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The map label for this gene is ltaA [H]

Identifier: 94309754

GI number: 94309754

Start: 884706

End: 885758

Strand: Direct

Name: ltaA [H]

Synonym: Rmet_0809

Alternate gene names: 94309754

Gene position: 884706-885758 (Clockwise)

Preceding gene: 94309753

Following gene: 94309755

Centisome position: 22.52

GC content: 63.44

Gene sequence:

>1053_bases
ATGACCTCCGCAGTCTCCACCATGCAGCAGTTCGCCTCGGACAATTACGCGGGTTTCTGCCCGGAATCGCTTAAGTATTT
TCTCGAGGCCAACGCCAGCGGCCATGAGAAGGCCTACGGCGACGACAGCTGGACGCAAAAGGTCTGCGATCGCATCCGCG
ATCTGTTCCAGACCGATTGCGAGGTCTTCTTCGTCTTCAACGGCACGGCGGCCAATTCGCTTGCGCTGTCGTCGCTGTGC
CAGTCTTACCACTCGGTGATCTGTCATGAACTCGCCCATATCGAAACGGACGAGTGCGGCGGCCCCGAGTTCTTCTCGAA
TGGGTCGAAGCTGCTCACCGCGCCCGGCGAGAACGGCAAGCTGACGCCCGATGCGGTGGAGGCGCTGGTCACTCGCCGCG
CCGATATCCACTATCCGAAGCCGCGTGTCGTCTCGCTGACGCAGGCCACTGAGGTGGGCACCGTCTACACGGTGGAGGAA
GTGCGTGCCATTGCGGCCATCGCCAAGCGGCGCCAGTTGCGCGTGCATATGGATGGCGCGCGATTCGCCAATGCGGTGGC
ATCGCTCGGTGTGCACCCGTCAGAAATCACCTGGCGTGCGGGCGTCGATGTGCTCTGCTTTGGCGGCACCAAGAATGGCT
TGCCCGTGGGGGAGGCCGTGGTTTTCTTCGACCGCAAGCTGGCGGAGGACTTTGCCTACCGCGTGAAGCAGGCGGGGCAA
CTGGCGTCGAAGATGCGTTTTATTTCGGCGCCATGGCTCGGCATGCTCGAAAACGACGTGTGGCTGAATAACGCGCGCCA
CGCCAACGCCATGGCGACGCTGCTTCACCAGCGCATCGCCGATATTCCTGGCGTGCGCATCATGTTCCCGACCGAGGCAA
ACGCCGTCTTTGCCGAGCTGCCGTTGCCGGCCATCGAGGCGCTGCGCGCCCGGGGCTGGCTGTTCTACACCTTCATCGGC
GCAGGCGGGTGCCGGCTGATGTGCGCGTGGGACCTGCAGCCAGACACCGTGGAAGCGTTTGCCGCCGATATCCGCACGGC
CTGCTCGGGTTGA

Upstream 100 bases:

>100_bases
GGCGCGGTCGACATCATCATCACCGACGTCAAGCGCGAGAACTGGGCTACCGGTGGCGAACTCTGGGCCGACAAGAAGTA
ACTTCTAGCAAGGCTGAACG

Downstream 100 bases:

>100_bases
AGGGCAGTTACGCATCCAGCATTCACCAACGATAACGAGACACGAGACAGAAGACAGGAGACCCCCGATGCATAACTATC
GTTTTTGCCCGCAATGCGGT

Product: low specificity l-threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTSAVSTMQQFASDNYAGFCPESLKYFLEANASGHEKAYGDDSWTQKVCDRIRDLFQTDCEVFFVFNGTAANSLALSSLC
QSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGENGKLTPDAVEALVTRRADIHYPKPRVVSLTQATEVGTVYTVEE
VRAIAAIAKRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQ
LASKMRFISAPWLGMLENDVWLNNARHANAMATLLHQRIADIPGVRIMFPTEANAVFAELPLPAIEALRARGWLFYTFIG
AGGCRLMCAWDLQPDTVEAFAADIRTACSG

Sequences:

>Translated_350_residues
MTSAVSTMQQFASDNYAGFCPESLKYFLEANASGHEKAYGDDSWTQKVCDRIRDLFQTDCEVFFVFNGTAANSLALSSLC
QSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGENGKLTPDAVEALVTRRADIHYPKPRVVSLTQATEVGTVYTVEE
VRAIAAIAKRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQ
LASKMRFISAPWLGMLENDVWLNNARHANAMATLLHQRIADIPGVRIMFPTEANAVFAELPLPAIEALRARGWLFYTFIG
AGGCRLMCAWDLQPDTVEAFAADIRTACSG
>Mature_349_residues
TSAVSTMQQFASDNYAGFCPESLKYFLEANASGHEKAYGDDSWTQKVCDRIRDLFQTDCEVFFVFNGTAANSLALSSLCQ
SYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGENGKLTPDAVEALVTRRADIHYPKPRVVSLTQATEVGTVYTVEEV
RAIAAIAKRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQL
ASKMRFISAPWLGMLENDVWLNNARHANAMATLLHQRIADIPGVRIMFPTEANAVFAELPLPAIEALRARGWLFYTFIGA
GGCRLMCAWDLQPDTVEAFAADIRTACSG

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=249, Percent_Identity=28.1124497991968, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193206520, Length=196, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193206522, Length=196, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193206524, Length=196, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320789, Length=346, Percent_Identity=23.9884393063584, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38312; Mature: 38181

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAVSTMQQFASDNYAGFCPESLKYFLEANASGHEKAYGDDSWTQKVCDRIRDLFQTDC
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
EVFFVFNGTAANSLALSSLCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGENGK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCC
LTPDAVEALVTRRADIHYPKPRVVSLTQATEVGTVYTVEEVRAIAAIAKRRQLRVHMDGA
CCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHEEEEECHH
RFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQ
HHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LASKMRFISAPWLGMLENDVWLNNARHANAMATLLHQRIADIPGVRIMFPTEANAVFAEL
HHHHHHHHCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEC
PLPAIEALRARGWLFYTFIGAGGCRLMCAWDLQPDTVEAFAADIRTACSG
CCHHHHHHHHCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSAVSTMQQFASDNYAGFCPESLKYFLEANASGHEKAYGDDSWTQKVCDRIRDLFQTDC
CHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
EVFFVFNGTAANSLALSSLCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGENGK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCC
LTPDAVEALVTRRADIHYPKPRVVSLTQATEVGTVYTVEEVRAIAAIAKRRQLRVHMDGA
CCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHEEEEECHH
RFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRKLAEDFAYRVKQAGQ
HHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LASKMRFISAPWLGMLENDVWLNNARHANAMATLLHQRIADIPGVRIMFPTEANAVFAEL
HHHHHHHHCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEC
PLPAIEALRARGWLFYTFIGAGGCRLMCAWDLQPDTVEAFAADIRTACSG
CCHHHHHHHHCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]