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The map label for this gene is ahcY [H]

Identifier: 94309115

GI number: 94309115

Start: 177630

End: 179048

Strand: Direct

Name: ahcY [H]

Synonym: Rmet_0170

Alternate gene names: 94309115

Gene position: 177630-179048 (Clockwise)

Preceding gene: 94309112

Following gene: 94309116

Centisome position: 4.52

GC content: 63.14

Gene sequence:

>1419_bases
ATGAACGCAGTGACCGACCTGAAGCAAGACTACATCGTGGCCGATATCGGCCTGGCCGGCTGGGGCCGCAAGGAAATCGC
CATCGCCGAGACCGAAATGCCCGGTCTGATGGCCATTCGCGACGAATTCGCCGCCGCGCAGCCGCTCAAGGGCGCGCGCA
TCGCCGGTTCGCTGCACATGACGATCCAGACCGCCGTGCTGATCGAAACGCTCAAGGCACTGGGCGCCGACGTGCGCTGG
GCCTCATGCAACATCTTCTCGACGCAGGATCACGCCGCCGCCGCCATCGCCGCGTCGGGCACGCCCGTGTTCGCCTTCAA
GGGCGAATCGCTGAAGGAATACTGGGACTTCACGCACCGCATCTTCGACTGGGCCGACGGCGGCACGCCGAACATGATCC
TGGACGATGGCGGCGACGCCACGCTGCTGCTGCACCTGGGTGCCCGCGCCGAAAAGGATGCGTCGCTGATCGCCAAGCCG
ACCAGCGAGGAAGAAACCTTCCTGTTCGCGGCCATCAAGGAAAAGCTGGCCAAGGATTCGACCTGGTACAGCCGCAACCT
GGCCGCCATTCGCGGCGTGACCGAGGAAACGACCACCGGCGTGCACCGCCTGTACCAGATGGCGCAAAAGGGTGAACTGA
AGTTCCCGGCCATCAACGTCAACGACTCGGTGACCAAGAGCAAGTTCGACAACCTCTACGGCTGCCGCGAATCGCTGGTG
GACGGCATCAAGCGCGCCACCGACGTGATGATCGCCGGCAAGATCGCCGTGGTTGCCGGTTACGGCGACGTGGGCAAGGG
CAGCGCCCAGGCTCTGCGCGCGCTGTCCGCGCAAGTGTGGGTGACCGAGATCGATCCGATTTGCGCGCTGCAAGCCGCCA
TGGAAGGCTACCGCGTGGTGACGATGGACTACGCCGCCGAGCACGGTGACATCTTCGTGACCTGCACCGGCAATTACCAC
GTGATCACGCACGACCACATGGCCAAGATGAAGGACCAGGCCATCGTCTGCAACATTGGCCACTTCGACAACGAAATCGA
CATCGCATCGGTCGAGAAGTACGAATGGGACGAGATCAAGCCGCAGGTTGACCACGTCAAGTTCCCGGACGGCAAGAAAA
TCATCATCCTGGCCAAGGGCCGTCTGGTGAACCTGGGCTGTGCCACGGGCCACCCGTCGTACGTGATGAGCAGCTCGTTC
GCCAACCAGACGATCGCCCAGATCGAACTGTGGGCCGAACGTGACAGCGGCAAGTACCCGGTTGGCGTGTACGTGCTGCC
GAAGCATCTGGACGAGAAGGTCGCGCGCCTGCAGCTCCGGAAGCTGAACGCGCAACTGACCGAGCTGACCGAGCAGCAGG
CGGCCTACATCGGCGTGAAGAAGGAAGGCCCGTACAAGGCCGACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CATGCCAAGTGCTGGCGCGGCCATCGGCACCCCATCGGGGCTGCCGTCATCTTGTCGCCCTCCCGTTTCTTGCGTGACCA
CTTCAACTACGGAGTGACGT

Downstream 100 bases:

>100_bases
TCGGCCACGGCTCTCGCCCCCGGCGCGGCTCCCCGCTCCCGCGCGGGAGCGGGGAGCCGCGCCGGCCGTGCGACACGGCG
TCATCAAGACCGTGCACAAT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNAVTDLKQDYIVADIGLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFDWADGGTPNMILDDGGDATLLLHLGARAEKDASLIAKP
TSEEETFLFAAIKEKLAKDSTWYSRNLAAIRGVTEETTTGVHRLYQMAQKGELKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWAERDSGKYPVGVYVLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY

Sequences:

>Translated_472_residues
MNAVTDLKQDYIVADIGLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFDWADGGTPNMILDDGGDATLLLHLGARAEKDASLIAKP
TSEEETFLFAAIKEKLAKDSTWYSRNLAAIRGVTEETTTGVHRLYQMAQKGELKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWAERDSGKYPVGVYVLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
>Mature_472_residues
MNAVTDLKQDYIVADIGLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFDWADGGTPNMILDDGGDATLLLHLGARAEKDASLIAKP
TSEEETFLFAAIKEKLAKDSTWYSRNLAAIRGVTEETTTGVHRLYQMAQKGELKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWAERDSGKYPVGVYVLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=470, Percent_Identity=61.063829787234, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI239937451, Length=445, Percent_Identity=60.6741573033708, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.247311827957, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.247311827957, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.247311827957, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.247311827957, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=48.1720430107527, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=58.7606837606838, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=58.6638830897704, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=59.5289079229122, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=48.7124463519313, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=48.6021505376344, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=48.4913793103448, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51805; Mature: 51805

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTDLKQDYIVADIGLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHM
CCCHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHH
IFDWADGGTPNMILDDGGDATLLLHLGARAEKDASLIAKPTSEEETFLFAAIKEKLAKDS
HHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCC
TWYSRNLAAIRGVTEETTTGVHRLYQMAQKGELKFPAINVNDSVTKSKFDNLYGCRESLV
CHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEECEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYEWDEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCCCCC
PQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWAERDSGKYP
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEEEECCCCCCC
VGVYVLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNAVTDLKQDYIVADIGLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHM
CCCHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHH
IFDWADGGTPNMILDDGGDATLLLHLGARAEKDASLIAKPTSEEETFLFAAIKEKLAKDS
HHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCC
TWYSRNLAAIRGVTEETTTGVHRLYQMAQKGELKFPAINVNDSVTKSKFDNLYGCRESLV
CHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKIAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEECEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYEWDEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCCCCC
PQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWAERDSGKYP
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEEEECCCCCCC
VGVYVLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA