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The map label for this gene is betA1 [H]

Identifier: 94309104

GI number: 94309104

Start: 164406

End: 166088

Strand: Direct

Name: betA1 [H]

Synonym: Rmet_0159

Alternate gene names: 94309104

Gene position: 164406-166088 (Clockwise)

Preceding gene: 94309102

Following gene: 94309107

Centisome position: 4.19

GC content: 69.04

Gene sequence:

>1683_bases
ATGGAAGCGACCTTTGACTATCTCGTCGTGGGCGCCGGCTCAGCCGGCTGCGCGCTGGCCGGGCGGCTGGCCGACAGTGG
CAACGACAGTATCGCGCTGCTCGAGGCAGGCGGCCACGATCACCATGTGCTGGTACGCACACCCGCCGCGGGCGCTGCGT
TCCTGCCACGGGCCGGCTCGCGCAACGTCGGATACCGGACCGTTCCGCAGGAAGGGCTGGACGGCAGGCGAGTCAGCCAG
CCGGCTGGACGCGGCCTCGGCGGCTCGTCCTTGATCTCCGCCATGATCTACACGCGCGGCCGCCCGGCCGACTACGACGC
CTGGGCCGATGCCGGCTGCGACGGCTGGTCGTGGGACGACGTGCTGCCGTATTTCCGCCGCGCCGAGTGCAACGAGCGTC
TGGCCGGCGAGGACGACGATCCGCTTCACGGTGGCACTGGGCCGCTGCACGTCAGCGACCTGCGCTCGCCGAACCCGTTC
GCGCACCATTTCATCGACGCAGCACAGCGCGCCGGCATCGTACGCAACGGCGACTTCAACGGCGACGAGCAGGAAGGCGT
GGGCTGGTATCAGGTGACCCAGCACAATGGCGAGCGATGGAATGCCGCGCGCGCCTATCTGCACGGCGGCAACGCCCGCA
ACCGGACCAGCAACGGCGGACGCAGCCACCTGCACGTGCTGACAGGGGTGCAGGTGCTGCGCGTGCTGTTCGAGCGCAGG
CGTGCGGTGGGCGTCGTGGCGTGGCGCGACGGCAAGGAACTGGAAATCCGCGCGCGGCGGGAGGTGATCCTTGCCGCAGG
CGCGTTCGGGTCTCCGCAATTGCTGATGGCCTCCGGCGTGGGGCCGATGATGCATCTGCGCGAGTTTGGCGTTCCGGTGG
TCCACGATCTGCCTGGCGTTGGCGCCAATCTGCAGGATCACGTGGATGTCGCGGTGCAAAGACGCGTGCGTGCGTCCGAG
CTGTTCGGCATTTCGCTGGGTAGCGCCTTCCGGCTGATTGGCGAAAGCCTGCGCTATCGGCGCGGGCGATCGGGCATGCT
GACATCGAACCTGGCCGAAGCAGGCGCCTTCGTGCGCAGCCGCCCCGGGCTGGCCGAGCCCGACCTGCAATTGAGTTTCG
TGGTGGGGCTCGTCGACGATGAGACGCGCCGCCTGCGCCTGGGGCATGGCTACGCGTGCCATGCCAGTGTGCTGCGCCCG
CGCAGCCGTGGCGTGGTGCGGCTGGCGTCGCCGGACTCGCGCAAGGCGCCGCTGATCGATCCGCATTATCTGTCGGACCC
GCAGGACATGGACGGCCTGCTCGACGGGTTGCGTATCGCGCGACGTATCCTGGCGCAGGCGCCGCTTGCGGCATTCGGCG
GGCAGGATCTGCGGCTGGGCCAACTGCGTGACGATGGCGGCAATGACGAAGCCGCGCGGGCCTGGATTCGCGCGCACGCG
CAATCGGCCTGTCAGCCGGTGGGCACCTGCCGCATGGGCATGGACCCGCTGGCGGTGGTGGACCCTCAACTGCGCGTGCG
CGGCATCGAGGGCCTGCGGGTGGTGGATGCATCGATCATGCCGACGCTGATAGGTGGTGACGCAAACGCGCCGGCGATCA
TGATCGGCGAGCGTGCCCACGACCTGATTCGCTACGCGCCGCATGTGACGTTGCGGATTCTCGAAACCGTGGCGGCCGAT
TGA

Upstream 100 bases:

>100_bases
GCCGCGCTTCACGACCCCCCGCGCCAGCGCCTACACTGGATTCTCGCGACACGCGTCCGCTGGGGACTGGCAGTACGGAC
ACCGACACGCGAGGAGACAG

Downstream 100 bases:

>100_bases
CGCAGGCCGCCGCGTTGGCGGCGTACCGGGTGACCTCCGTGGACGGCGTACTCAGACGCTCATCCTGAACTGGCCCACCA
TCTCGCGCAGCTTGCTGGCT

Product: choline dehydrogenase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MEATFDYLVVGAGSAGCALAGRLADSGNDSIALLEAGGHDHHVLVRTPAAGAAFLPRAGSRNVGYRTVPQEGLDGRRVSQ
PAGRGLGGSSLISAMIYTRGRPADYDAWADAGCDGWSWDDVLPYFRRAECNERLAGEDDDPLHGGTGPLHVSDLRSPNPF
AHHFIDAAQRAGIVRNGDFNGDEQEGVGWYQVTQHNGERWNAARAYLHGGNARNRTSNGGRSHLHVLTGVQVLRVLFERR
RAVGVVAWRDGKELEIRARREVILAAGAFGSPQLLMASGVGPMMHLREFGVPVVHDLPGVGANLQDHVDVAVQRRVRASE
LFGISLGSAFRLIGESLRYRRGRSGMLTSNLAEAGAFVRSRPGLAEPDLQLSFVVGLVDDETRRLRLGHGYACHASVLRP
RSRGVVRLASPDSRKAPLIDPHYLSDPQDMDGLLDGLRIARRILAQAPLAAFGGQDLRLGQLRDDGGNDEAARAWIRAHA
QSACQPVGTCRMGMDPLAVVDPQLRVRGIEGLRVVDASIMPTLIGGDANAPAIMIGERAHDLIRYAPHVTLRILETVAAD

Sequences:

>Translated_560_residues
MEATFDYLVVGAGSAGCALAGRLADSGNDSIALLEAGGHDHHVLVRTPAAGAAFLPRAGSRNVGYRTVPQEGLDGRRVSQ
PAGRGLGGSSLISAMIYTRGRPADYDAWADAGCDGWSWDDVLPYFRRAECNERLAGEDDDPLHGGTGPLHVSDLRSPNPF
AHHFIDAAQRAGIVRNGDFNGDEQEGVGWYQVTQHNGERWNAARAYLHGGNARNRTSNGGRSHLHVLTGVQVLRVLFERR
RAVGVVAWRDGKELEIRARREVILAAGAFGSPQLLMASGVGPMMHLREFGVPVVHDLPGVGANLQDHVDVAVQRRVRASE
LFGISLGSAFRLIGESLRYRRGRSGMLTSNLAEAGAFVRSRPGLAEPDLQLSFVVGLVDDETRRLRLGHGYACHASVLRP
RSRGVVRLASPDSRKAPLIDPHYLSDPQDMDGLLDGLRIARRILAQAPLAAFGGQDLRLGQLRDDGGNDEAARAWIRAHA
QSACQPVGTCRMGMDPLAVVDPQLRVRGIEGLRVVDASIMPTLIGGDANAPAIMIGERAHDLIRYAPHVTLRILETVAAD
>Mature_560_residues
MEATFDYLVVGAGSAGCALAGRLADSGNDSIALLEAGGHDHHVLVRTPAAGAAFLPRAGSRNVGYRTVPQEGLDGRRVSQ
PAGRGLGGSSLISAMIYTRGRPADYDAWADAGCDGWSWDDVLPYFRRAECNERLAGEDDDPLHGGTGPLHVSDLRSPNPF
AHHFIDAAQRAGIVRNGDFNGDEQEGVGWYQVTQHNGERWNAARAYLHGGNARNRTSNGGRSHLHVLTGVQVLRVLFERR
RAVGVVAWRDGKELEIRARREVILAAGAFGSPQLLMASGVGPMMHLREFGVPVVHDLPGVGANLQDHVDVAVQRRVRASE
LFGISLGSAFRLIGESLRYRRGRSGMLTSNLAEAGAFVRSRPGLAEPDLQLSFVVGLVDDETRRLRLGHGYACHASVLRP
RSRGVVRLASPDSRKAPLIDPHYLSDPQDMDGLLDGLRIARRILAQAPLAAFGGQDLRLGQLRDDGGNDEAARAWIRAHA
QSACQPVGTCRMGMDPLAVVDPQLRVRGIEGLRVVDASIMPTLIGGDANAPAIMIGERAHDLIRYAPHVTLRILETVAAD

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=557, Percent_Identity=41.4721723518851, Blast_Score=371, Evalue=1e-102,
Organism=Escherichia coli, GI1786503, Length=550, Percent_Identity=40.5454545454545, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532301, Length=557, Percent_Identity=37.1633752244165, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24642037, Length=581, Percent_Identity=36.4888123924269, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI18859995, Length=579, Percent_Identity=36.7875647668394, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24642055, Length=591, Percent_Identity=34.3485617597293, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24642035, Length=590, Percent_Identity=35.7627118644068, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24642048, Length=586, Percent_Identity=34.3003412969283, Blast_Score=295, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24642039, Length=580, Percent_Identity=35.6896551724138, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI45551458, Length=579, Percent_Identity=34.7150259067358, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45549471, Length=579, Percent_Identity=34.7150259067358, Blast_Score=286, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24642042, Length=580, Percent_Identity=35.5172413793103, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24642059, Length=584, Percent_Identity=33.9041095890411, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24650267, Length=579, Percent_Identity=33.5060449050086, Blast_Score=270, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17137792, Length=568, Percent_Identity=32.7464788732394, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI18859993, Length=583, Percent_Identity=32.9331046312178, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24642051, Length=577, Percent_Identity=29.9826689774697, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=29.3103448275862, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24642057, Length=605, Percent_Identity=28.4297520661157, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 60277; Mature: 60277

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEATFDYLVVGAGSAGCALAGRLADSGNDSIALLEAGGHDHHVLVRTPAAGAAFLPRAGS
CCCCEEEEEEECCCCCCCEEHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCEECCCCCC
RNVGYRTVPQEGLDGRRVSQPAGRGLGGSSLISAMIYTRGRPADYDAWADAGCDGWSWDD
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHH
VLPYFRRAECNERLAGEDDDPLHGGTGPLHVSDLRSPNPFAHHFIDAAQRAGIVRNGDFN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCCCCCHHHHHHHHHHHHCCCEECCCCC
GDEQEGVGWYQVTQHNGERWNAARAYLHGGNARNRTSNGGRSHLHVLTGVQVLRVLFERR
CCCCCCCCEEEEECCCCCCCHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RAVGVVAWRDGKELEIRARREVILAAGAFGSPQLLMASGVGPMMHLREFGVPVVHDLPGV
HHEEEEEECCCCCEEEEECEEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCEECCCCC
GANLQDHVDVAVQRRVRASELFGISLGSAFRLIGESLRYRRGRSGMLTSNLAEAGAFVRS
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
RPGLAEPDLQLSFVVGLVDDETRRLRLGHGYACHASVLRPRSRGVVRLASPDSRKAPLID
CCCCCCCCCEEEEEEEEECCCCCEEEECCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCC
PHYLSDPQDMDGLLDGLRIARRILAQAPLAAFGGQDLRLGQLRDDGGNDEAARAWIRAHA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHH
QSACQPVGTCRMGMDPLAVVDPQLRVRGIEGLRVVDASIMPTLIGGDANAPAIMIGERAH
HHHCCCHHHHHCCCCCCEEECCCCEEECCCCEEEECCHHCCEEECCCCCCCEEEECHHHH
DLIRYAPHVTLRILETVAAD
HHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEATFDYLVVGAGSAGCALAGRLADSGNDSIALLEAGGHDHHVLVRTPAAGAAFLPRAGS
CCCCEEEEEEECCCCCCCEEHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCEECCCCCC
RNVGYRTVPQEGLDGRRVSQPAGRGLGGSSLISAMIYTRGRPADYDAWADAGCDGWSWDD
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHH
VLPYFRRAECNERLAGEDDDPLHGGTGPLHVSDLRSPNPFAHHFIDAAQRAGIVRNGDFN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCCCCCHHHHHHHHHHHHCCCEECCCCC
GDEQEGVGWYQVTQHNGERWNAARAYLHGGNARNRTSNGGRSHLHVLTGVQVLRVLFERR
CCCCCCCCEEEEECCCCCCCHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RAVGVVAWRDGKELEIRARREVILAAGAFGSPQLLMASGVGPMMHLREFGVPVVHDLPGV
HHEEEEEECCCCCEEEEECEEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCEECCCCC
GANLQDHVDVAVQRRVRASELFGISLGSAFRLIGESLRYRRGRSGMLTSNLAEAGAFVRS
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
RPGLAEPDLQLSFVVGLVDDETRRLRLGHGYACHASVLRPRSRGVVRLASPDSRKAPLID
CCCCCCCCCEEEEEEEEECCCCCEEEECCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCC
PHYLSDPQDMDGLLDGLRIARRILAQAPLAAFGGQDLRLGQLRDDGGNDEAARAWIRAHA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHH
QSACQPVGTCRMGMDPLAVVDPQLRVRGIEGLRVVDASIMPTLIGGDANAPAIMIGERAH
HHHCCCHHHHHCCCCCCEEECCCCEEECCCCEEEECCHHCCEEECCCCCCCEEEECHHHH
DLIRYAPHVTLRILETVAAD
HHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]