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The map label for this gene is pcoA [H]

Identifier: 93005527

GI number: 93005527

Start: 827358

End: 829064

Strand: Reverse

Name: pcoA [H]

Synonym: Pcryo_0697

Alternate gene names: 93005527

Gene position: 829064-827358 (Counterclockwise)

Preceding gene: 93005528

Following gene: 93005526

Centisome position: 27.09

GC content: 46.81

Gene sequence:

>1707_bases
ATGAATAAACAGAACATATTGAACCGCCGACGTTTTTTAACTGGATCCTCCGCTGTCCTTGGCGCTTCCTTGATACCGAC
CATTGCCAGTAGTGCATTGGGACACTCAAGTCGTTCAGGCAGTCAGGGTGCTACTATCAATAGTGATCAAAACACTCATA
AAGTGCCTATATTGACCGGTAAAGAGTTTGACTTATACGTCAGTAAACAGTCCGCTATTGTCAACGGTAAAAAGAGCATG
GCAACGCTCATCAATAATTCACTGCCAGCACCGACGCTAAAGATGGTTGAGGGCGATACGGTGGTGATACGTGTTCATAA
TCAGATGGATGAATCCACCTCTATTCATTGGCATGGACTACTAGTACCGTTTGAGATGGATGGGGTACCGGGTATTAGCT
TTGATGGCATTCCTGCAAACAGCACCTTTACTTATAAATTCAAATTAAAACAATCAGGCACCTATTGGTATCACTCACAC
AGTGGGTTCCAAGAACAAACCGGTATGCTGGGTGCCATTGTGATTGAACCTAAAGGTCGTGAGCGTCATCCTATCGAAGA
AGACCACGTGATCGTGCTCAGTGATTGGACCAGCCGCAACCCGCATAATCTCTTAAAACTGCTCAAACAGCGCGCAGATT
TTGATAACTATCATCTGCCAGACTTCAAGAAGCTACTGTCTGATATTGCCGAAACAGATATGAAAACCGCGTTTGATAAA
CGCAAAATGTGGAATCAGATGCGCATGATGCCCACTGATTTTACTGACTTGTCGGGCGAAAACACCTTCACCTATCTTAT
GAATGGCAAAACCACCGCGGCTAATTGGGCGCAAATCGTCAAAGCAGGACAGCGCGTTAAATTACGCTTTATCAATGCTT
CAGCGCAAACCATCTTTGATGTGCGCATACCCGGTCTCAAAATGACTGTGGTGGCAACCGATGGTATTGATGTCGCACCC
GTTGCGATTGATGATTTTCGTATTGGCGTGGCTGAGACCTACGATGTCATCGTTACCCCTACCAAAGAGGCGCATACCAT
ATTCGCCCAAAACATAGACCGTTCAGGCTATGTTGCCGCAACGCTTGCCACCAAAGAAGGCGCTCGTGCGGCAACGCCTG
CTATGGACAAAATAGAATGGCTCACCATGGCAGATATGATGGGCGCTATGGGTGCTAATGGTTATAAAGCCAAGCATGCC
AAAACTGAGTATGACTTTAAGTCTGATATGCGTGTGGACAGTCCGCGTATGAACCTTGATGATCCAGGTATTAACCTGCG
TAACATTGATAGAAAGGTGCTGAACTATAGCCAGCTGCGCTCTGTCGATGAGGCAATATTTGCAGAGCAGCGCAAGCCTA
CCCGAGAGATCGAGCTACATTTAACCGGTAACATGGAGCGCTATATCTGGGCGTTTGATGGGGTTAAGTTCAGTGAAGCG
ACACCGGTTAATATTAAGCCGGGTGAGCGCGTGCGTATTACCTTAGTCAATGACACGATGATGAATCATCCGATGCATTT
ACACGGCATGTGGAGCGATTTGCGCATGCCTAACGGCGAGTTTCAGGTGCGCAAGCATACTATTATGGTGCAGCCGGCAC
AAAAAATCAGCTTTGATGTCACAGGAGAAGCTGGTCGATGGGCATGGCATTGTCATCTGCTCTATCACATGGAAGCCGGT
ATGTTTAGAGAAGTGGCAGTCATTTAA

Upstream 100 bases:

>100_bases
AAAAGCGGCTTAATAAGATTCCCAATCGTAATTGACGTATCGTTAAATATTATAACCATAAGCTTAACCACCATCTCTCA
AATTAAATTAGGTCATCATT

Downstream 100 bases:

>100_bases
GCAAATCTTTGATTGATAGGTGAGAGATGAGATGAAAATACATAAAGTAGGTTTACGGTTCGCTGGGGCATCATCATTGG
TACTGCTGGCATCATCATTT

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MNKQNILNRRRFLTGSSAVLGASLIPTIASSALGHSSRSGSQGATINSDQNTHKVPILTGKEFDLYVSKQSAIVNGKKSM
ATLINNSLPAPTLKMVEGDTVVIRVHNQMDESTSIHWHGLLVPFEMDGVPGISFDGIPANSTFTYKFKLKQSGTYWYHSH
SGFQEQTGMLGAIVIEPKGRERHPIEEDHVIVLSDWTSRNPHNLLKLLKQRADFDNYHLPDFKKLLSDIAETDMKTAFDK
RKMWNQMRMMPTDFTDLSGENTFTYLMNGKTTAANWAQIVKAGQRVKLRFINASAQTIFDVRIPGLKMTVVATDGIDVAP
VAIDDFRIGVAETYDVIVTPTKEAHTIFAQNIDRSGYVAATLATKEGARAATPAMDKIEWLTMADMMGAMGANGYKAKHA
KTEYDFKSDMRVDSPRMNLDDPGINLRNIDRKVLNYSQLRSVDEAIFAEQRKPTREIELHLTGNMERYIWAFDGVKFSEA
TPVNIKPGERVRITLVNDTMMNHPMHLHGMWSDLRMPNGEFQVRKHTIMVQPAQKISFDVTGEAGRWAWHCHLLYHMEAG
MFREVAVI

Sequences:

>Translated_568_residues
MNKQNILNRRRFLTGSSAVLGASLIPTIASSALGHSSRSGSQGATINSDQNTHKVPILTGKEFDLYVSKQSAIVNGKKSM
ATLINNSLPAPTLKMVEGDTVVIRVHNQMDESTSIHWHGLLVPFEMDGVPGISFDGIPANSTFTYKFKLKQSGTYWYHSH
SGFQEQTGMLGAIVIEPKGRERHPIEEDHVIVLSDWTSRNPHNLLKLLKQRADFDNYHLPDFKKLLSDIAETDMKTAFDK
RKMWNQMRMMPTDFTDLSGENTFTYLMNGKTTAANWAQIVKAGQRVKLRFINASAQTIFDVRIPGLKMTVVATDGIDVAP
VAIDDFRIGVAETYDVIVTPTKEAHTIFAQNIDRSGYVAATLATKEGARAATPAMDKIEWLTMADMMGAMGANGYKAKHA
KTEYDFKSDMRVDSPRMNLDDPGINLRNIDRKVLNYSQLRSVDEAIFAEQRKPTREIELHLTGNMERYIWAFDGVKFSEA
TPVNIKPGERVRITLVNDTMMNHPMHLHGMWSDLRMPNGEFQVRKHTIMVQPAQKISFDVTGEAGRWAWHCHLLYHMEAG
MFREVAVI
>Mature_568_residues
MNKQNILNRRRFLTGSSAVLGASLIPTIASSALGHSSRSGSQGATINSDQNTHKVPILTGKEFDLYVSKQSAIVNGKKSM
ATLINNSLPAPTLKMVEGDTVVIRVHNQMDESTSIHWHGLLVPFEMDGVPGISFDGIPANSTFTYKFKLKQSGTYWYHSH
SGFQEQTGMLGAIVIEPKGRERHPIEEDHVIVLSDWTSRNPHNLLKLLKQRADFDNYHLPDFKKLLSDIAETDMKTAFDK
RKMWNQMRMMPTDFTDLSGENTFTYLMNGKTTAANWAQIVKAGQRVKLRFINASAQTIFDVRIPGLKMTVVATDGIDVAP
VAIDDFRIGVAETYDVIVTPTKEAHTIFAQNIDRSGYVAATLATKEGARAATPAMDKIEWLTMADMMGAMGANGYKAKHA
KTEYDFKSDMRVDSPRMNLDDPGINLRNIDRKVLNYSQLRSVDEAIFAEQRKPTREIELHLTGNMERYIWAFDGVKFSEA
TPVNIKPGERVRITLVNDTMMNHPMHLHGMWSDLRMPNGEFQVRKHTIMVQPAQKISFDVTGEAGRWAWHCHLLYHMEAG
MFREVAVI

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=180, Percent_Identity=29.4444444444444, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320714, Length=528, Percent_Identity=21.5909090909091, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=521, Percent_Identity=23.6084452975048, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=139, Percent_Identity=33.8129496402878, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574104, Length=313, Percent_Identity=28.1150159744409, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650186, Length=326, Percent_Identity=25.1533742331288, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859919, Length=304, Percent_Identity=26.6447368421053, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330000, Length=285, Percent_Identity=28.0701754385965, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360167, Length=285, Percent_Identity=28.0701754385965, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585842, Length=285, Percent_Identity=28.0701754385965, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221329998, Length=285, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 63862; Mature: 63862

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQNILNRRRFLTGSSAVLGASLIPTIASSALGHSSRSGSQGATINSDQNTHKVPILTG
CCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCEEEEEEEC
KEFDLYVSKQSAIVNGKKSMATLINNSLPAPTLKMVEGDTVVIRVHNQMDESTSIHWHGL
CCEEEEEECCCEEECCHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCCEEEEEE
LVPFEMDGVPGISFDGIPANSTFTYKFKLKQSGTYWYHSHSGFQEQTGMLGAIVIEPKGR
EEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCEEEEEECCCCC
ERHPIEEDHVIVLSDWTSRNPHNLLKLLKQRADFDNYHLPDFKKLLSDIAETDMKTAFDK
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RKMWNQMRMMPTDFTDLSGENTFTYLMNGKTTAANWAQIVKAGQRVKLRFINASAQTIFD
HHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCEEEEE
VRIPGLKMTVVATDGIDVAPVAIDDFRIGVAETYDVIVTPTKEAHTIFAQNIDRSGYVAA
EECCCEEEEEEEECCCCEEEEEEECEEECCCCEEEEEEECCCHHHEEEECCCCCCCEEEE
TLATKEGARAATPAMDKIEWLTMADMMGAMGANGYKAKHAKTEYDFKSDMRVDSPRMNLD
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCC
DPGINLRNIDRKVLNYSQLRSVDEAIFAEQRKPTREIELHLTGNMERYIWAFDGVKFSEA
CCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCEEECCC
TPVNIKPGERVRITLVNDTMMNHPMHLHGMWSDLRMPNGEFQVRKHTIMVQPAQKISFDV
CCCCCCCCCEEEEEEEECHHHCCCEEEEECHHHHCCCCCCEEEEEEEEEEECHHHCEEEE
TGEAGRWAWHCHLLYHMEAGMFREVAVI
CCCCCCEEEEEEEEEEECCCCCEEEECC
>Mature Secondary Structure
MNKQNILNRRRFLTGSSAVLGASLIPTIASSALGHSSRSGSQGATINSDQNTHKVPILTG
CCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCEEEEEEEC
KEFDLYVSKQSAIVNGKKSMATLINNSLPAPTLKMVEGDTVVIRVHNQMDESTSIHWHGL
CCEEEEEECCCEEECCHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCCEEEEEE
LVPFEMDGVPGISFDGIPANSTFTYKFKLKQSGTYWYHSHSGFQEQTGMLGAIVIEPKGR
EEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCEEEEEECCCCC
ERHPIEEDHVIVLSDWTSRNPHNLLKLLKQRADFDNYHLPDFKKLLSDIAETDMKTAFDK
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RKMWNQMRMMPTDFTDLSGENTFTYLMNGKTTAANWAQIVKAGQRVKLRFINASAQTIFD
HHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCEEEEE
VRIPGLKMTVVATDGIDVAPVAIDDFRIGVAETYDVIVTPTKEAHTIFAQNIDRSGYVAA
EECCCEEEEEEEECCCCEEEEEEECEEECCCCEEEEEEECCCHHHEEEECCCCCCCEEEE
TLATKEGARAATPAMDKIEWLTMADMMGAMGANGYKAKHAKTEYDFKSDMRVDSPRMNLD
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCC
DPGINLRNIDRKVLNYSQLRSVDEAIFAEQRKPTREIELHLTGNMERYIWAFDGVKFSEA
CCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCEEECCC
TPVNIKPGERVRITLVNDTMMNHPMHLHGMWSDLRMPNGEFQVRKHTIMVQPAQKISFDV
CCCCCCCCCEEEEEEEECHHHCCCEEEEECHHHHCCCCCCEEEEEEEEEEECHHHCEEEE
TGEAGRWAWHCHLLYHMEAGMFREVAVI
CCCCCCEEEEEEEEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]