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The map label for this gene is ubiE [H]

Identifier: 93005518

GI number: 93005518

Start: 815477

End: 816565

Strand: Reverse

Name: ubiE [H]

Synonym: Pcryo_0688

Alternate gene names: 93005518

Gene position: 816565-815477 (Counterclockwise)

Preceding gene: 93005519

Following gene: 93005517

Centisome position: 26.69

GC content: 41.51

Gene sequence:

>1089_bases
ATGACTGATCATGTAAATAATAAAACGACTACTAATGGCCGTATACAAGATAAATTGGTTCAAGACAGTATCACTCATAA
CCAAAATATTACCGCTCAAGTAAAAGCACGTCAACATACCGCTACAAGTGTTAATAACGTTATTAACACTGACTTTACTC
ATGTTGAAGATCTACCCATAGGAACGCCACAAGGGCAACAAACCACTATGCCAAATGCTAATACTGAAAACCACGCTCAA
AATAGCACTGTAAATGACGCTGCACAGACAAATACTCAAGCCCCTAAGCAAACGCTTTTTAACCAGCGTGACGATATCAA
TAATCCACATACGTCTGATACCGATGGTCATGAAGAAACCCATTTTGGCTATAAGACCGTTAATAAAGCAGAAAAACAAG
CACGTGTGGCTGACGTATTTACCTCTGTCGCCAAAAAATACGACATCATGAATGACCTAATGTCATTTGGTATTCATCGC
TTGTGGAAGCGTTATGCCATTAGCTTATCTGGCGTGCGTGCTGGTCAACATGTATTAGATATCGCTGGCGGTACGGGTGA
TTTAGCCAAAGTCTTTAGCCGTGAAGTCGGTCGCAACGGTAAAGTCGTGTTGTCTGATATCAATGCGGCAATGCTAGAAG
TTGGTCGTGAGCGCTTGATTAATGCTGGCTGTAATAATGTCGATTTTGTTTTGGCGAACGCTGAAACCCTAGCACCATTT
GATGATAATAGCTTTGATCTGCTGACCATCAGCTTTGGTCTACGTAACGTCACAGATAAAGATGCTGCGTTAAAATCGAT
GTACCGTGTGCTCAAGCCAGGTGGTCGCTTATTAATACTAGAATTCTCAAAACCTATCTTTGAGCCATTATCAAAAGCCT
ATGATTTATATTCGTTCACAGCGCTACCGATGATGGGTAAGCTGGTTGCTAACGATTCAGAAAGCTATAAATATTTAGCT
GAATCGATTCGCATGCATCCTGATCAGCAGACGCTAAAGCAGATGATGGAGCAAGCAGGCTTTGAAAATTGTGATTATCA
TAATCTGACAGCTGGTATCGTCGCGGTACATCGCGGCTTTAAAGCATAA

Upstream 100 bases:

>100_bases
GCCCGCTGCGTTTGCTGTATGATAAGCGCTATTGTCTCAATAACTATTAGTATTTTATCTGACTAAAAACAAGCATAAAA
ATAAATCATAGGACACCGCG

Downstream 100 bases:

>100_bases
GATTAAGTTTTAAATGACAATACCTAGCGATAAGAATGCCATTATGTAAAATGATGGCAACTTATATTTATAAATAATGC
GCTCTTTTAAGGCGCTCAAT

Product: ubiquinone/menaquinone biosynthesis methyltransferases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTDHVNNKTTTNGRIQDKLVQDSITHNQNITAQVKARQHTATSVNNVINTDFTHVEDLPIGTPQGQQTTMPNANTENHAQ
NSTVNDAAQTNTQAPKQTLFNQRDDINNPHTSDTDGHEETHFGYKTVNKAEKQARVADVFTSVAKKYDIMNDLMSFGIHR
LWKRYAISLSGVRAGQHVLDIAGGTGDLAKVFSREVGRNGKVVLSDINAAMLEVGRERLINAGCNNVDFVLANAETLAPF
DDNSFDLLTISFGLRNVTDKDAALKSMYRVLKPGGRLLILEFSKPIFEPLSKAYDLYSFTALPMMGKLVANDSESYKYLA
ESIRMHPDQQTLKQMMEQAGFENCDYHNLTAGIVAVHRGFKA

Sequences:

>Translated_362_residues
MTDHVNNKTTTNGRIQDKLVQDSITHNQNITAQVKARQHTATSVNNVINTDFTHVEDLPIGTPQGQQTTMPNANTENHAQ
NSTVNDAAQTNTQAPKQTLFNQRDDINNPHTSDTDGHEETHFGYKTVNKAEKQARVADVFTSVAKKYDIMNDLMSFGIHR
LWKRYAISLSGVRAGQHVLDIAGGTGDLAKVFSREVGRNGKVVLSDINAAMLEVGRERLINAGCNNVDFVLANAETLAPF
DDNSFDLLTISFGLRNVTDKDAALKSMYRVLKPGGRLLILEFSKPIFEPLSKAYDLYSFTALPMMGKLVANDSESYKYLA
ESIRMHPDQQTLKQMMEQAGFENCDYHNLTAGIVAVHRGFKA
>Mature_361_residues
TDHVNNKTTTNGRIQDKLVQDSITHNQNITAQVKARQHTATSVNNVINTDFTHVEDLPIGTPQGQQTTMPNANTENHAQN
STVNDAAQTNTQAPKQTLFNQRDDINNPHTSDTDGHEETHFGYKTVNKAEKQARVADVFTSVAKKYDIMNDLMSFGIHRL
WKRYAISLSGVRAGQHVLDIAGGTGDLAKVFSREVGRNGKVVLSDINAAMLEVGRERLINAGCNNVDFVLANAETLAPFD
DNSFDLLTISFGLRNVTDKDAALKSMYRVLKPGGRLLILEFSKPIFEPLSKAYDLYSFTALPMMGKLVANDSESYKYLAE
SIRMHPDQQTLKQMMEQAGFENCDYHNLTAGIVAVHRGFKA

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=45.1263537906137, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=71.5447154471545, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17557039, Length=247, Percent_Identity=45.3441295546559, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=279, Percent_Identity=43.7275985663082, Blast_Score=210, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641702, Length=256, Percent_Identity=46.484375, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 40147; Mature: 40015

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHVNNKTTTNGRIQDKLVQDSITHNQNITAQVKARQHTATSVNNVINTDFTHVEDLPI
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
GTPQGQQTTMPNANTENHAQNSTVNDAAQTNTQAPKQTLFNQRDDINNPHTSDTDGHEET
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHH
HFGYKTVNKAEKQARVADVFTSVAKKYDIMNDLMSFGIHRLWKRYAISLSGVRAGQHVLD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
IAGGTGDLAKVFSREVGRNGKVVLSDINAAMLEVGRERLINAGCNNVDFVLANAETLAPF
ECCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEECCC
DDNSFDLLTISFGLRNVTDKDAALKSMYRVLKPGGRLLILEFSKPIFEPLSKAYDLYSFT
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ALPMMGKLVANDSESYKYLAESIRMHPDQQTLKQMMEQAGFENCDYHNLTAGIVAVHRGF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
KA
CC
>Mature Secondary Structure 
TDHVNNKTTTNGRIQDKLVQDSITHNQNITAQVKARQHTATSVNNVINTDFTHVEDLPI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
GTPQGQQTTMPNANTENHAQNSTVNDAAQTNTQAPKQTLFNQRDDINNPHTSDTDGHEET
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHH
HFGYKTVNKAEKQARVADVFTSVAKKYDIMNDLMSFGIHRLWKRYAISLSGVRAGQHVLD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
IAGGTGDLAKVFSREVGRNGKVVLSDINAAMLEVGRERLINAGCNNVDFVLANAETLAPF
ECCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEECCC
DDNSFDLLTISFGLRNVTDKDAALKSMYRVLKPGGRLLILEFSKPIFEPLSKAYDLYSFT
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ALPMMGKLVANDSESYKYLAESIRMHPDQQTLKQMMEQAGFENCDYHNLTAGIVAVHRGF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA