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The map label for this gene is envZ [H]

Identifier: 93007147

GI number: 93007147

Start: 2850955

End: 2852526

Strand: Direct

Name: envZ [H]

Synonym: Pcryo_2323

Alternate gene names: 93007147

Gene position: 2850955-2852526 (Clockwise)

Preceding gene: 93007142

Following gene: 93007160

Centisome position: 93.17

GC content: 44.66

Gene sequence:

>1572_bases
ATGATATTGCCAGCGTTGTCGATGAAAGCTGGCAGCGTTATTAATGGGTTATGCTATCCTAGCAATAGCATCTGTCACTG
CCTCATTATAATTTGGATTCCTATGACCACGCCAAACCCACCATTGCCTCATAAAAGCTGGTTACCCCGCTCTTACTCTA
ATAGTCTGCTAACCACTCTAATGGTGGCTTTTATTGTTCTCATTAGCGTCGGGGTATCAATTTTGTTTTTTTGGCGCAGT
CTATATTTACCAGAGCTCAAAAGCCATGCGCGCTATTTGACCAGCGAGCTTCGGCTGATGAACAGCGCCAATCGAGACTG
GCGGGACAATCCTGAAGTTCGTCAGTGGATTTATCAGCACTCACATGTAGTAGTGGTGGATAACCCAAGTGACTTTCCAG
AGGTTGCGGACAAAGCTTTTGTCAGTGTTTTTACGGATGTGTTGCAGCGAGAAATCAGCGCACAATTGGGCCGACCAGTT
GAAGTATATTTTAAATTTAAACCAACCCCTCAGCTTTGGGTACAAGACAGTCGTGATAGCAGTTTTTGGATACGCGAACC
TGTGGTCTATTATTCGCAGTACAGCCCTACTTTATTGATCTTGTTTTTGTTTGGGCTACCCATTTTGACACTGTTGACGA
TTATTTTATTAGCCCGTCAATTAAACCGTCCTCTACGTTATCTTCAACGTGCTGCTACCAACTATATTCAGTTGGGTCAT
GCAACAACGCTACCGACCCGTCATGGTCCTACCGAGATTCGCCAAGTAAATATGGCTTTTAACCGTCTGTTTACTACTCT
TAACCAGGCGCAAAAAGAGCGTACGATTATGTTAGCTGGCATCTCACACGATTTGCGTACCCCGCTGACTCGTATGCGCT
TAACTGCTGAAATGCTGCCCGATGATTTTTTTCGTGAAGGGTTGATTTACGATATCGAAGATATGGATGCTATTTTAGAG
CAATTTATCTCGTTTATGAAAGATGGCTCCGATGAGCCTGTACGCCTTACCAATTTAGATACCATATTTAATGAGATTAT
GGTGCAATTTGCGCCACTAGAGTTTATTTATCAGTCAGAATGCAGCAAGCTTGTGCCCGTACGTCCTATGTCGATTAAGC
GCCTGATTATCAATCTGGTGAATAATGCCAAGCGTTATGGTGAACCGCCTATTTATCTGTCTGCTGTTGTCATGCCAACC
TTTGTAGAAAAAGAGGTGATAGAATACAGCGATGTCGTGACCGAAAATACAGTCAATAAAGAAGCAAAAGAGCAGTTGAT
TATATGTGTGCGAGACTGCGGCGATGGGGTGGCAGAAGACCAACTCGAGCGTGTCATGCAGCCGTTTGAGCGTGGCGAAT
CAGCGCGTACCACTCAGGGTAGTGGACTCGGCTTGGCGATTGTTGACCGTATCGCGCGCTTGCATCATGGAACAGTTGAG
GCTATTAATCATCCAGATGGTGGTCTACAAGTCTGTATTCGCATCCCTCTCATTTCAGAAGTTGCCGGAGAGCAGCCTTT
GGATATCAATCCCGCTACAAAGCCATTTATTGAGACAGTTGATACTAAATAA

Upstream 100 bases:

>100_bases
ATTAACAATAGCTTAAATCGTTATGACTGTAAATAAGATTCATCATTCACGCTGCTAATATGATGGATACTCCTCTATCA
TATGCCTTTATCTTAAGCGG

Downstream 100 bases:

>100_bases
AATAGATACCTTATTTTATGGGGCGAGACTGGGACGAATTTTTCTCGCTTAATCACTTTTATATTGAACTGATCATAATA
GTGCCAATCAATCATACTAA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MILPALSMKAGSVINGLCYPSNSICHCLIIIWIPMTTPNPPLPHKSWLPRSYSNSLLTTLMVAFIVLISVGVSILFFWRS
LYLPELKSHARYLTSELRLMNSANRDWRDNPEVRQWIYQHSHVVVVDNPSDFPEVADKAFVSVFTDVLQREISAQLGRPV
EVYFKFKPTPQLWVQDSRDSSFWIREPVVYYSQYSPTLLILFLFGLPILTLLTIILLARQLNRPLRYLQRAATNYIQLGH
ATTLPTRHGPTEIRQVNMAFNRLFTTLNQAQKERTIMLAGISHDLRTPLTRMRLTAEMLPDDFFREGLIYDIEDMDAILE
QFISFMKDGSDEPVRLTNLDTIFNEIMVQFAPLEFIYQSECSKLVPVRPMSIKRLIINLVNNAKRYGEPPIYLSAVVMPT
FVEKEVIEYSDVVTENTVNKEAKEQLIICVRDCGDGVAEDQLERVMQPFERGESARTTQGSGLGLAIVDRIARLHHGTVE
AINHPDGGLQVCIRIPLISEVAGEQPLDINPATKPFIETVDTK

Sequences:

>Translated_523_residues
MILPALSMKAGSVINGLCYPSNSICHCLIIIWIPMTTPNPPLPHKSWLPRSYSNSLLTTLMVAFIVLISVGVSILFFWRS
LYLPELKSHARYLTSELRLMNSANRDWRDNPEVRQWIYQHSHVVVVDNPSDFPEVADKAFVSVFTDVLQREISAQLGRPV
EVYFKFKPTPQLWVQDSRDSSFWIREPVVYYSQYSPTLLILFLFGLPILTLLTIILLARQLNRPLRYLQRAATNYIQLGH
ATTLPTRHGPTEIRQVNMAFNRLFTTLNQAQKERTIMLAGISHDLRTPLTRMRLTAEMLPDDFFREGLIYDIEDMDAILE
QFISFMKDGSDEPVRLTNLDTIFNEIMVQFAPLEFIYQSECSKLVPVRPMSIKRLIINLVNNAKRYGEPPIYLSAVVMPT
FVEKEVIEYSDVVTENTVNKEAKEQLIICVRDCGDGVAEDQLERVMQPFERGESARTTQGSGLGLAIVDRIARLHHGTVE
AINHPDGGLQVCIRIPLISEVAGEQPLDINPATKPFIETVDTK
>Mature_523_residues
MILPALSMKAGSVINGLCYPSNSICHCLIIIWIPMTTPNPPLPHKSWLPRSYSNSLLTTLMVAFIVLISVGVSILFFWRS
LYLPELKSHARYLTSELRLMNSANRDWRDNPEVRQWIYQHSHVVVVDNPSDFPEVADKAFVSVFTDVLQREISAQLGRPV
EVYFKFKPTPQLWVQDSRDSSFWIREPVVYYSQYSPTLLILFLFGLPILTLLTIILLARQLNRPLRYLQRAATNYIQLGH
ATTLPTRHGPTEIRQVNMAFNRLFTTLNQAQKERTIMLAGISHDLRTPLTRMRLTAEMLPDDFFREGLIYDIEDMDAILE
QFISFMKDGSDEPVRLTNLDTIFNEIMVQFAPLEFIYQSECSKLVPVRPMSIKRLIINLVNNAKRYGEPPIYLSAVVMPT
FVEKEVIEYSDVVTENTVNKEAKEQLIICVRDCGDGVAEDQLERVMQPFERGESARTTQGSGLGLAIVDRIARLHHGTVE
AINHPDGGLQVCIRIPLISEVAGEQPLDINPATKPFIETVDTK

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=466, Percent_Identity=30.68669527897, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1789403, Length=305, Percent_Identity=28.8524590163934, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787894, Length=316, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=334, Percent_Identity=23.9520958083832, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=25.2032520325203, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59604; Mature: 59604

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPALSMKAGSVINGLCYPSNSICHCLIIIWIPMTTPNPPLPHKSWLPRSYSNSLLTTL
CCCCCCCCCCCCHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
MVAFIVLISVGVSILFFWRSLYLPELKSHARYLTSELRLMNSANRDWRDNPEVRQWIYQH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
SHVVVVDNPSDFPEVADKAFVSVFTDVLQREISAQLGRPVEVYFKFKPTPQLWVQDSRDS
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCC
SFWIREPVVYYSQYSPTLLILFLFGLPILTLLTIILLARQLNRPLRYLQRAATNYIQLGH
CEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
ATTLPTRHGPTEIRQVNMAFNRLFTTLNQAQKERTIMLAGISHDLRTPLTRMRLTAEMLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCC
DDFFREGLIYDIEDMDAILEQFISFMKDGSDEPVRLTNLDTIFNEIMVQFAPLEFIYQSE
HHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHH
CSKLVPVRPMSIKRLIINLVNNAKRYGEPPIYLSAVVMPTFVEKEVIEYSDVVTENTVNK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCH
EAKEQLIICVRDCGDGVAEDQLERVMQPFERGESARTTQGSGLGLAIVDRIARLHHGTVE
HHHHHHEEEEHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
AINHPDGGLQVCIRIPLISEVAGEQPLDINPATKPFIETVDTK
CCCCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MILPALSMKAGSVINGLCYPSNSICHCLIIIWIPMTTPNPPLPHKSWLPRSYSNSLLTTL
CCCCCCCCCCCCHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
MVAFIVLISVGVSILFFWRSLYLPELKSHARYLTSELRLMNSANRDWRDNPEVRQWIYQH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
SHVVVVDNPSDFPEVADKAFVSVFTDVLQREISAQLGRPVEVYFKFKPTPQLWVQDSRDS
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCC
SFWIREPVVYYSQYSPTLLILFLFGLPILTLLTIILLARQLNRPLRYLQRAATNYIQLGH
CEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
ATTLPTRHGPTEIRQVNMAFNRLFTTLNQAQKERTIMLAGISHDLRTPLTRMRLTAEMLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCC
DDFFREGLIYDIEDMDAILEQFISFMKDGSDEPVRLTNLDTIFNEIMVQFAPLEFIYQSE
HHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHH
CSKLVPVRPMSIKRLIINLVNNAKRYGEPPIYLSAVVMPTFVEKEVIEYSDVVTENTVNK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCH
EAKEQLIICVRDCGDGVAEDQLERVMQPFERGESARTTQGSGLGLAIVDRIARLHHGTVE
HHHHHHEEEEHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
AINHPDGGLQVCIRIPLISEVAGEQPLDINPATKPFIETVDTK
CCCCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]