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The map label for this gene is phoP [H]

Identifier: 94308973

GI number: 94308973

Start: 32264

End: 33070

Strand: Direct

Name: phoP [H]

Synonym: Rmet_0028

Alternate gene names: 94308973

Gene position: 32264-33070 (Clockwise)

Preceding gene: 94308971

Following gene: 335055474

Centisome position: 0.82

GC content: 65.3

Gene sequence:

>807_bases
ATGACAAGGATGGGACTGAGGGTTGCCTCGCTGGAGGACGACGCCGCCGAGGCCGCGAGGATTCGCGAGATCGTGACGGC
GGAAGGGCACGAGTGCGTAACGTTCGCCGATGGCAGGCGCATGCTGGTCACGTTGCGCAAGGTCACGTTCGACCTGCTGC
TGCTTGACTGGCACGTGCCGCATGTCTCGGGCCGGGAAGTACTGGACTGGGTGCGCGCGCACCTGGACCCGCGCATACCG
GTGATGTTCCTGACTGGGCGTGACACCGAGGCGGACATTGTCGCAACGTTGAGTGCCGGCGCCGACGACTATATGGTCAA
GCCGATCCGGCCGCGCGAACTCGGCGCGCGCATCGCAGCGCTGCTGCGGCGAGCGTACCCGGACTCTCGCCAGCCAGACG
ATGGACGGCTGACCTGGGGCTGTTTCCGCTTTGATGCCGTGACGCGCGAAGCCACGTGCCACGGGCAGGAGGTACGGCTG
ACGCCGAAGGAGTTCGAAGTCGCGCTGCTCCTGTTCCGCAATGAGGGCCGCGCCGTGCCGCGCGAATACATGCTTGCGGC
GATCTGGGGCAAGGAACTGCCACCGCTGTCGCGCACCATCGATACCCATGTCTCGCGCGTGCGTACCAAGCTCGGCCTGT
GGGAGCACAACGGCGTGCGGCTCCAGCCGCTCTACACGCATGGCTATCGTCTGGAACTGCTGACGACGCCGGGGATGGCG
CCACCGTCAACACCACCGCCAACTCCACCTTCGACTCCGCCATCGCAAAAAAAGAAAGGCACCCGAAGGTGCCTTTCTGC
CAACTGA

Upstream 100 bases:

>100_bases
GATGCAGAAAATGAGCATCGTCTTATAGGGTTTTCTCGCTCACACGCCTCTAATGGTCGTCAGCGATTTCACTGGACGCT
CCACGTGGGAGCGACGACGC

Downstream 100 bases:

>100_bases
TCAAACCAACAATCAGAAGATGTGGCGGATGCCAGCGCCGAAGCTGGTCTGGTTGTTGCGGCCCGGCAGTTCGGTCGTGG
TAGCGCCCGAAACCTTGTTG

Product: response regulator, OmpR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTRMGLRVASLEDDAAEAARIREIVTAEGHECVTFADGRRMLVTLRKVTFDLLLLDWHVPHVSGREVLDWVRAHLDPRIP
VMFLTGRDTEADIVATLSAGADDYMVKPIRPRELGARIAALLRRAYPDSRQPDDGRLTWGCFRFDAVTREATCHGQEVRL
TPKEFEVALLLFRNEGRAVPREYMLAAIWGKELPPLSRTIDTHVSRVRTKLGLWEHNGVRLQPLYTHGYRLELLTTPGMA
PPSTPPPTPPSTPPSQKKKGTRRCLSAN

Sequences:

>Translated_268_residues
MTRMGLRVASLEDDAAEAARIREIVTAEGHECVTFADGRRMLVTLRKVTFDLLLLDWHVPHVSGREVLDWVRAHLDPRIP
VMFLTGRDTEADIVATLSAGADDYMVKPIRPRELGARIAALLRRAYPDSRQPDDGRLTWGCFRFDAVTREATCHGQEVRL
TPKEFEVALLLFRNEGRAVPREYMLAAIWGKELPPLSRTIDTHVSRVRTKLGLWEHNGVRLQPLYTHGYRLELLTTPGMA
PPSTPPPTPPSTPPSQKKKGTRRCLSAN
>Mature_267_residues
TRMGLRVASLEDDAAEAARIREIVTAEGHECVTFADGRRMLVTLRKVTFDLLLLDWHVPHVSGREVLDWVRAHLDPRIPV
MFLTGRDTEADIVATLSAGADDYMVKPIRPRELGARIAALLRRAYPDSRQPDDGRLTWGCFRFDAVTREATCHGQEVRLT
PKEFEVALLLFRNEGRAVPREYMLAAIWGKELPPLSRTIDTHVSRVRTKLGLWEHNGVRLQPLYTHGYRLELLTTPGMAP
PSTPPPTPPSTPPSQKKKGTRRCLSAN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=32.5892857142857, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI2367329, Length=209, Percent_Identity=33.4928229665072, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789809, Length=205, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789402, Length=208, Percent_Identity=32.6923076923077, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790552, Length=207, Percent_Identity=31.4009661835749, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=29.6943231441048, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.3185840707965, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082012, Length=206, Percent_Identity=29.126213592233, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787375, Length=206, Percent_Identity=28.1553398058252, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786784, Length=162, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787229, Length=217, Percent_Identity=27.6497695852535, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1786911, Length=204, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=23.9130434782609, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30186; Mature: 30055

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRMGLRVASLEDDAAEAARIREIVTAEGHECVTFADGRRMLVTLRKVTFDLLLLDWHVP
CCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHEEEEEEECCC
HVSGREVLDWVRAHLDPRIPVMFLTGRDTEADIVATLSAGADDYMVKPIRPRELGARIAA
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHH
LLRRAYPDSRQPDDGRLTWGCFRFDAVTREATCHGQEVRLTPKEFEVALLLFRNEGRAVP
HHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCEEEECHHHEEEEEEEEECCCCCCC
REYMLAAIWGKELPPLSRTIDTHVSRVRTKLGLWEHNGVRLQPLYTHGYRLELLTTPGMA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECCCEEEEEEEECCEEEEEEECCCCC
PPSTPPPTPPSTPPSQKKKGTRRCLSAN
CCCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRMGLRVASLEDDAAEAARIREIVTAEGHECVTFADGRRMLVTLRKVTFDLLLLDWHVP
CCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHEEEEEEECCC
HVSGREVLDWVRAHLDPRIPVMFLTGRDTEADIVATLSAGADDYMVKPIRPRELGARIAA
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHH
LLRRAYPDSRQPDDGRLTWGCFRFDAVTREATCHGQEVRLTPKEFEVALLLFRNEGRAVP
HHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCEEEECHHHEEEEEEEEECCCCCCC
REYMLAAIWGKELPPLSRTIDTHVSRVRTKLGLWEHNGVRLQPLYTHGYRLELLTTPGMA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECCCEEEEEEEECCEEEEEEECCCCC
PPSTPPPTPPSTPPSQKKKGTRRCLSAN
CCCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]