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The map label for this gene is ethA [H]

Identifier: 93007114

GI number: 93007114

Start: 2816894

End: 2818516

Strand: Reverse

Name: ethA [H]

Synonym: Pcryo_2290

Alternate gene names: 93007114

Gene position: 2818516-2816894 (Counterclockwise)

Preceding gene: 93007115

Following gene: 93007110

Centisome position: 92.11

GC content: 44.55

Gene sequence:

>1623_bases
ATGCTTAATATGACTACTGCCAAGCAGGCGCTTAAGAAGCGCTTTAAAGCTAAACCTTATTCATCAGATGCTCCTGCAGA
TTATGAGGTACTGATTATTGGTGCGGGTATCGCAGGCATCAGCATGGCTTGCCATTTGCAGCAGCAGAGCTCGCAAAAAA
GTCATCGAAGTCTTTTTGATAGTAAAAGCGTTAAGCAGAAAAAACGCCTCAAACTTAATAGCCAACGATTTTTAATCGTA
GAAAAACGTGAGGATTTGGGCGGTACATGGGATTTGTTTACCTATCCTGGTATTCGTTCTGACTCGGATGCGCTGACTTT
TGGCTATAATTTCCGTCCGTGGTTGGATCATAAGATGCTTGCAAAAGGTGCAGACATTAAAAGCTATATTGCTGATACAG
CACGCGAGTTTAAAGTGGTAGAGCATATTCGCTATCAGCATGAAGTACAGCAGTTATCATGGTCAAGCGACAGTCAGCAA
TGGACGGCGATGATTAAAAATCATGCTACCAGTGAAGTATTGAGCTTAACGGCAAACTTTGTCGTTGGAGCGACCGGTTA
TTATGACTATGAAACTGGTTATAGACCACATTTTAAAAATGAAGAAAATTTCAAAGGTGAAATAGTCCACCCGCAGCATT
GGCAAGAAACACAATACGACGATAAAAAGGTCGTCGTCATTGGTAGTGGCGCGACGGCGATGACACTGATACCGGCATTG
GTCGATGAAAGTAGTAAACAATGTGCCCGTCATGTCACCATGCTGCAACGCTCACCGACGTATGTTGCAAGCGTACCAGG
CGATGATAATGCGCTTGACTGGCTATCAGGTAAATTCTCACCTTTATCAAAAGCACAGGCGTACACCTTGTTGCGTACGC
GCAATGTGATGTTTCAACAAGGTGTTTATCGGGTGGCGATTTATGCGCCAAAGATGATGAAAGCGCTATTAAACCATAAA
GTTAGAAAAGAGCTTAAAGGTAGTGGCGTGGATGTTGCCCATTTTAAGCCGGCTTATAATCCTTGGGAAGAGCGTTTGTG
TGCGGTACCTGATAGCGATTTGTTTCAAGCTTTGCATAGCAAGTGCGCTGAAGTGGTAACCGATAGCATAAGCCAGTTTA
CCTCAACGGGTATTGCATTAGCATCAGGCAAGCATTTGGACGCAGATATCATCGTTACTGCGACGGGTCTAAAATTACAG
ATGCTAGGCGGTGCAGCTTTATATGTCGATGGGGAGTCGATCGATGTAGGCGCACGAATGACCTACAAAGCAGTGATGCT
TGAGGGTGTACCAAATATGGCAATCATGTTTGGCTATACCAACGCGTCTTGGACATTGAAGATTGATTTGGCCTGTCAGT
ATGTGCTGCGTTTACTGAGTTATATGAATAAAGAAGGATACAAAACAGTATGTGCGCAGGCTGAGACTGAGCACGAAAAA
GTGAAAACGCAGGCAGATACGGTACTTGGGGCACTATCAGCAGGGTATGTCAGCCGTGCCAAGGATGAGCTGCCAAAACA
AGGTGATCGCTATCCTTGGCGGGTGAACAACAACTATGTCACCGATCGCATCATGCTCAAATACCGTAAAATCAAAGATG
AGTGGCTACAGTTTAATCGTTAG

Upstream 100 bases:

>100_bases
AATTACTAGATAAAGTTGCTAGGTAAAGCTGCTATGGAAAATTAGTAAGGCATCCTGCGCTCTAATAGGTCAGCCAACTT
GCAAAAACAAGGATTGTATT

Downstream 100 bases:

>100_bases
AATTTGCTAATTATTAATATTACTGAGCTTGATTGATAAAATCACTGACTTGTTTACTAAGCATTTGCCATAAGGTTTCT
TGCGCGCTTTTGCTGCCCCA

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MLNMTTAKQALKKRFKAKPYSSDAPADYEVLIIGAGIAGISMACHLQQQSSQKSHRSLFDSKSVKQKKRLKLNSQRFLIV
EKREDLGGTWDLFTYPGIRSDSDALTFGYNFRPWLDHKMLAKGADIKSYIADTAREFKVVEHIRYQHEVQQLSWSSDSQQ
WTAMIKNHATSEVLSLTANFVVGATGYYDYETGYRPHFKNEENFKGEIVHPQHWQETQYDDKKVVVIGSGATAMTLIPAL
VDESSKQCARHVTMLQRSPTYVASVPGDDNALDWLSGKFSPLSKAQAYTLLRTRNVMFQQGVYRVAIYAPKMMKALLNHK
VRKELKGSGVDVAHFKPAYNPWEERLCAVPDSDLFQALHSKCAEVVTDSISQFTSTGIALASGKHLDADIIVTATGLKLQ
MLGGAALYVDGESIDVGARMTYKAVMLEGVPNMAIMFGYTNASWTLKIDLACQYVLRLLSYMNKEGYKTVCAQAETEHEK
VKTQADTVLGALSAGYVSRAKDELPKQGDRYPWRVNNNYVTDRIMLKYRKIKDEWLQFNR

Sequences:

>Translated_540_residues
MLNMTTAKQALKKRFKAKPYSSDAPADYEVLIIGAGIAGISMACHLQQQSSQKSHRSLFDSKSVKQKKRLKLNSQRFLIV
EKREDLGGTWDLFTYPGIRSDSDALTFGYNFRPWLDHKMLAKGADIKSYIADTAREFKVVEHIRYQHEVQQLSWSSDSQQ
WTAMIKNHATSEVLSLTANFVVGATGYYDYETGYRPHFKNEENFKGEIVHPQHWQETQYDDKKVVVIGSGATAMTLIPAL
VDESSKQCARHVTMLQRSPTYVASVPGDDNALDWLSGKFSPLSKAQAYTLLRTRNVMFQQGVYRVAIYAPKMMKALLNHK
VRKELKGSGVDVAHFKPAYNPWEERLCAVPDSDLFQALHSKCAEVVTDSISQFTSTGIALASGKHLDADIIVTATGLKLQ
MLGGAALYVDGESIDVGARMTYKAVMLEGVPNMAIMFGYTNASWTLKIDLACQYVLRLLSYMNKEGYKTVCAQAETEHEK
VKTQADTVLGALSAGYVSRAKDELPKQGDRYPWRVNNNYVTDRIMLKYRKIKDEWLQFNR
>Mature_540_residues
MLNMTTAKQALKKRFKAKPYSSDAPADYEVLIIGAGIAGISMACHLQQQSSQKSHRSLFDSKSVKQKKRLKLNSQRFLIV
EKREDLGGTWDLFTYPGIRSDSDALTFGYNFRPWLDHKMLAKGADIKSYIADTAREFKVVEHIRYQHEVQQLSWSSDSQQ
WTAMIKNHATSEVLSLTANFVVGATGYYDYETGYRPHFKNEENFKGEIVHPQHWQETQYDDKKVVVIGSGATAMTLIPAL
VDESSKQCARHVTMLQRSPTYVASVPGDDNALDWLSGKFSPLSKAQAYTLLRTRNVMFQQGVYRVAIYAPKMMKALLNHK
VRKELKGSGVDVAHFKPAYNPWEERLCAVPDSDLFQALHSKCAEVVTDSISQFTSTGIALASGKHLDADIIVTATGLKLQ
MLGGAALYVDGESIDVGARMTYKAVMLEGVPNMAIMFGYTNASWTLKIDLACQYVLRLLSYMNKEGYKTVCAQAETEHEK
VKTQADTVLGALSAGYVSRAKDELPKQGDRYPWRVNNNYVTDRIMLKYRKIKDEWLQFNR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 60877; Mature: 60877

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNMTTAKQALKKRFKAKPYSSDAPADYEVLIIGAGIAGISMACHLQQQSSQKSHRSLFD
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
SKSVKQKKRLKLNSQRFLIVEKREDLGGTWDLFTYPGIRSDSDALTFGYNFRPWLDHKML
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCHHHH
AKGADIKSYIADTAREFKVVEHIRYQHEVQQLSWSSDSQQWTAMIKNHATSEVLSLTANF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VVGATGYYDYETGYRPHFKNEENFKGEIVHPQHWQETQYDDKKVVVIGSGATAMTLIPAL
EEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
VDESSKQCARHVTMLQRSPTYVASVPGDDNALDWLSGKFSPLSKAQAYTLLRTRNVMFQQ
HCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GVYRVAIYAPKMMKALLNHKVRKELKGSGVDVAHFKPAYNPWEERLCAVPDSDLFQALHS
CCEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHEECCCCHHHHHHHHH
KCAEVVTDSISQFTSTGIALASGKHLDADIIVTATGLKLQMLGGAALYVDGESIDVGARM
HHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCEEEEECCCEEECCCCC
TYKAVMLEGVPNMAIMFGYTNASWTLKIDLACQYVLRLLSYMNKEGYKTVCAQAETEHEK
EEEHHHHCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHH
VKTQADTVLGALSAGYVSRAKDELPKQGDRYPWRVNNNYVTDRIMLKYRKIKDEWLQFNR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNMTTAKQALKKRFKAKPYSSDAPADYEVLIIGAGIAGISMACHLQQQSSQKSHRSLFD
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
SKSVKQKKRLKLNSQRFLIVEKREDLGGTWDLFTYPGIRSDSDALTFGYNFRPWLDHKML
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCHHHH
AKGADIKSYIADTAREFKVVEHIRYQHEVQQLSWSSDSQQWTAMIKNHATSEVLSLTANF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VVGATGYYDYETGYRPHFKNEENFKGEIVHPQHWQETQYDDKKVVVIGSGATAMTLIPAL
EEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
VDESSKQCARHVTMLQRSPTYVASVPGDDNALDWLSGKFSPLSKAQAYTLLRTRNVMFQQ
HCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GVYRVAIYAPKMMKALLNHKVRKELKGSGVDVAHFKPAYNPWEERLCAVPDSDLFQALHS
CCEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHEECCCCHHHHHHHHH
KCAEVVTDSISQFTSTGIALASGKHLDADIIVTATGLKLQMLGGAALYVDGESIDVGARM
HHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCEEEEECCCEEECCCCC
TYKAVMLEGVPNMAIMFGYTNASWTLKIDLACQYVLRLLSYMNKEGYKTVCAQAETEHEK
EEEHHHHCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHH
VKTQADTVLGALSAGYVSRAKDELPKQGDRYPWRVNNNYVTDRIMLKYRKIKDEWLQFNR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]