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The map label for this gene is catF [H]

Identifier: 93006088

GI number: 93006088

Start: 1531195

End: 1532433

Strand: Reverse

Name: catF [H]

Synonym: Pcryo_1260

Alternate gene names: 93006088

Gene position: 1532433-1531195 (Counterclockwise)

Preceding gene: 93006089

Following gene: 93006087

Centisome position: 50.08

GC content: 49.23

Gene sequence:

>1239_bases
ATGATGACTGATTCAATCACTGGTTTAAATAATGCTTATATTATTGATGCCATTCGCACCCCTTTTGGTCGCTACGGCGG
CGGTCTAGCACCAGTACGTGCCGATGATTTAGGGGCTATACCTATCAAGGCGCTAATCGAACGTAATGCCAATGTCGATT
GGGTAAAAGTAGATGACGTTATTTACGGCTGTGCTAATCAGAGCGGTGAAGACAATCGCAACGTCGGGCGTATGTCGTCG
TTACTAGCTGGCCTACCTTATCAAGTGCCTGCCACTACGGTGAATCGCTTATGCGGCTCGTCAATGGATGCGTTAGCGAT
AGCGGCGCGTGCGATTAAAGCGGGTGAAGCCAACCTTATTATTGCAGGTGGTGTTGAGAGCATGAGCCGTGCGCCATTGG
TAATGGGCAAGTCAGATCAAGCGTTTGGTCGTAGTCAAAAGCTCGAAGATACCACTATGGGCTGGCGCTTTATCAATCCA
AAGCTTGATGAGCTATATGGTACGGAGACCATGCCGCAAACCGCCGAAAACGTCGCAGAGCAATTCAATATCAATCGCGC
TGACCAAGATGCATTTGCATTACGTAGTCAACAACGTACCGCAGCGGCGCAAGAGGCAGGGTTTTTCAAAGATGAGATTA
CTCCAGTCAGCATCCCGCAACGCAAAGGCGAGCCTATCACCGTCGATACCGACGAGCACCCTCGTGCTGATACCACGCTT
GAGAAGTTAACCAAACTGCGCCCTATCGTCACCGCAGAGGGTACAGTAACAGCTGGTAACGCTTCTGGTATCAATGATGG
TGCAGCGGCTTTTTTAGTGGCATCAGAGCAAGCCGTTAAAGAGTTTAGTCTCAAGCCGCGTGCACGTATTGTTGCCTCAA
CTACAGTAGGTGTTGAGCCGCGTATTATGGGCTTTGCTCCAGCACCGGCGATGAAAAAGCTGCTTAAGCAAACTGGACTG
TCACTTGATGAGATGGATGTCATTGAATTAAACGAAGCCTTTGCCGCTCAAGCTCTCGCTTGTACGCGTGACTTAGGGTT
ATCTGATGATAGCGCGCGCGTTAATCCGAATGGCGGTGCCATTGCCCTTGGTCACCCGCTTGGCGCCTCAGGCGCACGTT
TAATTTTAACAGCACTCAATCAACTTGAGAAAACTGATAAGCGTTATGCCATATGCTCAATGTGTATTGGCGTTGGACAA
GGTATCGCGATGATTATTGAGCGTGTTGTTAACGATTAA

Upstream 100 bases:

>100_bases
TCACTGAAATGGTCGATGGCTTAAGCTTTGCGGACTTACAAGCATTGACGGGTGCGACGCTAATTGACGCTACAAATTCA
AAATAATAAAAAGGACAAGG

Downstream 100 bases:

>100_bases
GCAGCACTATTAATAAATATCAATTAAATCACTCACCATTACTATTTCACGGACATCGTCAGGACTAAAAAGGATAATAA
TGATGCCTATATTTAACAAC

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MMTDSITGLNNAYIIDAIRTPFGRYGGGLAPVRADDLGAIPIKALIERNANVDWVKVDDVIYGCANQSGEDNRNVGRMSS
LLAGLPYQVPATTVNRLCGSSMDALAIAARAIKAGEANLIIAGGVESMSRAPLVMGKSDQAFGRSQKLEDTTMGWRFINP
KLDELYGTETMPQTAENVAEQFNINRADQDAFALRSQQRTAAAQEAGFFKDEITPVSIPQRKGEPITVDTDEHPRADTTL
EKLTKLRPIVTAEGTVTAGNASGINDGAAAFLVASEQAVKEFSLKPRARIVASTTVGVEPRIMGFAPAPAMKKLLKQTGL
SLDEMDVIELNEAFAAQALACTRDLGLSDDSARVNPNGGAIALGHPLGASGARLILTALNQLEKTDKRYAICSMCIGVGQ
GIAMIIERVVND

Sequences:

>Translated_412_residues
MMTDSITGLNNAYIIDAIRTPFGRYGGGLAPVRADDLGAIPIKALIERNANVDWVKVDDVIYGCANQSGEDNRNVGRMSS
LLAGLPYQVPATTVNRLCGSSMDALAIAARAIKAGEANLIIAGGVESMSRAPLVMGKSDQAFGRSQKLEDTTMGWRFINP
KLDELYGTETMPQTAENVAEQFNINRADQDAFALRSQQRTAAAQEAGFFKDEITPVSIPQRKGEPITVDTDEHPRADTTL
EKLTKLRPIVTAEGTVTAGNASGINDGAAAFLVASEQAVKEFSLKPRARIVASTTVGVEPRIMGFAPAPAMKKLLKQTGL
SLDEMDVIELNEAFAAQALACTRDLGLSDDSARVNPNGGAIALGHPLGASGARLILTALNQLEKTDKRYAICSMCIGVGQ
GIAMIIERVVND
>Mature_412_residues
MMTDSITGLNNAYIIDAIRTPFGRYGGGLAPVRADDLGAIPIKALIERNANVDWVKVDDVIYGCANQSGEDNRNVGRMSS
LLAGLPYQVPATTVNRLCGSSMDALAIAARAIKAGEANLIIAGGVESMSRAPLVMGKSDQAFGRSQKLEDTTMGWRFINP
KLDELYGTETMPQTAENVAEQFNINRADQDAFALRSQQRTAAAQEAGFFKDEITPVSIPQRKGEPITVDTDEHPRADTTL
EKLTKLRPIVTAEGTVTAGNASGINDGAAAFLVASEQAVKEFSLKPRARIVASTTVGVEPRIMGFAPAPAMKKLLKQTGL
SLDEMDVIELNEAFAAQALACTRDLGLSDDSARVNPNGGAIALGHPLGASGARLILTALNQLEKTDKRYAICSMCIGVGQ
GIAMIIERVVND

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=44.3890274314214, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=41.8316831683168, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.8712871287129, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4501853, Length=407, Percent_Identity=38.3292383292383, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=31.7016317016317, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI194353979, Length=399, Percent_Identity=29.8245614035088, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=62.0947630922693, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=45.049504950495, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=44.7761194029851, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=46.3840399002494, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=31.2941176470588, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=46.8671679197995, Blast_Score=338, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=35.5721393034826, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=34.3358395989975, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=34.2723004694836, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=28.9537712895377, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17537653, Length=335, Percent_Identity=23.5820895522388, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=37.2839506172839, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322031, Length=336, Percent_Identity=40.4761904761905, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=45.6359102244389, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI17648125, Length=403, Percent_Identity=43.424317617866, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=37.27959697733, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.7236533957845, Blast_Score=211, Evalue=6e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 43806; Mature: 43806

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDSITGLNNAYIIDAIRTPFGRYGGGLAPVRADDLGAIPIKALIERNANVDWVKVDDV
CCCCCCCCCCCEEEEEEHHCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECHH
IYGCANQSGEDNRNVGRMSSLLAGLPYQVPATTVNRLCGSSMDALAIAARAIKAGEANLI
HEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
IAGGVESMSRAPLVMGKSDQAFGRSQKLEDTTMGWRFINPKLDELYGTETMPQTAENVAE
EECCHHHHCCCCEEECCCCHHCCCCCCCCHHHCCEEEECCCHHHHCCCCCCHHHHHHHHH
QFNINRADQDAFALRSQQRTAAAQEAGFFKDEITPVSIPQRKGEPITVDTDEHPRADTTL
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCEEECCCCCCCCHHHH
EKLTKLRPIVTAEGTVTAGNASGINDGAAAFLVASEQAVKEFSLKPRARIVASTTVGVEP
HHHHHHCCEEEECCEEEECCCCCCCCCCEEEEEECHHHHHHHCCCCCCEEEEEEECCCCC
RIMGFAPAPAMKKLLKQTGLSLDEMDVIELNEAFAAQALACTRDLGLSDDSARVNPNGGA
EEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCE
IALGHPLGASGARLILTALNQLEKTDKRYAICSMCIGVGQGIAMIIERVVND
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMTDSITGLNNAYIIDAIRTPFGRYGGGLAPVRADDLGAIPIKALIERNANVDWVKVDDV
CCCCCCCCCCCEEEEEEHHCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECHH
IYGCANQSGEDNRNVGRMSSLLAGLPYQVPATTVNRLCGSSMDALAIAARAIKAGEANLI
HEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
IAGGVESMSRAPLVMGKSDQAFGRSQKLEDTTMGWRFINPKLDELYGTETMPQTAENVAE
EECCHHHHCCCCEEECCCCHHCCCCCCCCHHHCCEEEECCCHHHHCCCCCCHHHHHHHHH
QFNINRADQDAFALRSQQRTAAAQEAGFFKDEITPVSIPQRKGEPITVDTDEHPRADTTL
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCEEECCCCCCCCHHHH
EKLTKLRPIVTAEGTVTAGNASGINDGAAAFLVASEQAVKEFSLKPRARIVASTTVGVEP
HHHHHHCCEEEECCEEEECCCCCCCCCCEEEEEECHHHHHHHCCCCCCEEEEEEECCCCC
RIMGFAPAPAMKKLLKQTGLSLDEMDVIELNEAFAAQALACTRDLGLSDDSARVNPNGGA
EEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCE
IALGHPLGASGARLILTALNQLEKTDKRYAICSMCIGVGQGIAMIIERVVND
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]