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The map label for this gene is fghA [H]

Identifier: 93006820

GI number: 93006820

Start: 2454152

End: 2455042

Strand: Reverse

Name: fghA [H]

Synonym: Pcryo_1996

Alternate gene names: 93006820

Gene position: 2455042-2454152 (Counterclockwise)

Preceding gene: 93006821

Following gene: 93006819

Centisome position: 80.23

GC content: 44.56

Gene sequence:

>891_bases
ATGAATAATTCTTATAACCACAGTCTCTCAGCCAGCACCCAGCTTACGCAAAAAAGTGTCAATCGTTGTTTTGATGGTGA
GCAGCGTTATTACAGTCATCAATCAGCGGCTACCAAGACGCCGATGACCTTTAGTATTTATCTGCCTGATGAGGCACTAG
CAGGGCAGCGTTGTCCGGCGATTTTGTATTTATCAGGTCTCACTTGTAATGCTGATAACGTGACGCACAAAGCGCATTTT
CAACAGAAATGTAGTGAGCTTGGTATGATATTTATCGCGCCAGATACCTCTCCTAGAAGTAGTGAAGGCAATGACGTAGC
AAATGATGAGCGTTATTTTGTTGGTCAAGGCGCAAGCTACTATGTCGATGCGACGCAAGCACCTTGGGCTGAGCATTTTA
ATATGCAAAGTTACATCGTTGATGAGCTGTATGATTTATTACGCTCAGAGTTTCCGATTGATAGTATTGGTATCACGGGT
CACTCGATGGGTGGTCACGGTGCCTTATTATTAGGCTTTAAATTCCCAAGCAAGTTTGTCAGTGTGTCAGCTTTATCACC
TGTGTGCGCCGCTAGTGAGTCGGCATGGGGTCAAGCAGCTTATACAGAGTATTTTGGTGATGACAAGAGCTTGTGGGCGC
AAGCAGACGCTTCTCAGATGATTGAACAAGTCGGTCAGCAATACTCAAGCATCTTGGTTGACCAAGGTGCTGCCGACGAG
TTTTTGGCCGATGGTCAATTACAAACGTCAAAGTTACAACAAGCCTGTACAAAGGCCAAGCAGCCATTAACATTGCGCTA
TCAAGCTGATCACGACCATAGCTATTATTTTATTCAAACAGTGATCAATGAGCATATTGAACATCACTGGCGTATGGCAC
AGCTTAGCTAA

Upstream 100 bases:

>100_bases
GAACACAGCGAACTGATTTTTATCCCATTTTTAATCTGATGCTTTTTTAAATAAGCATCTGTTTTCAACTATTTTATCTT
AGCTAAAAAGGATAATGCTT

Downstream 100 bases:

>100_bases
AATTTGCTCTCATATTGTTCGTTATGGTTTTTCAGATTTAAAAGGTCGTATCTATGGCAAGTTATCAAGATTTAAGTACC
GTTACTGTCGATACTCCATC

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNNSYNHSLSASTQLTQKSVNRCFDGEQRYYSHQSAATKTPMTFSIYLPDEALAGQRCPAILYLSGLTCNADNVTHKAHF
QQKCSELGMIFIAPDTSPRSSEGNDVANDERYFVGQGASYYVDATQAPWAEHFNMQSYIVDELYDLLRSEFPIDSIGITG
HSMGGHGALLLGFKFPSKFVSVSALSPVCAASESAWGQAAYTEYFGDDKSLWAQADASQMIEQVGQQYSSILVDQGAADE
FLADGQLQTSKLQQACTKAKQPLTLRYQADHDHSYYFIQTVINEHIEHHWRMAQLS

Sequences:

>Translated_296_residues
MNNSYNHSLSASTQLTQKSVNRCFDGEQRYYSHQSAATKTPMTFSIYLPDEALAGQRCPAILYLSGLTCNADNVTHKAHF
QQKCSELGMIFIAPDTSPRSSEGNDVANDERYFVGQGASYYVDATQAPWAEHFNMQSYIVDELYDLLRSEFPIDSIGITG
HSMGGHGALLLGFKFPSKFVSVSALSPVCAASESAWGQAAYTEYFGDDKSLWAQADASQMIEQVGQQYSSILVDQGAADE
FLADGQLQTSKLQQACTKAKQPLTLRYQADHDHSYYFIQTVINEHIEHHWRMAQLS
>Mature_296_residues
MNNSYNHSLSASTQLTQKSVNRCFDGEQRYYSHQSAATKTPMTFSIYLPDEALAGQRCPAILYLSGLTCNADNVTHKAHF
QQKCSELGMIFIAPDTSPRSSEGNDVANDERYFVGQGASYYVDATQAPWAEHFNMQSYIVDELYDLLRSEFPIDSIGITG
HSMGGHGALLLGFKFPSKFVSVSALSPVCAASESAWGQAAYTEYFGDDKSLWAQADASQMIEQVGQQYSSILVDQGAADE
FLADGQLQTSKLQQACTKAKQPLTLRYQADHDHSYYFIQTVINEHIEHHWRMAQLS

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=277, Percent_Identity=44.7653429602888, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1788477, Length=271, Percent_Identity=45.0184501845018, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=43.6823104693141, Blast_Score=235, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=46.0992907801418, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322393, Length=286, Percent_Identity=37.7622377622378, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45551932, Length=289, Percent_Identity=41.1764705882353, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24648347, Length=278, Percent_Identity=42.0863309352518, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 32906; Mature: 32906

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSYNHSLSASTQLTQKSVNRCFDGEQRYYSHQSAATKTPMTFSIYLPDEALAGQRCPA
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCHHHCCCCCCE
ILYLSGLTCNADNVTHKAHFQQKCSELGMIFIAPDTSPRSSEGNDVANDERYFVGQGASY
EEEEECCEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCEE
YVDATQAPWAEHFNMQSYIVDELYDLLRSEFPIDSIGITGHSMGGHGALLLGFKFPSKFV
EEECCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHH
SVSALSPVCAASESAWGQAAYTEYFGDDKSLWAQADASQMIEQVGQQYSSILVDQGAADE
HHHHCCHHHHCCCCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHH
FLADGQLQTSKLQQACTKAKQPLTLRYQADHDHSYYFIQTVINEHIEHHWRMAQLS
HHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNSYNHSLSASTQLTQKSVNRCFDGEQRYYSHQSAATKTPMTFSIYLPDEALAGQRCPA
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCHHHCCCCCCE
ILYLSGLTCNADNVTHKAHFQQKCSELGMIFIAPDTSPRSSEGNDVANDERYFVGQGASY
EEEEECCEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCEE
YVDATQAPWAEHFNMQSYIVDELYDLLRSEFPIDSIGITGHSMGGHGALLLGFKFPSKFV
EEECCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHH
SVSALSPVCAASESAWGQAAYTEYFGDDKSLWAQADASQMIEQVGQQYSSILVDQGAADE
HHHHCCHHHHCCCCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHH
FLADGQLQTSKLQQACTKAKQPLTLRYQADHDHSYYFIQTVINEHIEHHWRMAQLS
HHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]