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The map label for this gene is hisI [H]

Identifier: 93007126

GI number: 93007126

Start: 2830364

End: 2831206

Strand: Direct

Name: hisI [H]

Synonym: Pcryo_2302

Alternate gene names: 93007126

Gene position: 2830364-2831206 (Clockwise)

Preceding gene: 93007120

Following gene: 93007127

Centisome position: 92.5

GC content: 44.25

Gene sequence:

>843_bases
ATGACTTCACCTGATTGGCTGGCTGCCGTAAATTTTAATGCTGATGGTTTGATTCCTGCAATTGCACAAGATTATGTGTC
AGGGCGTATTTTGATGATGGCTTGGATGAATGCCGAATCCCTACAATTAACCGCACAAACGCAGACGGCAGTGTATTTTT
CGCGTTCGCGTGGCAAGTTATGGCATAAGGGCGAATCCTCTGGACATACCCAACGCGTACATGATATTCGTCTAGATTGC
GACGCCGATGTGATTGTCCTTAGCGTCACTCAAGTCGGTGGTATTGCTTGTCATACTGGGCGCGAGTCTTGTTTTTATCA
GCGTTTGGATTTATCAGGGCAAACGCCTGCATGGCAAACCGTCGATAAGGTATTAAAAGATCCTGCTGATATTTATCATT
CAAGCGATGCAGAAAAAGCCACTCCTAAAACTAATGAGACGCAGGCTCACGATGTAATCCCTTCAGATGCCAATACCAAT
GACACTACTAATCGCTCTATTTTGCAACAGCTTGACGGTGTATTGGCTGAGCGCAAGCATACGGATGCCGATAGCTCATA
TGTAGCAAGCTTATACGCCAAGGGTTTGAATAAAATCTTAGAAAAAGTTGGTGAAGAAAGTACAGAGAGCATCATCGCTG
CCAAAGACTTTGCTAATTGCAATGAAAATACGGATAAAACCCAATATGACGAAGCGCGTCATGAGCTTATCTATGAAGTC
GCTGATGTTTGGTTCCATACTTTAGTAGGTTTGGCTTGGTTCGATATCGAATCAGAGGCAGTATTAAATGAGCTAGGTCG
ACGCTTTGGTCTCTCAGGTATTGATGAAAAGGCGGCTCGATAG

Upstream 100 bases:

>100_bases
TAAAGCGCTTACATGAATGACAAATAGGCTGAATAACTATTATTTAGCGAATACTTAGCGACTTTTTATTATTTTCTACT
TATAAGATGGCAACAAGATT

Downstream 100 bases:

>100_bases
CGTTTTATAAGATTAGCCATTACCCTGTTTGATTATTGTTGCTTTCACCTTTTTGTCATAACAGCAGGTTATAATATAGT
GACGTGTCACTTCGCATAAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTSPDWLAAVNFNADGLIPAIAQDYVSGRILMMAWMNAESLQLTAQTQTAVYFSRSRGKLWHKGESSGHTQRVHDIRLDC
DADVIVLSVTQVGGIACHTGRESCFYQRLDLSGQTPAWQTVDKVLKDPADIYHSSDAEKATPKTNETQAHDVIPSDANTN
DTTNRSILQQLDGVLAERKHTDADSSYVASLYAKGLNKILEKVGEESTESIIAAKDFANCNENTDKTQYDEARHELIYEV
ADVWFHTLVGLAWFDIESEAVLNELGRRFGLSGIDEKAAR

Sequences:

>Translated_280_residues
MTSPDWLAAVNFNADGLIPAIAQDYVSGRILMMAWMNAESLQLTAQTQTAVYFSRSRGKLWHKGESSGHTQRVHDIRLDC
DADVIVLSVTQVGGIACHTGRESCFYQRLDLSGQTPAWQTVDKVLKDPADIYHSSDAEKATPKTNETQAHDVIPSDANTN
DTTNRSILQQLDGVLAERKHTDADSSYVASLYAKGLNKILEKVGEESTESIIAAKDFANCNENTDKTQYDEARHELIYEV
ADVWFHTLVGLAWFDIESEAVLNELGRRFGLSGIDEKAAR
>Mature_279_residues
TSPDWLAAVNFNADGLIPAIAQDYVSGRILMMAWMNAESLQLTAQTQTAVYFSRSRGKLWHKGESSGHTQRVHDIRLDCD
ADVIVLSVTQVGGIACHTGRESCFYQRLDLSGQTPAWQTVDKVLKDPADIYHSSDAEKATPKTNETQAHDVIPSDANTND
TTNRSILQQLDGVLAERKHTDADSSYVASLYAKGLNKILEKVGEESTESIIAAKDFANCNENTDKTQYDEARHELIYEVA
DVWFHTLVGLAWFDIESEAVLNELGRRFGLSGIDEKAAR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=254, Percent_Identity=30.7086614173228, Blast_Score=104, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 31024; Mature: 30892

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPDWLAAVNFNADGLIPAIAQDYVSGRILMMAWMNAESLQLTAQTQTAVYFSRSRGKL
CCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEEECHHEEEEEECCCCCC
WHKGESSGHTQRVHDIRLDCDADVIVLSVTQVGGIACHTGRESCFYQRLDLSGQTPAWQT
EECCCCCCCCHHHHEEEECCCCCEEEEEEHHHCCEEEECCCHHHHHHHHCCCCCCCHHHH
VDKVLKDPADIYHSSDAEKATPKTNETQAHDVIPSDANTNDTTNRSILQQLDGVLAERKH
HHHHHHCHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TDADSSYVASLYAKGLNKILEKVGEESTESIIAAKDFANCNENTDKTQYDEARHELIYEV
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ADVWFHTLVGLAWFDIESEAVLNELGRRFGLSGIDEKAAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
TSPDWLAAVNFNADGLIPAIAQDYVSGRILMMAWMNAESLQLTAQTQTAVYFSRSRGKL
CCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEEECHHEEEEEECCCCCC
WHKGESSGHTQRVHDIRLDCDADVIVLSVTQVGGIACHTGRESCFYQRLDLSGQTPAWQT
EECCCCCCCCHHHHEEEECCCCCEEEEEEHHHCCEEEECCCHHHHHHHHCCCCCCCHHHH
VDKVLKDPADIYHSSDAEKATPKTNETQAHDVIPSDANTNDTTNRSILQQLDGVLAERKH
HHHHHHCHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TDADSSYVASLYAKGLNKILEKVGEESTESIIAAKDFANCNENTDKTQYDEARHELIYEV
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ADVWFHTLVGLAWFDIESEAVLNELGRRFGLSGIDEKAAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA