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The map label for this gene is pcp1 [H]

Identifier: 94309012

GI number: 94309012

Start: 74671

End: 75339

Strand: Direct

Name: pcp1 [H]

Synonym: Rmet_0067

Alternate gene names: 94309012

Gene position: 74671-75339 (Clockwise)

Preceding gene: 94309011

Following gene: 94309018

Centisome position: 1.9

GC content: 67.41

Gene sequence:

>669_bases
ATGACCACCCGTACTGTCCTGCTGACCGGCTTCGAGCCGTTCGAGAATGAACCGGTGAATCCGTCCTGGGAGGCGGTGCG
TGCGCTCGATGGCGAGCGCGTGGGCGATGCCTTGATCGTTGCGCGGCAGTTGCCCTGCGTCTTCGGCAAGGCCATCGAGG
CAATGGACGCGCTGGTCGATACGCTACGCCCTGACGTGGTGATCGCCGTCGGGCAGGCCGGTGGCCGCACCGAGCTGTCG
ATCGAGCGCGTGGCGATCAATGTCGACGATGCCCGCATTGCCGACAACGCCGGGGCCCAGCCGATCGACGCGCCGATCGC
CAAGGATGGCCCGGTCGCGTACTTCTCGACCCTGCCGATCAAGGCGATCGTGCGCGACATGCGCGCGGCCGGCGTGCCCG
CGATGGTCTCGCAGACCGCCGGTACCTTCGTCTGCAATCACGTGTTCTATGGGCTGATGCATGTGCTTGCCCATCGCAAG
GCGGGCAGCGCCGCCGCGCCCACGCGCGGGGGATTCATCCATATTCCCTATCTGCCCGAACAGGCCGCGCGTCATCCGGG
GGCGCCGAGCCTCGCACTCGATACGCTGATCGCGGGGTTGCGCGTGGCGGTGGCCACGTCGCTATCGACGGACGCGGATA
TTCGCGAGGGCGGCGGACAACTGCACTAG

Upstream 100 bases:

>100_bases
GACAAGAACGCCGTGATTCGCGCGCAGGTGCCTACCGCGCTGTGCATCCTGGTGGCCAATATCATCCTGCTGTACTTCCT
GATGTAACCGGAGCCTGGCC

Downstream 100 bases:

>100_bases
CAGGAGCGGCCTCAGGATTGCGGCCGCTTCGATTCCTGCTGCGCTTCCGTCGCGGCCGCCACCGCGCGCTCGGTGGCGCG
GCGCCTCGCGCGCCGCACCA

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTTRTVLLTGFEPFENEPVNPSWEAVRALDGERVGDALIVARQLPCVFGKAIEAMDALVDTLRPDVVIAVGQAGGRTELS
IERVAINVDDARIADNAGAQPIDAPIAKDGPVAYFSTLPIKAIVRDMRAAGVPAMVSQTAGTFVCNHVFYGLMHVLAHRK
AGSAAAPTRGGFIHIPYLPEQAARHPGAPSLALDTLIAGLRVAVATSLSTDADIREGGGQLH

Sequences:

>Translated_222_residues
MTTRTVLLTGFEPFENEPVNPSWEAVRALDGERVGDALIVARQLPCVFGKAIEAMDALVDTLRPDVVIAVGQAGGRTELS
IERVAINVDDARIADNAGAQPIDAPIAKDGPVAYFSTLPIKAIVRDMRAAGVPAMVSQTAGTFVCNHVFYGLMHVLAHRK
AGSAAAPTRGGFIHIPYLPEQAARHPGAPSLALDTLIAGLRVAVATSLSTDADIREGGGQLH
>Mature_221_residues
TTRTVLLTGFEPFENEPVNPSWEAVRALDGERVGDALIVARQLPCVFGKAIEAMDALVDTLRPDVVIAVGQAGGRTELSI
ERVAINVDDARIADNAGAQPIDAPIAKDGPVAYFSTLPIKAIVRDMRAAGVPAMVSQTAGTFVCNHVFYGLMHVLAHRKA
GSAAAPTRGGFIHIPYLPEQAARHPGAPSLALDTLIAGLRVAVATSLSTDADIREGGGQLH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=176, Percent_Identity=26.1363636363636, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23306; Mature: 23175

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTVLLTGFEPFENEPVNPSWEAVRALDGERVGDALIVARQLPCVFGKAIEAMDALVD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLRPDVVIAVGQAGGRTELSIERVAINVDDARIADNAGAQPIDAPIAKDGPVAYFSTLPI
HCCCCEEEEECCCCCCCEEEEEEEEEECCCHHCCCCCCCCCCCCCCCCCCCEEEHHHCCH
KAIVRDMRAAGVPAMVSQTAGTFVCNHVFYGLMHVLAHRKAGSAAAPTRGGFIHIPYLPE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCH
QAARHPGAPSLALDTLIAGLRVAVATSLSTDADIREGGGQLH
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TTRTVLLTGFEPFENEPVNPSWEAVRALDGERVGDALIVARQLPCVFGKAIEAMDALVD
CCEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLRPDVVIAVGQAGGRTELSIERVAINVDDARIADNAGAQPIDAPIAKDGPVAYFSTLPI
HCCCCEEEEECCCCCCCEEEEEEEEEECCCHHCCCCCCCCCCCCCCCCCCCEEEHHHCCH
KAIVRDMRAAGVPAMVSQTAGTFVCNHVFYGLMHVLAHRKAGSAAAPTRGGFIHIPYLPE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCH
QAARHPGAPSLALDTLIAGLRVAVATSLSTDADIREGGGQLH
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA