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The map label for this gene is gmk [H]

Identifier: 94309801

GI number: 94309801

Start: 936651

End: 937301

Strand: Direct

Name: gmk [H]

Synonym: Rmet_0856

Alternate gene names: 94309801

Gene position: 936651-937301 (Clockwise)

Preceding gene: 94309800

Following gene: 94309802

Centisome position: 23.84

GC content: 61.9

Gene sequence:

>651_bases
ATGAGCGAAACGACCCACACCGCCATCGATACCGCCTATCCGGGCAACCTGTTCATGGTGGTGGCCCCGTCCGGGGCCGG
CAAATCCACGCTGGTCAACGCGCTGCTGGCGCAGGACAAGGCAATCCGCCTGTCGATCTCGCACACCACGCGCAGTCCGC
GTCCCGGTGAGCAGAACGGCCGCGAGTACCACTTCATCTCCGTGGACGAGTTCCGCGCCGCGCGCGATCGGGGCGAATTC
CTGGAGTGGGCGGAAGTGCACGGCAATTACTACGCCACGTCCCGCGTCTGGATCGAGGAGCAGATGGCCCAGGGTACCGA
CGTGCTGCTGGAGATCGACTGGCAGGGTGCGCAGCAGGTGCACAAGCGGTTTTCGAACGCCGTCGAGATCTTCATCCTGC
CGCCGTCGCTGACGGCGCTGGAAGAACGCCTCAAGAAGCGGGGTCAGGACGAGCCCAATGTGATCGTCCGCCGCTTGCTT
GCTGCGGGTAGCGAGATGTCGCATGCATCGGAGTCCGATTACGTGATCATCAACGAGGTATTCGATGACGCGTTGAAGCA
GCTGCAGAACGTCGTTCATGCAACCCGTTTGCGCTTTTCGTCGCAGAAAGCACGGCACGCCGAGTTGTTCATCGAGCTCG
GAATTCACTAA

Upstream 100 bases:

>100_bases
GGCTCGAAAGCCGCCGCGAAGGAACTCGCCGATGCCTCGATGGAGCTCAAGCTCCTGATCGAGCAGATGCGCGAGCAGAT
TCAAAACCTCGAATAAGATC

Downstream 100 bases:

>100_bases
AGCAGGCGCGCGGCCGGAAGGTTCCGGCCGCGTGCTGTAAAATACTGGCCTGTCGAACAGGTTTCATCCCAAGGTGGATT
TGATATGGCGCGTATTACCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSETTHTAIDTAYPGNLFMVVAPSGAGKSTLVNALLAQDKAIRLSISHTTRSPRPGEQNGREYHFISVDEFRAARDRGEF
LEWAEVHGNYYATSRVWIEEQMAQGTDVLLEIDWQGAQQVHKRFSNAVEIFILPPSLTALEERLKKRGQDEPNVIVRRLL
AAGSEMSHASESDYVIINEVFDDALKQLQNVVHATRLRFSSQKARHAELFIELGIH

Sequences:

>Translated_216_residues
MSETTHTAIDTAYPGNLFMVVAPSGAGKSTLVNALLAQDKAIRLSISHTTRSPRPGEQNGREYHFISVDEFRAARDRGEF
LEWAEVHGNYYATSRVWIEEQMAQGTDVLLEIDWQGAQQVHKRFSNAVEIFILPPSLTALEERLKKRGQDEPNVIVRRLL
AAGSEMSHASESDYVIINEVFDDALKQLQNVVHATRLRFSSQKARHAELFIELGIH
>Mature_215_residues
SETTHTAIDTAYPGNLFMVVAPSGAGKSTLVNALLAQDKAIRLSISHTTRSPRPGEQNGREYHFISVDEFRAARDRGEFL
EWAEVHGNYYATSRVWIEEQMAQGTDVLLEIDWQGAQQVHKRFSNAVEIFILPPSLTALEERLKKRGQDEPNVIVRRLLA
AGSEMSHASESDYVIINEVFDDALKQLQNVVHATRLRFSSQKARHAELFIELGIH

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=172, Percent_Identity=39.5348837209302, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4504221, Length=172, Percent_Identity=39.5348837209302, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=38.8571428571429, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=28.4916201117318, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=25.5208333333333, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=52.2388059701493, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=32.6086956521739, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=32.6086956521739, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=39.5604395604396, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=39.6648044692737, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24341; Mature: 24209

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTHTAIDTAYPGNLFMVVAPSGAGKSTLVNALLAQDKAIRLSISHTTRSPRPGEQNG
CCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
REYHFISVDEFRAARDRGEFLEWAEVHGNYYATSRVWIEEQMAQGTDVLLEIDWQGAQQV
CEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCHHHH
HKRFSNAVEIFILPPSLTALEERLKKRGQDEPNVIVRRLLAAGSEMSHASESDYVIINEV
HHHHCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHH
FDDALKQLQNVVHATRLRFSSQKARHAELFIELGIH
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCC
>Mature Secondary Structure 
SETTHTAIDTAYPGNLFMVVAPSGAGKSTLVNALLAQDKAIRLSISHTTRSPRPGEQNG
CCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
REYHFISVDEFRAARDRGEFLEWAEVHGNYYATSRVWIEEQMAQGTDVLLEIDWQGAQQV
CEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCHHHH
HKRFSNAVEIFILPPSLTALEERLKKRGQDEPNVIVRRLLAAGSEMSHASESDYVIINEV
HHHHCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHH
FDDALKQLQNVVHATRLRFSSQKARHAELFIELGIH
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA