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The map label for this gene is norM [H]

Identifier: 93005994

GI number: 93005994

Start: 1413136

End: 1414503

Strand: Reverse

Name: norM [H]

Synonym: Pcryo_1166

Alternate gene names: 93005994

Gene position: 1414503-1413136 (Counterclockwise)

Preceding gene: 93005995

Following gene: 93005993

Centisome position: 46.23

GC content: 44.81

Gene sequence:

>1368_bases
ATGGTTTTCCCGTTGTCTTTTGTAGATTTTAAAAGTTACAGTTTACGCTTAGGTATACTCGCGCTGCCCATCTTAATCAC
CCAGTTTTGTCAAGCAGCGCTTGGTGTTGTCGATGCCATTATGGCAGGTCAAGTTTCGGCACTTGATTTGGCTGCTGTCG
CTGTCGGCTCAGGTATTTGGCTACCATTATTTTTATTAGCAACAGGTATTTTGATTGCGACTACGCCTCTGATCGGTGAA
GCCATTGGTCAAAACCAACTCGATAAAGTACCACATATCACGCAGCAGTCATTATGGACGGCTGGTGTCATTGGTATCCT
TGGTTTTATCATTGTTAACCTAGCACCCAATGTGCTTGCCCTCATGGGTGTTCCTGAAAATATACAACCGATAGCAACTC
AGTATTTGCATGGCGTATCATTTGGCTTCCCTGCAATTGCCGTTTATGCGGTGCTGCGTAGTTACTGTGAAGCGCTTGGT
CGACCAGAGCCTGTGACAGTTATTAGTATCATAGGGCTGCTTGCAGATATCCCGCTTAACTATATTTTTATCCATGGCTT
ATTTGGCATGCCTGAGATGGGTGGCGCTGGTTGCGGGGTAGCAACTGCTATCGTTTTGTGGATTAACGTCTTATTATTAG
CCGCTTATACCAGCTTTACTAAGCGTCAGCAATTTGCCAGTACGCGCTTTTTTTATGCCTTTGCCAGCCCAAATCGGGCA
CAGATAAAAAAACTTCTCAAGCTTGGTATTCCGATTGGCGTCTCTATCTTTTTTGAAGCCAGTCTATTTAGCTTAGGCGC
ACTGGTGATTAGTCCATTGGGTGAGCTGGCAACCGCATCGCACCAAGTCGCCTTATCAGTGACCTCGCAGTTGTTTATGA
TCCCAATTTCGGTCGCGATGGCACTGACCATTATGGTATCCAACCGCTTTGGTGAAAAAAACCTAATGGCACTGCGTCAA
GTACAAGCAACCGGTCTTATATGGACGGTACTTATTGCATTTGCCTGTATGATTGGTGTTTGGCTATTTAGACCACAATT
GGCAGCGGCATTCACTGACAATCCTGTCGTACGAGCTCAAGCCATGCATTTGCTCATCTTTGCGCTTGCTTATCAGCTAT
TTGATGGCTGGCAAGTTAATGTCGCGGGTATATTACGGGGCATGCAAGATACTACAATACCGATGTGGGTTACCCTATTT
TGCTACTGGATAGTGGCACTACCGCTTGGTATTTATCTAGTACGCTTTACTGATATTGGGGCGCAAGGTTTTTGGATGGC
TTTAATTACAGGGTTATTTTTATCGTCTATTTTACTTACCATACGTTTGCGATACCAACAAAAGAGATTGCTGGCAATGT
GGGGATAA

Upstream 100 bases:

>100_bases
ATTTTACTGTCTCGCTATTGATTTATTGATGGCTGTGTTTATTCATTAGTAAAATTTGTTTATCAAAAATAATTATTGTA
AAGAATAAAAGTTGCTCATT

Downstream 100 bases:

>100_bases
CAATAAGACTAGGTTTACACAAGTTTATCTAAATGTTATCTGTAATAATCATCACTGGCGCTCGCAAGTCACATAGACTA
TGATAAATTCTTGAGCATTT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MVFPLSFVDFKSYSLRLGILALPILITQFCQAALGVVDAIMAGQVSALDLAAVAVGSGIWLPLFLLATGILIATTPLIGE
AIGQNQLDKVPHITQQSLWTAGVIGILGFIIVNLAPNVLALMGVPENIQPIATQYLHGVSFGFPAIAVYAVLRSYCEALG
RPEPVTVISIIGLLADIPLNYIFIHGLFGMPEMGGAGCGVATAIVLWINVLLLAAYTSFTKRQQFASTRFFYAFASPNRA
QIKKLLKLGIPIGVSIFFEASLFSLGALVISPLGELATASHQVALSVTSQLFMIPISVAMALTIMVSNRFGEKNLMALRQ
VQATGLIWTVLIAFACMIGVWLFRPQLAAAFTDNPVVRAQAMHLLIFALAYQLFDGWQVNVAGILRGMQDTTIPMWVTLF
CYWIVALPLGIYLVRFTDIGAQGFWMALITGLFLSSILLTIRLRYQQKRLLAMWG

Sequences:

>Translated_455_residues
MVFPLSFVDFKSYSLRLGILALPILITQFCQAALGVVDAIMAGQVSALDLAAVAVGSGIWLPLFLLATGILIATTPLIGE
AIGQNQLDKVPHITQQSLWTAGVIGILGFIIVNLAPNVLALMGVPENIQPIATQYLHGVSFGFPAIAVYAVLRSYCEALG
RPEPVTVISIIGLLADIPLNYIFIHGLFGMPEMGGAGCGVATAIVLWINVLLLAAYTSFTKRQQFASTRFFYAFASPNRA
QIKKLLKLGIPIGVSIFFEASLFSLGALVISPLGELATASHQVALSVTSQLFMIPISVAMALTIMVSNRFGEKNLMALRQ
VQATGLIWTVLIAFACMIGVWLFRPQLAAAFTDNPVVRAQAMHLLIFALAYQLFDGWQVNVAGILRGMQDTTIPMWVTLF
CYWIVALPLGIYLVRFTDIGAQGFWMALITGLFLSSILLTIRLRYQQKRLLAMWG
>Mature_455_residues
MVFPLSFVDFKSYSLRLGILALPILITQFCQAALGVVDAIMAGQVSALDLAAVAVGSGIWLPLFLLATGILIATTPLIGE
AIGQNQLDKVPHITQQSLWTAGVIGILGFIIVNLAPNVLALMGVPENIQPIATQYLHGVSFGFPAIAVYAVLRSYCEALG
RPEPVTVISIIGLLADIPLNYIFIHGLFGMPEMGGAGCGVATAIVLWINVLLLAAYTSFTKRQQFASTRFFYAFASPNRA
QIKKLLKLGIPIGVSIFFEASLFSLGALVISPLGELATASHQVALSVTSQLFMIPISVAMALTIMVSNRFGEKNLMALRQ
VQATGLIWTVLIAFACMIGVWLFRPQLAAAFTDNPVVRAQAMHLLIFALAYQLFDGWQVNVAGILRGMQDTTIPMWVTLF
CYWIVALPLGIYLVRFTDIGAQGFWMALITGLFLSSILLTIRLRYQQKRLLAMWG

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=426, Percent_Identity=22.7699530516432, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=39.8633257403189, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI226510954, Length=438, Percent_Identity=21.2328767123288, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49357; Mature: 49357

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPLSFVDFKSYSLRLGILALPILITQFCQAALGVVDAIMAGQVSALDLAAVAVGSGIW
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LPLFLLATGILIATTPLIGEAIGQNQLDKVPHITQQSLWTAGVIGILGFIIVNLAPNVLA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMGVPENIQPIATQYLHGVSFGFPAIAVYAVLRSYCEALGRPEPVTVISIIGLLADIPLN
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
YIFIHGLFGMPEMGGAGCGVATAIVLWINVLLLAAYTSFTKRQQFASTRFFYAFASPNRA
HEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
QIKKLLKLGIPIGVSIFFEASLFSLGALVISPLGELATASHQVALSVTSQLFMIPISVAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ALTIMVSNRFGEKNLMALRQVQATGLIWTVLIAFACMIGVWLFRPQLAAAFTDNPVVRAQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AMHLLIFALAYQLFDGWQVNVAGILRGMQDTTIPMWVTLFCYWIVALPLGIYLVRFTDIG
HHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQGFWMALITGLFLSSILLTIRLRYQQKRLLAMWG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFPLSFVDFKSYSLRLGILALPILITQFCQAALGVVDAIMAGQVSALDLAAVAVGSGIW
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LPLFLLATGILIATTPLIGEAIGQNQLDKVPHITQQSLWTAGVIGILGFIIVNLAPNVLA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMGVPENIQPIATQYLHGVSFGFPAIAVYAVLRSYCEALGRPEPVTVISIIGLLADIPLN
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
YIFIHGLFGMPEMGGAGCGVATAIVLWINVLLLAAYTSFTKRQQFASTRFFYAFASPNRA
HEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
QIKKLLKLGIPIGVSIFFEASLFSLGALVISPLGELATASHQVALSVTSQLFMIPISVAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ALTIMVSNRFGEKNLMALRQVQATGLIWTVLIAFACMIGVWLFRPQLAAAFTDNPVVRAQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AMHLLIFALAYQLFDGWQVNVAGILRGMQDTTIPMWVTLFCYWIVALPLGIYLVRFTDIG
HHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQGFWMALITGLFLSSILLTIRLRYQQKRLLAMWG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA