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The map label for this gene is ribA [H]

Identifier: 94309139

GI number: 94309139

Start: 202936

End: 203532

Strand: Direct

Name: ribA [H]

Synonym: Rmet_0194

Alternate gene names: 94309139

Gene position: 202936-203532 (Clockwise)

Preceding gene: 335055480

Following gene: 94309140

Centisome position: 5.17

GC content: 61.47

Gene sequence:

>597_bases
ATGAAAGATCTAGAAAGTGAGCTGATCGGCTCTGCCCGGCTGCCGACCCGCTATGGAGAATTTACCGCACACGCCTTCCA
GGGCGTTGATACCGGTACTGAACATCTTGCGCTGTCGATGGGCGAAATCTCGGGCGAAAACCTGCTCGTGCGCCTGCATT
CGGAATGCCTGACCGGTGACGTCTTCGGTTCCTGCCGCTGCGACTGCGGCGAGCAACTTGACCTCGCGATGCAGCGGATC
GCCGAAGAGGGCCGCGGCATCCTGCTGTACCTGCGTGGTCACGAGGGGCGCGGCATCGGCCTGTCGAACAAGATCCGCGC
GTACGCGTTGCAGGATGGCGGACTGGATACGGTTGATGCCAATCTGGCGCTAGGCCAGGCGATCGATTCGCGCACCTATG
CGTTCGCGGCCGATTTCCTGCGTCAGTGGGGGGTGAGTTCGGTCCGTCTGATGAGCAACAACCCGATCAAGATCAAGGCG
CTCGAGGATGCAGGCATCAAGGTGACCGAGCAGGTCCGCCATGTGGTGCCGGCGAATGCCGAGAACGAGAAGTATCTGGC
CACCAAGCGGTCGCGCATGGGGCACCTGCTCGATTGA

Upstream 100 bases:

>100_bases
CCACGTCCGCGCCGCCTGCCCGGCGCCGCCCGGCGCGCCTGCCCCGGCCCGGTATCATGCCGCTCGGGCCCCACGGCGCA
TCAAGCATTTTGCATACCCT

Downstream 100 bases:

>100_bases
TCGACTGGGTTGTGGCCGCAGCCGATGGCTGACACCGAAGGCGCTTCGTATGACGAAGCGCCTTTTCTTTTATGCGTCGA
AATCGAAATCAAAATCAGTC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MKDLESELIGSARLPTRYGEFTAHAFQGVDTGTEHLALSMGEISGENLLVRLHSECLTGDVFGSCRCDCGEQLDLAMQRI
AEEGRGILLYLRGHEGRGIGLSNKIRAYALQDGGLDTVDANLALGQAIDSRTYAFAADFLRQWGVSSVRLMSNNPIKIKA
LEDAGIKVTEQVRHVVPANAENEKYLATKRSRMGHLLD

Sequences:

>Translated_198_residues
MKDLESELIGSARLPTRYGEFTAHAFQGVDTGTEHLALSMGEISGENLLVRLHSECLTGDVFGSCRCDCGEQLDLAMQRI
AEEGRGILLYLRGHEGRGIGLSNKIRAYALQDGGLDTVDANLALGQAIDSRTYAFAADFLRQWGVSSVRLMSNNPIKIKA
LEDAGIKVTEQVRHVVPANAENEKYLATKRSRMGHLLD
>Mature_198_residues
MKDLESELIGSARLPTRYGEFTAHAFQGVDTGTEHLALSMGEISGENLLVRLHSECLTGDVFGSCRCDCGEQLDLAMQRI
AEEGRGILLYLRGHEGRGIGLSNKIRAYALQDGGLDTVDANLALGQAIDSRTYAFAADFLRQWGVSSVRLMSNNPIKIKA
LEDAGIKVTEQVRHVVPANAENEKYLATKRSRMGHLLD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=191, Percent_Identity=54.4502617801047, Blast_Score=202, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=45.0867052023121, Blast_Score=127, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21648; Mature: 21648

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLESELIGSARLPTRYGEFTAHAFQGVDTGTEHLALSMGEISGENLLVRLHSECLTGD
CCCCHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHEEEECCCCCCCEEEEEEECHHHCCC
VFGSCRCDCGEQLDLAMQRIAEEGRGILLYLRGHEGRGIGLSNKIRAYALQDGGLDTVDA
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEC
NLALGQAIDSRTYAFAADFLRQWGVSSVRLMSNNPIKIKALEDAGIKVTEQVRHVVPANA
CHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCC
ENEKYLATKRSRMGHLLD
CCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKDLESELIGSARLPTRYGEFTAHAFQGVDTGTEHLALSMGEISGENLLVRLHSECLTGD
CCCCHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHEEEECCCCCCCEEEEEEECHHHCCC
VFGSCRCDCGEQLDLAMQRIAEEGRGILLYLRGHEGRGIGLSNKIRAYALQDGGLDTVDA
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEC
NLALGQAIDSRTYAFAADFLRQWGVSSVRLMSNNPIKIKALEDAGIKVTEQVRHVVPANA
CHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCC
ENEKYLATKRSRMGHLLD
CCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA