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The map label for this gene is tyrB [H]

Identifier: 94309963

GI number: 94309963

Start: 1107870

End: 1109066

Strand: Reverse

Name: tyrB [H]

Synonym: Rmet_1018

Alternate gene names: 94309963

Gene position: 1109066-1107870 (Counterclockwise)

Preceding gene: 94309977

Following gene: 94309962

Centisome position: 28.23

GC content: 65.0

Gene sequence:

>1197_bases
ATGAGTTTGTTTTCTGCCGTCGAGATGGCCCCGCGCGACCCGATCCTGGGCCTGAATGAAGCGTTCAATGCCGATACCCG
CGCCACCAAGGTGAACCTGGGCGTTGGCGTGTACTTCACCGACGAAGGGAAAATTCCGCTGCTGCGCGCCGTGCAGGAGG
CCGAAAAGGCCCGCCTGACGACCGCCACGCCGCGCGGCTACCTGCCGATCGAAGGCATCGCCGCCTATGACCAGGCCGTG
CAAACCTTGCTGTTCGGCAAGGAATCGCCCCTGATCACCGAAGGCCGCGTGGTGACGGCTCAGGCACTCGGCGGCACTGG
CGCCCTGAAGATCGGCGCCGACTTCCTGAAGCGCCTGTACCCGAACGCGTCGGTCGCGATCAGCGATCCGAGCTGGGAAA
ACCACCGCGCGCTGTTCGAAGCTGCCGGCTTCCCTGTGGTCAACTACGCCTACTACGACGCTGCCAGCCACGGCCTGAAC
TTCGCCGGCATGGTGGAATCGCTGAAGTCGTACCCGGCCAACACGATCGTCGTGCTGCACGCCTGCTGCCACAACCCGAC
CGGCGTGGACCTGGACGAAGCCCAGTGGAAGCAGGTCGTGGAACTGGTCAAGGAACGTAACCTGATCCCGTTCCTGGACA
TGGCCTACCAAGGCTTTGCCGAGGGTATCGAGCCGGACGGCGCCGCTGTGCGCCTGTTCGCGGAGTCGGGCCTGCCGTTC
TTCGTTTCCAGCTCGTTCTCGAAGAGCTTCTCGCTGTACGGCGAGCGCGTTGGCGCCCTGTCGATCGTGACCACGGGCAA
GGAAGAAGCCCAGCGCGTGATGTCGCAGATCAAGCGCGTCATCCGCACGAACTACTCGAACCCGCCGACCCACGGCGGCA
CTGTGGTGGCCACCGTGCTGAACAGCCCGGAACTGCGCGCCATGTGGGAGCAGGAACTGGCCGAAATGCGCGACCGCATC
AAGCTGATGCGCCATGCGCTGGTCGACAAGCTGGCCGCCAAGGGCGTGCCGGGCGACTTCTCGTTCGTGAAGGCCCAGCG
CGGCATGTTCTCGTACTCGGGCCTGACCTCGGCCCAGGTTGACCGCCTGCGCACCGAACACGGCATCTACGCCGTGGGCA
CGGGCCGCATCTGCGTGGCAGCGTTGAACAGCCGCAACATCGACGCCGTGGTGAACGCGATCGCCGCCGTCTACTAA

Upstream 100 bases:

>100_bases
GTTCTGTCAGGAGTGTGTTCCAGGTTCCGCTGCAGCCACTGCGCAGTCGAAGCGATTCTACGCCCTCCGTTTTGTTACAC
AGCTGACCACGAGATCCCAA

Downstream 100 bases:

>100_bases
ACCGGCAACATCGAACGGGTGCCGCACCAAAATGTGGCATCCGGCAGCGAAAGGCGACCTGGAGGCCACTCCGGTCGCCT
TTTTCTTTGGCCGCTCGGAA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAV
QTLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPNASVAISDPSWENHRALFEAAGFPVVNYAYYDAASHGLN
FAGMVESLKSYPANTIVVLHACCHNPTGVDLDEAQWKQVVELVKERNLIPFLDMAYQGFAEGIEPDGAAVRLFAESGLPF
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVMSQIKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEQELAEMRDRI
KLMRHALVDKLAAKGVPGDFSFVKAQRGMFSYSGLTSAQVDRLRTEHGIYAVGTGRICVAALNSRNIDAVVNAIAAVY

Sequences:

>Translated_398_residues
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAV
QTLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPNASVAISDPSWENHRALFEAAGFPVVNYAYYDAASHGLN
FAGMVESLKSYPANTIVVLHACCHNPTGVDLDEAQWKQVVELVKERNLIPFLDMAYQGFAEGIEPDGAAVRLFAESGLPF
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVMSQIKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEQELAEMRDRI
KLMRHALVDKLAAKGVPGDFSFVKAQRGMFSYSGLTSAQVDRLRTEHGIYAVGTGRICVAALNSRNIDAVVNAIAAVY
>Mature_397_residues
SLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAVQ
TLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPNASVAISDPSWENHRALFEAAGFPVVNYAYYDAASHGLNF
AGMVESLKSYPANTIVVLHACCHNPTGVDLDEAQWKQVVELVKERNLIPFLDMAYQGFAEGIEPDGAAVRLFAESGLPFF
VSSSFSKSFSLYGERVGALSIVTTGKEEAQRVMSQIKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEQELAEMRDRIK
LMRHALVDKLAAKGVPGDFSFVKAQRGMFSYSGLTSAQVDRLRTEHGIYAVGTGRICVAALNSRNIDAVVNAIAAVY

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=44.4444444444444, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI4504067, Length=401, Percent_Identity=43.3915211970075, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=29.242819843342, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=52.5125628140703, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1787159, Length=395, Percent_Identity=48.6075949367089, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71981858, Length=398, Percent_Identity=41.4572864321608, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=41.8136020151133, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17569539, Length=398, Percent_Identity=40.9547738693467, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17569537, Length=398, Percent_Identity=33.1658291457286, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17550384, Length=265, Percent_Identity=37.3584905660377, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25147136, Length=224, Percent_Identity=38.8392857142857, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=39.0123456790123, Blast_Score=315, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=33.1797235023041, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=44.2211055276382, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=44.2211055276382, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=44.2455242966752, Blast_Score=340, Evalue=9e-94,
Organism=Drosophila melanogaster, GI24654046, Length=399, Percent_Identity=40.1002506265664, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI19922362, Length=399, Percent_Identity=40.1002506265664, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43144; Mature: 43013

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLT
CCHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHEE
TATPRGYLPIEGIAAYDQAVQTLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLY
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCEEHHHHHHHHHHC
PNASVAISDPSWENHRALFEAAGFPVVNYAYYDAASHGLNFAGMVESLKSYPANTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHCCCCEEEEEE
ACCHNPTGVDLDEAQWKQVVELVKERNLIPFLDMAYQGFAEGIEPDGAAVRLFAESGLPF
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVMSQIKRVIRTNYSNPPTHGGTVVATVL
EEECCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
NSPELRAMWEQELAEMRDRIKLMRHALVDKLAAKGVPGDFSFVKAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHH
DRLRTEHGIYAVGTGRICVAALNSRNIDAVVNAIAAVY
HHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLT
CHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHEE
TATPRGYLPIEGIAAYDQAVQTLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLY
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCEEHHHHHHHHHHC
PNASVAISDPSWENHRALFEAAGFPVVNYAYYDAASHGLNFAGMVESLKSYPANTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHCCCCEEEEEE
ACCHNPTGVDLDEAQWKQVVELVKERNLIPFLDMAYQGFAEGIEPDGAAVRLFAESGLPF
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVMSQIKRVIRTNYSNPPTHGGTVVATVL
EEECCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
NSPELRAMWEQELAEMRDRIKLMRHALVDKLAAKGVPGDFSFVKAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHH
DRLRTEHGIYAVGTGRICVAALNSRNIDAVVNAIAAVY
HHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]