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The map label for this gene is dnaQ [H]

Identifier: 93005683

GI number: 93005683

Start: 1011925

End: 1013523

Strand: Reverse

Name: dnaQ [H]

Synonym: Pcryo_0855

Alternate gene names: 93005683

Gene position: 1013523-1011925 (Counterclockwise)

Preceding gene: 93005686

Following gene: 93005682

Centisome position: 33.12

GC content: 45.22

Gene sequence:

>1599_bases
ATGTCAGAAAATCGCAGCGCAGCGCAGCCATTTAACACCAGTAATGCCATAAACCCATTGGCTGCCAAAGCAGATACTAC
GGTTGCTTACACAGATGGCGCGTGTAAAGGCAATCCTGGTGCTGGTGGCTGGGGCGCTCATCTGATATTTAGCGACGGAC
GGACGCAGGATTTTTATGGCGGTGATAAAGAAACCACCAATAATCGTATGGAATTGATGGGTGCGATACAAGCGCTTACT
CATAGCTCACATGAGCAGAAACTCGAGATTTGGACAGACTCAAGTTATGTCAAAAAAGGCATCACTGAGTGGATTGAAGG
TTGGAAAAAAAGAGGCTGGAAGACGGCCAGTAAAAAACCCGTCGCCAATCAAGACCTATGGCAGCGACTCGATGAGCTCT
GTCAGAAACGCGATGTTGATTGGCATTGGGTCAAAGGTCATGCTGGACATGCTGGTAATGAAAAAGCGGATGAGCTTGCG
AACCTAGGTGTGACCTCACGTAGTGAAGATTTGATAACAGACGTTCAAGATAGTACTAAAAAAAAAGAGCCAATAATGGC
TGATAAAAAGCCATCAAGCAGCGATGATTGGCTAAATTTTGATCCATTAGGTTTTGATATGATGGATGATGAGCTTGATG
CCGAACTACTAGAGAATCAAAGTTATAATGACAGTGTAATAAATACTCATGCTTTCGCTGAAGAAAATATTAGTCCGTAC
AATGCCACCAATTCAATGAGTGCTATAGAAATGCCAGACGCCCAGACGCCTTTGATTGATACAAGCATCAATAACCATGC
GTCCAACATGGTTACTAATGTTGAAGCAGATACGCCAAAATTCGATGGTGACACCAGCCGTGCCAATCCATATTTTAAGC
CATTGCTACCCAAGCCAATAAACTGTCACCAATCTGATCGTCAGCTGATTATGGATACCGAGACCACGGGGCTGGATCCG
CAAAAAGGCGATCGTGTCATTGAAGTCGGTATTGTAGAGATGATTGGACGTAAGTTCACTGGCGAAAAGCTCCACGTCTA
TATCAACCCACAGCGCGGTATGGATGAAGAAGTTATTCGAATTCACGGTATTTCTGAAGCATTTTTAACGGACAAACCAA
CCTTTGATCAAGTCGCGCAGTCGCTCTATGACTTTATGGATGGTGCAGAAATCATCGCTCATAATGCCTCGTTTGATATG
AACTTCTTAAATATGGAGTTTGCCAAAGTTGGCATGCATGACTTTGCTGAGCGAGTAAAAGTGACCGACTCGCTGGTCAT
GGCAAAGCAGCAGTATCCTGGACAGAAAAATACTCTTGATGCTCTCGTACGTCGTTTAGACGTGGGCAAGCAAGACCGTA
CCTTTCACGGGGCATTACTAGATTCAGAGATTTTAGCAGAAGTCTATTTGGCGATGACTGGCGGACAAGTAACGCTAGGC
ATTGAGGATGACGCGCAAGCGGATGGCGGACACACAGCCCATGCTAGCTTTGCCAATTTAGCGGCTTTATTGCTTGAGTC
AAGTACTGATGAGGGCGCCAATCAAAGCTGGTATGCGTCGCTCGCAGAAGATTATCCTGAGCTGAAAGCCAAAATGTAA

Upstream 100 bases:

>100_bases
ACTCAATTCCAACATAGGTAGATAAAATTAGCCTCCAATATATCAGTGAAATCGCTTCGCTATATCCTGTATTTATTCTC
TATTAGGTCAGTAAATTTTT

Downstream 100 bases:

>100_bases
CAGGCATTAAAATCGCTTCTTATATTGGCGATTAGAGAATATAGTCTTGATTATTATAACGATAAAAAGTAAAACCTTAT
CTAGCGCTATTTTTTAATTT

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSENRSAAQPFNTSNAINPLAAKADTTVAYTDGACKGNPGAGGWGAHLIFSDGRTQDFYGGDKETTNNRMELMGAIQALT
HSSHEQKLEIWTDSSYVKKGITEWIEGWKKRGWKTASKKPVANQDLWQRLDELCQKRDVDWHWVKGHAGHAGNEKADELA
NLGVTSRSEDLITDVQDSTKKKEPIMADKKPSSSDDWLNFDPLGFDMMDDELDAELLENQSYNDSVINTHAFAEENISPY
NATNSMSAIEMPDAQTPLIDTSINNHASNMVTNVEADTPKFDGDTSRANPYFKPLLPKPINCHQSDRQLIMDTETTGLDP
QKGDRVIEVGIVEMIGRKFTGEKLHVYINPQRGMDEEVIRIHGISEAFLTDKPTFDQVAQSLYDFMDGAEIIAHNASFDM
NFLNMEFAKVGMHDFAERVKVTDSLVMAKQQYPGQKNTLDALVRRLDVGKQDRTFHGALLDSEILAEVYLAMTGGQVTLG
IEDDAQADGGHTAHASFANLAALLLESSTDEGANQSWYASLAEDYPELKAKM

Sequences:

>Translated_532_residues
MSENRSAAQPFNTSNAINPLAAKADTTVAYTDGACKGNPGAGGWGAHLIFSDGRTQDFYGGDKETTNNRMELMGAIQALT
HSSHEQKLEIWTDSSYVKKGITEWIEGWKKRGWKTASKKPVANQDLWQRLDELCQKRDVDWHWVKGHAGHAGNEKADELA
NLGVTSRSEDLITDVQDSTKKKEPIMADKKPSSSDDWLNFDPLGFDMMDDELDAELLENQSYNDSVINTHAFAEENISPY
NATNSMSAIEMPDAQTPLIDTSINNHASNMVTNVEADTPKFDGDTSRANPYFKPLLPKPINCHQSDRQLIMDTETTGLDP
QKGDRVIEVGIVEMIGRKFTGEKLHVYINPQRGMDEEVIRIHGISEAFLTDKPTFDQVAQSLYDFMDGAEIIAHNASFDM
NFLNMEFAKVGMHDFAERVKVTDSLVMAKQQYPGQKNTLDALVRRLDVGKQDRTFHGALLDSEILAEVYLAMTGGQVTLG
IEDDAQADGGHTAHASFANLAALLLESSTDEGANQSWYASLAEDYPELKAKM
>Mature_531_residues
SENRSAAQPFNTSNAINPLAAKADTTVAYTDGACKGNPGAGGWGAHLIFSDGRTQDFYGGDKETTNNRMELMGAIQALTH
SSHEQKLEIWTDSSYVKKGITEWIEGWKKRGWKTASKKPVANQDLWQRLDELCQKRDVDWHWVKGHAGHAGNEKADELAN
LGVTSRSEDLITDVQDSTKKKEPIMADKKPSSSDDWLNFDPLGFDMMDDELDAELLENQSYNDSVINTHAFAEENISPYN
ATNSMSAIEMPDAQTPLIDTSINNHASNMVTNVEADTPKFDGDTSRANPYFKPLLPKPINCHQSDRQLIMDTETTGLDPQ
KGDRVIEVGIVEMIGRKFTGEKLHVYINPQRGMDEEVIRIHGISEAFLTDKPTFDQVAQSLYDFMDGAEIIAHNASFDMN
FLNMEFAKVGMHDFAERVKVTDSLVMAKQQYPGQKNTLDALVRRLDVGKQDRTFHGALLDSEILAEVYLAMTGGQVTLGI
EDDAQADGGHTAHASFANLAALLLESSTDEGANQSWYASLAEDYPELKAKM

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI21359816, Length=157, Percent_Identity=38.8535031847134, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786409, Length=214, Percent_Identity=42.9906542056075, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786408, Length=132, Percent_Identity=57.5757575757576, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI115532542, Length=148, Percent_Identity=41.2162162162162, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137476, Length=144, Percent_Identity=37.5, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552509, Length=144, Percent_Identity=37.5, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006309
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58951; Mature: 58820

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENRSAAQPFNTSNAINPLAAKADTTVAYTDGACKGNPGAGGWGAHLIFSDGRTQDFYG
CCCCCCCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCC
GDKETTNNRMELMGAIQALTHSSHEQKLEIWTDSSYVKKGITEWIEGWKKRGWKTASKKP
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC
VANQDLWQRLDELCQKRDVDWHWVKGHAGHAGNEKADELANLGVTSRSEDLITDVQDSTK
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
KKEPIMADKKPSSSDDWLNFDPLGFDMMDDELDAELLENQSYNDSVINTHAFAEENISPY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
NATNSMSAIEMPDAQTPLIDTSINNHASNMVTNVEADTPKFDGDTSRANPYFKPLLPKPI
CCCCCCCEEECCCCCCCEEECCCCCHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NCHQSDRQLIMDTETTGLDPQKGDRVIEVGIVEMIGRKFTGEKLHVYINPQRGMDEEVIR
CCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHEE
IHGISEAFLTDKPTFDQVAQSLYDFMDGAEIIAHNASFDMNFLNMEFAKVGMHDFAERVK
EECCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHH
VTDSLVMAKQQYPGQKNTLDALVRRLDVGKQDRTFHGALLDSEILAEVYLAMTGGQVTLG
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHEECCEEEEE
IEDDAQADGGHTAHASFANLAALLLESSTDEGANQSWYASLAEDYPELKAKM
ECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SENRSAAQPFNTSNAINPLAAKADTTVAYTDGACKGNPGAGGWGAHLIFSDGRTQDFYG
CCCCCCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCC
GDKETTNNRMELMGAIQALTHSSHEQKLEIWTDSSYVKKGITEWIEGWKKRGWKTASKKP
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC
VANQDLWQRLDELCQKRDVDWHWVKGHAGHAGNEKADELANLGVTSRSEDLITDVQDSTK
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
KKEPIMADKKPSSSDDWLNFDPLGFDMMDDELDAELLENQSYNDSVINTHAFAEENISPY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
NATNSMSAIEMPDAQTPLIDTSINNHASNMVTNVEADTPKFDGDTSRANPYFKPLLPKPI
CCCCCCCEEECCCCCCCEEECCCCCHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NCHQSDRQLIMDTETTGLDPQKGDRVIEVGIVEMIGRKFTGEKLHVYINPQRGMDEEVIR
CCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHEE
IHGISEAFLTDKPTFDQVAQSLYDFMDGAEIIAHNASFDMNFLNMEFAKVGMHDFAERVK
EECCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHH
VTDSLVMAKQQYPGQKNTLDALVRRLDVGKQDRTFHGALLDSEILAEVYLAMTGGQVTLG
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHEECCEEEEE
IEDDAQADGGHTAHASFANLAALLLESSTDEGANQSWYASLAEDYPELKAKM
ECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]