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The map label for this gene is coaX

Identifier: 94309019

GI number: 94309019

Start: 81339

End: 82172

Strand: Direct

Name: coaX

Synonym: Rmet_0074

Alternate gene names: 94309019

Gene position: 81339-82172 (Clockwise)

Preceding gene: 94309018

Following gene: 94309020

Centisome position: 2.07

GC content: 70.14

Gene sequence:

>834_bases
ATGAGTCGGCTCCTGATCGACATCGGCAACACACGCCTCAAATGGGCGTGGTGCGATGACGCGCCCGTGGCTGCGGAGCA
TGTCGTCGAGGGTGGCGCGGTCCTGCCCTCACCTTGGCGACACGGCGGCGCGGCGGCGCACGCCGTGCCTGCCGAGCGCT
CGGCGCTGGTCGGCACATGGCGGCAACTTGCCGCCGGGACCACGCCCGAGATCTGGATTGCCAACGTGGCCGGCCCGACC
ATCGCGGCGGCCATGGAAGCCGTGATGGAGGATGCATTTGGCGCGGTGTCGCCACATTGGGTACGTACCACGGCCGCGCA
CGGCGACCTCGTCAACGGCTATCGCGAGCCCACGCAGCTTGGCGTGGACCGTTGGGTCGGCAGTATCGGGGCGCACCGGT
GGTTGCCCGGCGAGACCCTGCTGATCGTGACGGCGGGCACGGCCACCACACTCGATATCGTCACGGCCACGGCGGATGGC
GCCCGCTTCGAGGGTGGGCTGATCTTGCCCGGCCTTGAACTGATGCTCGGCACGCTGGCCCGCAATACTGCGCAATTGCC
TGAACTCGATGTGCTCGACACCGGCGCGGGCGCCGAACGAGCTGTTCGGGCGTTGGGCGCGGACAACACTCACGATGCGA
TCGCGGCGGGCTGTCTGGCCGCGCAGGCCGGTGCCATCGAGCGCTCCTGGCGTGCGCTCGCGGGACGCGGCCCGGTCCGC
TGCCTGCTCTCGGGCGGCGCGCGGCACGCGGTGGCTGGCGCGCTCGCGATGCCGTTCGAGATGCACGATAATCTCGTGCT
GCTCGGGTTGCACGCCATGGCGCTGCCTGCCTGA

Upstream 100 bases:

>100_bases
TGGCGCGTGGTGTGGATGGCGAAGGCTACCTGCTGCTGCACACGCCCGAGGGGCTGCAGCGCATCGCCAGTGGCGAAGTC
TCGCTGCGCGGAGCCAGTGC

Downstream 100 bases:

>100_bases
CATACCTGCGCAACCCCTATCCGTCGCCTGTCATTCGTCACCATGCTCCGCAAAGGTTTCAACGCCCTGCTGCTGATCCT
GCTGCTCGTCAACCTTTGGC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSRLLIDIGNTRLKWAWCDDAPVAAEHVVEGGAVLPSPWRHGGAAAHAVPAERSALVGTWRQLAAGTTPEIWIANVAGPT
IAAAMEAVMEDAFGAVSPHWVRTTAAHGDLVNGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTATADG
ARFEGGLILPGLELMLGTLARNTAQLPELDVLDTGAGAERAVRALGADNTHDAIAAGCLAAQAGAIERSWRALAGRGPVR
CLLSGGARHAVAGALAMPFEMHDNLVLLGLHAMALPA

Sequences:

>Translated_277_residues
MSRLLIDIGNTRLKWAWCDDAPVAAEHVVEGGAVLPSPWRHGGAAAHAVPAERSALVGTWRQLAAGTTPEIWIANVAGPT
IAAAMEAVMEDAFGAVSPHWVRTTAAHGDLVNGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTATADG
ARFEGGLILPGLELMLGTLARNTAQLPELDVLDTGAGAERAVRALGADNTHDAIAAGCLAAQAGAIERSWRALAGRGPVR
CLLSGGARHAVAGALAMPFEMHDNLVLLGLHAMALPA
>Mature_276_residues
SRLLIDIGNTRLKWAWCDDAPVAAEHVVEGGAVLPSPWRHGGAAAHAVPAERSALVGTWRQLAAGTTPEIWIANVAGPTI
AAAMEAVMEDAFGAVSPHWVRTTAAHGDLVNGYREPTQLGVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTATADGA
RFEGGLILPGLELMLGTLARNTAQLPELDVLDTGAGAERAVRALGADNTHDAIAAGCLAAQAGAIERSWRALAGRGPVRC
LLSGGARHAVAGALAMPFEMHDNLVLLGLHAMALPA

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_RALME (Q1LSB6)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582229.1
- ProteinModelPortal:   Q1LSB6
- SMR:   Q1LSB6
- STRING:   Q1LSB6
- GeneID:   4036858
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0074
- eggNOG:   COG1521
- HOGENOM:   HBG634537
- OMA:   RTTIRSR
- ProtClustDB:   PRK13328
- BioCyc:   RMET266264:RMET_0074-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 28670; Mature: 28539

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00213 LIPOCALIN

Important sites: ACT_SITE 123-123 BINDING 114-114 BINDING 147-147 BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLLIDIGNTRLKWAWCDDAPVAAEHVVEGGAVLPSPWRHGGAAAHAVPAERSALVGTW
CCEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RQLAAGTTPEIWIANVAGPTIAAAMEAVMEDAFGAVSPHWVRTTAAHGDLVNGYREPTQL
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCHHHH
GVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTATADGARFEGGLILPGLELMLGTLA
HHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHH
RNTAQLPELDVLDTGAGAERAVRALGADNTHDAIAAGCLAAQAGAIERSWRALAGRGPVR
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
CLLSGGARHAVAGALAMPFEMHDNLVLLGLHAMALPA
EEECCCCHHHHHHHHHCCHHHCCCEEEEEEHHHHCCC
>Mature Secondary Structure 
SRLLIDIGNTRLKWAWCDDAPVAAEHVVEGGAVLPSPWRHGGAAAHAVPAERSALVGTW
CEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RQLAAGTTPEIWIANVAGPTIAAAMEAVMEDAFGAVSPHWVRTTAAHGDLVNGYREPTQL
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCHHHH
GVDRWVGSIGAHRWLPGETLLIVTAGTATTLDIVTATADGARFEGGLILPGLELMLGTLA
HHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHH
RNTAQLPELDVLDTGAGAERAVRALGADNTHDAIAAGCLAAQAGAIERSWRALAGRGPVR
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
CLLSGGARHAVAGALAMPFEMHDNLVLLGLHAMALPA
EEECCCCHHHHHHHHHCCHHHCCCEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA