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The map label for this gene is hutH [H]

Identifier: 94309176

GI number: 94309176

Start: 246473

End: 248074

Strand: Direct

Name: hutH [H]

Synonym: Rmet_0231

Alternate gene names: 94309176

Gene position: 246473-248074 (Clockwise)

Preceding gene: 94309175

Following gene: 94309180

Centisome position: 6.27

GC content: 66.85

Gene sequence:

>1602_bases
ATGCCCCACGCCCATCCGGCCGACATCGACGGCCACCACCTGACCCCCGACACCGTCGCCGCCATCGCACGCGGCCAGCG
CGCCGCCATCGTCCCGGAGCCCGTCCTCGGCAAGGTTGCCGATGCCCGCGCCCGCTTCGAGCAGGTGGCTGCGGCCAATG
TGCCGATCTACGGCGTCTCCACGGGCTTTGGCGAACTGGTACACAACTGGGTCGACATCGAACATGGCCGTGCGCTGCAG
GAGAACCTGTTGCGCAGCCATTGCGCGGGTGTGGGTCCGCTGTTTTCGCGCGACGAGGTCCGCGCGATGATGGTCGCGCG
TGCCAATGCGTTGGCACGCGGATACTCGGCGGTGCGGCCGGCCGTTATCGAACAACTGCTGAAGTATCTGGAAGCCGGCA
TCACGCCAGCCGTGCCGCAGGTGGGTTCGCTCGGGGCCAGCGGTGATCTCGCGCCTCTGTCGCACGTCGCCATCACGCTG
ATCGGCGAAGGCAAGGTGCTGACCGAGGATGGCGGTACGGCACCCACGGCCGAAGTCCTGCGCGAGCGTGGCATCACGCC
GCTCGCGCTGGCGTACAAGGAAGGGCTGGCGCTGATCAACGGGACATCGGCCATGACCGGGGTGTCGTGCCTGTTGCTGG
AGACGCTGCGCGCGCAGGTCCAGCAGGCCGAGATCATCGCGGCGCTGGCGCTCGAAGGACTATCCGCCTCGGCCGATGCC
TTCATGGCCCATGGGCACGACATCGCCAAACCGCATCCGGGACAGATCCGCTCGGCGGCGAACATGCGCGCGCTGCTGGC
CGATTCGGCACGGCTCTCCGGACATGGCGAACTGTCCGCCGAGATGAAGACACGCGCGGGCGAGGCCAAGAACACCGGCA
CTGGCGTGTTCATCCAGAAGGCCTACACGCTGCGCTGCATTCCGCAGGTGCTTGGCGCGGTGCGCGATACGCTCGACCAT
TGCGCCACCGTGGTCGAGCGCGAACTGAATTCATCGAATGACAATCCGCTGTTCTTCGAAGACGGCGAGCTGTTCCACGG
CGGCAACTTCCACGGCCAGCAGGTGGCATTCGCAATGGACTTCCTGGCCATCGCCGCCACGCAACTGGGCGTGGTGTCGG
AGCGCCGCCTGAACCGCCTGCTGAGCCCGCATCTGAACAACAATCTGCCGGCGTTCCTGGCGGCGGCGAACGAGGGGTTG
TCGTGCGGGTTTGCCGGGGCACAGTATCCGGCCACGGCGTTGATTGCCGAGAACCGCACGATCTGCAGCCCGGCGAGCAT
CCAGAGTGTGCCGTCGAACGGCGACAACCAGGATGTGGTCAGCATGGGGCTGATCGCTGCCCGCAATGCCCGCCGCATTC
TCGACAATAACCAGTACATCCTCGCGCTGGAGTTGCTGGCGTCATGTCAGGCCGCCGAACTCGCGGGCGCGGTCGAGCAA
CTGGCGCCGGCAGGCCGCGCCGTGTTCGCGTTCGTGCGGGAGCGCGTGCCGTTCCTGTCGATCGATCGCTATATGACCGA
CGACATCGAGGCTATGGCGGCGCTGCTCCGTCAGGGCGCGCTGGTTGAGGTCGTGCGTGGCGCGGGCATCGAACTGGCCT
GA

Upstream 100 bases:

>100_bases
TGGCCCGGCTCTCTTCCCCGGCTTCCTGTCCCGCGATATCCCGCGAGCGGAATAACGGCAGGGCAGAGGGCAAGCGCCTC
CATTGCTACCGCCCCGACCC

Downstream 100 bases:

>100_bases
CGAACTCTGGCGGTAACTTTCGGTAACTAGCGGTTTCCTACTTCCACATGCCGCGCATTCGGCTGGCGAGGTCTACCTGC
GGTAGCGAGGCCTTCGCCTG

Product: Histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MPHAHPADIDGHHLTPDTVAAIARGQRAAIVPEPVLGKVADARARFEQVAAANVPIYGVSTGFGELVHNWVDIEHGRALQ
ENLLRSHCAGVGPLFSRDEVRAMMVARANALARGYSAVRPAVIEQLLKYLEAGITPAVPQVGSLGASGDLAPLSHVAITL
IGEGKVLTEDGGTAPTAEVLRERGITPLALAYKEGLALINGTSAMTGVSCLLLETLRAQVQQAEIIAALALEGLSASADA
FMAHGHDIAKPHPGQIRSAANMRALLADSARLSGHGELSAEMKTRAGEAKNTGTGVFIQKAYTLRCIPQVLGAVRDTLDH
CATVVERELNSSNDNPLFFEDGELFHGGNFHGQQVAFAMDFLAIAATQLGVVSERRLNRLLSPHLNNNLPAFLAAANEGL
SCGFAGAQYPATALIAENRTICSPASIQSVPSNGDNQDVVSMGLIAARNARRILDNNQYILALELLASCQAAELAGAVEQ
LAPAGRAVFAFVRERVPFLSIDRYMTDDIEAMAALLRQGALVEVVRGAGIELA

Sequences:

>Translated_533_residues
MPHAHPADIDGHHLTPDTVAAIARGQRAAIVPEPVLGKVADARARFEQVAAANVPIYGVSTGFGELVHNWVDIEHGRALQ
ENLLRSHCAGVGPLFSRDEVRAMMVARANALARGYSAVRPAVIEQLLKYLEAGITPAVPQVGSLGASGDLAPLSHVAITL
IGEGKVLTEDGGTAPTAEVLRERGITPLALAYKEGLALINGTSAMTGVSCLLLETLRAQVQQAEIIAALALEGLSASADA
FMAHGHDIAKPHPGQIRSAANMRALLADSARLSGHGELSAEMKTRAGEAKNTGTGVFIQKAYTLRCIPQVLGAVRDTLDH
CATVVERELNSSNDNPLFFEDGELFHGGNFHGQQVAFAMDFLAIAATQLGVVSERRLNRLLSPHLNNNLPAFLAAANEGL
SCGFAGAQYPATALIAENRTICSPASIQSVPSNGDNQDVVSMGLIAARNARRILDNNQYILALELLASCQAAELAGAVEQ
LAPAGRAVFAFVRERVPFLSIDRYMTDDIEAMAALLRQGALVEVVRGAGIELA
>Mature_532_residues
PHAHPADIDGHHLTPDTVAAIARGQRAAIVPEPVLGKVADARARFEQVAAANVPIYGVSTGFGELVHNWVDIEHGRALQE
NLLRSHCAGVGPLFSRDEVRAMMVARANALARGYSAVRPAVIEQLLKYLEAGITPAVPQVGSLGASGDLAPLSHVAITLI
GEGKVLTEDGGTAPTAEVLRERGITPLALAYKEGLALINGTSAMTGVSCLLLETLRAQVQQAEIIAALALEGLSASADAF
MAHGHDIAKPHPGQIRSAANMRALLADSARLSGHGELSAEMKTRAGEAKNTGTGVFIQKAYTLRCIPQVLGAVRDTLDHC
ATVVERELNSSNDNPLFFEDGELFHGGNFHGQQVAFAMDFLAIAATQLGVVSERRLNRLLSPHLNNNLPAFLAAANEGLS
CGFAGAQYPATALIAENRTICSPASIQSVPSNGDNQDVVSMGLIAARNARRILDNNQYILALELLASCQAAELAGAVEQL
APAGRAVFAFVRERVPFLSIDRYMTDDIEAMAALLRQGALVEVVRGAGIELA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=518, Percent_Identity=38.996138996139, Blast_Score=345, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17567831, Length=518, Percent_Identity=37.6447876447876, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56164; Mature: 56033

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHAHPADIDGHHLTPDTVAAIARGQRAAIVPEPVLGKVADARARFEQVAAANVPIYGVS
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
TGFGELVHNWVDIEHGRALQENLLRSHCAGVGPLFSRDEVRAMMVARANALARGYSAVRP
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AVIEQLLKYLEAGITPAVPQVGSLGASGDLAPLSHVAITLIGEGKVLTEDGGTAPTAEVL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEECCEEEECCCCCCCHHHHH
RERGITPLALAYKEGLALINGTSAMTGVSCLLLETLRAQVQQAEIIAALALEGLSASADA
HHCCCCCEEHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FMAHGHDIAKPHPGQIRSAANMRALLADSARLSGHGELSAEMKTRAGEAKNTGTGVFIQK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEH
AYTLRCIPQVLGAVRDTLDHCATVVERELNSSNDNPLFFEDGELFHGGNFHGQQVAFAMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCCHHHHHHHH
FLAIAATQLGVVSERRLNRLLSPHLNNNLPAFLAAANEGLSCGFAGAQYPATALIAENRT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCC
ICSPASIQSVPSNGDNQDVVSMGLIAARNARRILDNNQYILALELLASCQAAELAGAVEQ
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHHHH
LAPAGRAVFAFVRERVPFLSIDRYMTDDIEAMAALLRQGALVEVVRGAGIELA
HCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
PHAHPADIDGHHLTPDTVAAIARGQRAAIVPEPVLGKVADARARFEQVAAANVPIYGVS
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
TGFGELVHNWVDIEHGRALQENLLRSHCAGVGPLFSRDEVRAMMVARANALARGYSAVRP
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AVIEQLLKYLEAGITPAVPQVGSLGASGDLAPLSHVAITLIGEGKVLTEDGGTAPTAEVL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEECCEEEECCCCCCCHHHHH
RERGITPLALAYKEGLALINGTSAMTGVSCLLLETLRAQVQQAEIIAALALEGLSASADA
HHCCCCCEEHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FMAHGHDIAKPHPGQIRSAANMRALLADSARLSGHGELSAEMKTRAGEAKNTGTGVFIQK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEH
AYTLRCIPQVLGAVRDTLDHCATVVERELNSSNDNPLFFEDGELFHGGNFHGQQVAFAMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCCHHHHHHHH
FLAIAATQLGVVSERRLNRLLSPHLNNNLPAFLAAANEGLSCGFAGAQYPATALIAENRT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCC
ICSPASIQSVPSNGDNQDVVSMGLIAARNARRILDNNQYILALELLASCQAAELAGAVEQ
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHHHH
LAPAGRAVFAFVRERVPFLSIDRYMTDDIEAMAALLRQGALVEVVRGAGIELA
HCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA