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The map label for this gene is lysR [H]

Identifier: 94309644

GI number: 94309644

Start: 771330

End: 772283

Strand: Reverse

Name: lysR [H]

Synonym: Rmet_0699

Alternate gene names: 94309644

Gene position: 772283-771330 (Counterclockwise)

Preceding gene: 94309647

Following gene: 94309643

Centisome position: 19.66

GC content: 67.4

Gene sequence:

>954_bases
ATGCGCCTGCGCCAGATTGAAGTGTTCCGTGCCGTAATGCTGACCGGTACCGTCAGCGAGGCGGCGCGCCTGCTCCATGT
GTCCCAGCCCGTGGTCAGCCGCGTACTGCAGCATGCGGAATCGTCGCTGGGCTTCCGCCTGTTCGATCGCCAGCGCGGCA
GGCTGCAGCCGACGCCGGAAGCGCTTGCGCTCTATGGCGATGTCGAAAGGCTATATGGTGAGATCGAGCGTGTGCGGCGC
GTATCGGAAAGCCTGCGCCACAAGGGCACGGGACGCCTGCGCGTGGCCGCCACGCCAAGCCTGGCCAACCCGCTGCTGGT
GCCGGCGGTGCGCCGCTTCTGCGCGCGGCATCCGGAAACCCAGGTTCAGGTGCTGACGCACCATACGAGCGAGATCGTCG
AGGCGCTGCTGGCCAACCAGATCGACGTGGGCTTCGCCTTTTCGCCGCCCAGGCACGAGGCAATCACCAGCGAGCCCGTG
GCCGCCGGGCGAATGCTGCTGGCCGTGCCACGCCCGCAGGCACTGCCCTCGGGCGGCCGGCGCGGCATCGTGTCGATCCG
CAAGCTGATGGAGCGGCCGTTCATCGGCTATGACGACGACAGCTCGCTAGGGCTGCTGGTCCGGCAAACGCTGGCCCGGC
ACGCGCTGGAACCACATTCGACGCTCGAGGTCCAAACCTATTCCCTCGCGCTGGCCCTGGTGGATGCGGGCCTGGGCGTC
ACGCTGCTCGACCAGTACACCGCGTTGAGCGCCAATCCGGCCAATGTCGCGCTGCACGACGTGCAACCCGAATTGCCGTT
CGAAATCCAGATGCTGCGCGCCACCCATCGTGGCAAATCGAGCCTGGTCGATGATATGCGGACACAGTTCGCGGCCGCCG
CCTCGGCGCTGGCCGCGACGCTCGACGATCGTCTGGATTCGCCCGTCGTCCAGTTTGATCCTGCCCCGCGCTGA

Upstream 100 bases:

>100_bases
CAAGCTATAGGGGCCCGCCACCCGGGTCTACCCGTAGTGCGGAGCACCATTTCCCGCACCAACACGAACACCAGCGCGAA
CATTCCCCCGCACCAGAACC

Downstream 100 bases:

>100_bases
CTGGCAGACATTTACCAGACAATTGACAGGCCCCCGCCTGTGCACCAATATCAACACGCCCAGATCGGCGCGTGAATAAC
TTATGTTCGTACTGATCCTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MRLRQIEVFRAVMLTGTVSEAARLLHVSQPVVSRVLQHAESSLGFRLFDRQRGRLQPTPEALALYGDVERLYGEIERVRR
VSESLRHKGTGRLRVAATPSLANPLLVPAVRRFCARHPETQVQVLTHHTSEIVEALLANQIDVGFAFSPPRHEAITSEPV
AAGRMLLAVPRPQALPSGGRRGIVSIRKLMERPFIGYDDDSSLGLLVRQTLARHALEPHSTLEVQTYSLALALVDAGLGV
TLLDQYTALSANPANVALHDVQPELPFEIQMLRATHRGKSSLVDDMRTQFAAAASALAATLDDRLDSPVVQFDPAPR

Sequences:

>Translated_317_residues
MRLRQIEVFRAVMLTGTVSEAARLLHVSQPVVSRVLQHAESSLGFRLFDRQRGRLQPTPEALALYGDVERLYGEIERVRR
VSESLRHKGTGRLRVAATPSLANPLLVPAVRRFCARHPETQVQVLTHHTSEIVEALLANQIDVGFAFSPPRHEAITSEPV
AAGRMLLAVPRPQALPSGGRRGIVSIRKLMERPFIGYDDDSSLGLLVRQTLARHALEPHSTLEVQTYSLALALVDAGLGV
TLLDQYTALSANPANVALHDVQPELPFEIQMLRATHRGKSSLVDDMRTQFAAAASALAATLDDRLDSPVVQFDPAPR
>Mature_317_residues
MRLRQIEVFRAVMLTGTVSEAARLLHVSQPVVSRVLQHAESSLGFRLFDRQRGRLQPTPEALALYGDVERLYGEIERVRR
VSESLRHKGTGRLRVAATPSLANPLLVPAVRRFCARHPETQVQVLTHHTSEIVEALLANQIDVGFAFSPPRHEAITSEPV
AAGRMLLAVPRPQALPSGGRRGIVSIRKLMERPFIGYDDDSSLGLLVRQTLARHALEPHSTLEVQTYSLALALVDAGLGV
TLLDQYTALSANPANVALHDVQPELPFEIQMLRATHRGKSSLVDDMRTQFAAAASALAATLDDRLDSPVVQFDPAPR

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=310, Percent_Identity=29.0322580645161, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=24.4813278008299, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788481, Length=285, Percent_Identity=25.6140350877193, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI157672245, Length=163, Percent_Identity=34.9693251533742, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=239, Percent_Identity=22.1757322175732, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=30.8219178082192, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34834; Mature: 34834

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRQIEVFRAVMLTGTVSEAARLLHVSQPVVSRVLQHAESSLGFRLFDRQRGRLQPTPE
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCCCCHH
ALALYGDVERLYGEIERVRRVSESLRHKGTGRLRVAATPSLANPLLVPAVRRFCARHPET
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCC
QVQVLTHHTSEIVEALLANQIDVGFAFSPPRHEAITSEPVAAGRMLLAVPRPQALPSGGR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCC
RGIVSIRKLMERPFIGYDDDSSLGLLVRQTLARHALEPHSTLEVQTYSLALALVDAGLGV
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCH
TLLDQYTALSANPANVALHDVQPELPFEIQMLRATHRGKSSLVDDMRTQFAAAASALAAT
HHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDDRLDSPVVQFDPAPR
HHHHCCCCCEECCCCCC
>Mature Secondary Structure
MRLRQIEVFRAVMLTGTVSEAARLLHVSQPVVSRVLQHAESSLGFRLFDRQRGRLQPTPE
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCCCCHH
ALALYGDVERLYGEIERVRRVSESLRHKGTGRLRVAATPSLANPLLVPAVRRFCARHPET
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCC
QVQVLTHHTSEIVEALLANQIDVGFAFSPPRHEAITSEPVAAGRMLLAVPRPQALPSGGR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCC
RGIVSIRKLMERPFIGYDDDSSLGLLVRQTLARHALEPHSTLEVQTYSLALALVDAGLGV
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCH
TLLDQYTALSANPANVALHDVQPELPFEIQMLRATHRGKSSLVDDMRTQFAAAASALAAT
HHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDDRLDSPVVQFDPAPR
HHHHCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]