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The map label for this gene is gabT [H]

Identifier: 93005649

GI number: 93005649

Start: 967862

End: 969202

Strand: Direct

Name: gabT [H]

Synonym: Pcryo_0819

Alternate gene names: 93005649

Gene position: 967862-969202 (Clockwise)

Preceding gene: 93005648

Following gene: 93005650

Centisome position: 31.63

GC content: 44.97

Gene sequence:

>1341_bases
ATGAATCCCAACTGTAATTCACTCTATAAACCGCCATCACTTCACTGGCATCTACGTAAAAAGAAAGAAAAGGACATTCT
TATGACTACCAATCAATCATTACTTGCACGCCGTAAAGCGGTATTACCAACCGGACTGGGTGTGGCTTTTCCTATCTTTG
CCGAAAAAGCAAAAAACTCAGAAGTTTGGGATATTGAAGGCAATCGTTATATCGATTTCGTTGGCGGCATCTCAGTACTA
AATACCGGTCACAGTCATCCAAAAATCACGCAGCGTGTGCATGAGCAGCTAGACAAATTCACCCATACTGCTGCGCAAAT
GATTAACTATGAATGCTATGTCGATCTTGCCGAAAAACTGTGTGAAAAAGCGCCTATCAGTGGCGACACAAAGGCATTCT
TCTTGACCACTGGTGCAGAAGCGGTTGAAAACTGTATCAAAATTGCTCGTGCAAAAACCCGTCGTCCAGGCGTGATTTCT
TTCGTTGGCGGTTGGCATGGCCGCACGCTTATGTGCATGAGCTTGACTGGTAAAGTATTGCCATACAAAAAGAACTTTGG
TCCGATGCCAGGGCCTGTATTCCATGCACTATTCCCATGCGATGAGCTGAATGTTACTGAAGAACAAGCATTGCATAGCC
TTGAGATGATTTTCCAAGCGGATATCGATCCTAGTGAAGTGGCGGCGATGATTATCGAGCCAGTACAAGGTGAGGGTGGC
TTCCATCAAGTCACGCCATCATTTGCTAAGTCTTTACGCGATATCTGTGATGAGCACGGCATTGTCCTAATCTTTGATGA
AGTACAGTGTGGTTTTGCGCGTACGGGTACGTTGTTTGCCTGTGAACAATTGGGCGTTGAGCCAGATCTTATGACCAGTG
CTAAGAGCTTGGCAGGTGGTTATCCTATTTCTGCCGTTATTGGTCGTGCCGATATTATGGATGCCCCGCAAGTAGGTGGC
TTGGGTGGTACTTATGCTGGCAACCCACTTGCTTGTGTAGCCGCTTTAGCAGTCATCGAAGTCATCGAAGAGGAAAACCT
ACTTGAGCGTAGTATTGAAATTGGCGACAAAATTGAGTCATTTTTAAAGGGCTTAAACTTAAGTAGTATCGGACATATTC
GCCATAAAGGCGCCATGCTCGCGTTTGAATTAATCGATAGTGATGGTAAGCCTGACGTTGAAGCGACGACTAACCTAAAA
GCGAAATCATTTGAGCAAGGTTTGTTACTAGCATCTTGCGGTATGCATGGCAATGCCATTCGTGTGATGGTGCCATTGAC
GGTTGAAGATGAAGTGCTACAAGAAGGTCTTGATATCATCAAAGGTATTTTGACTGCCTAA

Upstream 100 bases:

>100_bases
AATACTGGTGTTCTGACGTCAGCTAAGCTTTTAAGTTTTATTTTCTATTTTAATGGTCACACATTCAATTGTCACATAGC
ACGAAACGGGATTCAGTACT

Downstream 100 bases:

>100_bases
GTATTTGATAGCTTAAAGGATAACAAGTGCTAAAGGTTAGGCTGTGTTTATAGTCAAATCCTAAGCAGTGTTGGTACAAC
GGCGCCTTGCAAGTCAAGAC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNPNCNSLYKPPSLHWHLRKKKEKDILMTTNQSLLARRKAVLPTGLGVAFPIFAEKAKNSEVWDIEGNRYIDFVGGISVL
NTGHSHPKITQRVHEQLDKFTHTAAQMINYECYVDLAEKLCEKAPISGDTKAFFLTTGAEAVENCIKIARAKTRRPGVIS
FVGGWHGRTLMCMSLTGKVLPYKKNFGPMPGPVFHALFPCDELNVTEEQALHSLEMIFQADIDPSEVAAMIIEPVQGEGG
FHQVTPSFAKSLRDICDEHGIVLIFDEVQCGFARTGTLFACEQLGVEPDLMTSAKSLAGGYPISAVIGRADIMDAPQVGG
LGGTYAGNPLACVAALAVIEVIEEENLLERSIEIGDKIESFLKGLNLSSIGHIRHKGAMLAFELIDSDGKPDVEATTNLK
AKSFEQGLLLASCGMHGNAIRVMVPLTVEDEVLQEGLDIIKGILTA

Sequences:

>Translated_446_residues
MNPNCNSLYKPPSLHWHLRKKKEKDILMTTNQSLLARRKAVLPTGLGVAFPIFAEKAKNSEVWDIEGNRYIDFVGGISVL
NTGHSHPKITQRVHEQLDKFTHTAAQMINYECYVDLAEKLCEKAPISGDTKAFFLTTGAEAVENCIKIARAKTRRPGVIS
FVGGWHGRTLMCMSLTGKVLPYKKNFGPMPGPVFHALFPCDELNVTEEQALHSLEMIFQADIDPSEVAAMIIEPVQGEGG
FHQVTPSFAKSLRDICDEHGIVLIFDEVQCGFARTGTLFACEQLGVEPDLMTSAKSLAGGYPISAVIGRADIMDAPQVGG
LGGTYAGNPLACVAALAVIEVIEEENLLERSIEIGDKIESFLKGLNLSSIGHIRHKGAMLAFELIDSDGKPDVEATTNLK
AKSFEQGLLLASCGMHGNAIRVMVPLTVEDEVLQEGLDIIKGILTA
>Mature_446_residues
MNPNCNSLYKPPSLHWHLRKKKEKDILMTTNQSLLARRKAVLPTGLGVAFPIFAEKAKNSEVWDIEGNRYIDFVGGISVL
NTGHSHPKITQRVHEQLDKFTHTAAQMINYECYVDLAEKLCEKAPISGDTKAFFLTTGAEAVENCIKIARAKTRRPGVIS
FVGGWHGRTLMCMSLTGKVLPYKKNFGPMPGPVFHALFPCDELNVTEEQALHSLEMIFQADIDPSEVAAMIIEPVQGEGG
FHQVTPSFAKSLRDICDEHGIVLIFDEVQCGFARTGTLFACEQLGVEPDLMTSAKSLAGGYPISAVIGRADIMDAPQVGG
LGGTYAGNPLACVAALAVIEVIEEENLLERSIEIGDKIESFLKGLNLSSIGHIRHKGAMLAFELIDSDGKPDVEATTNLK
AKSFEQGLLLASCGMHGNAIRVMVPLTVEDEVLQEGLDIIKGILTA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=412, Percent_Identity=33.0097087378641, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=33.5403726708075, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI13994255, Length=429, Percent_Identity=28.2051282051282, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI37574042, Length=444, Percent_Identity=26.1261261261261, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI24119277, Length=435, Percent_Identity=24.367816091954, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226442705, Length=444, Percent_Identity=26.1261261261261, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI188536080, Length=455, Percent_Identity=26.1538461538462, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI38679950, Length=455, Percent_Identity=26.1538461538462, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI38679946, Length=455, Percent_Identity=26.1538461538462, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=26.4935064935065, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=51.3189448441247, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=50.3579952267303, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=34.2233009708738, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=33.5858585858586, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=33.6842105263158, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786349, Length=377, Percent_Identity=30.2387267904509, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1786991, Length=436, Percent_Identity=28.2110091743119, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=32.9493087557604, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25144271, Length=410, Percent_Identity=32.9268292682927, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71992977, Length=452, Percent_Identity=28.7610619469027, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=282, Percent_Identity=34.3971631205674, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=381, Percent_Identity=28.8713910761155, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=105, Percent_Identity=35.2380952380952, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=33.743842364532, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=31.7073170731707, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321456, Length=424, Percent_Identity=26.4150943396226, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=312, Percent_Identity=24.3589743589744, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=32.0388349514563, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28574759, Length=455, Percent_Identity=30.3296703296703, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=30.5986696230599, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=29.0697674418605, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281366494, Length=344, Percent_Identity=25.5813953488372, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667139, Length=344, Percent_Identity=25.5813953488372, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667143, Length=344, Percent_Identity=25.5813953488372, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 48485; Mature: 48485

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00095 C5_MTASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNCNSLYKPPSLHWHLRKKKEKDILMTTNQSLLARRKAVLPTGLGVAFPIFAEKAKNS
CCCCCCCCCCCCCCEEHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
EVWDIEGNRYIDFVGGISVLNTGHSHPKITQRVHEQLDKFTHTAAQMINYECYVDLAEKL
CEEEECCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CEKAPISGDTKAFFLTTGAEAVENCIKIARAKTRRPGVISFVGGWHGRTLMCMSLTGKVL
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCC
PYKKNFGPMPGPVFHALFPCDELNVTEEQALHSLEMIFQADIDPSEVAAMIIEPVQGEGG
CCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
FHQVTPSFAKSLRDICDEHGIVLIFDEVQCGFARTGTLFACEQLGVEPDLMTSAKSLAGG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCC
YPISAVIGRADIMDAPQVGGLGGTYAGNPLACVAALAVIEVIEEENLLERSIEIGDKIES
CCHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLKGLNLSSIGHIRHKGAMLAFELIDSDGKPDVEATTNLKAKSFEQGLLLASCGMHGNAI
HHHCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCEE
RVMVPLTVEDEVLQEGLDIIKGILTA
EEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPNCNSLYKPPSLHWHLRKKKEKDILMTTNQSLLARRKAVLPTGLGVAFPIFAEKAKNS
CCCCCCCCCCCCCCEEHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
EVWDIEGNRYIDFVGGISVLNTGHSHPKITQRVHEQLDKFTHTAAQMINYECYVDLAEKL
CEEEECCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CEKAPISGDTKAFFLTTGAEAVENCIKIARAKTRRPGVISFVGGWHGRTLMCMSLTGKVL
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCC
PYKKNFGPMPGPVFHALFPCDELNVTEEQALHSLEMIFQADIDPSEVAAMIIEPVQGEGG
CCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
FHQVTPSFAKSLRDICDEHGIVLIFDEVQCGFARTGTLFACEQLGVEPDLMTSAKSLAGG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCC
YPISAVIGRADIMDAPQVGGLGGTYAGNPLACVAALAVIEVIEEENLLERSIEIGDKIES
CCHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLKGLNLSSIGHIRHKGAMLAFELIDSDGKPDVEATTNLKAKSFEQGLLLASCGMHGNAI
HHHCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCEE
RVMVPLTVEDEVLQEGLDIIKGILTA
EEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]