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The map label for this gene is gltP2 [H]

Identifier: 94310067

GI number: 94310067

Start: 1227739

End: 1229031

Strand: Direct

Name: gltP2 [H]

Synonym: Rmet_1122

Alternate gene names: 94310067

Gene position: 1227739-1229031 (Clockwise)

Preceding gene: 94310053

Following gene: 94310068

Centisome position: 31.26

GC content: 62.72

Gene sequence:

>1293_bases
ATGAGCACGAAGTCCCATATCACGACCTGGATTCTGATTGCGATGATCCTGGGCGCCGCCGTTGGCTATGCGTGCTACAT
CGCGTTTCCCGACCCGAAGATGGCCAAGGAAGTGGCCGGGTACATCTCGCTCATCACGGATGTGTTCCTGCGGCTGATCA
AGATGATCATCGCGCCACTTGTGTTCTCTACGCTGGTGATCGGCATCGCCCATATGGGGGATGCGGGCACTGTGGGGCGG
GTGGGCGGCAAGGCGATGGCGTGGTTCATTACCGCGTCGCTGGTGTCGCTGACCCTTGGCCTGATCATGGCGACGGTGCT
GGCGCCGGGCCACAACATCGGCCTGCCGTTGCCCGACGTGGGCTCCGCGACCAACCTCAAAACCAACGCCTTCACGCTGA
AGGACTTCGTCACCCATCTGGTGCCCAAATCGGTGGGCGAGGCGATGGCGAACAACGAGATCCTGCAGATCGTGGTGTTC
TCGATCTTCTTCGGCACCGCGATCTCGATGCTCGGCGAACGTGGCGCGCGCATGGCCGGCGTGATCGACGACCTCGCGCA
GATCATGCTCAAGATCACCGGCGCGGTGATGTGGCTGGCACCGATCGCGGTGTTTGCGGCGATTGCGTCCACGGTGACCA
CGCAGGGGCTCGGCATCCTGGTGACCTTCGCCAAGTTCATGGGCAGCTTCTACCTGTCGCTGTTCGTGCTCTGGGCGCTA
CTGGCGCTGGCCGGCTACATTTTCCTCGGTAGCCGCGTCTTCACGCTGATCCGGCTCATCCGCGAGCCGTTCCTGATTTC
GTTTTCGACGGCGAGCTCCGAAGCGGCCTATCCGAAGCTGCTCGATTCGCTCGACCGTTTCGGTGTCGATCGCAAGATCT
CGAGCTTCGTGCTGCCGCTCGGCTATTCGTTCAACCTTGACGGTTCAATGATGTACTGCACGTTCGCTGTGCTGTTCATT
GCGCAGGCGTATGACATCCACCTGCCGCTGGGCACGCAGATCACGATGCTGCTGCTGCTGATGCTGACTTCGAAGGGAAT
GGCCGGCGTGCCGCGCGCCTCGCTGGTGGTGATCGCCGCCACGCTGAACCAGTTCGGCATTCCGGAGGCGGGTTTGCTGC
TGATCATGGGCGTGGACCAGTTCCTCGACATGGGCAGGTCGGCGACCAACGCGGTCGGCAATTCGATCGCCGCCGCTGTG
GTGGCCAAGTGGGAAGGGCAGCTGTCATCCGGGCCGGTTGCCGAGACCGAGAGCGCGATCGCCGCGGACGATGCGAGCAC
GGCGGAGGCCTGA

Upstream 100 bases:

>100_bases
AGAGTGCTGGCGCAGACGCAGGACATGCAGGCTGGCACGGCATGTATGACACGCAGGACACGCAGGACATCCGTATGGCC
GCCCCCCCAAAGGAGATGTC

Downstream 100 bases:

>100_bases
CATCATGGCGGCGCGTTTGCCGGGAATGCTGGCCGCACTGTGGCTGGGGCTGGTCGCGACGTTTGGCGCGACGCTGGCCG
TGGCCCAGGACGCCACCGTG

Product: dicarboxylate/amino acid:cation (Na+ or H+) symporter, DAACS family

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSTKSHITTWILIAMILGAAVGYACYIAFPDPKMAKEVAGYISLITDVFLRLIKMIIAPLVFSTLVIGIAHMGDAGTVGR
VGGKAMAWFITASLVSLTLGLIMATVLAPGHNIGLPLPDVGSATNLKTNAFTLKDFVTHLVPKSVGEAMANNEILQIVVF
SIFFGTAISMLGERGARMAGVIDDLAQIMLKITGAVMWLAPIAVFAAIASTVTTQGLGILVTFAKFMGSFYLSLFVLWAL
LALAGYIFLGSRVFTLIRLIREPFLISFSTASSEAAYPKLLDSLDRFGVDRKISSFVLPLGYSFNLDGSMMYCTFAVLFI
AQAYDIHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFGIPEAGLLLIMGVDQFLDMGRSATNAVGNSIAAAV
VAKWEGQLSSGPVAETESAIAADDASTAEA

Sequences:

>Translated_430_residues
MSTKSHITTWILIAMILGAAVGYACYIAFPDPKMAKEVAGYISLITDVFLRLIKMIIAPLVFSTLVIGIAHMGDAGTVGR
VGGKAMAWFITASLVSLTLGLIMATVLAPGHNIGLPLPDVGSATNLKTNAFTLKDFVTHLVPKSVGEAMANNEILQIVVF
SIFFGTAISMLGERGARMAGVIDDLAQIMLKITGAVMWLAPIAVFAAIASTVTTQGLGILVTFAKFMGSFYLSLFVLWAL
LALAGYIFLGSRVFTLIRLIREPFLISFSTASSEAAYPKLLDSLDRFGVDRKISSFVLPLGYSFNLDGSMMYCTFAVLFI
AQAYDIHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFGIPEAGLLLIMGVDQFLDMGRSATNAVGNSIAAAV
VAKWEGQLSSGPVAETESAIAADDASTAEA
>Mature_429_residues
STKSHITTWILIAMILGAAVGYACYIAFPDPKMAKEVAGYISLITDVFLRLIKMIIAPLVFSTLVIGIAHMGDAGTVGRV
GGKAMAWFITASLVSLTLGLIMATVLAPGHNIGLPLPDVGSATNLKTNAFTLKDFVTHLVPKSVGEAMANNEILQIVVFS
IFFGTAISMLGERGARMAGVIDDLAQIMLKITGAVMWLAPIAVFAAIASTVTTQGLGILVTFAKFMGSFYLSLFVLWALL
ALAGYIFLGSRVFTLIRLIREPFLISFSTASSEAAYPKLLDSLDRFGVDRKISSFVLPLGYSFNLDGSMMYCTFAVLFIA
QAYDIHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFGIPEAGLLLIMGVDQFLDMGRSATNAVGNSIAAAVV
AKWEGQLSSGPVAETESAIAADDASTAEA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane. This transport system plays an important role in the energy supply of rhizobium-legume symbionts [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=406, Percent_Identity=27.3399014778325, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI169790839, Length=468, Percent_Identity=26.0683760683761, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI40254478, Length=457, Percent_Identity=24.72647702407, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI194239697, Length=462, Percent_Identity=26.1904761904762, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4827012, Length=253, Percent_Identity=32.4110671936759, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI66773030, Length=417, Percent_Identity=24.220623501199, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI5032093, Length=390, Percent_Identity=26.1538461538462, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223468566, Length=290, Percent_Identity=26.2068965517241, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI223468564, Length=265, Percent_Identity=27.5471698113208, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI262359914, Length=388, Percent_Identity=24.4845360824742, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI301601644, Length=171, Percent_Identity=32.1637426900585, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1789947, Length=401, Percent_Identity=39.1521197007481, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1790514, Length=429, Percent_Identity=37.2960372960373, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788024, Length=422, Percent_Identity=23.4597156398104, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789473, Length=240, Percent_Identity=25.8333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=458, Percent_Identity=25.5458515283843, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983099, Length=460, Percent_Identity=25.6521739130435, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71983106, Length=454, Percent_Identity=25.7709251101322, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71996953, Length=462, Percent_Identity=26.6233766233766, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193206505, Length=414, Percent_Identity=28.0193236714976, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=469, Percent_Identity=23.6673773987207, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17541374, Length=404, Percent_Identity=24.7524752475248, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=24.7663551401869, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=24.7663551401869, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=24.7663551401869, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360481, Length=432, Percent_Identity=24.537037037037, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281360483, Length=432, Percent_Identity=24.537037037037, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137666, Length=432, Percent_Identity=24.537037037037, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45486; Mature: 45354

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCC
>Mature Secondary Structure 
STKSHITTWILIAMILGAAVGYACYIAFPDPKMAKEVAGYISLITDVFLRLIKMIIAPL
CCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSTLVIGIAHMGDAGTVGRVGGKAMAWFITASLVSLTLGLIMATVLAPGHNIGLPLPDV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GSATNLKTNAFTLKDFVTHLVPKSVGEAMANNEILQIVVFSIFFGTAISMLGERGARMAG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VIDDLAQIMLKITGAVMWLAPIAVFAAIASTVTTQGLGILVTFAKFMGSFYLSLFVLWAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LALAGYIFLGSRVFTLIRLIREPFLISFSTASSEAAYPKLLDSLDRFGVDRKISSFVLPL
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCC
GYSFNLDGSMMYCTFAVLFIAQAYDIHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAA
CCEECCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TLNQFGIPEAGLLLIMGVDQFLDMGRSATNAVGNSIAAAVVAKWEGQLSSGPVAETESAI
HHHHCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
AADDASTAEA
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]