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The map label for this gene is aptA [C]

Identifier: 94309150

GI number: 94309150

Start: 214386

End: 215717

Strand: Direct

Name: aptA [C]

Synonym: Rmet_0205

Alternate gene names: 94309150

Gene position: 214386-215717 (Clockwise)

Preceding gene: 94309148

Following gene: 94309151

Centisome position: 5.46

GC content: 66.07

Gene sequence:

>1332_bases
ATGGACGCCGCCAAGACCGTGATCCCCGATCTCGAATCCCTGTGGATGCCCTTTACGGCCAATCGCCAGTACAAGTCCGC
GCCGCGCCTGCTGGTATCGGCCAGCGGCATGTACTACACGACCCATGACGGTCGCCAGATCCTGGACGGTTGCGCCGGCC
TCTGGTGCGTGGCCGCGGGCCACGCCCGCAAGGAAATCGTCGAGGCGATCGCGCAACAGGCCGCCACGCTCGACTACGCG
CCGCCGTTCCAGATGGGCCACCCGCTCGAATTCGAAGCGGCGACCAAGGTGGCGTCGCTGATGCCGCAGGGGCTGGACCG
CATCTTCTTCACGAACTCCGGTTCCGAATCGGTCGATACCGCGCTGAAGATCGCGCTGGCCTATCACCGTGCCCGTGGCG
AAGGCCAGCGCACGCGCATCATCGGCCGCGAGCGCGGCTACCACGGCGTGGGCTTCGGCGGCATGGGCGTTGGCGGTATC
GGGCCGAACCGCAAGATGTGGTCGGCCAATGTGATGCCCGGCACCGACCACCTGCCGGCCACGCTGAACATCGCAGAGGC
CGCGTACTCGAAGGGCCAGCCGCAATGGGGCGCCCATCTGGCCGATGAACTCGAGCGGCTGGTCGCGCTGCACGATGCCT
CGAACATCGCCGCTGTGATCGTGGAGCCGATGGCCGGTTCGGCCGGCGTGCTGATTCCGCCGGTCGGATATCTGGAAAAA
CTGCGCGAGATCACCAGCAAGCACGGCATCCTGCTGATCTTCGACGAAGTGATCACTGCGTTCGGCCGCCTGGGCGCCGC
AACCGGCGCCGAGCGTCTGAAGGTGACGCCGGACCTGATCACCATGGCCAAGGCCATCAACAACGCCGCCGTGCCGATGG
GCGCCGTGGCCGTGCGCCGCGAAGTGCATGACGCGGTGATCAACGCCACGCCGCAAGGCGGCATCGAGCTGCCGCACGGT
TACACGTACTCGGGCCATCCGCTGGCGATGGCGGCCTGTATCGCCACGCTCGACATCTACAAGCGCGACAAGCTGTTCGA
ACGCGCGGCCGAGATGTCGCCGAAGTTCGAGTCGGCCGTCCACGGCTTGCGTGGTGCGCCGTATGTGAAGGACATCCGCA
ACCTTGGCCTGGTGGCGGGCGTGGAACTGGAATCGCGCCCCGGCGCGCCGGGCGCACGTGCCTACGAGGCATTCCTGAAA
TGCCTGGAGCTGGGTCTGCTGGTACGCTACACGGGCGATATCCTGGCGTTCTCGCCGCCGCTGATCATTTCGGAGGCCGA
GATCGACCAAATGTTCGACACCGTGCGCCAAGCCTTGCATAGCATCAAGTAA

Upstream 100 bases:

>100_bases
TGCCAGACCTCGCCGGTAGAGTTGCCCGAAACCGTGGCCGAACTCCCGAAATGAGCCCGGCTCCGCCCCACAACGCCTCA
CACCGCCATCAGGAGAATGT

Downstream 100 bases:

>100_bases
GACCCGCCCCAGAGCGCCAGAGACAACGAGGAAGACCGCAGTGAACATTGCAGAAAACCGGCAGATCGCCGAAATCCATC
ACTACGTTGGCGGAACCGTG

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MDAAKTVIPDLESLWMPFTANRQYKSAPRLLVSASGMYYTTHDGRQILDGCAGLWCVAAGHARKEIVEAIAQQAATLDYA
PPFQMGHPLEFEAATKVASLMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRIIGRERGYHGVGFGGMGVGGI
GPNRKMWSANVMPGTDHLPATLNIAEAAYSKGQPQWGAHLADELERLVALHDASNIAAVIVEPMAGSAGVLIPPVGYLEK
LREITSKHGILLIFDEVITAFGRLGAATGAERLKVTPDLITMAKAINNAAVPMGAVAVRREVHDAVINATPQGGIELPHG
YTYSGHPLAMAACIATLDIYKRDKLFERAAEMSPKFESAVHGLRGAPYVKDIRNLGLVAGVELESRPGAPGARAYEAFLK
CLELGLLVRYTGDILAFSPPLIISEAEIDQMFDTVRQALHSIK

Sequences:

>Translated_443_residues
MDAAKTVIPDLESLWMPFTANRQYKSAPRLLVSASGMYYTTHDGRQILDGCAGLWCVAAGHARKEIVEAIAQQAATLDYA
PPFQMGHPLEFEAATKVASLMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRIIGRERGYHGVGFGGMGVGGI
GPNRKMWSANVMPGTDHLPATLNIAEAAYSKGQPQWGAHLADELERLVALHDASNIAAVIVEPMAGSAGVLIPPVGYLEK
LREITSKHGILLIFDEVITAFGRLGAATGAERLKVTPDLITMAKAINNAAVPMGAVAVRREVHDAVINATPQGGIELPHG
YTYSGHPLAMAACIATLDIYKRDKLFERAAEMSPKFESAVHGLRGAPYVKDIRNLGLVAGVELESRPGAPGARAYEAFLK
CLELGLLVRYTGDILAFSPPLIISEAEIDQMFDTVRQALHSIK
>Mature_443_residues
MDAAKTVIPDLESLWMPFTANRQYKSAPRLLVSASGMYYTTHDGRQILDGCAGLWCVAAGHARKEIVEAIAQQAATLDYA
PPFQMGHPLEFEAATKVASLMPQGLDRIFFTNSGSESVDTALKIALAYHRARGEGQRTRIIGRERGYHGVGFGGMGVGGI
GPNRKMWSANVMPGTDHLPATLNIAEAAYSKGQPQWGAHLADELERLVALHDASNIAAVIVEPMAGSAGVLIPPVGYLEK
LREITSKHGILLIFDEVITAFGRLGAATGAERLKVTPDLITMAKAINNAAVPMGAVAVRREVHDAVINATPQGGIELPHG
YTYSGHPLAMAACIATLDIYKRDKLFERAAEMSPKFESAVHGLRGAPYVKDIRNLGLVAGVELESRPGAPGARAYEAFLK
CLELGLLVRYTGDILAFSPPLIISEAEIDQMFDTVRQALHSIK

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=28.0459770114943, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=27.6643990929705, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=27.5862068965517, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=28.2758620689655, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=28.0701754385965, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI284507298, Length=243, Percent_Identity=32.5102880658436, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=27.4599542334096, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786991, Length=436, Percent_Identity=30.045871559633, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI145693181, Length=406, Percent_Identity=26.8472906403941, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1788044, Length=414, Percent_Identity=28.5024154589372, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=27.9518072289157, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=27.8571428571429, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=27.5184275184275, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786349, Length=368, Percent_Identity=29.3478260869565, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=29.2134831460674, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=28.9293849658314, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=27.122641509434, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=238, Percent_Identity=33.6134453781513, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=444, Percent_Identity=22.5225225225225, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=26.4976958525346, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324386, Length=487, Percent_Identity=24.6406570841889, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=418, Percent_Identity=25.8373205741627, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=26.9585253456221, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI161085790, Length=441, Percent_Identity=26.984126984127, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=27.2108843537415, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=27.0454545454545, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47585; Mature: 47585

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAKTVIPDLESLWMPFTANRQYKSAPRLLVSASGMYYTTHDGRQILDGCAGLWCVAAG
CCCCHHHHCCHHHHCCCCCCCCCHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHCC
HARKEIVEAIAQQAATLDYAPPFQMGHPLEFEAATKVASLMPQGLDRIFFTNSGSESVDT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRIIGRERGYHGVGFGGMGVGGIGPNRKMWSANVMPGTDHLPA
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
TLNIAEAAYSKGQPQWGAHLADELERLVALHDASNIAAVIVEPMAGSAGVLIPPVGYLEK
EEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHH
LREITSKHGILLIFDEVITAFGRLGAATGAERLKVTPDLITMAKAINNAAVPMGAVAVRR
HHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHCCCCCCHHHHHHHH
EVHDAVINATPQGGIELPHGYTYSGHPLAMAACIATLDIYKRDKLFERAAEMSPKFESAV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
HGLRGAPYVKDIRNLGLVAGVELESRPGAPGARAYEAFLKCLELGLLVRYTGDILAFSPP
HHCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEECCCEEEECCC
LIISEAEIDQMFDTVRQALHSIK
EEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDAAKTVIPDLESLWMPFTANRQYKSAPRLLVSASGMYYTTHDGRQILDGCAGLWCVAAG
CCCCHHHHCCHHHHCCCCCCCCCHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHCC
HARKEIVEAIAQQAATLDYAPPFQMGHPLEFEAATKVASLMPQGLDRIFFTNSGSESVDT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRIIGRERGYHGVGFGGMGVGGIGPNRKMWSANVMPGTDHLPA
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
TLNIAEAAYSKGQPQWGAHLADELERLVALHDASNIAAVIVEPMAGSAGVLIPPVGYLEK
EEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHH
LREITSKHGILLIFDEVITAFGRLGAATGAERLKVTPDLITMAKAINNAAVPMGAVAVRR
HHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHCCCCCCHHHHHHHH
EVHDAVINATPQGGIELPHGYTYSGHPLAMAACIATLDIYKRDKLFERAAEMSPKFESAV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
HGLRGAPYVKDIRNLGLVAGVELESRPGAPGARAYEAFLKCLELGLLVRYTGDILAFSPP
HHCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEECCCEEEECCC
LIISEAEIDQMFDTVRQALHSIK
EEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]