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The map label for this gene is cobW

Identifier: 94309070

GI number: 94309070

Start: 130815

End: 131990

Strand: Reverse

Name: cobW

Synonym: Rmet_0125

Alternate gene names: NA

Gene position: 131990-130815 (Counterclockwise)

Preceding gene: 94309071

Following gene: 94309069

Centisome position: 3.36

GC content: 68.62

Gene sequence:

>1176_bases
ATGGCCGTTCGTCTGCCCGTCACCGTGCTGTCCGGATTTACCGGCGCCGGCAAGACCACCGTGCTGCGCCACCTGGAAGC
CCAGGCCGGCGCGCGCGTGGCCGTGGTCGACAGCCATGGCGACCTGCTTGCCGAAGTCGAACGGCTGGCCCAGACCGGCC
AGTACGATCATGTGGTGATCGAAGCCGGTGCCACCGATGAACCGCTGGGCCTGGCCGAGGGCTTCGCCTTCGAGGACGAG
CACGGCGAGACCACCAGCGTGGGGCACCTCGACACGCTGGTCACGGTGATCGACGCCAGCCGCTTCTTGCAGGACTACCA
CGACGCCGACTTTCTGTCGGCCCGCGCACTGGCCGCGCACGATGACGACGACCGTACGGTCGTCGATGTGCTGATCGACC
AGGTCGAGGTATGCGACGTCCTCGTCGTCAACAAGATCGACCTCGTCGATGCCGGCCAGCTCGGGCGCCTGCACGTGATG
CTCCATGCGCTCAATCCGCGCGCCGACATCGTCGACGCGAGCCACGGCCAAGTGCCCGCCGCACGCGTGCTGGATACCGG
ACGCTTCGATATCGACGCCACACCCAACGCCGCCGGCTGGCAAGCCGCGCTGCAGGGCGATACGGTGCCCGATGCCGCCG
GCGTGTCGACGCTGGTCTACCGCCGGCGCCGCCCGTTCCACCCGCAGCGTTTCGCGGACCTGATCCATACCGAATGGATG
CGCGAGCATGGCGACGTGCTGCGTTCGAAAGGTCTGTTCTGGCTCGCCAGCCGCATGGACATCGCCGGCGACTGGAGCCA
GGCAGGCGGCGTGTGCCGTCCCGGCGCCGCCGGTGCATGGTGGGCAGCGATCGACGCCGAAGAATGGCCGCCCGAAGGTC
CGGCACGCGCCGCCATCGAGGCCGATCTGATCGAGGACGGCCTGCCCGCAGAGTACGGCGACCGTCGCCAGGAACTGGTG
CTGATCGGCCTGGATCTCGACGCGCACGCGCTGGAAGCGCAGCTCGATGCGTGCCTGCTCACCGACGACGAAATGGCCGC
CGGCCCCGAGGCATGGGCGGCCTACCCCGATCCGTTCCCCGACTGGGGCAACGCGTTCGACGACGACCACGACCATGATC
ACGGCCACGACCACGATCATGGCGACGGGCCGTGCGATTGCGGACATGCACACTGA

Upstream 100 bases:

>100_bases
TTGCGACACTACCATTGCAGAATGATTTCAGAATGACCGCCTGTCCCCGGGGCAGGCTTTCTGCTACAGTCGCAACTTTG
TTGCATCAACATCGATCATC

Downstream 100 bases:

>100_bases
GTCCTGCACCCTCTCTCGCTTGCGCGCGCGCGGCCCGAGCCTTTGGGCCGTGCTGTGGCTGGTCGCGTGCCTGCTGCTCG
CCCAGCACGCGGGTCTGGTC

Product: cobalamin (vitamin B12) synthesis

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAVRLPVTVLSGFTGAGKTTVLRHLEAQAGARVAVVDSHGDLLAEVERLAQTGQYDHVVIEAGATDEPLGLAEGFAFEDE
HGETTSVGHLDTLVTVIDASRFLQDYHDADFLSARALAAHDDDDRTVVDVLIDQVEVCDVLVVNKIDLVDAGQLGRLHVM
LHALNPRADIVDASHGQVPAARVLDTGRFDIDATPNAAGWQAALQGDTVPDAAGVSTLVYRRRRPFHPQRFADLIHTEWM
REHGDVLRSKGLFWLASRMDIAGDWSQAGGVCRPGAAGAWWAAIDAEEWPPEGPARAAIEADLIEDGLPAEYGDRRQELV
LIGLDLDAHALEAQLDACLLTDDEMAAGPEAWAAYPDPFPDWGNAFDDDHDHDHGHDHDHGDGPCDCGHAH

Sequences:

>Translated_391_residues
MAVRLPVTVLSGFTGAGKTTVLRHLEAQAGARVAVVDSHGDLLAEVERLAQTGQYDHVVIEAGATDEPLGLAEGFAFEDE
HGETTSVGHLDTLVTVIDASRFLQDYHDADFLSARALAAHDDDDRTVVDVLIDQVEVCDVLVVNKIDLVDAGQLGRLHVM
LHALNPRADIVDASHGQVPAARVLDTGRFDIDATPNAAGWQAALQGDTVPDAAGVSTLVYRRRRPFHPQRFADLIHTEWM
REHGDVLRSKGLFWLASRMDIAGDWSQAGGVCRPGAAGAWWAAIDAEEWPPEGPARAAIEADLIEDGLPAEYGDRRQELV
LIGLDLDAHALEAQLDACLLTDDEMAAGPEAWAAYPDPFPDWGNAFDDDHDHDHGHDHDHGDGPCDCGHAH
>Mature_390_residues
AVRLPVTVLSGFTGAGKTTVLRHLEAQAGARVAVVDSHGDLLAEVERLAQTGQYDHVVIEAGATDEPLGLAEGFAFEDEH
GETTSVGHLDTLVTVIDASRFLQDYHDADFLSARALAAHDDDDRTVVDVLIDQVEVCDVLVVNKIDLVDAGQLGRLHVML
HALNPRADIVDASHGQVPAARVLDTGRFDIDATPNAAGWQAALQGDTVPDAAGVSTLVYRRRRPFHPQRFADLIHTEWMR
EHGDVLRSKGLFWLASRMDIAGDWSQAGGVCRPGAAGAWWAAIDAEEWPPEGPARAAIEADLIEDGLPAEYGDRRQELVL
IGLDLDAHALEAQLDACLLTDDEMAAGPEAWAAYPDPFPDWGNAFDDDHDHDHGHDHDHGDGPCDCGHAH

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 42228; Mature: 42097

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRLPVTVLSGFTGAGKTTVLRHLEAQAGARVAVVDSHGDLLAEVERLAQTGQYDHVVI
CEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEE
EAGATDEPLGLAEGFAFEDEHGETTSVGHLDTLVTVIDASRFLQDYHDADFLSARALAAH
ECCCCCCCCCHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DDDDRTVVDVLIDQVEVCDVLVVNKIDLVDAGQLGRLHVMLHALNPRADIVDASHGQVPA
CCCCHHHHHHHHHHHHHHCEEEECCCCEECCCCCCEEEEEEEECCCCCCEEECCCCCCCH
ARVLDTGRFDIDATPNAAGWQAALQGDTVPDAAGVSTLVYRRRRPFHPQRFADLIHTEWM
HHHCCCCCEEECCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
REHGDVLRSKGLFWLASRMDIAGDWSQAGGVCRPGAAGAWWAAIDAEEWPPEGPARAAIE
HHHHHHHHHCCEEEEEECCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
ADLIEDGLPAEYGDRRQELVLIGLDLDAHALEAQLDACLLTDDEMAAGPEAWAAYPDPFP
HHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCEEEECCCHHHCCCCCCCCCCCCCC
DWGNAFDDDHDHDHGHDHDHGDGPCDCGHAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVRLPVTVLSGFTGAGKTTVLRHLEAQAGARVAVVDSHGDLLAEVERLAQTGQYDHVVI
EEEEEHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEE
EAGATDEPLGLAEGFAFEDEHGETTSVGHLDTLVTVIDASRFLQDYHDADFLSARALAAH
ECCCCCCCCCHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DDDDRTVVDVLIDQVEVCDVLVVNKIDLVDAGQLGRLHVMLHALNPRADIVDASHGQVPA
CCCCHHHHHHHHHHHHHHCEEEECCCCEECCCCCCEEEEEEEECCCCCCEEECCCCCCCH
ARVLDTGRFDIDATPNAAGWQAALQGDTVPDAAGVSTLVYRRRRPFHPQRFADLIHTEWM
HHHCCCCCEEECCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
REHGDVLRSKGLFWLASRMDIAGDWSQAGGVCRPGAAGAWWAAIDAEEWPPEGPARAAIE
HHHHHHHHHCCEEEEEECCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
ADLIEDGLPAEYGDRRQELVLIGLDLDAHALEAQLDACLLTDDEMAAGPEAWAAYPDPFP
HHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCEEEECCCHHHCCCCCCCCCCCCCC
DWGNAFDDDHDHDHGHDHDHGDGPCDCGHAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]