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The map label for this gene is strD [H]

Identifier: 93006520

GI number: 93006520

Start: 2096552

End: 2097280

Strand: Reverse

Name: strD [H]

Synonym: Pcryo_1696

Alternate gene names: 93006520

Gene position: 2097280-2096552 (Counterclockwise)

Preceding gene: 93006521

Following gene: 93006513

Centisome position: 68.54

GC content: 44.58

Gene sequence:

>729_bases
ATGTCGGTAATAACGCAAGCCATGATTTTGGCAGCCGGTAAGGGTACGCGCCTGCGTCCATTAACCTTAGAGACCCCAAA
GCCGTTAGTGGAAGTAGGTGGGCAGCCACTTATTATTTGGCATATTAAAGCGCTACAAGCCGCTGGTATTACTGATATTA
CAATTAATGCCTCTTGGCTGGCTGATAAGTTGATGAATACGATTGGCGATGGTACGCAGTTTGGCGTACAGTTGCATTGG
TCACTTGAAGCTGACGCGCCATTAGAGACAGCAGGTGGTATTTTTAAAGCGCTACAAACTGGAAAGTTAAAAAATGAACC
ATTTATCTTAGTCAACTCTGACGTATGGACGACGTTTGATTTTAGTCAGTTGGTCACGTATGAGTTAAGCGCAGACCAGC
GCGCCCATTTATTGTTGATTGATAATCCTGAGCATAATGAGGGTGGCGACTTTGCTATTAACAATGGTTTGGCAAGCGAG
CAGGCCATTGGTGAAGCCGATAAATATACTTTTGCTGGCATCAGTGTTGTGTCGCCACGACTGGTTGATGGCTTGGTATC
AGGTCAATCTGCCGCCCTTGGACCATTACTTAGACAAGCAATGATAAAATTCCAAGTAACGGCTGAGATCATGCCTGATA
ATTGGATAGATGTTGGTACGCCTGAACGCCTAGAGCAGGTAAATACCTTTATAGAAAATAAAGGTGTAAGCGAACATTGC
GGTGCTTAA

Upstream 100 bases:

>100_bases
GCAGCAATATATTTAACGCTCATATATTTAATGCCAATGTATTCAAAGCTAGTGATCATCAGTCGCCTCGTATAAATTTC
GCCAAGAATAAGGATTATCT

Downstream 100 bases:

>100_bases
TCTATAATATCTAGTAGTAATAGGCCATAAAAAACCGCAGCGCTAATCATTGATTAGGGCTGCGGTTTTTTATGAATAGC
TAATGGGATAACTATTTATA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSVITQAMILAAGKGTRLRPLTLETPKPLVEVGGQPLIIWHIKALQAAGITDITINASWLADKLMNTIGDGTQFGVQLHW
SLEADAPLETAGGIFKALQTGKLKNEPFILVNSDVWTTFDFSQLVTYELSADQRAHLLLIDNPEHNEGGDFAINNGLASE
QAIGEADKYTFAGISVVSPRLVDGLVSGQSAALGPLLRQAMIKFQVTAEIMPDNWIDVGTPERLEQVNTFIENKGVSEHC
GA

Sequences:

>Translated_242_residues
MSVITQAMILAAGKGTRLRPLTLETPKPLVEVGGQPLIIWHIKALQAAGITDITINASWLADKLMNTIGDGTQFGVQLHW
SLEADAPLETAGGIFKALQTGKLKNEPFILVNSDVWTTFDFSQLVTYELSADQRAHLLLIDNPEHNEGGDFAINNGLASE
QAIGEADKYTFAGISVVSPRLVDGLVSGQSAALGPLLRQAMIKFQVTAEIMPDNWIDVGTPERLEQVNTFIENKGVSEHC
GA
>Mature_241_residues
SVITQAMILAAGKGTRLRPLTLETPKPLVEVGGQPLIIWHIKALQAAGITDITINASWLADKLMNTIGDGTQFGVQLHWS
LEADAPLETAGGIFKALQTGKLKNEPFILVNSDVWTTFDFSQLVTYELSADQRAHLLLIDNPEHNEGGDFAINNGLASEQ
AIGEADKYTFAGISVVSPRLVDGLVSGQSAALGPLLRQAMIKFQVTAEIMPDNWIDVGTPERLEQVNTFIENKGVSEHCG
A

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=225, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI11761619, Length=224, Percent_Identity=27.6785714285714, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=224, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=190, Percent_Identity=33.1578947368421, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21355443, Length=223, Percent_Identity=28.6995515695067, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24644084, Length=223, Percent_Identity=28.6995515695067, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 26103; Mature: 25972

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVITQAMILAAGKGTRLRPLTLETPKPLVEVGGQPLIIWHIKALQAAGITDITINASWL
CCHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEHHHCCCEEEEEEHHHH
ADKLMNTIGDGTQFGVQLHWSLEADAPLETAGGIFKALQTGKLKNEPFILVNSDVWTTFD
HHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEE
FSQLVTYELSADQRAHLLLIDNPEHNEGGDFAINNGLASEQAIGEADKYTFAGISVVSPR
HHHEEEEEECCCCCEEEEEEECCCCCCCCCEEECCCCCCHHHCCCCCCEEEECEEECCHH
LVDGLVSGQSAALGPLLRQAMIKFQVTAEIMPDNWIDVGTPERLEQVNTFIENKGVSEHC
HHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
GA
CC
>Mature Secondary Structure 
SVITQAMILAAGKGTRLRPLTLETPKPLVEVGGQPLIIWHIKALQAAGITDITINASWL
CHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEHHHCCCEEEEEEHHHH
ADKLMNTIGDGTQFGVQLHWSLEADAPLETAGGIFKALQTGKLKNEPFILVNSDVWTTFD
HHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEE
FSQLVTYELSADQRAHLLLIDNPEHNEGGDFAINNGLASEQAIGEADKYTFAGISVVSPR
HHHEEEEEECCCCCEEEEEEECCCCCCCCCEEECCCCCCHHHCCCCCCEEEECEEECCHH
LVDGLVSGQSAALGPLLRQAMIKFQVTAEIMPDNWIDVGTPERLEQVNTFIENKGVSEHC
HHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]