Click here to switch to the map view.

The map label for this gene is clcB [C]

Identifier: 94309400

GI number: 94309400

Start: 482296

End: 483978

Strand: Reverse

Name: clcB [C]

Synonym: Rmet_0455

Alternate gene names: 94309400

Gene position: 483978-482296 (Counterclockwise)

Preceding gene: 94309403

Following gene: 94309399

Centisome position: 12.32

GC content: 68.87

Gene sequence:

>1683_bases
ATGCGGCTCCGTTTTCTCGAAGATCAAGAAGTCACGCTTTTCGCGGCCATCCCCGTGGGGATCCTGGCCGGCATCGTCAC
GACGCTGTTCAAGGCCGCGCTCGAATCGAGCGGGCTGGTCATGTTCGGCACCGAGGCGGACATCGTCATGGTGTTCGCCG
GGCTCGCCGTCGCCTGGCGCGTGGTGATCCCCGCACTTGGCGGCGCGCTGGCCGGCGGGTTGCTCGTGCTGGCCAACCGC
CTGGCTGCCGCCGAGCCCGGCCCGGCCGATTACATGGACGCGGTGTCTCGCGGCACGGGGCAGCTGCCGCTGAAGATCAC
GCTGCTGCGCTCGTTGTCGTCGTTCTGCTCAATCATCTCCGGCAGTTCGGTCGGCAAGGAAGGCGCGATGATCCAGCTTG
CGGCGCTATGCGGCTCGCTGTTCCCGTCGGCGCGTGCCGACCACACCTCGGGCGACACCAATATGCGCCGGATGCTGACC
GCCTGCGGCGCGGCAGCCGGCCTGGCCTCGGTCTATCACACGCCGCTTTCGGCCGCCGTCTTCGTCGCCGAAGTCGTGTT
CGGCGCACTGGCCGTGCAGCGGCTGATGCCGCTGTTCCTGGCCTCTGTGGCGGGCGCGATGGTCAGCCAGTGGCATGGCG
GCCTGCAACCGCTCTATCCCGGCCTCCATATCGAACCCGACCTGCGCCCGCAGATGCTGATGGCAGCGGTCTTGCTCGGC
GTGCTGGCCGGCGCGGCCGGTGCCCTGTTCATGCGCGCCACCACGATTGCACGCAACGGCTTCCGTCACGTGCCCGGTGG
CCCGGTCGCCCGTCTGGCGCTCGGCGGCGCACTGGTCGGGCTGCTGGCGATCGTGGTGCCGGAGGTGGTCGGCAACGGCT
ACTTCACGATCCAGACGATCCTCCAGGGCCATCCGCTGTCGGTGCCTGTCTGGGGTGTGCTGGTGGCGAAGCTCGTGGCC
ACCGTGGCCAGCATCGGTTCGGGGGCGGTGGGTGGCGTCTTCACGCCATCGCTGTTCGTCGGCGCGGCCCTTGGCCAGTT
GCTGGCGATGCTCGTGCCCGGTGGCGGCATGGCCCCGGTGCTGCCGCTGGTCGGCATGACCGCGTTCCTGGCGGCTACCA
GCCAGGCGCCGCTAATGTCGGTGCTGATGGTATTCGAGATGACGCTGGCCCCGGCGCTGCTGCTGCCGTCGATGATCGGC
GCCGTGGCGGCCTACTACACGGCGTCGCGCTGCCAAACCCTGTCGCTCTACAGCGTGGTGGTGGAGCGCGAGCAGGCTTC
CGCGGCCGCCGAGCGCGCCCGCAGGCTCCAGCTGGCGGGCCTGTGCGACCCGACCGACACAGTCATCGACCCCGGCGCCA
GCGTGGCCCAGGCCGCCGACAAGTTTGCCGAGACCGGCACGCGCTACCTCTATCTGGTCAATGCCGACGGCGCGCTGATC
GGGGCAATCTCGATCCACGCCGTCCAGCGCGCCCAACGCGATGCACCCTCGGCAAATCTGCTGGACCTCGGCGACCTCGG
CTTTCCGTCGCTGACGCCGGATTCGCGCCTGCGTGACGCGCTGGAGATTTTCTCGGTCCATGGCATCAACCGGATTCCGT
TGGTCCGCGACACCACCAGCCGCGAACTGATGGGCACGGTGTCCAAGCAACGGGTGCTGCAGGAAGCCTCCTCCTTGTTC
TGA

Upstream 100 bases:

>100_bases
TACCAGTCTGGCGAGAGGCCCGGAGCGATACGATAACGAGGTGGCGCTGCGCTATCATTGCGGCCACCCGGCCCGGCGCC
CCACGTCACCGCTCATCGCC

Downstream 100 bases:

>100_bases
ATACGCCACACCGGGCCGGGCCACCGTCCCCGATCCGGGGACAAAAGGGTAGAATCGCGGCCTATCCTGCCAGCGCGATG
CCGGCCGTTTTCGGGACCGC

Product: putative voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MRLRFLEDQEVTLFAAIPVGILAGIVTTLFKAALESSGLVMFGTEADIVMVFAGLAVAWRVVIPALGGALAGGLLVLANR
LAAAEPGPADYMDAVSRGTGQLPLKITLLRSLSSFCSIISGSSVGKEGAMIQLAALCGSLFPSARADHTSGDTNMRRMLT
ACGAAAGLASVYHTPLSAAVFVAEVVFGALAVQRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIEPDLRPQMLMAAVLLG
VLAGAAGALFMRATTIARNGFRHVPGGPVARLALGGALVGLLAIVVPEVVGNGYFTIQTILQGHPLSVPVWGVLVAKLVA
TVASIGSGAVGGVFTPSLFVGAALGQLLAMLVPGGGMAPVLPLVGMTAFLAATSQAPLMSVLMVFEMTLAPALLLPSMIG
AVAAYYTASRCQTLSLYSVVVEREQASAAAERARRLQLAGLCDPTDTVIDPGASVAQAADKFAETGTRYLYLVNADGALI
GAISIHAVQRAQRDAPSANLLDLGDLGFPSLTPDSRLRDALEIFSVHGINRIPLVRDTTSRELMGTVSKQRVLQEASSLF

Sequences:

>Translated_560_residues
MRLRFLEDQEVTLFAAIPVGILAGIVTTLFKAALESSGLVMFGTEADIVMVFAGLAVAWRVVIPALGGALAGGLLVLANR
LAAAEPGPADYMDAVSRGTGQLPLKITLLRSLSSFCSIISGSSVGKEGAMIQLAALCGSLFPSARADHTSGDTNMRRMLT
ACGAAAGLASVYHTPLSAAVFVAEVVFGALAVQRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIEPDLRPQMLMAAVLLG
VLAGAAGALFMRATTIARNGFRHVPGGPVARLALGGALVGLLAIVVPEVVGNGYFTIQTILQGHPLSVPVWGVLVAKLVA
TVASIGSGAVGGVFTPSLFVGAALGQLLAMLVPGGGMAPVLPLVGMTAFLAATSQAPLMSVLMVFEMTLAPALLLPSMIG
AVAAYYTASRCQTLSLYSVVVEREQASAAAERARRLQLAGLCDPTDTVIDPGASVAQAADKFAETGTRYLYLVNADGALI
GAISIHAVQRAQRDAPSANLLDLGDLGFPSLTPDSRLRDALEIFSVHGINRIPLVRDTTSRELMGTVSKQRVLQEASSLF
>Mature_560_residues
MRLRFLEDQEVTLFAAIPVGILAGIVTTLFKAALESSGLVMFGTEADIVMVFAGLAVAWRVVIPALGGALAGGLLVLANR
LAAAEPGPADYMDAVSRGTGQLPLKITLLRSLSSFCSIISGSSVGKEGAMIQLAALCGSLFPSARADHTSGDTNMRRMLT
ACGAAAGLASVYHTPLSAAVFVAEVVFGALAVQRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIEPDLRPQMLMAAVLLG
VLAGAAGALFMRATTIARNGFRHVPGGPVARLALGGALVGLLAIVVPEVVGNGYFTIQTILQGHPLSVPVWGVLVAKLVA
TVASIGSGAVGGVFTPSLFVGAALGQLLAMLVPGGGMAPVLPLVGMTAFLAATSQAPLMSVLMVFEMTLAPALLLPSMIG
AVAAYYTASRCQTLSLYSVVVEREQASAAAERARRLQLAGLCDPTDTVIDPGASVAQAADKFAETGTRYLYLVNADGALI
GAISIHAVQRAQRDAPSANLLDLGDLGFPSLTPDSRLRDALEIFSVHGINRIPLVRDTTSRELMGTVSKQRVLQEASSLF

Specific function: Unknown

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=401, Percent_Identity=37.6558603491272, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1786350, Length=218, Percent_Identity=31.651376146789, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 57799; Mature: 57799

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRFLEDQEVTLFAAIPVGILAGIVTTLFKAALESSGLVMFGTEADIVMVFAGLAVAWR
CCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
VVIPALGGALAGGLLVLANRLAAAEPGPADYMDAVSRGTGQLPLKITLLRSLSSFCSIIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
GSSVGKEGAMIQLAALCGSLFPSARADHTSGDTNMRRMLTACGAAAGLASVYHTPLSAAV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
FVAEVVFGALAVQRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIEPDLRPQMLMAAVLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VLAGAAGALFMRATTIARNGFRHVPGGPVARLALGGALVGLLAIVVPEVVGNGYFTIQTI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
LQGHPLSVPVWGVLVAKLVATVASIGSGAVGGVFTPSLFVGAALGQLLAMLVPGGGMAPV
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
LPLVGMTAFLAATSQAPLMSVLMVFEMTLAPALLLPSMIGAVAAYYTASRCQTLSLYSVV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEREQASAAAERARRLQLAGLCDPTDTVIDPGASVAQAADKFAETGTRYLYLVNADGALI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEE
GAISIHAVQRAQRDAPSANLLDLGDLGFPSLTPDSRLRDALEIFSVHGINRIPLVRDTTS
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCH
RELMGTVSKQRVLQEASSLF
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLRFLEDQEVTLFAAIPVGILAGIVTTLFKAALESSGLVMFGTEADIVMVFAGLAVAWR
CCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
VVIPALGGALAGGLLVLANRLAAAEPGPADYMDAVSRGTGQLPLKITLLRSLSSFCSIIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
GSSVGKEGAMIQLAALCGSLFPSARADHTSGDTNMRRMLTACGAAAGLASVYHTPLSAAV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
FVAEVVFGALAVQRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIEPDLRPQMLMAAVLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VLAGAAGALFMRATTIARNGFRHVPGGPVARLALGGALVGLLAIVVPEVVGNGYFTIQTI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
LQGHPLSVPVWGVLVAKLVATVASIGSGAVGGVFTPSLFVGAALGQLLAMLVPGGGMAPV
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
LPLVGMTAFLAATSQAPLMSVLMVFEMTLAPALLLPSMIGAVAAYYTASRCQTLSLYSVV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEREQASAAAERARRLQLAGLCDPTDTVIDPGASVAQAADKFAETGTRYLYLVNADGALI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEE
GAISIHAVQRAQRDAPSANLLDLGDLGFPSLTPDSRLRDALEIFSVHGINRIPLVRDTTS
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCH
RELMGTVSKQRVLQEASSLF
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]