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The map label for this gene is fkpA [H]

Identifier: 93007230

GI number: 93007230

Start: 2962159

End: 2962890

Strand: Reverse

Name: fkpA [H]

Synonym: Pcryo_2406

Alternate gene names: 93007230

Gene position: 2962890-2962159 (Counterclockwise)

Preceding gene: 93007232

Following gene: 93007228

Centisome position: 96.83

GC content: 43.03

Gene sequence:

>732_bases
ATGAAAAAAATCACTACCCTAAGCATCAGTGCCCTTGCTAGTGCTATGTTATTAATCACAGGCTGTAGCGCAAACAATGG
CAGTAAAGAAACAGCTACCAAAAGTGTTTCAGTGACTGAACAAAGCCCTGCCAAGGAAAAAGTAGGCTATAGCTTGGGCT
ATATGATGGCAGAAGGGAATAAAGAAGCGGTTGGGGATCTGCACCTAGATACGTTTGAAAAAGGTTTCCGTGATGGCTAT
GAAGGCAAAAAAGCGGCATTGACAGAAGAGCAAATGCAAGAAGTGTTAATGGCCTATCAAAAAGAACAGGAAGCGAAGTT
TGTGAAAGATATGGAATCTAAAGCGGGTGCAAACAAAACTAAGGGCGCCGCATTCTTAGTAGAGAATGGCAAAAAAGCTG
GCGTAAAAACCACTGCTTCAGGTCTACAATATAAAGTAGTGACCGCAGGTACTGGCAAGTCGCCAAAAGCTACGGACGTG
GTTGAAGTAAACTACGAAGGTAAATTGATTGACGGCACTGTATTCGATAGCTCATATGAGCGTGGTGAGCCAATTGAATT
CCCACTAAACCAAGTAATCGCTGGTTGGACTGAAGGTCTACAGTTGATGAAAGAGGGCGGTAAATACGAGTTTTATATCC
CATCTGATATCGCTTATGGTGAAGCGGGTAACGCAGGTATCGAGCCTAATAGCACGCTAATCTTTACCGTTGAGCTATTA
AAGGTAAAGTAA

Upstream 100 bases:

>100_bases
GACCGATAATTTCAAGTGAGTCATAGCAGGCAAAACTAAGATTTGCTATTATAGATAAATGTGACATCTCGCCACTATTA
TTACAATTTGAGAGCATTTT

Downstream 100 bases:

>100_bases
TTAGCAGTAATTAATGCCAATTTAGTATTGATACAATAGACGTTAAAAGAAGCCCTCTTACATTAAGAGGGCTTCTTTTT
GCGTAAGAAATAGCACTTAA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKKITTLSISALASAMLLITGCSANNGSKETATKSVSVTEQSPAKEKVGYSLGYMMAEGNKEAVGDLHLDTFEKGFRDGY
EGKKAALTEEQMQEVLMAYQKEQEAKFVKDMESKAGANKTKGAAFLVENGKKAGVKTTASGLQYKVVTAGTGKSPKATDV
VEVNYEGKLIDGTVFDSSYERGEPIEFPLNQVIAGWTEGLQLMKEGGKYEFYIPSDIAYGEAGNAGIEPNSTLIFTVELL
KVK

Sequences:

>Translated_243_residues
MKKITTLSISALASAMLLITGCSANNGSKETATKSVSVTEQSPAKEKVGYSLGYMMAEGNKEAVGDLHLDTFEKGFRDGY
EGKKAALTEEQMQEVLMAYQKEQEAKFVKDMESKAGANKTKGAAFLVENGKKAGVKTTASGLQYKVVTAGTGKSPKATDV
VEVNYEGKLIDGTVFDSSYERGEPIEFPLNQVIAGWTEGLQLMKEGGKYEFYIPSDIAYGEAGNAGIEPNSTLIFTVELL
KVK
>Mature_243_residues
MKKITTLSISALASAMLLITGCSANNGSKETATKSVSVTEQSPAKEKVGYSLGYMMAEGNKEAVGDLHLDTFEKGFRDGY
EGKKAALTEEQMQEVLMAYQKEQEAKFVKDMESKAGANKTKGAAFLVENGKKAGVKTTASGLQYKVVTAGTGKSPKATDV
VEVNYEGKLIDGTVFDSSYERGEPIEFPLNQVIAGWTEGLQLMKEGGKYEFYIPSDIAYGEAGNAGIEPNSTLIFTVELL
KVK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.0560747663551, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.0560747663551, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=49.4252873563218, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=49.4252873563218, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=49.4252873563218, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224809329, Length=102, Percent_Identity=42.156862745098, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI224809327, Length=102, Percent_Identity=42.156862745098, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4758384, Length=102, Percent_Identity=42.156862745098, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI224809331, Length=102, Percent_Identity=42.156862745098, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=38.5416666666667, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=196, Percent_Identity=43.3673469387755, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789745, Length=199, Percent_Identity=45.2261306532663, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17561782, Length=90, Percent_Identity=44.4444444444444, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=51.685393258427, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=44.5544554455446, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=43.9252336448598, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=91, Percent_Identity=47.2527472527472, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281363946, Length=92, Percent_Identity=43.4782608695652, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17352457, Length=92, Percent_Identity=43.4782608695652, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26116; Mature: 26116

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITTLSISALASAMLLITGCSANNGSKETATKSVSVTEQSPAKEKVGYSLGYMMAEGN
CCCEEEEEHHHHHHHHHHEECCCCCCCCCHHHCCEEEECCCCCCHHHHCHHEEEEEECCC
KEAVGDLHLDTFEKGFRDGYEGKKAALTEEQMQEVLMAYQKEQEAKFVKDMESKAGANKT
CCHHCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KGAAFLVENGKKAGVKTTASGLQYKVVTAGTGKSPKATDVVEVNYEGKLIDGTVFDSSYE
CCEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEECEEECCCCC
RGEPIEFPLNQVIAGWTEGLQLMKEGGKYEFYIPSDIAYGEAGNAGIEPNSTLIFTVELL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEE
KVK
EEC
>Mature Secondary Structure
MKKITTLSISALASAMLLITGCSANNGSKETATKSVSVTEQSPAKEKVGYSLGYMMAEGN
CCCEEEEEHHHHHHHHHHEECCCCCCCCCHHHCCEEEECCCCCCHHHHCHHEEEEEECCC
KEAVGDLHLDTFEKGFRDGYEGKKAALTEEQMQEVLMAYQKEQEAKFVKDMESKAGANKT
CCHHCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KGAAFLVENGKKAGVKTTASGLQYKVVTAGTGKSPKATDVVEVNYEGKLIDGTVFDSSYE
CCEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEECEEECCCCC
RGEPIEFPLNQVIAGWTEGLQLMKEGGKYEFYIPSDIAYGEAGNAGIEPNSTLIFTVELL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEE
KVK
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]