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The map label for this gene is hslU [H]

Identifier: 94309077

GI number: 94309077

Start: 137875

End: 139194

Strand: Direct

Name: hslU [H]

Synonym: Rmet_0132

Alternate gene names: 94309077

Gene position: 137875-139194 (Clockwise)

Preceding gene: 94309076

Following gene: 94309079

Centisome position: 3.51

GC content: 62.73

Gene sequence:

>1320_bases
ATGACCCCGTCGGAAATCGTTTCCGAACTCGACAAGCACATCATCGGCCAGAACAAGGCCAAGAAGGCCGTGGCCGTGGC
GCTGCGCAACCGCTGGCGCCGCCAGCAGGTGGCAGAGCCGCTGCGCCAGGAAATCACGCCGAAGAACATCCTGATGATCG
GGCCGACTGGCGTCGGCAAGACCGAAATCGCGCGCCGTCTGGCCAAGCTGGCCGATGCGCCGTTCATCAAGATCGAGGCA
ACCAAGTTCACTGAAGTCGGCTACGTCGGCCGCGATGTGGACACGATCGTGCGTGACCTGGCCGAAATGGCCGTCAAGCA
GACGCGCGAATCGGAAATGAAGAAGGTGCGCACCAAGGCCGAAGACGCCGCCGAGGACCGCCTGCTGGACGTGCTGCTGC
CGCCGCCGCGCGACATCGGCTTTGCCCAGCACGAGGAGAAGGACTCGAACACGCGCCAGGTCTTCCGCAAGAAACTGCGC
GAGGGCGAGCTCGACGAGAAGGACATCGAGCTCGAGGTCTCCGCTGGGATGCCGAACATGGACATCATGGGCCCCCCGGG
CATGGAAGACATGACCGAGCAGATCCGTTCGATGTTCGCGGGTCTGGGCCAGGGCAAGAAGGCGCGCCGCAAGATGAAGG
TCAAGGACGCGTTCAAGCTGCTGATCGATGAAGAGGCCGCCAAGCTCGTCAATGAAGAAGAGCTCAAGCACAAGGCCATC
GCCAACGTCGAACAGAACGGCATCGTGTTCCTGGACGAGATCGACAAGATCGCCAGCCGCAGCGAAGTGGGCGGCGGCGA
AGTGTCGCGCCAGGGCGTGCAGCGAGATCTGCTGCCGCTGGTGGAAGGCACCACGGTGAACACGAAGTACGGGATGATCA
AGACCGACCACATCCTGTTCATCGCGTCCGGCGCGTTCCATCTGTCGAAGCCGAGTGACCTGATTCCGGAACTGCAGGGT
CGCTTCCCGATCCGCGTGGAACTCGAATCGCTGTCGGTGCAGGACTTCGAGGCCATCCTCACGCAGACCGATGCCAGCCT
GACCAAGCAGTACCAGGCGTTGCTGAAGACCGAGGAAGTGGAACTGCAGTTCTCGCCGGATGGCATTCGCCGCCTGGCCG
AGATCGCGTTCTCGGTCAACGAGAAGGTCGAGAACATCGGCGCGCGCCGCCTGTACACGGTGATGGAGCGCCTGCTCGAG
GACCTGTCGTTCCACGCAACGAAGTCGTCGGGGGAAACCGTGACAGTCGATGCGGCATACGTCGATGCGCGCCTGGGTGA
CCTGGCGGGCAACGAGGATCTGTCGCGCTACGTGCTGTAA

Upstream 100 bases:

>100_bases
GGCCCTGACCATCGCGGGCGAGCTCTGCATCTACACGAACACCAATTTCGTTATCGAAACCCTCGACTGACGCGCTGAAC
GGATTCCCATGTCGCACACC

Downstream 100 bases:

>100_bases
CGCAGGCCGAAGTCTGAAAGTAAAAGAGCCGGGTGACCGGCTCTTTTCGTTTGGGGTGGCGTCGGACGCCCGGTTACTCA
GTGCGAGTGCACGTGGCCGC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEA
TKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRTKAEDAAEDRLLDVLLPPPRDIGFAQHEEKDSNTRQVFRKKLR
EGELDEKDIELEVSAGMPNMDIMGPPGMEDMTEQIRSMFAGLGQGKKARRKMKVKDAFKLLIDEEAAKLVNEEELKHKAI
ANVEQNGIVFLDEIDKIASRSEVGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILFIASGAFHLSKPSDLIPELQG
RFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFSPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLE
DLSFHATKSSGETVTVDAAYVDARLGDLAGNEDLSRYVL

Sequences:

>Translated_439_residues
MTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEA
TKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRTKAEDAAEDRLLDVLLPPPRDIGFAQHEEKDSNTRQVFRKKLR
EGELDEKDIELEVSAGMPNMDIMGPPGMEDMTEQIRSMFAGLGQGKKARRKMKVKDAFKLLIDEEAAKLVNEEELKHKAI
ANVEQNGIVFLDEIDKIASRSEVGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILFIASGAFHLSKPSDLIPELQG
RFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFSPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLE
DLSFHATKSSGETVTVDAAYVDARLGDLAGNEDLSRYVL
>Mature_438_residues
TPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEAT
KFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRTKAEDAAEDRLLDVLLPPPRDIGFAQHEEKDSNTRQVFRKKLRE
GELDEKDIELEVSAGMPNMDIMGPPGMEDMTEQIRSMFAGLGQGKKARRKMKVKDAFKLLIDEEAAKLVNEEELKHKAIA
NVEQNGIVFLDEIDKIASRSEVGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILFIASGAFHLSKPSDLIPELQGR
FPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFSPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLED
LSFHATKSSGETVTVDAAYVDARLGDLAGNEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=440, Percent_Identity=64.3181818181818, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=48, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24648291, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648289, Length=108, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49108; Mature: 48977

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRTKA
HHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDAAEDRLLDVLLPPPRDIGFAQHEEKDSNTRQVFRKKLREGELDEKDIELEVSAGMPNM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
DIMGPPGMEDMTEQIRSMFAGLGQGKKARRKMKVKDAFKLLIDEEAAKLVNEEELKHKAI
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ANVEQNGIVFLDEIDKIASRSEVGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILF
HCCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEECCEEE
IASGAFHLSKPSDLIPELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEV
EEECCCCCCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ELQFSPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHATKSSGETVTVDAAY
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
VDARLGDLAGNEDLSRYVL
HHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
TPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRTKA
HHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDAAEDRLLDVLLPPPRDIGFAQHEEKDSNTRQVFRKKLREGELDEKDIELEVSAGMPNM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
DIMGPPGMEDMTEQIRSMFAGLGQGKKARRKMKVKDAFKLLIDEEAAKLVNEEELKHKAI
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ANVEQNGIVFLDEIDKIASRSEVGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIKTDHILF
HCCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEECCEEE
IASGAFHLSKPSDLIPELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEV
EEECCCCCCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ELQFSPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHATKSSGETVTVDAAY
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
VDARLGDLAGNEDLSRYVL
HHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA