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The map label for this gene is msrAB [H]

Identifier: 93006253

GI number: 93006253

Start: 1753471

End: 1754721

Strand: Reverse

Name: msrAB [H]

Synonym: Pcryo_1427

Alternate gene names: 93006253

Gene position: 1754721-1753471 (Counterclockwise)

Preceding gene: 93006254

Following gene: 93006252

Centisome position: 57.35

GC content: 44.04

Gene sequence:

>1251_bases
ATGACACACCGATTATTAGTGAATTATAAATTACCAGCTAAAGTCGTGGGTATGGCGATAGTAGCGAGCAGTGTCTTTTA
TGTCGGTTGCGCCTCCACTGAAAAACCGCCTACCATAAAAGATGTTTCCATTGACAATCCTTATGCGCCTACTGACCCTA
ATTTAGCAGTAGCGACGGTCGCTGGTGGCTGCTTTTGGTGTGTCGAGGCGGGTTATGAAAAGATTCCTGGTGTGGTAGAG
GTGGTGTCAGGTTATACAGGTGGCGAATCTAAAAACCCAACTTATAAACAAGTATCAGCAGGTGGTACGGGTCATACGGA
AGCGGCTCAAGTTTATTATGATCCGACCAAGATTACCTACAATGGTATCGTTCAAGCACTATGGCGAATCGCTGATCCTA
CTGATGATAAAGGTCAGTTTGTAGATAGAGGCACCCAGTATCGCCCAGCTATTTTTTATAATAGTGAGCAAGAAAAACAG
ATAGCCGAAGCTGCCAAGCAATCGCTGCAAGCCTCTGGCGTCTATAAAAAGCCAGTCGTAATCGAGATTGTGCCTGTTAG
CGAATTTTATCCAGCAGAAGAGTATCATCAGGATTATTACAAAAAGAATCCACTACGTTATAAGGCCTATACGTTTAACT
CTGGTCGCTACCAGTTCATTGAAAGTGTCTATGGCAAAAAATATGAGTTAGATTTCAACCAATTCAAACCGACTGTAACC
AGTGCAAAGTCAGCAATGTCGAATACCTCGTCAGCTGCAGTAAAGCCGTCGACAGTTAAGACAAGTGCAGGCTTTGACCC
AGATACCTTTGTAAAACCGACAAAAGCTGATCTTAAAAAATCACTAAGTGACATTCAATATAAAGTCTCTCAGGAAGATA
GTACTGAGCGCGCTTTTGATAACGAATATTGGGATAATAAAGAACCTGGACTGTATGTCGATGTAGTATCAGGTGAACCA
TTATATTCGTCTCGTGATCAATACAAGTCCGGTACAGGTTGGCCGAGCTTTACTCGTCCACTGAATGCTAGCTTTGTCGT
AGAAAAGGCAGATCGAGGAATATTTGGCACCCGTACCGAGATTCGTAGCCGTTATGCAGATTCACACGTCGGTCATGTAT
TTGACGATGGTCCGGCACCGACGGGTAAGCGCTATTGCATGAACTCAGCAGCAATGCGTTTTATCCCACTGGCGCAGATG
GAAGCGGCTGGCTATGGTAGATGGATCAATGACGTAAAATCAGCTAGCTAA

Upstream 100 bases:

>100_bases
CCATTCATTAAATATGGTGTATATAAACAACACTTTAGGAATATTTCTGTGAGACCTAAGGGTTACGATGGTTACATGAT
ATTACCCTTAGGAGCCTTTC

Downstream 100 bases:

>100_bases
TTCCCTTACTGTCATAAGAAATCAAAAACCGCTTATCATATCAGTAGTTAACTACTGATATGATAAGCGGTTTTTGTATG
TGATGCTATATAGTCTTATT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTHRLLVNYKLPAKVVGMAIVASSVFYVGCASTEKPPTIKDVSIDNPYAPTDPNLAVATVAGGCFWCVEAGYEKIPGVVE
VVSGYTGGESKNPTYKQVSAGGTGHTEAAQVYYDPTKITYNGIVQALWRIADPTDDKGQFVDRGTQYRPAIFYNSEQEKQ
IAEAAKQSLQASGVYKKPVVIEIVPVSEFYPAEEYHQDYYKKNPLRYKAYTFNSGRYQFIESVYGKKYELDFNQFKPTVT
SAKSAMSNTSSAAVKPSTVKTSAGFDPDTFVKPTKADLKKSLSDIQYKVSQEDSTERAFDNEYWDNKEPGLYVDVVSGEP
LYSSRDQYKSGTGWPSFTRPLNASFVVEKADRGIFGTRTEIRSRYADSHVGHVFDDGPAPTGKRYCMNSAAMRFIPLAQM
EAAGYGRWINDVKSAS

Sequences:

>Translated_416_residues
MTHRLLVNYKLPAKVVGMAIVASSVFYVGCASTEKPPTIKDVSIDNPYAPTDPNLAVATVAGGCFWCVEAGYEKIPGVVE
VVSGYTGGESKNPTYKQVSAGGTGHTEAAQVYYDPTKITYNGIVQALWRIADPTDDKGQFVDRGTQYRPAIFYNSEQEKQ
IAEAAKQSLQASGVYKKPVVIEIVPVSEFYPAEEYHQDYYKKNPLRYKAYTFNSGRYQFIESVYGKKYELDFNQFKPTVT
SAKSAMSNTSSAAVKPSTVKTSAGFDPDTFVKPTKADLKKSLSDIQYKVSQEDSTERAFDNEYWDNKEPGLYVDVVSGEP
LYSSRDQYKSGTGWPSFTRPLNASFVVEKADRGIFGTRTEIRSRYADSHVGHVFDDGPAPTGKRYCMNSAAMRFIPLAQM
EAAGYGRWINDVKSAS
>Mature_415_residues
THRLLVNYKLPAKVVGMAIVASSVFYVGCASTEKPPTIKDVSIDNPYAPTDPNLAVATVAGGCFWCVEAGYEKIPGVVEV
VSGYTGGESKNPTYKQVSAGGTGHTEAAQVYYDPTKITYNGIVQALWRIADPTDDKGQFVDRGTQYRPAIFYNSEQEKQI
AEAAKQSLQASGVYKKPVVIEIVPVSEFYPAEEYHQDYYKKNPLRYKAYTFNSGRYQFIESVYGKKYELDFNQFKPTVTS
AKSAMSNTSSAAVKPSTVKTSAGFDPDTFVKPTKADLKKSLSDIQYKVSQEDSTERAFDNEYWDNKEPGLYVDVVSGEPL
YSSRDQYKSGTGWPSFTRPLNASFVVEKADRGIFGTRTEIRSRYADSHVGHVFDDGPAPTGKRYCMNSAAMRFIPLAQME
AAGYGRWINDVKSAS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=123, Percent_Identity=45.5284552845528, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI301336162, Length=123, Percent_Identity=45.5284552845528, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI73089054, Length=123, Percent_Identity=45.5284552845528, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI37620216, Length=123, Percent_Identity=45.5284552845528, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI117606353, Length=129, Percent_Identity=39.5348837209302, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=36.6013071895425, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=35.625, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=39.8692810457516, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788077, Length=123, Percent_Identity=43.9024390243902, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115532676, Length=122, Percent_Identity=36.8852459016393, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17553450, Length=122, Percent_Identity=36.8852459016393, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17533973, Length=137, Percent_Identity=33.5766423357664, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=37.7358490566038, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553335, Length=122, Percent_Identity=44.2622950819672, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21356369, Length=122, Percent_Identity=44.2622950819672, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24645799, Length=122, Percent_Identity=44.2622950819672, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24645804, Length=133, Percent_Identity=41.3533834586466, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221378664, Length=125, Percent_Identity=43.2, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645801, Length=133, Percent_Identity=41.3533834586466, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378662, Length=132, Percent_Identity=40.9090909090909, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24664627, Length=174, Percent_Identity=33.9080459770115, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=35.9712230215827, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664631, Length=162, Percent_Identity=33.9506172839506, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 46054; Mature: 45923

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRLLVNYKLPAKVVGMAIVASSVFYVGCASTEKPPTIKDVSIDNPYAPTDPNLAVATV
CCCEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEE
AGGCFWCVEAGYEKIPGVVEVVSGYTGGESKNPTYKQVSAGGTGHTEAAQVYYDPTKITY
CCCEEEEEHHCHHHCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEH
NGIVQALWRIADPTDDKGQFVDRGTQYRPAIFYNSEQEKQIAEAAKQSLQASGVYKKPVV
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEE
IEIVPVSEFYPAEEYHQDYYKKNPLRYKAYTFNSGRYQFIESVYGKKYELDFNQFKPTVT
EEEEECHHCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCEEEECHHHHCCHHH
SAKSAMSNTSSAAVKPSTVKTSAGFDPDTFVKPTKADLKKSLSDIQYKVSQEDSTERAFD
HHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHC
NEYWDNKEPGLYVDVVSGEPLYSSRDQYKSGTGWPSFTRPLNASFVVEKADRGIFGTRTE
CCCCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
IRSRYADSHVGHVFDDGPAPTGKRYCMNSAAMRFIPLAQMEAAGYGRWINDVKSAS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
THRLLVNYKLPAKVVGMAIVASSVFYVGCASTEKPPTIKDVSIDNPYAPTDPNLAVATV
CCEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEE
AGGCFWCVEAGYEKIPGVVEVVSGYTGGESKNPTYKQVSAGGTGHTEAAQVYYDPTKITY
CCCEEEEEHHCHHHCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEH
NGIVQALWRIADPTDDKGQFVDRGTQYRPAIFYNSEQEKQIAEAAKQSLQASGVYKKPVV
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEE
IEIVPVSEFYPAEEYHQDYYKKNPLRYKAYTFNSGRYQFIESVYGKKYELDFNQFKPTVT
EEEEECHHCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCEEEECHHHHCCHHH
SAKSAMSNTSSAAVKPSTVKTSAGFDPDTFVKPTKADLKKSLSDIQYKVSQEDSTERAFD
HHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHC
NEYWDNKEPGLYVDVVSGEPLYSSRDQYKSGTGWPSFTRPLNASFVVEKADRGIFGTRTE
CCCCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
IRSRYADSHVGHVFDDGPAPTGKRYCMNSAAMRFIPLAQMEAAGYGRWINDVKSAS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]