Click here to switch to the map view.

The map label for this gene is hutC [H]

Identifier: 93006753

GI number: 93006753

Start: 2379777

End: 2380559

Strand: Reverse

Name: hutC [H]

Synonym: Pcryo_1929

Alternate gene names: 93006753

Gene position: 2380559-2379777 (Counterclockwise)

Preceding gene: 93006759

Following gene: 93006752

Centisome position: 77.8

GC content: 44.57

Gene sequence:

>783_bases
ATGGATACGATAAAGGCGATTCCGGCATATCAACGCATTAAAAATGCGATATTGGACAATATTCATTCAGGTAAATGGCA
GGCGGGCAATGCGATTTCTACCGAAATGGCGTTGGCAGAAGAGTTTGGTGTCTCTCGTATGACGGTCAACCGTGCTTTAA
AGGAATTGAGCGAAGAGCGAGTATTGGAGCGCCGGCAAGGGTCGGGGACGTTTGTTGCGCAGCAGCAGTTTAATCATACG
TTTGTAGAAGTGCGTAATATCGCTCAAGATTTAAAGTCTGCCAATCGTGATTATCAAGCAAAAGTTGTCAGTAAGCGTGG
CATTACTGCTGCTATGCTCAATGATGAGCTACGGCGTAAATTTGGTCTTGAGAAGGCTATTAAATCGTCTGAGTTAAAAG
ACGCTACTGACATTAGAAGCATCAAGAATCTTGATAGCGAAGCCGCTGTTTTATATGAGGTTAAGATCATCCATTTTGCA
GATGGTCAGCCGATACAGTTTGAAGAGCGTTGGGTAGATGCTCTAAAGGTTCCAGAGTTTATCGAGCAAGATTTTAGCGT
GGTCAATACCAGTGATTATCTCATTGCAAAAAGCCCACTGGAGCGTGGTAGCTATACTATTCGAGCACTAGCCGCACCCG
ATGAGATTGCAGCGTTATTACAGATTACCGCGCAGTCGCCTACATTGGTACTTTGTCGTCAAACTTACTCAGCGGGTCAA
GTACTGACTTTTGTCAAAATGTGGCATGCAGGTGAGCGGTACCAGTTTTCAGGTGAACTATAA

Upstream 100 bases:

>100_bases
ATTAGACAAACATGCAGCTGCCATATGGTTTTGCTGAGGTTTGTATGATTATCTCGTGTTACTATGACGCTATTCTTATT
GGTAAAACTAACGGTTAAAA

Downstream 100 bases:

>100_bases
CAACCTTACGCATATTCACTATTTTTGTACGTTTATTCTTTCTAAATTGCGTTAACATACACATGAGCAGGTATTTAATG
GGCGGATTTAGAATAAGTAT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MDTIKAIPAYQRIKNAILDNIHSGKWQAGNAISTEMALAEEFGVSRMTVNRALKELSEERVLERRQGSGTFVAQQQFNHT
FVEVRNIAQDLKSANRDYQAKVVSKRGITAAMLNDELRRKFGLEKAIKSSELKDATDIRSIKNLDSEAAVLYEVKIIHFA
DGQPIQFEERWVDALKVPEFIEQDFSVVNTSDYLIAKSPLERGSYTIRALAAPDEIAALLQITAQSPTLVLCRQTYSAGQ
VLTFVKMWHAGERYQFSGEL

Sequences:

>Translated_260_residues
MDTIKAIPAYQRIKNAILDNIHSGKWQAGNAISTEMALAEEFGVSRMTVNRALKELSEERVLERRQGSGTFVAQQQFNHT
FVEVRNIAQDLKSANRDYQAKVVSKRGITAAMLNDELRRKFGLEKAIKSSELKDATDIRSIKNLDSEAAVLYEVKIIHFA
DGQPIQFEERWVDALKVPEFIEQDFSVVNTSDYLIAKSPLERGSYTIRALAAPDEIAALLQITAQSPTLVLCRQTYSAGQ
VLTFVKMWHAGERYQFSGEL
>Mature_260_residues
MDTIKAIPAYQRIKNAILDNIHSGKWQAGNAISTEMALAEEFGVSRMTVNRALKELSEERVLERRQGSGTFVAQQQFNHT
FVEVRNIAQDLKSANRDYQAKVVSKRGITAAMLNDELRRKFGLEKAIKSSELKDATDIRSIKNLDSEAAVLYEVKIIHFA
DGQPIQFEERWVDALKVPEFIEQDFSVVNTSDYLIAKSPLERGSYTIRALAAPDEIAALLQITAQSPTLVLCRQTYSAGQ
VLTFVKMWHAGERYQFSGEL

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=255, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082252, Length=173, Percent_Identity=24.8554913294798, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 29286; Mature: 29286

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIKAIPAYQRIKNAILDNIHSGKWQAGNAISTEMALAEEFGVSRMTVNRALKELSEER
CCCCHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLERRQGSGTFVAQQQFNHTFVEVRNIAQDLKSANRDYQAKVVSKRGITAAMLNDELRRK
HHHHHCCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
FGLEKAIKSSELKDATDIRSIKNLDSEAAVLYEVKIIHFADGQPIQFEERWVDALKVPEF
HCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHCCHHH
IEQDFSVVNTSDYLIAKSPLERGSYTIRALAAPDEIAALLQITAQSPTLVLCRQTYSAGQ
HHHHHHEECCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCH
VLTFVKMWHAGERYQFSGEL
HHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MDTIKAIPAYQRIKNAILDNIHSGKWQAGNAISTEMALAEEFGVSRMTVNRALKELSEER
CCCCHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLERRQGSGTFVAQQQFNHTFVEVRNIAQDLKSANRDYQAKVVSKRGITAAMLNDELRRK
HHHHHCCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
FGLEKAIKSSELKDATDIRSIKNLDSEAAVLYEVKIIHFADGQPIQFEERWVDALKVPEF
HCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHCCHHH
IEQDFSVVNTSDYLIAKSPLERGSYTIRALAAPDEIAALLQITAQSPTLVLCRQTYSAGQ
HHHHHHEECCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCH
VLTFVKMWHAGERYQFSGEL
HHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203754; 2834335 [H]