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The map label for this gene is pyrD [H]

Identifier: 94310158

GI number: 94310158

Start: 1332251

End: 1333327

Strand: Reverse

Name: pyrD [H]

Synonym: Rmet_1213

Alternate gene names: 94310158

Gene position: 1333327-1332251 (Counterclockwise)

Preceding gene: 94310159

Following gene: 94310157

Centisome position: 33.94

GC content: 65.55

Gene sequence:

>1077_bases
TTGGTTCCGACTCCTCGCCGGCCCTGGCCGCGCCCCACCCTCGTGCTCAACGCGCTTTACCCCCTGCTGCGCCCCGCCCT
GTTTTCCATGGATGCGGAGGACGCCCACCATTTCACGCTCAATAACCTGATGCGCGCCAAGCGCATGGGGCTGGCCGGAT
GCATCGGCAACAGCATCGCCGACGACCCGCGCACGGTCATGGGCGTTCGCTTTCCGAATCCAGTCGGCCTGGCGGCCGGC
CTGGATAAGGATGGCGCCTATATCGATGGCCTGGCGGCATTCGGCTTCGGCTTCATCGAAGTCGGTACGGTCACACCTCG
GGCGCAGCCGGGCAACCCGCGCCCGCGCATGTTCCGACTGCCGCAGGCCGACGCGCTAATCAACCGCATGGGCTTCAACA
ACGGGGGCGTCGATGCATTCATCCGAAATGTCCAGGCATCCCGCTGGAAGGCCGAAGGCGGTGTGCTGGGGCTCAATATT
GGCAAGAACGCCGATACGCCGATCGAGCGCGCGGCAGACGATTACCTGTACTGTCTTGAGCGCGTCTATCCGCACGCAAG
CTATGTCACGGTGAATATCTCATCGCCTAACACGAAGAACCTGCGCCAGCTCCAGGGTGCCAGCGAACTCGATAGCCTGC
TGTCCACACTCAAGGCTGCCCAGCAGCGCCTGGCCGACCAGCACAAGCGCTACGTGCCCGTGGCGCTCAAGATCGCTCCC
GATCTCGACGATGACCAGGTTCGCAACATCGGCGATGCGCTGGTGCGCCACAAGATTGACGGCGTGATCGCCACAAACAC
GACGATCTCGCGCGACGCCGTGAAGGGCCTGCCTCATGCCGAGGAAGCTGGCGGCCTGTCCGGCCGGCCGGTGTTCGAAG
CCTCCACGCGGGTGGTGCGCGCGTTGCGTGAAGTCATTGGCGACGCGCTGCCGATCATCGGCGTGGGCGGCATCTTCAGC
GGCGCCGATGCGCGCGCCAAGATCGACGCCGGCGCGCAGCTCGTGCAGGTCTACAGCGGCCTGATCTATCGCGGGCCGAC
GCTGGTGCGCGAATGCGCCAGCGCCCTGCGCCGATAG

Upstream 100 bases:

>100_bases
CAGTGGCACACCTTCAAGGCTCCGGCGGAAGCATCCGGGCAACCGGCACCCGACCCAGCCCTGGAGTAAAAACGGGCGCA
GGAGGCGCTACAATGCCGCC

Downstream 100 bases:

>100_bases
CGCTTTTCAGGCATTCTGTCGGCCGACACGATCCAGGGAAACACCATGAAAATGATCCGACTCGGCCGCAGCGACCTCGA
AGTCTCGCGCATCTGCCTCG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVPTPRRPWPRPTLVLNALYPLLRPALFSMDAEDAHHFTLNNLMRAKRMGLAGCIGNSIADDPRTVMGVRFPNPVGLAAG
LDKDGAYIDGLAAFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIRNVQASRWKAEGGVLGLNI
GKNADTPIERAADDYLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAP
DLDDDQVRNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEASTRVVRALREVIGDALPIIGVGGIFS
GADARAKIDAGAQLVQVYSGLIYRGPTLVRECASALRR

Sequences:

>Translated_358_residues
MVPTPRRPWPRPTLVLNALYPLLRPALFSMDAEDAHHFTLNNLMRAKRMGLAGCIGNSIADDPRTVMGVRFPNPVGLAAG
LDKDGAYIDGLAAFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIRNVQASRWKAEGGVLGLNI
GKNADTPIERAADDYLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAP
DLDDDQVRNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEASTRVVRALREVIGDALPIIGVGGIFS
GADARAKIDAGAQLVQVYSGLIYRGPTLVRECASALRR
>Mature_358_residues
MVPTPRRPWPRPTLVLNALYPLLRPALFSMDAEDAHHFTLNNLMRAKRMGLAGCIGNSIADDPRTVMGVRFPNPVGLAAG
LDKDGAYIDGLAAFGFGFIEVGTVTPRAQPGNPRPRMFRLPQADALINRMGFNNGGVDAFIRNVQASRWKAEGGVLGLNI
GKNADTPIERAADDYLYCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAP
DLDDDQVRNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEASTRVVRALREVIGDALPIIGVGGIFS
GADARAKIDAGAQLVQVYSGLIYRGPTLVRECASALRR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=303, Percent_Identity=46.2046204620462, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=52.5222551928783, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17509475, Length=361, Percent_Identity=41.2742382271468, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI281361352, Length=343, Percent_Identity=41.1078717201166, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17137316, Length=343, Percent_Identity=41.1078717201166, Blast_Score=239, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38632; Mature: 38632

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPTPRRPWPRPTLVLNALYPLLRPALFSMDAEDAHHFTLNNLMRAKRMGLAGCIGNSIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLAAFGFGFIEVGTVTPRAQPGNPRPRMFRL
CCCCCEEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEC
PQADALINRMGFNNGGVDAFIRNVQASRWKAEGGVLGLNIGKNADTPIERAADDYLYCLE
CCHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHH
RVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAP
HHCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
DLDDDQVRNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEASTRVVR
CCCHHHHHHHHHHHHHHHHCCEEECCCEECHHHHHCCCCHHHCCCCCCCCHHHHHHHHHH
ALREVIGDALPIIGVGGIFSGADARAKIDAGAQLVQVYSGLIYRGPTLVRECASALRR
HHHHHHCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVPTPRRPWPRPTLVLNALYPLLRPALFSMDAEDAHHFTLNNLMRAKRMGLAGCIGNSIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DDPRTVMGVRFPNPVGLAAGLDKDGAYIDGLAAFGFGFIEVGTVTPRAQPGNPRPRMFRL
CCCCCEEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEC
PQADALINRMGFNNGGVDAFIRNVQASRWKAEGGVLGLNIGKNADTPIERAADDYLYCLE
CCHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHH
RVYPHASYVTVNISSPNTKNLRQLQGASELDSLLSTLKAAQQRLADQHKRYVPVALKIAP
HHCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
DLDDDQVRNIGDALVRHKIDGVIATNTTISRDAVKGLPHAEEAGGLSGRPVFEASTRVVR
CCCHHHHHHHHHHHHHHHHCCEEECCCEECHHHHHCCCCHHHCCCCCCCCHHHHHHHHHH
ALREVIGDALPIIGVGGIFSGADARAKIDAGAQLVQVYSGLIYRGPTLVRECASALRR
HHHHHHCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA