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The map label for this gene is aidB [H]

Identifier: 94309106

GI number: 94309106

Start: 167867

End: 169552

Strand: Reverse

Name: aidB [H]

Synonym: Rmet_0161

Alternate gene names: 94309106

Gene position: 169552-167867 (Counterclockwise)

Preceding gene: 335055479

Following gene: 94309105

Centisome position: 4.32

GC content: 68.21

Gene sequence:

>1686_bases
ATGGACGCCACATCCTTTCCCGATGCCGGCAGTGCGCAAACCCATACGGTGTTCAACCAGGTGCCCGATCTGGCGCACTA
CAACCTGTTCGAATCGGACCCCGGCCTGCGTGCCGCGCTGGATCGCCTGGGCGGCGCGTGGCACGCGGATACGCTCGCCG
CATTCGGCGCGCGGCTGGGCGATCCGGAGGTGCAGGCATGGGCCGCGGACGCCAACCGATTTACCCCCGAACTGCATACG
CACAGCCGCACTGGCGAGCGGATCGACCAGGTGGAGTTCCACCCGTCGTGGCACAACCTGCTGGCGCTGCTGCGCAGCCA
GCAACTCCAGGCCATGCCCTTCGCCCAGCCACGCCCCGGCGTCTGGGCCGCGCGCACGGTGGGCTACTTCCTGCAGGCCC
AGGTTGAATCTGGCTCGCTGTGTCCCACCACGATGACGCTCGCAAGTATTCCGGTCCTGCGCAAGGAACCCGCGTTGTTC
TGTGATCTCGAACCGCGCCTCTACGCCACCGAACACGATGCGCGCGACCTGCCGTGGCGCGGCAAGACCGCCGTGATGAT
CGGCATGGGCATGACCGAGAAACAGGGCGGCTCAGACGTGCGCGCCAACACCACGGTGGCGCTGCCCGTGCGCGGCGACG
GCCGGGGCGCGGAATATGCGCTGACAGGCCACAAGTGGTTTTTCTCGGCGCCGATGTGCGACGCGCATCTGGTGGTCGCC
CGCATGGGCGCGGCCGACGGGCCGCTCTCGTGCTTCTTCGTGCCGCGCTTCCGCGACGACGGCAGCAAGAATCCGATCCT
GATCCAGCGGCTCAAGGACAAGCTCGGCAACCGCTCCAACTCGAGCAGCGAAGTCGAGTTCCGCGGCACCACCGGTATCC
TGATTGGCGAGGAAGGCCGGGGCATCCCCACAATCATCGAGATGGCCACCAACACGCGACTCGACTGCGTGATCGGCAGC
GCGGCGCTGCTGCGAGCCGGTCTGGTGCAGGCGCTCCACCATGCACGGCACCGCATGGCGTTCGGCAGGCTGCTGGCGGA
CCAGCCGCTGATGCGCAACGTGCTGGCCGACCTGACGCTCGAATCCGAGGCCGCCACACTGATGATGATGGCGCTGGCAC
ATGCCTTCGAACATGCCGACGACGATCCGCTGGCCGCCGCCTGGAAACGCGTGATGACCCCGGCGGCCAAATTCTGGATC
TGCAAGCGCGCGCTGGAGGCCACCGGCGAGACGATGGAGGTCTGGGGCGGCAACGGCTACGTGGAGGACGGCCCGATGGC
GCGGCTGTATCGCGAAGCGCCGGTCAACTCGATCTGGGAAGGCTCGGGCAACATCATGTGCCTGGATGTCCTGCGCGCAC
TCCAGCGTGACCCCGGCGATGGCGCGCGCATCCTGCAGGATCTGGCGCGGCTGTCGAATGGTGACGCCGCCGTGCGCGCG
GAGCTGGCGTCGCTGCAGGCAATGCTGCGAGGGCCCGCTGAACAGCTCGAAACCAGCGCGCGACGTTTTGCGCAAGGACT
GGTGCTGACGGCACAGGCCGCGCTGATGATCGCGCACGGCAATGCCGAATCGGCGGCGCTGTTCGTCGCAAGCCGGCTTG
GCCGCCAACACGGCCGCGTGTTCGGCACGCTCGACGCCGACGCCAGCACGCTGGCGCGCATCGCGGCACGCGCCTGGCCC
GCCTGA

Upstream 100 bases:

>100_bases
TCTTGTGGCGGGATTCGGCAGTGTTGCGCGCGCCGTTGTTGCCGTACCATGAACCGCATCAGGCTGCCCCCTCGATCGAA
TTCCGCACGCAGGAGATGCC

Downstream 100 bases:

>100_bases
GGCCACCGAAAAGCAACGACAGACCGTGTGGAGAGATCGCACGAAAGTTGATGTGCCGCAATTCACTCATCTTCATGGGG
ATGCGTGCACTCCGTAAACG

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MDATSFPDAGSAQTHTVFNQVPDLAHYNLFESDPGLRAALDRLGGAWHADTLAAFGARLGDPEVQAWAADANRFTPELHT
HSRTGERIDQVEFHPSWHNLLALLRSQQLQAMPFAQPRPGVWAARTVGYFLQAQVESGSLCPTTMTLASIPVLRKEPALF
CDLEPRLYATEHDARDLPWRGKTAVMIGMGMTEKQGGSDVRANTTVALPVRGDGRGAEYALTGHKWFFSAPMCDAHLVVA
RMGAADGPLSCFFVPRFRDDGSKNPILIQRLKDKLGNRSNSSSEVEFRGTTGILIGEEGRGIPTIIEMATNTRLDCVIGS
AALLRAGLVQALHHARHRMAFGRLLADQPLMRNVLADLTLESEAATLMMMALAHAFEHADDDPLAAAWKRVMTPAAKFWI
CKRALEATGETMEVWGGNGYVEDGPMARLYREAPVNSIWEGSGNIMCLDVLRALQRDPGDGARILQDLARLSNGDAAVRA
ELASLQAMLRGPAEQLETSARRFAQGLVLTAQAALMIAHGNAESAALFVASRLGRQHGRVFGTLDADASTLARIAARAWP
A

Sequences:

>Translated_561_residues
MDATSFPDAGSAQTHTVFNQVPDLAHYNLFESDPGLRAALDRLGGAWHADTLAAFGARLGDPEVQAWAADANRFTPELHT
HSRTGERIDQVEFHPSWHNLLALLRSQQLQAMPFAQPRPGVWAARTVGYFLQAQVESGSLCPTTMTLASIPVLRKEPALF
CDLEPRLYATEHDARDLPWRGKTAVMIGMGMTEKQGGSDVRANTTVALPVRGDGRGAEYALTGHKWFFSAPMCDAHLVVA
RMGAADGPLSCFFVPRFRDDGSKNPILIQRLKDKLGNRSNSSSEVEFRGTTGILIGEEGRGIPTIIEMATNTRLDCVIGS
AALLRAGLVQALHHARHRMAFGRLLADQPLMRNVLADLTLESEAATLMMMALAHAFEHADDDPLAAAWKRVMTPAAKFWI
CKRALEATGETMEVWGGNGYVEDGPMARLYREAPVNSIWEGSGNIMCLDVLRALQRDPGDGARILQDLARLSNGDAAVRA
ELASLQAMLRGPAEQLETSARRFAQGLVLTAQAALMIAHGNAESAALFVASRLGRQHGRVFGTLDADASTLARIAARAWP
A
>Mature_561_residues
MDATSFPDAGSAQTHTVFNQVPDLAHYNLFESDPGLRAALDRLGGAWHADTLAAFGARLGDPEVQAWAADANRFTPELHT
HSRTGERIDQVEFHPSWHNLLALLRSQQLQAMPFAQPRPGVWAARTVGYFLQAQVESGSLCPTTMTLASIPVLRKEPALF
CDLEPRLYATEHDARDLPWRGKTAVMIGMGMTEKQGGSDVRANTTVALPVRGDGRGAEYALTGHKWFFSAPMCDAHLVVA
RMGAADGPLSCFFVPRFRDDGSKNPILIQRLKDKLGNRSNSSSEVEFRGTTGILIGEEGRGIPTIIEMATNTRLDCVIGS
AALLRAGLVQALHHARHRMAFGRLLADQPLMRNVLADLTLESEAATLMMMALAHAFEHADDDPLAAAWKRVMTPAAKFWI
CKRALEATGETMEVWGGNGYVEDGPMARLYREAPVNSIWEGSGNIMCLDVLRALQRDPGDGARILQDLARLSNGDAAVRA
ELASLQAMLRGPAEQLETSARRFAQGLVLTAQAALMIAHGNAESAALFVASRLGRQHGRVFGTLDADASTLARIAARAWP
A

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=324, Percent_Identity=25.6172839506173, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI226958412, Length=273, Percent_Identity=24.9084249084249, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226958414, Length=273, Percent_Identity=24.9084249084249, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4557235, Length=302, Percent_Identity=24.8344370860927, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI76496475, Length=302, Percent_Identity=24.8344370860927, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7656849, Length=275, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4557233, Length=274, Percent_Identity=27.007299270073, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI4557231, Length=278, Percent_Identity=23.3812949640288, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI187960098, Length=278, Percent_Identity=23.3812949640288, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI87082384, Length=511, Percent_Identity=46.1839530332681, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI86563381, Length=543, Percent_Identity=28.1767955801105, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI86563383, Length=543, Percent_Identity=28.1767955801105, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17538396, Length=301, Percent_Identity=26.2458471760797, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=301, Percent_Identity=25.9136212624585, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=284, Percent_Identity=25, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551932, Length=177, Percent_Identity=29.9435028248588, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=187, Percent_Identity=29.9465240641711, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=300, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=272, Percent_Identity=25.7352941176471, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355753, Length=315, Percent_Identity=24.4444444444444, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281363737, Length=295, Percent_Identity=22.7118644067797, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=273, Percent_Identity=24.9084249084249, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666513, Length=338, Percent_Identity=23.3727810650888, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24660351, Length=274, Percent_Identity=24.4525547445255, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60868; Mature: 60868

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2 ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATSFPDAGSAQTHTVFNQVPDLAHYNLFESDPGLRAALDRLGGAWHADTLAAFGARLG
CCCCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
DPEVQAWAADANRFTPELHTHSRTGERIDQVEFHPSWHNLLALLRSQQLQAMPFAQPRPG
CCCHHEEECCCHHCCCCHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
VWAARTVGYFLQAQVESGSLCPTTMTLASIPVLRKEPALFCDLEPRLYATEHDARDLPWR
CHHHHHHHHHHEEECCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEECCCCCCCCCCC
GKTAVMIGMGMTEKQGGSDVRANTTVALPVRGDGRGAEYALTGHKWFFSAPMCDAHLVVA
CCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCEEEEECCCCCHHHHHH
RMGAADGPLSCFFVPRFRDDGSKNPILIQRLKDKLGNRSNSSSEVEFRGTTGILIGEEGR
HCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCC
GIPTIIEMATNTRLDCVIGSAALLRAGLVQALHHARHRMAFGRLLADQPLMRNVLADLTL
CCHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
ESEAATLMMMALAHAFEHADDDPLAAAWKRVMTPAAKFWICKRALEATGETMEVWGGNGY
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCE
VEDGPMARLYREAPVNSIWEGSGNIMCLDVLRALQRDPGDGARILQDLARLSNGDAAVRA
ECCCHHHHHHHHCCCCCEECCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
ELASLQAMLRGPAEQLETSARRFAQGLVLTAQAALMIAHGNAESAALFVASRLGRQHGRV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCE
FGTLDADASTLARIAARAWPA
EEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDATSFPDAGSAQTHTVFNQVPDLAHYNLFESDPGLRAALDRLGGAWHADTLAAFGARLG
CCCCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
DPEVQAWAADANRFTPELHTHSRTGERIDQVEFHPSWHNLLALLRSQQLQAMPFAQPRPG
CCCHHEEECCCHHCCCCHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
VWAARTVGYFLQAQVESGSLCPTTMTLASIPVLRKEPALFCDLEPRLYATEHDARDLPWR
CHHHHHHHHHHEEECCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEECCCCCCCCCCC
GKTAVMIGMGMTEKQGGSDVRANTTVALPVRGDGRGAEYALTGHKWFFSAPMCDAHLVVA
CCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCEEEEECCCCCHHHHHH
RMGAADGPLSCFFVPRFRDDGSKNPILIQRLKDKLGNRSNSSSEVEFRGTTGILIGEEGR
HCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCC
GIPTIIEMATNTRLDCVIGSAALLRAGLVQALHHARHRMAFGRLLADQPLMRNVLADLTL
CCHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
ESEAATLMMMALAHAFEHADDDPLAAAWKRVMTPAAKFWICKRALEATGETMEVWGGNGY
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCE
VEDGPMARLYREAPVNSIWEGSGNIMCLDVLRALQRDPGDGARILQDLARLSNGDAAVRA
ECCCHHHHHHHHCCCCCEECCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
ELASLQAMLRGPAEQLETSARRFAQGLVLTAQAALMIAHGNAESAALFVASRLGRQHGRV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCE
FGTLDADASTLARIAARAWPA
EEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]