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The map label for this gene is allB [H]

Identifier: 94310048

GI number: 94310048

Start: 1199767

End: 1201164

Strand: Direct

Name: allB [H]

Synonym: Rmet_1103

Alternate gene names: 94310048

Gene position: 1199767-1201164 (Clockwise)

Preceding gene: 94310047

Following gene: 94310050

Centisome position: 30.54

GC content: 64.81

Gene sequence:

>1398_bases
GTGACGGATGGAACAGTCCCCGGCGTTGGGCTGCCATCGGCACGCCGCCATGCGGACTTGCTGGTGATCGGCGGGGCCCT
CGTCACCCCCAACGGTGTCGAGCGCGCCGATGTCGCATGTGCGGCCGGTCGCATCGTGGCGCTTGGAGACCTCCAGTGCT
CGTGGACGGCCGATGCCACGCTCGACGCGAAGGGTCTGCACGTACTGCCGGGGGTTATCGATAGTCAGGTGCATTTCCGC
GAGCCCGGTTTGACGCACAAGGAAACGTTGGAGGCGGGCACGCGCGGTGCGGCGCTGGGCGGCGTCACGGCGGTATTCGA
GATGCCGAACACGCAACCGCTCACATTGCGTGCGGAGGATCTCCGGGCCAAGCTTGATGCGGCACAAGGCCGTGCGTGGT
GCGACCACGCGTTCTACATCGGCGGGTCGTCGGTGAATGCCGAGCACCTGGAGTACCTGGAGAGTCTGCCTGGCTGTGCT
GGCGTGAAGATCTTCATGGGCAGCTCGTTCGGCGACCTGCTGGCGGATGACGACGAGGTGCTATGCCGGATCCTGGCGCA
CGGTCGCCGCAGGATGGCCGTGCATGCTGAGGATGAGGCCCGGCTGCGCGAACGCAGGATCATCGCTGAGTCGAGCGGCG
ACGTGCGCCAGCACCCGGTCTGGCGAGACGCCCGCAGCGCATTGCTGGCCACGCAGCGCATCGTGAAGCTTGCTGGGGAT
ACTGGCCGGCGCCTTCATATCCTGCATGTTTCGACTGCCGAAGAGATTGCCTTCCTGGCGGATCGGAAGGATCGCGTGAC
AGTTGAAGTGACGCCGCACCACCTGACCCTGGAGGCGCCAGAATGCTACGAGCGACTGGGGACGCTGGCTCAAATGAATC
CACCAGTCCGTGAACGTTGCCACCGGAACGCACTATGGCAGGCGATTCGCGAGGGCGTCGGCGATGTCATCGGTAGTGAC
CATGCGCCTCACACGCCTAAGGAAAAGAGTCGTCCATATCCAGCTTCGCCCAGCGGCATGACCGGTGTGCAGACACTGGT
GCCGGTGATGCTCGACCATGTGCATCGTGGCCAATTGAGTCTTCAGCGATTCGTCGACCTGACAAGCGCCGGACCGGCCC
GGATCTTCGGTGTCGAAGGGAAAGGCCGTATCGCGCTTGGCTACGACGCCGACTTGACGCTGGTCGATCTGGCGGCTCGC
CGGACCATTCGCAACGACTGGATCGCGAGTGTCAGTGGGTGGACACCCTATGACGGCATCGGCGTTACGGGCTGGCCGAT
CCATACCGTGGTGCGTGGCCACATCGTCGTGCGGGACGAAGCGCTCGTCGGGACGACCCCTCTGGGGCGACCGTTGCGCT
TCCTCGAAGCGCCACCTCGAGTGCCAGCCGGAGTCTGA

Upstream 100 bases:

>100_bases
CGCGTTGGTGCGCGGATACAAAGCCATCCAGAACGAGTTCTGAAACATGTCAGTTGCTCCCACGCTCCACGCTGCCACGC
GCAATCGTGGAGGACACAGC

Downstream 100 bases:

>100_bases
AATCAGGCGGCAGGGGGCCGGGCCAGGTCGGGGCAGCCAATGAATGCTGATGGTGCGCGTGGTCGTCAGAACTGCAGCGA
CGCGTTCGCCAGGAACGTGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTDGTVPGVGLPSARRHADLLVIGGALVTPNGVERADVACAAGRIVALGDLQCSWTADATLDAKGLHVLPGVIDSQVHFR
EPGLTHKETLEAGTRGAALGGVTAVFEMPNTQPLTLRAEDLRAKLDAAQGRAWCDHAFYIGGSSVNAEHLEYLESLPGCA
GVKIFMGSSFGDLLADDDEVLCRILAHGRRRMAVHAEDEARLRERRIIAESSGDVRQHPVWRDARSALLATQRIVKLAGD
TGRRLHILHVSTAEEIAFLADRKDRVTVEVTPHHLTLEAPECYERLGTLAQMNPPVRERCHRNALWQAIREGVGDVIGSD
HAPHTPKEKSRPYPASPSGMTGVQTLVPVMLDHVHRGQLSLQRFVDLTSAGPARIFGVEGKGRIALGYDADLTLVDLAAR
RTIRNDWIASVSGWTPYDGIGVTGWPIHTVVRGHIVVRDEALVGTTPLGRPLRFLEAPPRVPAGV

Sequences:

>Translated_465_residues
MTDGTVPGVGLPSARRHADLLVIGGALVTPNGVERADVACAAGRIVALGDLQCSWTADATLDAKGLHVLPGVIDSQVHFR
EPGLTHKETLEAGTRGAALGGVTAVFEMPNTQPLTLRAEDLRAKLDAAQGRAWCDHAFYIGGSSVNAEHLEYLESLPGCA
GVKIFMGSSFGDLLADDDEVLCRILAHGRRRMAVHAEDEARLRERRIIAESSGDVRQHPVWRDARSALLATQRIVKLAGD
TGRRLHILHVSTAEEIAFLADRKDRVTVEVTPHHLTLEAPECYERLGTLAQMNPPVRERCHRNALWQAIREGVGDVIGSD
HAPHTPKEKSRPYPASPSGMTGVQTLVPVMLDHVHRGQLSLQRFVDLTSAGPARIFGVEGKGRIALGYDADLTLVDLAAR
RTIRNDWIASVSGWTPYDGIGVTGWPIHTVVRGHIVVRDEALVGTTPLGRPLRFLEAPPRVPAGV
>Mature_464_residues
TDGTVPGVGLPSARRHADLLVIGGALVTPNGVERADVACAAGRIVALGDLQCSWTADATLDAKGLHVLPGVIDSQVHFRE
PGLTHKETLEAGTRGAALGGVTAVFEMPNTQPLTLRAEDLRAKLDAAQGRAWCDHAFYIGGSSVNAEHLEYLESLPGCAG
VKIFMGSSFGDLLADDDEVLCRILAHGRRRMAVHAEDEARLRERRIIAESSGDVRQHPVWRDARSALLATQRIVKLAGDT
GRRLHILHVSTAEEIAFLADRKDRVTVEVTPHHLTLEAPECYERLGTLAQMNPPVRERCHRNALWQAIREGVGDVIGSDH
APHTPKEKSRPYPASPSGMTGVQTLVPVMLDHVHRGQLSLQRFVDLTSAGPARIFGVEGKGRIALGYDADLTLVDLAARR
TIRNDWIASVSGWTPYDGIGVTGWPIHTVVRGHIVVRDEALVGTTPLGRPLRFLEAPPRVPAGV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=447, Percent_Identity=30.8724832214765, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI19923821, Length=463, Percent_Identity=26.5658747300216, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503375, Length=443, Percent_Identity=27.0880361173815, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503379, Length=456, Percent_Identity=25.219298245614, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=24.9448123620309, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=24.9448123620309, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503377, Length=451, Percent_Identity=25.9423503325942, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI190194363, Length=458, Percent_Identity=26.4192139737991, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786722, Length=454, Percent_Identity=31.4977973568282, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87082175, Length=465, Percent_Identity=26.8817204301075, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=426, Percent_Identity=30.0469483568075, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71989490, Length=445, Percent_Identity=25.8426966292135, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17539558, Length=443, Percent_Identity=26.410835214447, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=402, Percent_Identity=32.3383084577114, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24642586, Length=396, Percent_Identity=33.0808080808081, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI18859883, Length=429, Percent_Identity=29.1375291375291, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221377917, Length=435, Percent_Identity=27.5862068965517, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17137462, Length=432, Percent_Identity=27.5462962962963, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50257; Mature: 50126

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTVPGVGLPSARRHADLLVIGGALVTPNGVERADVACAAGRIVALGDLQCSWTADAT
CCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCCEEEEECCEEEECCCCE
LDAKGLHVLPGVIDSQVHFREPGLTHKETLEAGTRGAALGGVTAVFEMPNTQPLTLRAED
ECCCCCEECCCCCCCCEEECCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHH
LRAKLDAAQGRAWCDHAFYIGGSSVNAEHLEYLESLPGCAGVKIFMGSSFGDLLADDDEV
HHHHHHHHCCCEEECEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCHHH
LCRILAHGRRRMAVHAEDEARLRERRIIAESSGDVRQHPVWRDARSALLATQRIVKLAGD
HHHHHHCCCCEEEEECCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGRRLHILHVSTAEEIAFLADRKDRVTVEVTPHHLTLEAPECYERLGTLAQMNPPVRERC
CCCEEEEEEECCHHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHCCCHHHHHH
HRNALWQAIREGVGDVIGSDHAPHTPKEKSRPYPASPSGMTGVQTLVPVMLDHVHRGQLS
HHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LQRFVDLTSAGPARIFGVEGKGRIALGYDADLTLVDLAARRTIRNDWIASVSGWTPYDGI
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCC
GVTGWPIHTVVRGHIVVRDEALVGTTPLGRPLRFLEAPPRVPAGV
CCCCCHHHHEEEEEEEEECCEEECCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
TDGTVPGVGLPSARRHADLLVIGGALVTPNGVERADVACAAGRIVALGDLQCSWTADAT
CCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCCEEEEECCEEEECCCCE
LDAKGLHVLPGVIDSQVHFREPGLTHKETLEAGTRGAALGGVTAVFEMPNTQPLTLRAED
ECCCCCEECCCCCCCCEEECCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHH
LRAKLDAAQGRAWCDHAFYIGGSSVNAEHLEYLESLPGCAGVKIFMGSSFGDLLADDDEV
HHHHHHHHCCCEEECEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCHHH
LCRILAHGRRRMAVHAEDEARLRERRIIAESSGDVRQHPVWRDARSALLATQRIVKLAGD
HHHHHHCCCCEEEEECCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGRRLHILHVSTAEEIAFLADRKDRVTVEVTPHHLTLEAPECYERLGTLAQMNPPVRERC
CCCEEEEEEECCHHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHCCCHHHHHH
HRNALWQAIREGVGDVIGSDHAPHTPKEKSRPYPASPSGMTGVQTLVPVMLDHVHRGQLS
HHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LQRFVDLTSAGPARIFGVEGKGRIALGYDADLTLVDLAARRTIRNDWIASVSGWTPYDGI
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCC
GVTGWPIHTVVRGHIVVRDEALVGTTPLGRPLRFLEAPPRVPAGV
CCCCCHHHHEEEEEEEEECCEEECCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]