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The map label for this gene is fabR [H]

Identifier: 93006352

GI number: 93006352

Start: 1877626

End: 1878306

Strand: Direct

Name: fabR [H]

Synonym: Pcryo_1526

Alternate gene names: 93006352

Gene position: 1877626-1878306 (Clockwise)

Preceding gene: 93006351

Following gene: 93006361

Centisome position: 61.36

GC content: 43.91

Gene sequence:

>681_bases
ATGAGCAGTCGCGAACAAAAAAAACTTCAAACTCGGCACGCTTTTTTTAATGCAGTGCTCGATTTATGTATGACAGGACA
ATCTTTTAGCTCTATTAGCCTCAGACAAGTCACGCGCGAGGTTGGTGTCGTGCCGACCGCATTTTATCGCCATTTTGATG
ATATGGAATCGCTCGGTCGCGCTTTGGTGATTGAAGAGCTAGGTGGTACATTAGCCACTTTGAGTGAGAGTTTGCATATT
GGACGTAAACGCAGCTTTGAGCGTCAAATTGCCAAAAGTATCCAGCTATTCTTGCATATGGTCAGTGAGCAACCCTACTA
TTGGCAGTTTTTGGTCAGTGAGCGCTATGGTGGCTCAGACGCCGTCCGTAAAGCCATCAATGAGCTTATCAAACAGCATG
GGGGAAGCTTGGCAGACGATTTGGCGTTACAGCCTGCTTTTACCCACATTAATACTTATGATCGTAGACTGCTGGCTGAG
GCTGGGGTCAATATGTTCTTCTCTTGGATTATTGATTGGCTAGAGCTGACTTATACTGAAGATCATGATGATGAAGTCGA
CTTGGCTGAAATTGAACAACGAAAGCAGCTGATGCTACATAATTGTACGCGCCAAGCACAGATGTTGTTTTATGGCGCTT
ATAATTGGAAATCTACTGAAGAAACTCATTTAAGTGATTAA

Upstream 100 bases:

>100_bases
TGGGGGACTGTCGTTTAAAAGCGACATTTAAGTGTATTTCATTCGTATTTTTGCAATGAAATGAGTATGATAGACATCTA
TCAGTTAATTTTGAAATATT

Downstream 100 bases:

>100_bases
TAAGACATATATTTGGTTGTTTTTGATGATTATCGTTTAGTGATAATCATCAAAAATTCGGTCGAAATGCCCAAAGTCGT
TGCGTCAACACGCGAACCTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSSREQKKLQTRHAFFNAVLDLCMTGQSFSSISLRQVTREVGVVPTAFYRHFDDMESLGRALVIEELGGTLATLSESLHI
GRKRSFERQIAKSIQLFLHMVSEQPYYWQFLVSERYGGSDAVRKAINELIKQHGGSLADDLALQPAFTHINTYDRRLLAE
AGVNMFFSWIIDWLELTYTEDHDDEVDLAEIEQRKQLMLHNCTRQAQMLFYGAYNWKSTEETHLSD

Sequences:

>Translated_226_residues
MSSREQKKLQTRHAFFNAVLDLCMTGQSFSSISLRQVTREVGVVPTAFYRHFDDMESLGRALVIEELGGTLATLSESLHI
GRKRSFERQIAKSIQLFLHMVSEQPYYWQFLVSERYGGSDAVRKAINELIKQHGGSLADDLALQPAFTHINTYDRRLLAE
AGVNMFFSWIIDWLELTYTEDHDDEVDLAEIEQRKQLMLHNCTRQAQMLFYGAYNWKSTEETHLSD
>Mature_225_residues
SSREQKKLQTRHAFFNAVLDLCMTGQSFSSISLRQVTREVGVVPTAFYRHFDDMESLGRALVIEELGGTLATLSESLHIG
RKRSFERQIAKSIQLFLHMVSEQPYYWQFLVSERYGGSDAVRKAINELIKQHGGSLADDLALQPAFTHINTYDRRLLAEA
GVNMFFSWIIDWLELTYTEDHDDEVDLAEIEQRKQLMLHNCTRQAQMLFYGAYNWKSTEETHLSD

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=228, Percent_Identity=32.0175438596491, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26133; Mature: 26002

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSREQKKLQTRHAFFNAVLDLCMTGQSFSSISLRQVTREVGVVPTAFYRHFDDMESLGR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALVIEELGGTLATLSESLHIGRKRSFERQIAKSIQLFLHMVSEQPYYWQFLVSERYGGSD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
AVRKAINELIKQHGGSLADDLALQPAFTHINTYDRRLLAEAGVNMFFSWIIDWLELTYTE
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHDDEVDLAEIEQRKQLMLHNCTRQAQMLFYGAYNWKSTEETHLSD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SSREQKKLQTRHAFFNAVLDLCMTGQSFSSISLRQVTREVGVVPTAFYRHFDDMESLGR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALVIEELGGTLATLSESLHIGRKRSFERQIAKSIQLFLHMVSEQPYYWQFLVSERYGGSD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
AVRKAINELIKQHGGSLADDLALQPAFTHINTYDRRLLAEAGVNMFFSWIIDWLELTYTE
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHDDEVDLAEIEQRKQLMLHNCTRQAQMLFYGAYNWKSTEETHLSD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA