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The map label for this gene is fumC [H]

Identifier: 93006718

GI number: 93006718

Start: 2339756

End: 2341159

Strand: Reverse

Name: fumC [H]

Synonym: Pcryo_1894

Alternate gene names: 93006718

Gene position: 2341159-2339756 (Counterclockwise)

Preceding gene: 93006721

Following gene: 93006717

Centisome position: 76.51

GC content: 45.94

Gene sequence:

>1404_bases
ATGTCAACACAGAATCAGGCAACTCGTACCGAAAAAGACACCATGGGCAATGTAGAAGTCCCAGCTGACGCTTATTGGGG
TGCACAAACCCAACGTAGCCGCGAAAACTTTAAAATCGGTGGCGAGACCTTGCCGCGTCCGATGATTGAAGCGATGGCAC
TGGTCAAAAAAGCCGCTGCGATTACCAATGCGAGCCTTGAGCGTATCGAAGATGATAAGCGCGATTTAATCGTACAAGCT
GCTGATGAAGTTATCAACGGTGGTCTAACCGATCAGTTTCCGCTAGTCGTTTGGCAGACCGGTTCTGGTACTCAATCAAA
CATGAATATGAATGAAGTATTAGCGAATCGTGCCAATGAAATCGCAGGGAACGCGCGCGGCAGCTATACGCCGATTCACC
CAAATGACCATGTAAATCATGCTCAATCTACCAATGATAGCTTCCCAACGGCGATTCGTGTTGCCGCTGCTCGTGAAATC
AACGGCTTATTGATTCCAGCGGTAAAAGCCCTGCGTGATACGCTAGATGCTAAAGCAAAAGAATTCGATAGCATCGTGAA
AATCGGTCGTACGCATTTACAAGACGCCACGCCTTTGACTTTAGGTCAAGAGTTTAGCGGCTATGTTAGCCAACTTGATC
ATTCATTGGTACGTATTGATAATGCGCTACAAGGCTTGTATGAATTGCCATTAGGCGGTACGGCGGTTGGTACAGGTCTA
AACGCCCATCCTGATTATGCAGTAAAATCAGCTGAGCAATTGGCGACATTGTCTGGTCTTCCATTTGTGACGTCACCGAA
TAAATTTGAAGCACTAGCTGCTCGTGATGCCGAAGTATTTGCGTCAGGCGCATTAAAAACGCTAGCAAGTAGCTTGAATA
AAATCGCTAACGACGTACGTTGGTTGGCATCAGGTCCTCGTTGTGGTTTGGGCGAGTTGACGATTCCTGAGAATGAGCCA
GGCTCTTCTATCATGCCGGGCAAAGTAAACCCAACGCAGTCAGAAGCAATGACCATGGTTGTGGCGCAAGTCATGGGTAA
CGATGTCACTATCAGCATGGCAGGCGCGTCAGGTAACTTTGAGCTAAACGTTTATAAGCCAGTTATCGCGTTTAACTTGT
TGCAATCTATCAAACTGCTTGGCGATGCGTGCAATAGCTTTAATGAAAACTGTGCTGTTGGTATCCAGCCAGTAAAAGAC
AAAATCGATGACTTCTTGCACAACTCATTGATGCTAGTGACTGCGCTTAACCGTCATGTTGGTTATGAGAATGCCGCAAA
AATCGCTAAGACTGCTTATAAAGAAAACAAAACCTTGAAGCAAGTTGCGGTTGAGTTAGAGCTATTAACTGAAGCACAGT
TTGATGAGTGGGTAATTCCTGCTGATATGGTAAATCCTAGATAA

Upstream 100 bases:

>100_bases
TATCATAACGCCACTTTACAGCGTATTTTTCTTTGTGTGCAGCAGCTGTTGCACTTTTTATGACAAACCATTCATTACCA
AACCATCAAAGAGGGTAGTT

Downstream 100 bases:

>100_bases
GCAGTAGACCAAATAATGACCTGCTACGGTGTCAGACTTGCTTAATGTACGATAGGTACCATTTGTACTGCTAGTAGCAG
CATCATATTTGTTCCACTAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSTQNQATRTEKDTMGNVEVPADAYWGAQTQRSRENFKIGGETLPRPMIEAMALVKKAAAITNASLERIEDDKRDLIVQA
ADEVINGGLTDQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGNARGSYTPIHPNDHVNHAQSTNDSFPTAIRVAAAREI
NGLLIPAVKALRDTLDAKAKEFDSIVKIGRTHLQDATPLTLGQEFSGYVSQLDHSLVRIDNALQGLYELPLGGTAVGTGL
NAHPDYAVKSAEQLATLSGLPFVTSPNKFEALAARDAEVFASGALKTLASSLNKIANDVRWLASGPRCGLGELTIPENEP
GSSIMPGKVNPTQSEAMTMVVAQVMGNDVTISMAGASGNFELNVYKPVIAFNLLQSIKLLGDACNSFNENCAVGIQPVKD
KIDDFLHNSLMLVTALNRHVGYENAAKIAKTAYKENKTLKQVAVELELLTEAQFDEWVIPADMVNPR

Sequences:

>Translated_467_residues
MSTQNQATRTEKDTMGNVEVPADAYWGAQTQRSRENFKIGGETLPRPMIEAMALVKKAAAITNASLERIEDDKRDLIVQA
ADEVINGGLTDQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGNARGSYTPIHPNDHVNHAQSTNDSFPTAIRVAAAREI
NGLLIPAVKALRDTLDAKAKEFDSIVKIGRTHLQDATPLTLGQEFSGYVSQLDHSLVRIDNALQGLYELPLGGTAVGTGL
NAHPDYAVKSAEQLATLSGLPFVTSPNKFEALAARDAEVFASGALKTLASSLNKIANDVRWLASGPRCGLGELTIPENEP
GSSIMPGKVNPTQSEAMTMVVAQVMGNDVTISMAGASGNFELNVYKPVIAFNLLQSIKLLGDACNSFNENCAVGIQPVKD
KIDDFLHNSLMLVTALNRHVGYENAAKIAKTAYKENKTLKQVAVELELLTEAQFDEWVIPADMVNPR
>Mature_466_residues
STQNQATRTEKDTMGNVEVPADAYWGAQTQRSRENFKIGGETLPRPMIEAMALVKKAAAITNASLERIEDDKRDLIVQAA
DEVINGGLTDQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGNARGSYTPIHPNDHVNHAQSTNDSFPTAIRVAAAREIN
GLLIPAVKALRDTLDAKAKEFDSIVKIGRTHLQDATPLTLGQEFSGYVSQLDHSLVRIDNALQGLYELPLGGTAVGTGLN
AHPDYAVKSAEQLATLSGLPFVTSPNKFEALAARDAEVFASGALKTLASSLNKIANDVRWLASGPRCGLGELTIPENEPG
SSIMPGKVNPTQSEAMTMVVAQVMGNDVTISMAGASGNFELNVYKPVIAFNLLQSIKLLGDACNSFNENCAVGIQPVKDK
IDDFLHNSLMLVTALNRHVGYENAAKIAKTAYKENKTLKQVAVELELLTEAQFDEWVIPADMVNPR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=469, Percent_Identity=60.1279317697228, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=62.0614035087719, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=42.0824295010846, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=60.7375271149675, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=61.4678899082569, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=58.7096774193548, Blast_Score=552, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640179, Length=466, Percent_Identity=58.7982832618026, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640177, Length=466, Percent_Identity=58.7982832618026, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24662684, Length=469, Percent_Identity=58.63539445629, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=57.451403887689, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.0518358531317, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50309; Mature: 50178

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQNQATRTEKDTMGNVEVPADAYWGAQTQRSRENFKIGGETLPRPMIEAMALVKKAAA
CCCCCCHHCCHHHCCCCCCCCCHHHCCCCHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
ITNASLERIEDDKRDLIVQAADEVINGGLTDQFPLVVWQTGSGTQSNMNMNEVLANRANE
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
IAGNARGSYTPIHPNDHVNHAQSTNDSFPTAIRVAAAREINGLLIPAVKALRDTLDAKAK
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EFDSIVKIGRTHLQDATPLTLGQEFSGYVSQLDHSLVRIDNALQGLYELPLGGTAVGTGL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
NAHPDYAVKSAEQLATLSGLPFVTSPNKFEALAARDAEVFASGALKTLASSLNKIANDVR
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WLASGPRCGLGELTIPENEPGSSIMPGKVNPTQSEAMTMVVAQVMGNDVTISMAGASGNF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCE
ELNVYKPVIAFNLLQSIKLLGDACNSFNENCAVGIQPVKDKIDDFLHNSLMLVTALNRHV
EEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHC
GYENAAKIAKTAYKENKTLKQVAVELELLTEAQFDEWVIPADMVNPR
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCHHCCCCC
>Mature Secondary Structure 
STQNQATRTEKDTMGNVEVPADAYWGAQTQRSRENFKIGGETLPRPMIEAMALVKKAAA
CCCCCHHCCHHHCCCCCCCCCHHHCCCCHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
ITNASLERIEDDKRDLIVQAADEVINGGLTDQFPLVVWQTGSGTQSNMNMNEVLANRANE
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
IAGNARGSYTPIHPNDHVNHAQSTNDSFPTAIRVAAAREINGLLIPAVKALRDTLDAKAK
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EFDSIVKIGRTHLQDATPLTLGQEFSGYVSQLDHSLVRIDNALQGLYELPLGGTAVGTGL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
NAHPDYAVKSAEQLATLSGLPFVTSPNKFEALAARDAEVFASGALKTLASSLNKIANDVR
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WLASGPRCGLGELTIPENEPGSSIMPGKVNPTQSEAMTMVVAQVMGNDVTISMAGASGNF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCE
ELNVYKPVIAFNLLQSIKLLGDACNSFNENCAVGIQPVKDKIDDFLHNSLMLVTALNRHV
EEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHC
GYENAAKIAKTAYKENKTLKQVAVELELLTEAQFDEWVIPADMVNPR
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]