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The map label for this gene is gpwA [H]

Identifier: 94308963

GI number: 94308963

Start: 22066

End: 22692

Strand: Direct

Name: gpwA [H]

Synonym: Rmet_0018

Alternate gene names: 94308963

Gene position: 22066-22692 (Clockwise)

Preceding gene: 94308962

Following gene: 94308964

Centisome position: 0.56

GC content: 63.64

Gene sequence:

>627_bases
ATGTCCCGCCAACGTACCCTGGAATCCGTGCAACGAACCGCTCTGGCTGGCGCGCTGACGCTGGCTGCCGCCGTGGCAGT
CATGCTGCCGCCACCTGCTCACGCCGCCGAAAAGGCCGTGCCGGCGGCCGCGCAGCCGGCGGGCAATTGCCCGGCGTCGT
TGAACTTCCGCTTCCCGCGGCTCCAGGACGAATCGCCGCAGAACCTGTGCCAGTACGCTGGCAAGGTGGTGCTGGTCGTG
AACACGGCCAGCTATTGCGGCTTCACGCCGCAGTACGAGGGCCTTGAGGCGCTCTACGCCAAGTACCGCGAACGCGGGCT
GGTGGTGCTCGGTTTCCCGTCCAACGACTTTTCCCAGGAACCCGGCTCGTCCAAGGACATTGCAGACTTTTGCTACAACA
CCTACGGGGTCAAGTTCCCGATGCTCGGCAAGAGCCATGTGCGCGGCAGCGACGCCAATCCGATGTACGCACTGCTGGCC
CAGGAGACGGGCACCGCGCCGAAGTGGAACTTCTACAAGTACCTGATCGACCGCAAGGGGCAGGTCATCGGCAGCTACAA
CAGCATGGTCAAGCCGGACGACAAGCAGTTTGTCTCGAAGATCGAAGAACTGCTGAACGCGCGCTGA

Upstream 100 bases:

>100_bases
CCAGGGAAGAGGCCGGGTGTGCCCGAATGACGCGAATCGGCCGAGAGCGTAGACTTCCTTGCACCTAAAGTCACTCCTCA
AGCCACCGGAGCCCCGATTC

Downstream 100 bases:

>100_bases
TGCGCGGCTTGCCCCGCAGCGTGTCCATGCGGCTGTCGTTTCGTAGCTTGTTTCTGCCATAGTTTGATCACCGTCAATAA
AGAAACGCCTACGTCTCATT

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSRQRTLESVQRTALAGALTLAAAVAVMLPPPAHAAEKAVPAAAQPAGNCPASLNFRFPRLQDESPQNLCQYAGKVVLVV
NTASYCGFTPQYEGLEALYAKYRERGLVVLGFPSNDFSQEPGSSKDIADFCYNTYGVKFPMLGKSHVRGSDANPMYALLA
QETGTAPKWNFYKYLIDRKGQVIGSYNSMVKPDDKQFVSKIEELLNAR

Sequences:

>Translated_208_residues
MSRQRTLESVQRTALAGALTLAAAVAVMLPPPAHAAEKAVPAAAQPAGNCPASLNFRFPRLQDESPQNLCQYAGKVVLVV
NTASYCGFTPQYEGLEALYAKYRERGLVVLGFPSNDFSQEPGSSKDIADFCYNTYGVKFPMLGKSHVRGSDANPMYALLA
QETGTAPKWNFYKYLIDRKGQVIGSYNSMVKPDDKQFVSKIEELLNAR
>Mature_207_residues
SRQRTLESVQRTALAGALTLAAAVAVMLPPPAHAAEKAVPAAAQPAGNCPASLNFRFPRLQDESPQNLCQYAGKVVLVVN
TASYCGFTPQYEGLEALYAKYRERGLVVLGFPSNDFSQEPGSSKDIADFCYNTYGVKFPMLGKSHVRGSDANPMYALLAQ
ETGTAPKWNFYKYLIDRKGQVIGSYNSMVKPDDKQFVSKIEELLNAR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=129, Percent_Identity=44.1860465116279, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI90903240, Length=173, Percent_Identity=38.150289017341, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI192455698, Length=141, Percent_Identity=36.1702127659575, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI75709200, Length=200, Percent_Identity=34.5, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI90903238, Length=182, Percent_Identity=33.5164835164835, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4557629, Length=141, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1788003, Length=165, Percent_Identity=38.1818181818182, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71993584, Length=143, Percent_Identity=38.4615384615385, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17535473, Length=146, Percent_Identity=38.3561643835616, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193210707, Length=148, Percent_Identity=37.8378378378378, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17506887, Length=146, Percent_Identity=35.6164383561644, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550320, Length=195, Percent_Identity=28.7179487179487, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193209493, Length=154, Percent_Identity=29.2207792207792, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322228, Length=141, Percent_Identity=49.645390070922, Blast_Score=138, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319721, Length=128, Percent_Identity=50.78125, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322826, Length=139, Percent_Identity=43.1654676258993, Blast_Score=118, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24656772, Length=145, Percent_Identity=40.6896551724138, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656777, Length=144, Percent_Identity=40.9722222222222, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI85726443, Length=131, Percent_Identity=37.4045801526718, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656767, Length=144, Percent_Identity=40.9722222222222, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 22750; Mature: 22619

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQRTLESVQRTALAGALTLAAAVAVMLPPPAHAAEKAVPAAAQPAGNCPASLNFRFPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
LQDESPQNLCQYAGKVVLVVNTASYCGFTPQYEGLEALYAKYRERGLVVLGFPSNDFSQE
CCCCCHHHHHHHCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCC
PGSSKDIADFCYNTYGVKFPMLGKSHVRGSDANPMYALLAQETGTAPKWNFYKYLIDRKG
CCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCC
QVIGSYNSMVKPDDKQFVSKIEELLNAR
CEEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRQRTLESVQRTALAGALTLAAAVAVMLPPPAHAAEKAVPAAAQPAGNCPASLNFRFPR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
LQDESPQNLCQYAGKVVLVVNTASYCGFTPQYEGLEALYAKYRERGLVVLGFPSNDFSQE
CCCCCHHHHHHHCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCC
PGSSKDIADFCYNTYGVKFPMLGKSHVRGSDANPMYALLAQETGTAPKWNFYKYLIDRKG
CCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCC
QVIGSYNSMVKPDDKQFVSKIEELLNAR
CEEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA