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The map label for this gene is lpxD [H]

Identifier: 93006531

GI number: 93006531

Start: 2112081

End: 2113097

Strand: Reverse

Name: lpxD [H]

Synonym: Pcryo_1707

Alternate gene names: 93006531

Gene position: 2113097-2112081 (Counterclockwise)

Preceding gene: 93006532

Following gene: 93006530

Centisome position: 69.06

GC content: 47.3

Gene sequence:

>1017_bases
ATGATAACGATTGAGCAACTCATCTCCCAGATTGAGCAGCGTCAGCCTGTTCTTAACAAGGCTGAGCTTAGCGCTGAGCA
GCGCCGTCTATCCTTAGAGGGTATTGGTAATTTAACGATGGCTAATCGGCAGCAGTTGAGCTTTTTGGCCAATCCTCACT
ATCTTTCTAGTCTAGCTAATACTGATGCTGGGGCAGTACTCATCACTGAAGAGCATCATGAAGAAGTGCCAAATGATACG
GTAGCTTTAATTGTTGCTGTCCCTTATTTGGCTTATGCTAGTGTGAGTCAAATTTTTGCTCGCCAACATTCATTTAGCGG
TATTCATCCGACAGCCTTCATCGCCGACAGTGCCGTTATTGGCAATAAAGTGACTATCGGCGCTTTTTGTGTCATCGGTG
AGCAAGTGCAGATTGGTGATCGCAGCGTGCTTGAGGCTCATGTAGTCATCGAGGATAATACTACCATTGGTACAGATGGT
GTTATCAAATCACAAGTGGTGATAGGACATGACTGTATTATTGGTAGTCATGTTAGGTTGCACGCTGGGGTGACGATAGG
CTCGGAAGGCTTTGGCTTTGCACCCACTGCCAATCCTAGTGTCACAGGTTGGGAGCGTATTGCACAGTTAGGGCGTGTGC
TGATAGGTGATCATGTACGCATTGGCAGTCAAACCTGTATAGATCGCGGTGCCATCGATGATACGGTGATTGGAAATCAT
GTTATTATTGATAACCTCGTACAAGTAGCACACAACGTCCGTATTGGTGATGGTACGGCTATCGCTGCTCATACAGGTAT
TGCAGGTAGTACTACAATTGGCAAACGCTGCATTATTGGCGGGGCGGTCGGTATTACCGGACATATTGATATCACAGATG
ATGTTACCTTATCGGGTATGACTATGGTCACTAAGTCAATCACCACTGCCGGATCTTACTCTTCTGGCACGGCTGCTATG
CCAACTGCTAACTGGCGCCGTGCGGCTGTCCGTTTTCGCCAGCTTGGTCGTGATTAG

Upstream 100 bases:

>100_bases
AGCCCTTTAGGTAATTGAAGCGTTCGTTAGATTTAGCCGGTCGTCAAGATGATATCTCAACTTGACGACCCTCTCATTCC
TGCCAATACTAATACTGATT

Downstream 100 bases:

>100_bases
CGTTTAAAGATTCATAGTTAAAGAAAATTGATACTTAGATTATTTATAATATTAAAACTCAGCAAAGCTTTACTCTCAAG
CAAGACTTTAAATACAGCAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLANTDAGAVLITEEHHEEVPNDT
VALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVIGNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDG
VIKSQVVIGHDCIIGSHVRLHAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNH
VIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGMTMVTKSITTAGSYSSGTAAM
PTANWRRAAVRFRQLGRD

Sequences:

>Translated_338_residues
MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLANTDAGAVLITEEHHEEVPNDT
VALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVIGNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDG
VIKSQVVIGHDCIIGSHVRLHAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNH
VIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGMTMVTKSITTAGSYSSGTAAM
PTANWRRAAVRFRQLGRD
>Mature_338_residues
MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLANTDAGAVLITEEHHEEVPNDT
VALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVIGNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDG
VIKSQVVIGHDCIIGSHVRLHAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNH
VIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGMTMVTKSITTAGSYSSGTAAM
PTANWRRAAVRFRQLGRD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=300, Percent_Identity=41.6666666666667, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786378, Length=199, Percent_Identity=31.1557788944724, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35733; Mature: 35733

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLAN
CCCHHHHHHHHHHCCCCHHHHHHCHHHHEEECCCCCCCEECCHHHHHHHCCCHHHHHHCC
TDAGAVLITEEHHEEVPNDTVALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVI
CCCCEEEEECCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCEEE
GNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDGVIKSQVVIGHDCIIGSHVRL
CCCEEEEEEEEECCEEECCCCCEEEEEEEEECCCEECCCCCEECEEEEECCEEECCCEEE
HAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNH
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHCCCCCCCCCCCCH
VIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGM
HHHHHHHHHHHCEECCCCCEEEEECCCCCCCCCCCEEEEECCEEEEEEEEECCCCEECCH
TMVTKSITTAGSYSSGTAAMPTANWRRAAVRFRQLGRD
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITIEQLISQIEQRQPVLNKAELSAEQRRLSLEGIGNLTMANRQQLSFLANPHYLSSLAN
CCCHHHHHHHHHHCCCCHHHHHHCHHHHEEECCCCCCCEECCHHHHHHHCCCHHHHHHCC
TDAGAVLITEEHHEEVPNDTVALIVAVPYLAYASVSQIFARQHSFSGIHPTAFIADSAVI
CCCCEEEEECCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCEEE
GNKVTIGAFCVIGEQVQIGDRSVLEAHVVIEDNTTIGTDGVIKSQVVIGHDCIIGSHVRL
CCCEEEEEEEEECCEEECCCCCEEEEEEEEECCCEECCCCCEECEEEEECCEEECCCEEE
HAGVTIGSEGFGFAPTANPSVTGWERIAQLGRVLIGDHVRIGSQTCIDRGAIDDTVIGNH
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHCCCCCCCCCCCCH
VIIDNLVQVAHNVRIGDGTAIAAHTGIAGSTTIGKRCIIGGAVGITGHIDITDDVTLSGM
HHHHHHHHHHHCEECCCCCEEEEECCCCCCCCCCCEEEEECCEEEEEEEEECCCCEECCH
TMVTKSITTAGSYSSGTAAMPTANWRRAAVRFRQLGRD
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA