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The map label for this gene is ppnK [H]

Identifier: 93006467

GI number: 93006467

Start: 2021799

End: 2022818

Strand: Reverse

Name: ppnK [H]

Synonym: Pcryo_1643

Alternate gene names: 93006467

Gene position: 2022818-2021799 (Counterclockwise)

Preceding gene: 93006469

Following gene: 93006466

Centisome position: 66.11

GC content: 47.25

Gene sequence:

>1020_bases
ATGCCGAGTCGTTTTATGGAAACCTCAGCGCAGTCCGCAAGATTGCCGCACCTACATGAATCAGAGCTGTTCCACGCTAT
CAAAAATCCAGCTTTTCGCCGTATTGGCTTGATGGGTCGTGCTGGAAAGCGCAGCGTAACCCAAAGTCTTGGGCAGATTG
CCCAAATAATTAACGATATGAATCTTACGTTGATTATGGATGTGCAAACTGCTAACTTGCCAACTCTGAATCTCACTGAT
ATTGAGAGGGTCAAAATTGTTAAGCGTAGCCTTATCGGTGAGATTTGTGATTTGGTCATTGTGGTTGGCGGTGATGGTTC
TATACTCCATGCTGCCGAAGCACTAGCGCGCTATCGTGTACCTGTCTTGGGGGTTAACCGTGGCCGCCTTGGTTTTTTAG
CCGATGTCAAACCTGATGAAGCGGCGTTTAAATTGCGCCAAGTACTGATGGGCGATTATCAGTTAGACCATAGATTTTTA
CTCACAATGGAGATTCGTGAAGGTCGTAAGATTATTCATGAAGACATGGCACTCAATGATATCGTGTTGCACGCTGGTAA
GTCTGTCCATATGATTGATTTTCAGATGAAAATCGATGGGCATGATGTTTATCGGCAGCACAGTGATGGTCTCATCGTAG
CGACACCGACGGGCTCGACAGCTTATGCGCTCTCTGGTGGTGGTCCTATTATACATCCAAGCATGGATGCCATATGTTTG
GTGCCTATGCACCCGCACACGCTGTCAAGTCGCCCTATTGTGGTCAGTGGCACCAGCGAGATTTGTATTCGTATTCATGA
GGACAACCGCACCCAACCGATGGTCAGTGCTGACGGTAAACCAAGCACGCCGCTTGAACAAGAGCAGCGTCTATATATTC
GTAAGCACCCGGATAAATTAACCTTGCTACATCCGCCAGGGTTTGACTTTTATGAAGCGTGCCGGACGAAGTTACACTGG
AATGTGCATGCTGAGGAATTCAGTCTCGACGCTGATGATGATATCATGGACGATGAATAA

Upstream 100 bases:

>100_bases
CTTTTATATGGGGTCAATTACGACCGTTAACAACGATAATTGATAAACAGGCTAGTCTAATCGCCCATTTCTCGTTATCA
TTACTCTGTAATTTACCATC

Downstream 100 bases:

>100_bases
GCGTCTTTATTAGACAAAAATGTGATATAAAAATAGTAGTGGAGAGTAGGCACGATGGACAAACAAACGATATTAGCAAG
CCTAACACCTGAAGTGGTCG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPSRFMETSAQSARLPHLHESELFHAIKNPAFRRIGLMGRAGKRSVTQSLGQIAQIINDMNLTLIMDVQTANLPTLNLTD
IERVKIVKRSLIGEICDLVIVVGGDGSILHAAEALARYRVPVLGVNRGRLGFLADVKPDEAAFKLRQVLMGDYQLDHRFL
LTMEIREGRKIIHEDMALNDIVLHAGKSVHMIDFQMKIDGHDVYRQHSDGLIVATPTGSTAYALSGGGPIIHPSMDAICL
VPMHPHTLSSRPIVVSGTSEICIRIHEDNRTQPMVSADGKPSTPLEQEQRLYIRKHPDKLTLLHPPGFDFYEACRTKLHW
NVHAEEFSLDADDDIMDDE

Sequences:

>Translated_339_residues
MPSRFMETSAQSARLPHLHESELFHAIKNPAFRRIGLMGRAGKRSVTQSLGQIAQIINDMNLTLIMDVQTANLPTLNLTD
IERVKIVKRSLIGEICDLVIVVGGDGSILHAAEALARYRVPVLGVNRGRLGFLADVKPDEAAFKLRQVLMGDYQLDHRFL
LTMEIREGRKIIHEDMALNDIVLHAGKSVHMIDFQMKIDGHDVYRQHSDGLIVATPTGSTAYALSGGGPIIHPSMDAICL
VPMHPHTLSSRPIVVSGTSEICIRIHEDNRTQPMVSADGKPSTPLEQEQRLYIRKHPDKLTLLHPPGFDFYEACRTKLHW
NVHAEEFSLDADDDIMDDE
>Mature_338_residues
PSRFMETSAQSARLPHLHESELFHAIKNPAFRRIGLMGRAGKRSVTQSLGQIAQIINDMNLTLIMDVQTANLPTLNLTDI
ERVKIVKRSLIGEICDLVIVVGGDGSILHAAEALARYRVPVLGVNRGRLGFLADVKPDEAAFKLRQVLMGDYQLDHRFLL
TMEIREGRKIIHEDMALNDIVLHAGKSVHMIDFQMKIDGHDVYRQHSDGLIVATPTGSTAYALSGGGPIIHPSMDAICLV
PMHPHTLSSRPIVVSGTSEICIRIHEDNRTQPMVSADGKPSTPLEQEQRLYIRKHPDKLTLLHPPGFDFYEACRTKLHWN
VHAEEFSLDADDDIMDDE

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=258, Percent_Identity=29.8449612403101, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788968, Length=293, Percent_Identity=39.9317406143345, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320794, Length=262, Percent_Identity=30.1526717557252, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322509, Length=265, Percent_Identity=29.0566037735849, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325068, Length=208, Percent_Identity=35.0961538461538, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161077047, Length=302, Percent_Identity=29.8013245033113, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28573830, Length=302, Percent_Identity=29.8013245033113, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28573828, Length=302, Percent_Identity=29.8013245033113, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28573826, Length=302, Percent_Identity=29.8013245033113, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28573832, Length=302, Percent_Identity=29.8013245033113, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20129957, Length=284, Percent_Identity=28.8732394366197, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281363323, Length=284, Percent_Identity=28.8732394366197, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281363321, Length=284, Percent_Identity=28.8732394366197, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653424, Length=284, Percent_Identity=28.8732394366197, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653422, Length=284, Percent_Identity=28.8732394366197, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 37849; Mature: 37718

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRFMETSAQSARLPHLHESELFHAIKNPAFRRIGLMGRAGKRSVTQSLGQIAQIINDM
CCCHHHHCCCHHCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
NLTLIMDVQTANLPTLNLTDIERVKIVKRSLIGEICDLVIVVGGDGSILHAAEALARYRV
CEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHCC
PVLGVNRGRLGFLADVKPDEAAFKLRQVLMGDYQLDHRFLLTMEIREGRKIIHEDMALND
CEEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEECCEEEEEEEECCCHHHHHHHHHHHH
IVLHAGKSVHMIDFQMKIDGHDVYRQHSDGLIVATPTGSTAYALSGGGPIIHPSMDAICL
HEEECCCEEEEEEEEEEECCHHHHHCCCCCEEEEECCCCEEEEECCCCCEECCCCCEEEE
VPMHPHTLSSRPIVVSGTSEICIRIHEDNRTQPMVSADGKPSTPLEQEQRLYIRKHPDKL
EECCCCCCCCCCEEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHCEEEEECCCEE
TLLHPPGFDFYEACRTKLHWNVHAEEFSLDADDDIMDDE
EEECCCCCCHHHHHHHEEEEEEEHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PSRFMETSAQSARLPHLHESELFHAIKNPAFRRIGLMGRAGKRSVTQSLGQIAQIINDM
CCHHHHCCCHHCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
NLTLIMDVQTANLPTLNLTDIERVKIVKRSLIGEICDLVIVVGGDGSILHAAEALARYRV
CEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHCC
PVLGVNRGRLGFLADVKPDEAAFKLRQVLMGDYQLDHRFLLTMEIREGRKIIHEDMALND
CEEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEECCEEEEEEEECCCHHHHHHHHHHHH
IVLHAGKSVHMIDFQMKIDGHDVYRQHSDGLIVATPTGSTAYALSGGGPIIHPSMDAICL
HEEECCCEEEEEEEEEEECCHHHHHCCCCCEEEEECCCCEEEEECCCCCEECCCCCEEEE
VPMHPHTLSSRPIVVSGTSEICIRIHEDNRTQPMVSADGKPSTPLEQEQRLYIRKHPDKL
EECCCCCCCCCCEEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHCEEEEECCCEE
TLLHPPGFDFYEACRTKLHWNVHAEEFSLDADDDIMDDE
EEECCCCCCHHHHHHHEEEEEEEHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA