCC
GTWPPAGWENAGELVRLYIGLEDTRDLIADLKQALESQLR
CCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASDSSRYIKTIAVQPELDIAPGFDSFSTPTYRGSTVVFRNLAELRAYGDRSKTYWRYG
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
LHATPTSEALCQQLAQIEGGRHTLLFPSGLGAISLVYFGLLRTGDDVLVPENVYGPNRDH
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
GDWMAREFGITVRPYHPSVGAGIASMIQPNTRLIWMESPGSVTMEVPDTEAIVAAAKARG
CHHHHHHHCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCC
VLTAIDNTWSAGVYYRPFEKGIDISVQALTKYQSGGSDVLMGAVITRDDHLHDRLKRTRM
EEEEECCCCCCCEEECCHHCCCCEEEEHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHH
LMGWGVSADDCYLVLRGLASMPVRLAAHDRAAREVAEWLTKRPEVARVLHPALPDCPGHA
HHCCCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHH
EWLRDFSGASGLFSIILHSRYTREQVDAFVEALKLFAIGWSWGGAHSLAVPYHVDTMRPA
HHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEECCCCCC
GTWPPAGWENAGELVRLYIGLEDTRDLIADLKQALESQLR
CCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]