| Definition | Psychrobacter cryohalolentis K5 chromosome, complete genome. |
|---|---|
| Accession | NC_007969 |
| Length | 3,059,876 |
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The map label for this gene is hdhA [H]
Identifier: 93006885
GI number: 93006885
Start: 2529863
End: 2530654
Strand: Reverse
Name: hdhA [H]
Synonym: Pcryo_2061
Alternate gene names: 93006885
Gene position: 2530654-2529863 (Counterclockwise)
Preceding gene: 93006890
Following gene: 93006881
Centisome position: 82.7
GC content: 45.2
Gene sequence:
>792_bases ATGCAAGAATTTCAACATAAAGCATTTAACGAATTATTCGATTTGTCAGGTAAAGTTGCCGTTGTGACGGGCGGTGCAAA TGGTATTGGTAAAGCCACGGCGCTACGTTTGGCAGAAGCGGGTGCTAACATTGCGATTGCTGATTTAAAACTTGAAGATG CACAAGCAGCAGTAAAAGATATTGAGGCGCTTGGGGTAAAAGCACTTGCCGTACAATGTAATATTCTAAAAGACGATGAT TTGGTCGCTATGGTCGATACAGTAGTCGCTGAGTTTGGGACTGTTAATGTCTTAATCAACAATGCGGGCGGCGGTGGTGG CGGTCGTGAAAACCCAGATACAGCATCGGTCGATGACATTCGCCGTGATTTTGAGTTAAACGTCTTTAGTGGCTGGCGCT TAAGTCAACTGTGCGCGCCGCATATGAAAAAATCAGGATATGGCTCGATTGTATTTACTACCTCGATGTCAAGTGTTAAT AAAAGCCCGAATATGAGCGGCTATGCAGGCTCAAAAGCAGCTGTCAATCATATGGTAGCAAACTTGGCACATGATTTCGG TCCTGAAGTACGCGTCAATGCAGTAGGTCCAGGGGCTACGCGTACCGATGCTTTGAAGACGGTGCTAACGCCAGAGATTG AGAAGAAAATGCTAGCAAATACGCCTATTAAGCGTTTGGGTGAGGCTGATGATATCGCTGGTGCTATGTTATATTTTGCT GCGCCAATATCGACTTGGGTCAGTGGTCAAACCATATTTGTGAATGGTGGTGGTGTACAGACTTTGGATTAA
Upstream 100 bases:
>100_bases TATTCTTAAGATTGATGCAGGTATTAGCCATACGCTTTCAATAGCTATGCATTTAATAGTGCTGTAAACGAGCTGAGTAA ATCTATATTGAGGAATCATT
Downstream 100 bases:
>100_bases TAGACAGTAGTTTTTATGATATAGGTGATCCACTTTTAAAAGAGTACAGAACTACTGGGTTTAATTATTCGCAGCCTCTG TCTGCGTAGGCACAGCAAGC
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 263; Mature: 263
Protein sequence:
>263_residues MQEFQHKAFNELFDLSGKVAVVTGGANGIGKATALRLAEAGANIAIADLKLEDAQAAVKDIEALGVKALAVQCNILKDDD LVAMVDTVVAEFGTVNVLINNAGGGGGGRENPDTASVDDIRRDFELNVFSGWRLSQLCAPHMKKSGYGSIVFTTSMSSVN KSPNMSGYAGSKAAVNHMVANLAHDFGPEVRVNAVGPGATRTDALKTVLTPEIEKKMLANTPIKRLGEADDIAGAMLYFA APISTWVSGQTIFVNGGGVQTLD
Sequences:
>Translated_263_residues MQEFQHKAFNELFDLSGKVAVVTGGANGIGKATALRLAEAGANIAIADLKLEDAQAAVKDIEALGVKALAVQCNILKDDD LVAMVDTVVAEFGTVNVLINNAGGGGGGRENPDTASVDDIRRDFELNVFSGWRLSQLCAPHMKKSGYGSIVFTTSMSSVN KSPNMSGYAGSKAAVNHMVANLAHDFGPEVRVNAVGPGATRTDALKTVLTPEIEKKMLANTPIKRLGEADDIAGAMLYFA APISTWVSGQTIFVNGGGVQTLD >Mature_263_residues MQEFQHKAFNELFDLSGKVAVVTGGANGIGKATALRLAEAGANIAIADLKLEDAQAAVKDIEALGVKALAVQCNILKDDD LVAMVDTVVAEFGTVNVLINNAGGGGGGRENPDTASVDDIRRDFELNVFSGWRLSQLCAPHMKKSGYGSIVFTTSMSSVN KSPNMSGYAGSKAAVNHMVANLAHDFGPEVRVNAVGPGATRTDALKTVLTPEIEKKMLANTPIKRLGEADDIAGAMLYFA APISTWVSGQTIFVNGGGVQTLD
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=30.4, Blast_Score=122, Evalue=4e-28, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI10190704, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=26.7441860465116, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.9795918367347, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI59889578, Length=225, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=28.8, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI40254986, Length=214, Percent_Identity=29.9065420560748, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI33667109, Length=204, Percent_Identity=31.3725490196078, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI7706318, Length=220, Percent_Identity=25.4545454545455, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI209862901, Length=213, Percent_Identity=29.1079812206573, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI19923983, Length=213, Percent_Identity=29.1079812206573, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4503301, Length=251, Percent_Identity=28.2868525896414, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=26.2745098039216, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI4557649, Length=202, Percent_Identity=28.7128712871287, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI142976729, Length=232, Percent_Identity=26.2931034482759, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI225579078, Length=205, Percent_Identity=29.7560975609756, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI31542939, Length=230, Percent_Identity=28.695652173913, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=48.8, Blast_Score=230, Evalue=6e-62, Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=30.1587301587302, Blast_Score=112, Evalue=3e-26, Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=32.6612903225806, Blast_Score=110, Evalue=8e-26, Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=30.8300395256917, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=31.2, Blast_Score=95, Evalue=5e-21, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=28.1632653061224, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=29.8387096774194, Blast_Score=87, Evalue=2e-18, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=26.3779527559055, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=28.6274509803922, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1787526, Length=210, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=26.5384615384615, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1788891, Length=215, Percent_Identity=27.4418604651163, Blast_Score=61, Evalue=9e-11, Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=29.5275590551181, Blast_Score=117, Evalue=5e-27, Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=28.8, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=30.6818181818182, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=30.6513409961686, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=29.4354838709677, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=31.4176245210728, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=30.4, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=31.4176245210728, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17559104, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=30.8270676691729, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=30.2681992337165, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=28.6764705882353, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=28.7878787878788, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=29.6577946768061, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562990, Length=270, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=29.0076335877863, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=29.1338582677165, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=30, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=272, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=28.2945736434109, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=28.2352941176471, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=29.1187739463602, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=29.4573643410853, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI193203117, Length=216, Percent_Identity=25, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=29.1338582677165, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI193203115, Length=214, Percent_Identity=25.2336448598131, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=29.8969072164948, Blast_Score=65, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17568967, Length=184, Percent_Identity=28.804347826087, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=249, Percent_Identity=28.5140562248996, Blast_Score=92, Evalue=8e-20, Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=28.7179487179487, Blast_Score=70, Evalue=3e-13, Organism=Saccharomyces cerevisiae, GI6322861, Length=214, Percent_Identity=27.1028037383178, Blast_Score=68, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=27.9187817258883, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=30.3643724696356, Blast_Score=121, Evalue=4e-28, Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=31.1740890688259, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=29.3650793650794, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI24649181, Length=205, Percent_Identity=34.6341463414634, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24640492, Length=173, Percent_Identity=32.9479768786127, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=27.3809523809524, Blast_Score=87, Evalue=9e-18, Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=31.6205533596838, Blast_Score=87, Evalue=2e-17, Organism=Drosophila melanogaster, GI281364892, Length=249, Percent_Identity=26.9076305220884, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=27.710843373494, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.4820717131474, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI24580925, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=27.9352226720648, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI21358495, Length=214, Percent_Identity=27.5700934579439, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI21357673, Length=215, Percent_Identity=29.7674418604651, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI18859837, Length=214, Percent_Identity=28.5046728971963, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI116007236, Length=247, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI24640442, Length=241, Percent_Identity=28.2157676348548, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI28574402, Length=202, Percent_Identity=29.2079207920792, Blast_Score=64, Evalue=1e-10,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 27481; Mature: 27481
Theoretical pI: Translated: 5.10; Mature: 5.10
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQEFQHKAFNELFDLSGKVAVVTGGANGIGKATALRLAEAGANIAIADLKLEDAQAAVKD CCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH IEALGVKALAVQCNILKDDDLVAMVDTVVAEFGTVNVLINNAGGGGGGRENPDTASVDDI HHHHCEEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHH RRDFELNVFSGWRLSQLCAPHMKKSGYGSIVFTTSMSSVNKSPNMSGYAGSKAAVNHMVA HHCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHH NLAHDFGPEVRVNAVGPGATRTDALKTVLTPEIEKKMLANTPIKRLGEADDIAGAMLYFA HHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHH APISTWVSGQTIFVNGGGVQTLD HHHHHHCCCCEEEEECCCEECCC >Mature Secondary Structure MQEFQHKAFNELFDLSGKVAVVTGGANGIGKATALRLAEAGANIAIADLKLEDAQAAVKD CCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH IEALGVKALAVQCNILKDDDLVAMVDTVVAEFGTVNVLINNAGGGGGGRENPDTASVDDI HHHHCEEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHH RRDFELNVFSGWRLSQLCAPHMKKSGYGSIVFTTSMSSVNKSPNMSGYAGSKAAVNHMVA HHCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHH NLAHDFGPEVRVNAVGPGATRTDALKTVLTPEIEKKMLANTPIKRLGEADDIAGAMLYFA HHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHH APISTWVSGQTIFVNGGGVQTLD HHHHHHCCCCEEEEECCCEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]