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The map label for this gene is copA [C]

Identifier: 93006695

GI number: 93006695

Start: 2310613

End: 2312973

Strand: Reverse

Name: copA [C]

Synonym: Pcryo_1871

Alternate gene names: 93006695

Gene position: 2312973-2310613 (Counterclockwise)

Preceding gene: 93006696

Following gene: 93006694

Centisome position: 75.59

GC content: 47.23

Gene sequence:

>2361_bases
ATGAATGATTCTACCCATACCGATACCCATAATTCTTATGATGTAGAGACTGATATTCAGTCTAATACCCCGCTTACGCC
GCAGCGTGCGCACTTGCAGCTGGCGATAGAGGGTATGACGTGTCAGGCCTGTGCATCACGGATTGAAAAGGTTTTGAATA
AAAAGCCATCAGTCTATGAGGTCAGCGTGAACTTCGCAGGCGAGACCGCCAATGTGGATTATGATCCGACACAGACGACG
GCAGAGCAGGTGACGGAATGGGTCAACAAAACGGGTTTTGTCGCCAATTTGCAGGCGGCTGATAGCTTGTTTGCTCAAAA
AGGTGAGGATGCAAGCACTCAGTATCCATGGCGTTTGATTGGACTATGGGTCTGTTTGGTGCCGTTTTTAATTGGTATGG
CAGGTATGCTCTTTGGGCAGGGTATGGCATGGATGCCACCGGTTTGGATGCAATTCATATTAGCGACCATTGTACAGTTT
GGATTTGCTTTACCATTTTATAAAAGTGCTTGGGCGTCTATTAGAGGCGGTCTTGCCAATATGGACGTATTGGTCGTCAT
CGGTACGGTAACCATTTGGGCATATTCAACGTATCTTTGGCTGACCCATGGTGATGGTAGCTTAAATAGTCTGTTGCAAA
GTGGGCATACTGGCGGTCATGGTGCGAGTGGCAGTCCTGCGGTATATTTTGAAGCAGGTGTGATGGTTATTGCTTTTGTG
CGCACGGGTAAATACCTTGAAGAGCGCACTAAAAAGCACAGTCTGAATAGTATTGATTTACTATTATCGCTGACACCAGA
CGAAGTTGAGCAACAGCAGCCAAATGGTGAGTTTAAAAATATCGCTCTCAAAGAGGTACAAGTGGGTGATATCTTGCGTG
CTAAGCAAGGAAGCCGCGTTGCAACCGATGGTACGGTCATCGATGGTGCTGGCTGGTGTGTCGAAAGTCATTTAACCGGT
GAGTCAGTACCGCTTAAGAAAGAAGTAGGCGATGGATTATTAGCGGGTGCCTTGGTCGAAAACGGTAGCTTGTTATACCG
CGTCAATGCCAAGGGTAGCGATACTAAACTTGGTGATATGGTACAAGCCCTCAGCGATGCCCAAGGCTCAAAAGCCAATT
TGGCACGCCTTGCTGATAGAGTCACTGCGGTCTTTGTGCCCGTTGTGGTAGTAATTGCACTGGTTGCCTTTGGTGTGACG
TGGTGGCTAACCGGTATGCTCGATACGGCTTTGATGCACGCAGTATCTGTATTGGTCATTGCTTGTCCATGTGCGCTTGG
TTTGGCGACACCAGCCGCAATCATGGCAGGTATGGGCGTGGCTGCGCGTCACGGTGTTTGGTTTAAAGATGCGCAAAGCC
TAGAAGCGGCAGGCAATATCGATATAGTAGTGCTCGATAAGACGGGTACCTTAACCATTGGCAAACCGACCATCGTCGAT
GAAGTTATGGTTGATAAATCAATAGCGGTTGATGATGTACTACAGATTGCCGCAAGTATTGAAGTACATGCCAGTCATCC
GCTTGCAACTGCTTTGGTCAATGCAGCGACAGCACGTGGTTTATCCTTATTCGATGTGTCTGATATCAGCGTTATCAAAG
GCGCAGGTATACAGGCAAATATTGAAGGCTTAGGTGTGGTAAAGGTTGGCACAGCAGAGTTTGCCAATCTTGTATTGCCT
AAATTGATGCCAAAGGTATGGCAAATTGCCAGTACTGTTGCGATTAGTATTAACGATGAAGCACTAGGCGCATTTGCTTT
AGCGGATGACTTAAAATCAGATACGCCGCAGGCAATTACTGCGCTACAAGATGCGGGTATTAATGTTATTTTGATGAGTG
GTGACAAACAATCTGTCGTCGATCACGTTGCCGGACAGCTTGGTATCGAAAAAGCGTATGGAAAGATGAGTCCACGTGAC
AAGGCCAGCCAAATTGCTCTACTGCAAACAGCGGGTCATAAAGTCGCTATGGCAGGAGATGGGGTCAATGATGCACCAGC
GATGGCAACTGCCGATGCCAGCTTTGCCATGTTTGAAGGCACGGATGTCGCCCAACATAGTGCCTCTGCGCGCTTGATGG
GTGAGTCGCTGATGCATATCGACGCAGCGCAAAAAATTGCGAATGCCACGCTGCGTAATATCAAACAAAATCTGTTTTTT
GCCTTTATTTATAATTGCCTTGGTATTCCGCTCGCTGCTTTTGGCTTTTTGAATCCTATGATTGCCGCTGCCGCTATGGC
GCTTAGCTCAATTTCTGTATTGATGAATGCGCTGCGTTTAACGCGTTTTAAGACAAAGGTTGAGCTGAATAATACCGTAT
CAGACTCCCACACTAAAGCAGATCGTCTAACAAAAGCGTAA

Upstream 100 bases:

>100_bases
TCTTTAGAATGTACTGCTTGTTTGATTTGGATTTTTATTCCTCCACTGATAGATTTTTATAGCTCATACAAATTTATAAA
CGCCATAACGAGTTTTATTT

Downstream 100 bases:

>100_bases
GAGTTATATAACGTTTGATATCATAGGTACTGAGATAAATTGATAGTGGCTCATTTGACTATTGATTGGCGATTTTATGA
CCGTCCGTTGCTTTAAGATA

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MNDSTHTDTHNSYDVETDIQSNTPLTPQRAHLQLAIEGMTCQACASRIEKVLNKKPSVYEVSVNFAGETANVDYDPTQTT
AEQVTEWVNKTGFVANLQAADSLFAQKGEDASTQYPWRLIGLWVCLVPFLIGMAGMLFGQGMAWMPPVWMQFILATIVQF
GFALPFYKSAWASIRGGLANMDVLVVIGTVTIWAYSTYLWLTHGDGSLNSLLQSGHTGGHGASGSPAVYFEAGVMVIAFV
RTGKYLEERTKKHSLNSIDLLLSLTPDEVEQQQPNGEFKNIALKEVQVGDILRAKQGSRVATDGTVIDGAGWCVESHLTG
ESVPLKKEVGDGLLAGALVENGSLLYRVNAKGSDTKLGDMVQALSDAQGSKANLARLADRVTAVFVPVVVVIALVAFGVT
WWLTGMLDTALMHAVSVLVIACPCALGLATPAAIMAGMGVAARHGVWFKDAQSLEAAGNIDIVVLDKTGTLTIGKPTIVD
EVMVDKSIAVDDVLQIAASIEVHASHPLATALVNAATARGLSLFDVSDISVIKGAGIQANIEGLGVVKVGTAEFANLVLP
KLMPKVWQIASTVAISINDEALGAFALADDLKSDTPQAITALQDAGINVILMSGDKQSVVDHVAGQLGIEKAYGKMSPRD
KASQIALLQTAGHKVAMAGDGVNDAPAMATADASFAMFEGTDVAQHSASARLMGESLMHIDAAQKIANATLRNIKQNLFF
AFIYNCLGIPLAAFGFLNPMIAAAAMALSSISVLMNALRLTRFKTKVELNNTVSDSHTKADRLTKA

Sequences:

>Translated_786_residues
MNDSTHTDTHNSYDVETDIQSNTPLTPQRAHLQLAIEGMTCQACASRIEKVLNKKPSVYEVSVNFAGETANVDYDPTQTT
AEQVTEWVNKTGFVANLQAADSLFAQKGEDASTQYPWRLIGLWVCLVPFLIGMAGMLFGQGMAWMPPVWMQFILATIVQF
GFALPFYKSAWASIRGGLANMDVLVVIGTVTIWAYSTYLWLTHGDGSLNSLLQSGHTGGHGASGSPAVYFEAGVMVIAFV
RTGKYLEERTKKHSLNSIDLLLSLTPDEVEQQQPNGEFKNIALKEVQVGDILRAKQGSRVATDGTVIDGAGWCVESHLTG
ESVPLKKEVGDGLLAGALVENGSLLYRVNAKGSDTKLGDMVQALSDAQGSKANLARLADRVTAVFVPVVVVIALVAFGVT
WWLTGMLDTALMHAVSVLVIACPCALGLATPAAIMAGMGVAARHGVWFKDAQSLEAAGNIDIVVLDKTGTLTIGKPTIVD
EVMVDKSIAVDDVLQIAASIEVHASHPLATALVNAATARGLSLFDVSDISVIKGAGIQANIEGLGVVKVGTAEFANLVLP
KLMPKVWQIASTVAISINDEALGAFALADDLKSDTPQAITALQDAGINVILMSGDKQSVVDHVAGQLGIEKAYGKMSPRD
KASQIALLQTAGHKVAMAGDGVNDAPAMATADASFAMFEGTDVAQHSASARLMGESLMHIDAAQKIANATLRNIKQNLFF
AFIYNCLGIPLAAFGFLNPMIAAAAMALSSISVLMNALRLTRFKTKVELNNTVSDSHTKADRLTKA
>Mature_786_residues
MNDSTHTDTHNSYDVETDIQSNTPLTPQRAHLQLAIEGMTCQACASRIEKVLNKKPSVYEVSVNFAGETANVDYDPTQTT
AEQVTEWVNKTGFVANLQAADSLFAQKGEDASTQYPWRLIGLWVCLVPFLIGMAGMLFGQGMAWMPPVWMQFILATIVQF
GFALPFYKSAWASIRGGLANMDVLVVIGTVTIWAYSTYLWLTHGDGSLNSLLQSGHTGGHGASGSPAVYFEAGVMVIAFV
RTGKYLEERTKKHSLNSIDLLLSLTPDEVEQQQPNGEFKNIALKEVQVGDILRAKQGSRVATDGTVIDGAGWCVESHLTG
ESVPLKKEVGDGLLAGALVENGSLLYRVNAKGSDTKLGDMVQALSDAQGSKANLARLADRVTAVFVPVVVVIALVAFGVT
WWLTGMLDTALMHAVSVLVIACPCALGLATPAAIMAGMGVAARHGVWFKDAQSLEAAGNIDIVVLDKTGTLTIGKPTIVD
EVMVDKSIAVDDVLQIAASIEVHASHPLATALVNAATARGLSLFDVSDISVIKGAGIQANIEGLGVVKVGTAEFANLVLP
KLMPKVWQIASTVAISINDEALGAFALADDLKSDTPQAITALQDAGINVILMSGDKQSVVDHVAGQLGIEKAYGKMSPRD
KASQIALLQTAGHKVAMAGDGVNDAPAMATADASFAMFEGTDVAQHSASARLMGESLMHIDAAQKIANATLRNIKQNLFF
AFIYNCLGIPLAAFGFLNPMIAAAAMALSSISVLMNALRLTRFKTKVELNNTVSDSHTKADRLTKA

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=812, Percent_Identity=28.8177339901478, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI115529486, Length=583, Percent_Identity=29.8456260720412, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI55743073, Length=505, Percent_Identity=30.8910891089109, Blast_Score=230, Evalue=4e-60,
Organism=Escherichia coli, GI1786691, Length=766, Percent_Identity=36.9451697127937, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1789879, Length=740, Percent_Identity=28.1081081081081, Blast_Score=234, Evalue=2e-62,
Organism=Escherichia coli, GI1786914, Length=436, Percent_Identity=26.1467889908257, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI2367363, Length=570, Percent_Identity=21.7543859649123, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17556548, Length=820, Percent_Identity=27.0731707317073, Blast_Score=276, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6320475, Length=646, Percent_Identity=30.9597523219814, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6319772, Length=658, Percent_Identity=27.9635258358663, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321430, Length=516, Percent_Identity=23.4496124031008, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6325221, Length=516, Percent_Identity=23.062015503876, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221329854, Length=564, Percent_Identity=30.4964539007092, Blast_Score=216, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 83296; Mature: 83296

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSTHTDTHNSYDVETDIQSNTPLTPQRAHLQLAIEGMTCQACASRIEKVLNKKPSVYE
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEE
VSVNFAGETANVDYDPTQTTAEQVTEWVNKTGFVANLQAADSLFAQKGEDASTQYPWRLI
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHH
GLWVCLVPFLIGMAGMLFGQGMAWMPPVWMQFILATIVQFGFALPFYKSAWASIRGGLAN
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
MDVLVVIGTVTIWAYSTYLWLTHGDGSLNSLLQSGHTGGHGASGSPAVYFEAGVMVIAFV
CEEEEEEHHHHHEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEHH
RTGKYLEERTKKHSLNSIDLLLSLTPDEVEQQQPNGEFKNIALKEVQVGDILRAKQGSRV
HCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCHHCEEEEHHHHHHHHHHCCCCEE
ATDGTVIDGAGWCVESHLTGESVPLKKEVGDGLLAGALVENGSLLYRVNAKGSDTKLGDM
ECCCEEECCCCCEEECCCCCCCCCCHHHHCCCHHHHHEECCCCEEEEEECCCCCCHHHHH
VQALSDAQGSKANLARLADRVTAVFVPVVVVIALVAFGVTWWLTGMLDTALMHAVSVLVI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACPCALGLATPAAIMAGMGVAARHGVWFKDAQSLEAAGNIDIVVLDKTGTLTIGKPTIVD
HHHHHHHHCCHHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCCEEEECCCHHHH
EVMVDKSIAVDDVLQIAASIEVHASHPLATALVNAATARGLSLFDVSDISVIKGAGIQAN
HHHHCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCEEC
IEGLGVVKVGTAEFANLVLPKLMPKVWQIASTVAISINDEALGAFALADDLKSDTPQAIT
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCHHHHH
ALQDAGINVILMSGDKQSVVDHVAGQLGIEKAYGKMSPRDKASQIALLQTAGHKVAMAGD
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCEEEEECC
GVNDAPAMATADASFAMFEGTDVAQHSASARLMGESLMHIDAAQKIANATLRNIKQNLFF
CCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFIYNCLGIPLAAFGFLNPMIAAAAMALSSISVLMNALRLTRFKTKVELNNTVSDSHTKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHH
DRLTKA
HHHCCC
>Mature Secondary Structure
MNDSTHTDTHNSYDVETDIQSNTPLTPQRAHLQLAIEGMTCQACASRIEKVLNKKPSVYE
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEE
VSVNFAGETANVDYDPTQTTAEQVTEWVNKTGFVANLQAADSLFAQKGEDASTQYPWRLI
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHH
GLWVCLVPFLIGMAGMLFGQGMAWMPPVWMQFILATIVQFGFALPFYKSAWASIRGGLAN
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
MDVLVVIGTVTIWAYSTYLWLTHGDGSLNSLLQSGHTGGHGASGSPAVYFEAGVMVIAFV
CEEEEEEHHHHHEEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEHH
RTGKYLEERTKKHSLNSIDLLLSLTPDEVEQQQPNGEFKNIALKEVQVGDILRAKQGSRV
HCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCHHCEEEEHHHHHHHHHHCCCCEE
ATDGTVIDGAGWCVESHLTGESVPLKKEVGDGLLAGALVENGSLLYRVNAKGSDTKLGDM
ECCCEEECCCCCEEECCCCCCCCCCHHHHCCCHHHHHEECCCCEEEEEECCCCCCHHHHH
VQALSDAQGSKANLARLADRVTAVFVPVVVVIALVAFGVTWWLTGMLDTALMHAVSVLVI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACPCALGLATPAAIMAGMGVAARHGVWFKDAQSLEAAGNIDIVVLDKTGTLTIGKPTIVD
HHHHHHHHCCHHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCCEEEECCCHHHH
EVMVDKSIAVDDVLQIAASIEVHASHPLATALVNAATARGLSLFDVSDISVIKGAGIQAN
HHHHCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCEEC
IEGLGVVKVGTAEFANLVLPKLMPKVWQIASTVAISINDEALGAFALADDLKSDTPQAIT
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCHHHHH
ALQDAGINVILMSGDKQSVVDHVAGQLGIEKAYGKMSPRDKASQIALLQTAGHKVAMAGD
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCEEEEECC
GVNDAPAMATADASFAMFEGTDVAQHSASARLMGESLMHIDAAQKIANATLRNIKQNLFF
CCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFIYNCLGIPLAAFGFLNPMIAAAAMALSSISVLMNALRLTRFKTKVELNNTVSDSHTKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHH
DRLTKA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]