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The map label for this gene is mvaB [H]

Identifier: 94309552

GI number: 94309552

Start: 658789

End: 659721

Strand: Reverse

Name: mvaB [H]

Synonym: Rmet_0607

Alternate gene names: 94309552

Gene position: 659721-658789 (Counterclockwise)

Preceding gene: 94309553

Following gene: 94309551

Centisome position: 16.79

GC content: 67.31

Gene sequence:

>933_bases
ATGACAATCCCCCAGTACGTAAAGATCGTCGAAGTCGGCCCGCGCGACGGGCTGCAGAATGAAAAGGCGATGGTGCCCAC
CGACGTCAAGGTGGCGCTGATCAACCGGCTGACCGACGCGGGCTTCGTCAACATCGAGGCCGCATCGTTCGTCTCGCCGA
AGTGGGTGCCGCAGATGGCTGACGGCGCCGACGTGATGGCCCGCATCACGCGACGCCCCGGCACGCTGTACTCGGTGCTG
ACGCCGAACATGAAGGGCTTCGAGGGCGCCGTTGCCGCCGGTGCCGACGAGGTGGTGATCTTCGGCGCGGCCAGCGAGGC
CTTCTCGCAGAAGAACATCAACTGCTCGATCGCCGAGTCGATCGCCCGCTTCGAACCGGTGGCCGCTGCCGCGAAGGAAG
CTGGCGTGCGGCTGCGCGGCAGCATTTCGTGCGCGCTCGGCTGCCCGTATCAGGGCGAGGTGTCGGTGCATGCCGTGGTG
GACGTCGTGCGCCGCCTGCGCGAACTCGGCTGCGACGAGATCGACATCGCCGACACGATCGGCGTGGGCACGCCTACCCG
GGTGCAGGAAGTCATGCGCGCCGCGGCGGCCGAGTTTTCGATCGACCGCCTGTCCGGCCATTTCCACGACACCTATGGGC
AGGCGCTGTCGAACATCCTGGCCAGCCTCGAGGTCGGCATCGCCATCTTCCACGCGTCGGTGGCCGGCCTGGGTGGCTGC
CCCTACGCGAAAGGCGCCACCGGCAACGTGGCGACCGAAGACGTGCTGTACATGCTGCACGGCATGGGCTTGCACACCGG
CATCGAACTCGATGACGTAGTGCGTGCCGGCGATTTCATCTCGCAGGCCATCGGCCGCGCCAACAGCTCGCGCGTTGGCC
GGGCGTTGCTGACAAAGTGGGCCTCCCAGGCGGGCGAGGCGAGCTGCGCGTAA

Upstream 100 bases:

>100_bases
GAAATGGCTTCTAACTGTTTTGGCTCCCCTCCCCCGCTGTGCGGGAGAGGGGCAGCGCATAACATCGGCCTGGCGTGACA
AACAGGCTCTGGAGACCCCC

Downstream 100 bases:

>100_bases
CCAGACCACTGACACGCCGTCCTTGCGGCGGCCGTGATCGCGCCTAGACTCAGGTTCTGTGAAGTCCGCTCGGAAACAGA
ACCATGAGACGACAACGGCG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTIPQYVKIVEVGPRDGLQNEKAMVPTDVKVALINRLTDAGFVNIEAASFVSPKWVPQMADGADVMARITRRPGTLYSVL
TPNMKGFEGAVAAGADEVVIFGAASEAFSQKNINCSIAESIARFEPVAAAAKEAGVRLRGSISCALGCPYQGEVSVHAVV
DVVRRLRELGCDEIDIADTIGVGTPTRVQEVMRAAAAEFSIDRLSGHFHDTYGQALSNILASLEVGIAIFHASVAGLGGC
PYAKGATGNVATEDVLYMLHGMGLHTGIELDDVVRAGDFISQAIGRANSSRVGRALLTKWASQAGEASCA

Sequences:

>Translated_310_residues
MTIPQYVKIVEVGPRDGLQNEKAMVPTDVKVALINRLTDAGFVNIEAASFVSPKWVPQMADGADVMARITRRPGTLYSVL
TPNMKGFEGAVAAGADEVVIFGAASEAFSQKNINCSIAESIARFEPVAAAAKEAGVRLRGSISCALGCPYQGEVSVHAVV
DVVRRLRELGCDEIDIADTIGVGTPTRVQEVMRAAAAEFSIDRLSGHFHDTYGQALSNILASLEVGIAIFHASVAGLGGC
PYAKGATGNVATEDVLYMLHGMGLHTGIELDDVVRAGDFISQAIGRANSSRVGRALLTKWASQAGEASCA
>Mature_309_residues
TIPQYVKIVEVGPRDGLQNEKAMVPTDVKVALINRLTDAGFVNIEAASFVSPKWVPQMADGADVMARITRRPGTLYSVLT
PNMKGFEGAVAAGADEVVIFGAASEAFSQKNINCSIAESIARFEPVAAAAKEAGVRLRGSISCALGCPYQGEVSVHAVVD
VVRRLRELGCDEIDIADTIGVGTPTRVQEVMRAAAAEFSIDRLSGHFHDTYGQALSNILASLEVGIAIFHASVAGLGGCP
YAKGATGNVATEDVLYMLHGMGLHTGIELDDVVRAGDFISQAIGRANSSRVGRALLTKWASQAGEASCA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=56.8027210884354, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=55.6313993174061, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=55.6313993174061, Blast_Score=357, Evalue=8e-99,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=50.7462686567164, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17510563, Length=293, Percent_Identity=49.1467576791809, Blast_Score=298, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=56.401384083045, Blast_Score=343, Evalue=7e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32534; Mature: 32403

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPQYVKIVEVGPRDGLQNEKAMVPTDVKVALINRLTDAGFVNIEAASFVSPKWVPQMA
CCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCC
DGADVMARITRRPGTLYSVLTPNMKGFEGAVAAGADEVVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAAAAKEAGVRLRGSISCALGCPYQGEVSVHAVVDVVRRLRELGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPTRVQEVMRAAAAEFSIDRLSGHFHDTYGQALSNILASLEVGIAIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYMLHGMGLHTGIELDDVVRAGDFISQAIGRANSSRVGRALLTKW
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ASQAGEASCA
HHHCCCCCCC
>Mature Secondary Structure 
TIPQYVKIVEVGPRDGLQNEKAMVPTDVKVALINRLTDAGFVNIEAASFVSPKWVPQMA
CCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCC
DGADVMARITRRPGTLYSVLTPNMKGFEGAVAAGADEVVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAAAAKEAGVRLRGSISCALGCPYQGEVSVHAVVDVVRRLRELGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPTRVQEVMRAAAAEFSIDRLSGHFHDTYGQALSNILASLEVGIAIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYMLHGMGLHTGIELDDVVRAGDFISQAIGRANSSRVGRALLTKW
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ASQAGEASCA
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]