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The map label for this gene is pqqL [C]

Identifier: 94309227

GI number: 94309227

Start: 298242

End: 299756

Strand: Direct

Name: pqqL [C]

Synonym: Rmet_0282

Alternate gene names: 94309227

Gene position: 298242-299756 (Clockwise)

Preceding gene: 335055485

Following gene: 94309228

Centisome position: 7.59

GC content: 62.57

Gene sequence:

>1515_bases
ATGAACCATTGCGCTGACGTGTCCGGAGCGGGTGTCGCGAAATTTCCGCGGCGCATTCTTTCTTCTCTCATTCTTGCTTC
CCTGATCGGCCCCTTGGCCGGCACTGCGTGGTCCCAGACCCCAGGCGAAGCGCCCACTACCGCCACGTCTGCCTCGCCAC
GACAGGGGCCACCACCAACCCAGCCAACGGCGACAGTTGGTCAGGCCCAGGCCGGCACGACCGAATTCCGCTTGTCCAAT
GGCTTGCGCGTGATCGTCAAGGAAGACCATCGAGCGCCCACGGTGGCCCACATGATTTTCTACCGCGTGGGCGGATTCGA
CGAGGTCAGCGGCACCACCGGCGTAGCCCACATGCTCGAACACATGATGTTCAAGGGCACGCCGAAGGTACCGGTGGGTG
AGTTCTCGCGCCAGATCGCCCTGCTGGGCGGCCGCGAGAACGCCCTGACCAACCGAGACTTCACGCTCTACTACCAGCAG
ATCTCCAAGCAATACCTGCCGAAGATGATGGAGCTCGAGGCCGACCGCATGGCCAACCTCATCTTCAAGAAGGAAGAGTT
CGAGCGAGAGATGAAGGTGGTGATGGAAGAGCGTCGCCTGCGCACCGATGATTCTCCCCGCGGCACCGTCTACGAGCAGT
TGCTGGCCACGGTCTACACGGCGATGCCGTACCGGCACCCGGTCATCGGCTGGATGGACGACCTGGTCAACATGCGGGTC
GAGGACGTGCACGACTGGTACAAGACCTGGTACGTGCCCAACAACGCCATGGTGATCGTGACCGGCGACGTCAAACCGGA
TGAGGTTCGCGCGCTGGCCGAACGCTACTACGGCAAGCTGAAACCGCATCCGCTGCCGCTGCGCAAGACGCAGATCGAGG
CGCCGCAGAAGGGCATCAAGCGTATTTGGGTCAAGGCGCCTGCCGAGAATCCCTACATGGTGATGGCCTACAAGGTGCCG
CGCCTGCGCGACGTGGAAAAGGATGTCGATCCGTACGCGCTGGAAGTCCTGTCCGCCGTGCTGAATGGCTACGACAATGC
GCGTCTGACACGTGAACTCGTGCGTGAACGGCGACTGGCCGACGACGTGAACGTCGGCTACGACAGCATCAACCGCGCGG
ACTCTCTGTTCGTGCTGGATGGCACGCCCGCCAACGGCCACACGACGGAAGAGATTGAGGCCGCGCTGCGCGAGGAGATC
CAGCGCATTGCCAAGAACGGCGTGTCCGAGGAAGAGCTCAAGCGCGTCAAGGCCCAGGTCGTGGCAGGCCAGATCTACAA
GCGCGACTCGGTGTTCGGCCAGGGCATGGAAATCGGCGTGTCGGAAATCTCTGAAATCTCTTGGCGCCAGATCGACCGCA
TGCTCGACAAGATCAAGGAAGTCACGCCGGCCCAGGTGCAGGCCGTCGCCGCCAAGTATTTCAGCGACGACAACCTGACC
GTGGCCACGCTTCTGCCGCAGCCGATCGACCCCAACAAGCCCAAGACCCCGGTCCCCGAAGGCCTGCGTCACTAG

Upstream 100 bases:

>100_bases
GAGCCGGTTCGGCCTTGCGCTTCTTCCAGAAACTAAACATTGGGAAAGGGGTCAATACCCCGGTAGAATCAATCGGCAAA
ATTCTAGCAGACGGGGTCGC

Downstream 100 bases:

>100_bases
GAGCAACAATGTCCTTGTCTGTCATGACGATTGCGTCTCCGCGTCTGTTGCGCCGGCTTGCCGGCGCGGCCTTCGGGGCA
GCGGCGCTGCTCGCCGGCGC

Product: peptidase M16-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MNHCADVSGAGVAKFPRRILSSLILASLIGPLAGTAWSQTPGEAPTTATSASPRQGPPPTQPTATVGQAQAGTTEFRLSN
GLRVIVKEDHRAPTVAHMIFYRVGGFDEVSGTTGVAHMLEHMMFKGTPKVPVGEFSRQIALLGGRENALTNRDFTLYYQQ
ISKQYLPKMMELEADRMANLIFKKEEFEREMKVVMEERRLRTDDSPRGTVYEQLLATVYTAMPYRHPVIGWMDDLVNMRV
EDVHDWYKTWYVPNNAMVIVTGDVKPDEVRALAERYYGKLKPHPLPLRKTQIEAPQKGIKRIWVKAPAENPYMVMAYKVP
RLRDVEKDVDPYALEVLSAVLNGYDNARLTRELVRERRLADDVNVGYDSINRADSLFVLDGTPANGHTTEEIEAALREEI
QRIAKNGVSEEELKRVKAQVVAGQIYKRDSVFGQGMEIGVSEISEISWRQIDRMLDKIKEVTPAQVQAVAAKYFSDDNLT
VATLLPQPIDPNKPKTPVPEGLRH

Sequences:

>Translated_504_residues
MNHCADVSGAGVAKFPRRILSSLILASLIGPLAGTAWSQTPGEAPTTATSASPRQGPPPTQPTATVGQAQAGTTEFRLSN
GLRVIVKEDHRAPTVAHMIFYRVGGFDEVSGTTGVAHMLEHMMFKGTPKVPVGEFSRQIALLGGRENALTNRDFTLYYQQ
ISKQYLPKMMELEADRMANLIFKKEEFEREMKVVMEERRLRTDDSPRGTVYEQLLATVYTAMPYRHPVIGWMDDLVNMRV
EDVHDWYKTWYVPNNAMVIVTGDVKPDEVRALAERYYGKLKPHPLPLRKTQIEAPQKGIKRIWVKAPAENPYMVMAYKVP
RLRDVEKDVDPYALEVLSAVLNGYDNARLTRELVRERRLADDVNVGYDSINRADSLFVLDGTPANGHTTEEIEAALREEI
QRIAKNGVSEEELKRVKAQVVAGQIYKRDSVFGQGMEIGVSEISEISWRQIDRMLDKIKEVTPAQVQAVAAKYFSDDNLT
VATLLPQPIDPNKPKTPVPEGLRH
>Mature_504_residues
MNHCADVSGAGVAKFPRRILSSLILASLIGPLAGTAWSQTPGEAPTTATSASPRQGPPPTQPTATVGQAQAGTTEFRLSN
GLRVIVKEDHRAPTVAHMIFYRVGGFDEVSGTTGVAHMLEHMMFKGTPKVPVGEFSRQIALLGGRENALTNRDFTLYYQQ
ISKQYLPKMMELEADRMANLIFKKEEFEREMKVVMEERRLRTDDSPRGTVYEQLLATVYTAMPYRHPVIGWMDDLVNMRV
EDVHDWYKTWYVPNNAMVIVTGDVKPDEVRALAERYYGKLKPHPLPLRKTQIEAPQKGIKRIWVKAPAENPYMVMAYKVP
RLRDVEKDVDPYALEVLSAVLNGYDNARLTRELVRERRLADDVNVGYDSINRADSLFVLDGTPANGHTTEEIEAALREEI
QRIAKNGVSEEELKRVKAQVVAGQIYKRDSVFGQGMEIGVSEISEISWRQIDRMLDKIKEVTPAQVQAVAAKYFSDDNLT
VATLLPQPIDPNKPKTPVPEGLRH

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=226, Percent_Identity=28.3185840707965, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI94538354, Length=201, Percent_Identity=29.8507462686567, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1787770, Length=214, Percent_Identity=33.1775700934579, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71999683, Length=204, Percent_Identity=26.9607843137255, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17553678, Length=434, Percent_Identity=22.8110599078341, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=454, Percent_Identity=23.1277533039648, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323421, Length=317, Percent_Identity=20.820189274448, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357875, Length=214, Percent_Identity=30.8411214953271, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646943, Length=214, Percent_Identity=30.8411214953271, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641429, Length=206, Percent_Identity=28.6407766990291, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 56582; Mature: 56582

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHCADVSGAGVAKFPRRILSSLILASLIGPLAGTAWSQTPGEAPTTATSASPRQGPPPT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPTATVGQAQAGTTEFRLSNGLRVIVKEDHRAPTVAHMIFYRVGGFDEVSGTTGVAHMLE
CCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HMMFKGTPKVPVGEFSRQIALLGGRENALTNRDFTLYYQQISKQYLPKMMELEADRMANL
HHHHCCCCCCCHHHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKKEEFEREMKVVMEERRLRTDDSPRGTVYEQLLATVYTAMPYRHPVIGWMDDLVNMRV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EDVHDWYKTWYVPNNAMVIVTGDVKPDEVRALAERYYGKLKPHPLPLRKTQIEAPQKGIK
HHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHH
RIWVKAPAENPYMVMAYKVPRLRDVEKDVDPYALEVLSAVLNGYDNARLTRELVRERRLA
EEEEECCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DDVNVGYDSINRADSLFVLDGTPANGHTTEEIEAALREEIQRIAKNGVSEEELKRVKAQV
HHCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAGQIYKRDSVFGQGMEIGVSEISEISWRQIDRMLDKIKEVTPAQVQAVAAKYFSDDNLT
HHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
VATLLPQPIDPNKPKTPVPEGLRH
EEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNHCADVSGAGVAKFPRRILSSLILASLIGPLAGTAWSQTPGEAPTTATSASPRQGPPPT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPTATVGQAQAGTTEFRLSNGLRVIVKEDHRAPTVAHMIFYRVGGFDEVSGTTGVAHMLE
CCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HMMFKGTPKVPVGEFSRQIALLGGRENALTNRDFTLYYQQISKQYLPKMMELEADRMANL
HHHHCCCCCCCHHHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKKEEFEREMKVVMEERRLRTDDSPRGTVYEQLLATVYTAMPYRHPVIGWMDDLVNMRV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EDVHDWYKTWYVPNNAMVIVTGDVKPDEVRALAERYYGKLKPHPLPLRKTQIEAPQKGIK
HHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHH
RIWVKAPAENPYMVMAYKVPRLRDVEKDVDPYALEVLSAVLNGYDNARLTRELVRERRLA
EEEEECCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DDVNVGYDSINRADSLFVLDGTPANGHTTEEIEAALREEIQRIAKNGVSEEELKRVKAQV
HHCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAGQIYKRDSVFGQGMEIGVSEISEISWRQIDRMLDKIKEVTPAQVQAVAAKYFSDDNLT
HHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
VATLLPQPIDPNKPKTPVPEGLRH
EEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]