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The map label for this gene is degP [H]

Identifier: 93005943

GI number: 93005943

Start: 1344781

End: 1346109

Strand: Direct

Name: degP [H]

Synonym: Pcryo_1115

Alternate gene names: 93005943

Gene position: 1344781-1346109 (Clockwise)

Preceding gene: 93005940

Following gene: 93005955

Centisome position: 43.95

GC content: 47.86

Gene sequence:

>1329_bases
ATGTCGTCATCCCCGAATGCCGAGAACAAGGCTGGTCTCTTAAAGTGGTTACCTTGGGTTTTACTGCTATTGGTCACAGC
TGCCTTTATTTGGTTATTTGTGAGTATGAAGACAGCATCGGAGGCAAAATGGGAGCCGCCAAAGACCACACCTGCTGAGC
AGCAAGCTTCCGAGCCGGTATCGGACTCACCAACGCCTATCGCCTCTTATCATAATGGTGTGGCTCGAGCCTCCCAGTCT
GTGGTCAATATCTATACCACGCAGACGATGGCAGAACATCCTTATATGAACGATCCGGTGTTGCGCCGGTTTTTTGAATA
TCATGGCGCGCCGTCAGAAGAGCAAGGCAATACCAACCTAGGTTCAGGCGTTATCGTGTCGGATGATGGTTATATCGTCA
CCAATGCCCATGTGATTGAAAAAGCCGATGAAATTACCGTTGCGTTTAATGATGGTCGTAAAAGCCGTGCAAAATTAATT
GGCACAGACCCAGATAGTGATTTGGCAGTGATTAAAGTCGATATGACTGGGCTTACACCATTAGGCTTTCGTGAAAAACC
AACGCTTGTCGGCGATGTAGCACTAGCGATTGGTAATCCATTTGGTGTCGGTCAAACCGTTACCCAAGGTATTATTTCAG
CGACTGGACGTACAGGGCTTGGCGTTAATAAGTTTGAAGACTTTATTCAAACTGATGCGGCTATCAATCCGGGTAACTCG
GGCGGCGCATTGGTTGATGCACGTGGTGAGCTGATTGGTATCAATACTGCCATCTACTCACGCTCTGGTGGCTCTATGGG
TATTGGATTTGCTATTCCCACCGCTATCGTTGAGCAAGTGATGAATGCTCTGATCAAAGATGGCAAGGTCAGTCGTGGTT
GGCTGGGTATTGAGATACAATCGCAGCTGAGAGATCCGACACAGCTCGAATCATCAACAGGCGTAGAGGTACTTAACGTG
GTTCCTAAGAGCCCAGCTGCTAAGAGCGGTCTAAAAGTTGGCGATATTGTTTTGACCATTGATGGGGTTGAGATGACTGA
TGCCAATACCTTGATTCAGTATGTCGCTCGTAAAGCACCTAATACCACGCTGCATGCTCAAATCTTACGTCAAGGTAAAA
ATGCGCAAGTGAAGATATTGCTAGAGGAGCGTCCAGTTGAAGAGCCAGTCACCGTTCCTGTTGTGATTCAAGATGAAACG
CTTGGCGGTGCGCAGCCACCAACGCTACAAGCGCCAGAACAAGACACCCCTATGATGTCAGAGGCTGAACGTGACCGTAT
GCGTGAAGAGCTTTTATTACTGTTCGAAAGAGATGGTGCACCTTTGTAA

Upstream 100 bases:

>100_bases
GGACAGCTATAATTTACACATGTGAAAGTGCCTTATATCAAGGCGTACGCCTGATATGGCTTAATACCGATTGTCCATGT
GAAATTATAGAGGTTTTTAT

Downstream 100 bases:

>100_bases
AGAGAGTGTTTACCGATTCTCTGATCTCTAAGAGCAATAACAAAAAGCGCACTATCTATAAGATAGCGCGCTTTTTTAAT
AAGTTTTGATTGATCGAATA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSSSPNAENKAGLLKWLPWVLLLLVTAAFIWLFVSMKTASEAKWEPPKTTPAEQQASEPVSDSPTPIASYHNGVARASQS
VVNIYTTQTMAEHPYMNDPVLRRFFEYHGAPSEEQGNTNLGSGVIVSDDGYIVTNAHVIEKADEITVAFNDGRKSRAKLI
GTDPDSDLAVIKVDMTGLTPLGFREKPTLVGDVALAIGNPFGVGQTVTQGIISATGRTGLGVNKFEDFIQTDAAINPGNS
GGALVDARGELIGINTAIYSRSGGSMGIGFAIPTAIVEQVMNALIKDGKVSRGWLGIEIQSQLRDPTQLESSTGVEVLNV
VPKSPAAKSGLKVGDIVLTIDGVEMTDANTLIQYVARKAPNTTLHAQILRQGKNAQVKILLEERPVEEPVTVPVVIQDET
LGGAQPPTLQAPEQDTPMMSEAERDRMREELLLLFERDGAPL

Sequences:

>Translated_442_residues
MSSSPNAENKAGLLKWLPWVLLLLVTAAFIWLFVSMKTASEAKWEPPKTTPAEQQASEPVSDSPTPIASYHNGVARASQS
VVNIYTTQTMAEHPYMNDPVLRRFFEYHGAPSEEQGNTNLGSGVIVSDDGYIVTNAHVIEKADEITVAFNDGRKSRAKLI
GTDPDSDLAVIKVDMTGLTPLGFREKPTLVGDVALAIGNPFGVGQTVTQGIISATGRTGLGVNKFEDFIQTDAAINPGNS
GGALVDARGELIGINTAIYSRSGGSMGIGFAIPTAIVEQVMNALIKDGKVSRGWLGIEIQSQLRDPTQLESSTGVEVLNV
VPKSPAAKSGLKVGDIVLTIDGVEMTDANTLIQYVARKAPNTTLHAQILRQGKNAQVKILLEERPVEEPVTVPVVIQDET
LGGAQPPTLQAPEQDTPMMSEAERDRMREELLLLFERDGAPL
>Mature_441_residues
SSSPNAENKAGLLKWLPWVLLLLVTAAFIWLFVSMKTASEAKWEPPKTTPAEQQASEPVSDSPTPIASYHNGVARASQSV
VNIYTTQTMAEHPYMNDPVLRRFFEYHGAPSEEQGNTNLGSGVIVSDDGYIVTNAHVIEKADEITVAFNDGRKSRAKLIG
TDPDSDLAVIKVDMTGLTPLGFREKPTLVGDVALAIGNPFGVGQTVTQGIISATGRTGLGVNKFEDFIQTDAAINPGNSG
GALVDARGELIGINTAIYSRSGGSMGIGFAIPTAIVEQVMNALIKDGKVSRGWLGIEIQSQLRDPTQLESSTGVEVLNVV
PKSPAAKSGLKVGDIVLTIDGVEMTDANTLIQYVARKAPNTTLHAQILRQGKNAQVKILLEERPVEEPVTVPVVIQDETL
GGAQPPTLQAPEQDTPMMSEAERDRMREELLLLFERDGAPL

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=282, Percent_Identity=35.4609929078014, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI22129776, Length=267, Percent_Identity=35.2059925093633, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI24308541, Length=281, Percent_Identity=32.3843416370107, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7019477, Length=241, Percent_Identity=34.4398340248963, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786356, Length=270, Percent_Identity=46.2962962962963, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1789629, Length=288, Percent_Identity=43.4027777777778, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789630, Length=382, Percent_Identity=38.4816753926702, Blast_Score=220, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24646839, Length=308, Percent_Identity=33.1168831168831, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47345; Mature: 47214

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSPNAENKAGLLKWLPWVLLLLVTAAFIWLFVSMKTASEAKWEPPKTTPAEQQASEPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCC
SDSPTPIASYHNGVARASQSVVNIYTTQTMAEHPYMNDPVLRRFFEYHGAPSEEQGNTNL
CCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
GSGVIVSDDGYIVTNAHVIEKADEITVAFNDGRKSRAKLIGTDPDSDLAVIKVDMTGLTP
CCCEEECCCCEEEECCHHEECCCEEEEEECCCCCCCCEEECCCCCCCEEEEEEEECCCCC
LGFREKPTLVGDVALAIGNPFGVGQTVTQGIISATGRTGLGVNKFEDFIQTDAAINPGNS
CCCCCCCCCCEEEHEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCC
GGALVDARGELIGINTAIYSRSGGSMGIGFAIPTAIVEQVMNALIKDGKVSRGWLGIEIQ
CCEEEECCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
SQLRDPTQLESSTGVEVLNVVPKSPAAKSGLKVGDIVLTIDGVEMTDANTLIQYVARKAP
HHCCCCHHHCCCCCCEEEEECCCCCCHHCCCEECEEEEEECCCEECCHHHHHHHHHHCCC
NTTLHAQILRQGKNAQVKILLEERPVEEPVTVPVVIQDETLGGAQPPTLQAPEQDTPMMS
CCHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
EAERDRMREELLLLFERDGAPL
HHHHHHHHHHHEEEEECCCCCC
>Mature Secondary Structure 
SSSPNAENKAGLLKWLPWVLLLLVTAAFIWLFVSMKTASEAKWEPPKTTPAEQQASEPV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCC
SDSPTPIASYHNGVARASQSVVNIYTTQTMAEHPYMNDPVLRRFFEYHGAPSEEQGNTNL
CCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
GSGVIVSDDGYIVTNAHVIEKADEITVAFNDGRKSRAKLIGTDPDSDLAVIKVDMTGLTP
CCCEEECCCCEEEECCHHEECCCEEEEEECCCCCCCCEEECCCCCCCEEEEEEEECCCCC
LGFREKPTLVGDVALAIGNPFGVGQTVTQGIISATGRTGLGVNKFEDFIQTDAAINPGNS
CCCCCCCCCCEEEHEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCC
GGALVDARGELIGINTAIYSRSGGSMGIGFAIPTAIVEQVMNALIKDGKVSRGWLGIEIQ
CCEEEECCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
SQLRDPTQLESSTGVEVLNVVPKSPAAKSGLKVGDIVLTIDGVEMTDANTLIQYVARKAP
HHCCCCHHHCCCCCCEEEEECCCCCCHHCCCEECEEEEEECCCEECCHHHHHHHHHHCCC
NTTLHAQILRQGKNAQVKILLEERPVEEPVTVPVVIQDETLGGAQPPTLQAPEQDTPMMS
CCHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
EAERDRMREELLLLFERDGAPL
HHHHHHHHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]