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The map label for this gene is nuoL [H]

Identifier: 94309883

GI number: 94309883

Start: 1022490

End: 1024568

Strand: Direct

Name: nuoL [H]

Synonym: Rmet_0938

Alternate gene names: 94309883

Gene position: 1022490-1024568 (Clockwise)

Preceding gene: 94309882

Following gene: 94309884

Centisome position: 26.03

GC content: 61.28

Gene sequence:

>2079_bases
ATGGCAACCACGCTCAACCCCAACCTGCTGCTGGCGATTCCGCTGGCGCCGCTCGCCGGCGCCGCGATAGCTGGTCTGTT
CGGTACCAAGTTCTTCGGCACGTTTTCCTCGGAGTCGCGCGGCGGCCGGATCGTGGCGCATTCGGCAACGATTCTCGGCG
TCGCCATCGCTTTCGTCCTGTCGGTGATGGTGCTGCTCGACGTGCTCAACGGCGCGGGCTACAACGCCACCGTGTACGAG
TGGATGACGATCGGCAGCCTGAAGATGGAGGTCGGCTTCCTGGTCGACTCCCTGACCGCGATGATGATGGTGGTCGTGAC
CTTCGTCTCGCTGATGGTGCACATCTACACCGTCGGTTACATGGAAGGGGACCCCGGCTACAACCGATTCTTCGCCTACA
TCTCGCTCTTCACCTTCTCGATGCTGATGCTGGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTG
GGCCTGGTGTCGTACCTGCTGATCGGTTTCTGGTACACCCGCCCGACGGCGATCTTCGCGAACCTGAAGGCGTTCCTGGT
CAACCGTGTGGGTGACTTCGGCTTCATCCTCGGTATCGGCCTGCTGCTGGCATACAGCGGCAGCATGAACTACACGGATG
TCTTCGCTACCCGCGAGCAGCTGGCTACCGTGATCTTCCCGGGTACCGACTGGATGATGATCACCGTGGCCTGCATCTGC
CTGTTCATCGGCGCGATGGGCAAGTCGGCGCAGTTCCCGCTGCACGTCTGGCTGCCTGACTCGATGGAAGGCCCGACCCC
GATCTCGGCACTGATTCACGCGGCAACCATGGTGACCGCCGGTATCTTCATGGTGGCGCGCATGTCGCCGCTGTTCGAAC
TGTCGGACACCGCGCTGTCGTTTGTACTGGTCATCGGCGCGATCACCGCGCTGTTCATGGGCTTCCTGGGCATCATCCAG
AACGATATCAAGCGCGTGGTTGCTTACTCCACGCTGTCGCAGCTCGGTTACATGACCGTCGCGCTGGGCGCTTCGGCTTA
CTCGGTAGCCGTGTTCCACCTGATGACCCACGCGTTCTTCAAGGCACTGCTGTTCCTTGCCGCGGGCTCAGTGATCATCG
GCATGCACCATGACCAGGACATCCGCAACATGGGCGGCCTGCGCAAGTACATGCCGATCACGTGGATCACGTCGTTGGTC
GGTTCGCTGGCCCTGATCGGCACGCCGTTCTTCGCGGGCTTCTACTCGAAGGACTCGATCATCGAGGCGGTGGCCGAATC
GCATATCGCTGGCTCGGGCTTCGCGTACTTCGCGGTGCTGGCCGGTGTGTTCGTGACCGCCTTCTATTCGTTCCGCATGT
ACTTCCTGGTGTTCCACGGTGAAGAGCGCTTCGGCAAGGCCGATGACCACCATGGCAACCACCATGACGAGGAAGTCTCG
CACGACCATCACCACGGCCTGGCTCCGGGCCAGAAGCCGCATGAGTCCCCGTGGGTCGTGACGCTGCCGCTGGTGCTGCT
GGCCATCCCGTCGGTGATCGTTGGCGCCATCGCCATCGAGCCGATGCTGTTCGGCGAGTTCTTCAAGCATGGCGTGGCCT
TCAAGGACGTGATCTTCGTCGGCGAGAACCATCATGCGATGGAAGAGCTGAAGGAAGCGTTCCATGGCTGGGTGCCGATG
GCGATTCACTCGCTGACGACGCCGGTGCTGTGGCTGGCTATCGCAGGCGTGGTGCTGTCGTGGTTCTTCTACATGAAGCG
CCCGGACATCCCCGCGGCGATCAAGCAACGTTTCTCCGGTCTCTACAAGCTGCTGGACAACAAGTACTACATGGACGCGA
TCAACGAAGCGGTTTTCGCTCGCGGCGCGCGCCTGCTGGGTACCGGCCTGTGGAAGGGTGGTGACCAGAGCTTCATCGAC
GGCCTGTTCGTCAATGGTTCGGCCCGCGTGGTGGCGTCGTTTGCTGCGGCCAGCCGCTACCTGCAGTCCGGTTATATCTA
CCATTACGCTTTCGCGATGATCATCGGCATGTTGGTGCTCCTGACGCTGACGATCACTGGCGTGATAGGCACCAAGTGA

Upstream 100 bases:

>100_bases
ACGATCAACGTGGACGACATGGATACCCTCAAGGGCTGATTCATGACCGCATCCACATTGAACCAAGACTGCTCCCCGAT
CGCACACCAATAAGCGTCCT

Downstream 100 bases:

>100_bases
TAGGCACCAAAGCAAGGAAAACATAGAAATGGTTCTGTCTTTCGCAATCTGGCTGCCTATCTTCTTCGGGCTGGTGGTAT
TGATGTTCGGCTCCGACCGA

Product: NADH:ubiquinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGTFSSESRGGRIVAHSATILGVAIAFVLSVMVLLDVLNGAGYNATVYE
WMTIGSLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMEGDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAV
GLVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYTDVFATREQLATVIFPGTDWMMITVACIC
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLVIGAITALFMGFLGIIQ
NDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLV
GSLALIGTPFFAGFYSKDSIIEAVAESHIAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGEERFGKADDHHGNHHDEEVS
HDHHHGLAPGQKPHESPWVVTLPLVLLAIPSVIVGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMEELKEAFHGWVPM
AIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPAAIKQRFSGLYKLLDNKYYMDAINEAVFARGARLLGTGLWKGGDQSFID
GLFVNGSARVVASFAAASRYLQSGYIYHYAFAMIIGMLVLLTLTITGVIGTK

Sequences:

>Translated_692_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGTFSSESRGGRIVAHSATILGVAIAFVLSVMVLLDVLNGAGYNATVYE
WMTIGSLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMEGDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAV
GLVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYTDVFATREQLATVIFPGTDWMMITVACIC
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLVIGAITALFMGFLGIIQ
NDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLV
GSLALIGTPFFAGFYSKDSIIEAVAESHIAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGEERFGKADDHHGNHHDEEVS
HDHHHGLAPGQKPHESPWVVTLPLVLLAIPSVIVGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMEELKEAFHGWVPM
AIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPAAIKQRFSGLYKLLDNKYYMDAINEAVFARGARLLGTGLWKGGDQSFID
GLFVNGSARVVASFAAASRYLQSGYIYHYAFAMIIGMLVLLTLTITGVIGTK
>Mature_691_residues
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGTFSSESRGGRIVAHSATILGVAIAFVLSVMVLLDVLNGAGYNATVYEW
MTIGSLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMEGDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVG
LVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYTDVFATREQLATVIFPGTDWMMITVACICL
FIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLVIGAITALFMGFLGIIQN
DIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVG
SLALIGTPFFAGFYSKDSIIEAVAESHIAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGEERFGKADDHHGNHHDEEVSH
DHHHGLAPGQKPHESPWVVTLPLVLLAIPSVIVGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMEELKEAFHGWVPMA
IHSLTTPVLWLAIAGVVLSWFFYMKRPDIPAAIKQRFSGLYKLLDNKYYMDAINEAVFARGARLLGTGLWKGGDQSFIDG
LFVNGSARVVASFAAASRYLQSGYIYHYAFAMIIGMLVLLTLTITGVIGTK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=396, Percent_Identity=42.1717171717172, Blast_Score=308, Evalue=1e-83,
Organism=Escherichia coli, GI1788614, Length=554, Percent_Identity=40.072202166065, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1788829, Length=342, Percent_Identity=31.2865497076023, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788831, Length=360, Percent_Identity=27.7777777777778, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI1788827, Length=409, Percent_Identity=29.3398533007335, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367154, Length=192, Percent_Identity=30.2083333333333, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=398, Percent_Identity=24.1206030150754, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI145693160, Length=391, Percent_Identity=24.8081841432225, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75601; Mature: 75470

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGTFSSESRGGRIVAHSATILGVAIAFVL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
SVMVLLDVLNGAGYNATVYEWMTIGSLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGY
HHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MEGDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIFA
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHH
NLKAFLVNRVGDFGFILGIGLLLAYSGSMNYTDVFATREQLATVIFPGTDWMMITVACIC
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALS
HHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FVLVIGAITALFMGFLGIIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KALLFLAAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVGSLALIGTPFFAGFYSKDSI
HHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
IEAVAESHIAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGEERFGKADDHHGNHHDEEVS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCCCCCCHHCC
HDHHHGLAPGQKPHESPWVVTLPLVLLAIPSVIVGAIAIEPMLFGEFFKHGVAFKDVIFV
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHEEEE
GENHHAMEELKEAFHGWVPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPAAIKQRFSG
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LYKLLDNKYYMDAINEAVFARGARLLGTGLWKGGDQSFIDGLFVNGSARVVASFAAASRY
HHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHH
LQSGYIYHYAFAMIIGMLVLLTLTITGVIGTK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGTFSSESRGGRIVAHSATILGVAIAFVL
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
SVMVLLDVLNGAGYNATVYEWMTIGSLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGY
HHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MEGDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIFA
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHH
NLKAFLVNRVGDFGFILGIGLLLAYSGSMNYTDVFATREQLATVIFPGTDWMMITVACIC
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALS
HHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FVLVIGAITALFMGFLGIIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KALLFLAAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVGSLALIGTPFFAGFYSKDSI
HHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
IEAVAESHIAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGEERFGKADDHHGNHHDEEVS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCCCCCCHHCC
HDHHHGLAPGQKPHESPWVVTLPLVLLAIPSVIVGAIAIEPMLFGEFFKHGVAFKDVIFV
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHEEEE
GENHHAMEELKEAFHGWVPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPAAIKQRFSG
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LYKLLDNKYYMDAINEAVFARGARLLGTGLWKGGDQSFIDGLFVNGSARVVASFAAASRY
HHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHH
LQSGYIYHYAFAMIIGMLVLLTLTITGVIGTK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]