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The map label for this gene is dacC [H]

Identifier: 93005488

GI number: 93005488

Start: 780042

End: 781208

Strand: Reverse

Name: dacC [H]

Synonym: Pcryo_0658

Alternate gene names: 93005488

Gene position: 781208-780042 (Counterclockwise)

Preceding gene: 93005489

Following gene: 93005473

Centisome position: 25.53

GC content: 44.99

Gene sequence:

>1167_bases
ATGACAGTAAAGCGTGTGAAAAAACAGCTGGTGCAGCTGGTAGTGGGTGTCAGTATTTCTATGGGTGCAGTGATGGCAAG
TGCAGCCATACAGCCGCCTGAGATGGCAAATACTGCGTATGTATTAATGGACTATAACACGGGTGAAATTTTGGCACAGA
AAAATGCCAATCAAGCCTTGCCGCCAGCATCTTTGACCAAAATGATGACCAGTTACATCATTGAACAGCGCTTAGCTTCA
GGCGATCTCAAAGAAACCGATCAGGTATTGATGAGTCCAAGTGCTTGGTGCCGCGGCAGTAGTAGCCAGTCGTGCATGTA
TGTACCGGTGAATAAGAGCGCGAGTGTTATAGATATGCTACGCGGTATTATTATTCAATCAGGTAATGACGCCTCAAAAG
CAATGGCTGAGCATATCGCTGGTAGCGAAGCATCGTTTGCTATCTTGATGAATGAGCAAGCGCAAAAGATTGGTATGAAG
AATACCCATTTCGTCAACTCTACTGGTATGCCTGATGAGGGTCACCAAGCATCTGCTCTAGATTTGGCCAAGCTATCACG
CGCCATTATCAAAAACAGCGGCGATTACTACAGCATTTATTCAGAAAAAGAGTTTACCTATAACGGTATTACTCAAGGTA
ATCGTAATGCCCTACTGGCCACCGACCCTACTGTTGATGGTCTAAAAACAGGACATACGGATGCAGCTGGGTATTGCTTA
GCAGCCTCAAGCAACCGTGAAGGTATGCGCCTAATCTCTGTCATTATGGGCACTGAAAGTCAGCAAGCACGTGCTGATCA
GTCGCGTGAGTTGCTCAATTGGGGTTTTGGTCACTTCACAACGGTTACTCAAGCACCTGCTGGTCAGTTTGTCAGCAAAG
TTCCTGTCTGGTTTGGTGAAGCAAAAGAGATAGAAGTAGCGACTGGTGATAATTTGCAGATTTTGACCACTAAAACACAA
AAGAATAAAATCACTACTGTGGTCGATATTCCTGAAAGCTTAGAAGCGCCTATCAAAAAGGGTCAAGAAATCGGTAAAAT
GATGGCTGTGATAGATGGCAAAGCAGTGGCTTCTGTGCCTGTGATTGCGACAAGCGACATTGAGCAATCAGGTTTTATGA
GCCGTATCTGGCAACGTTTTTCTCGTTGGACCCAGAACTTATTTTAA

Upstream 100 bases:

>100_bases
TAACCTGAGATTTAACATAGTCTGCCAAAGATTGTGTAAAGGTATGGTGTTGGGGACAAGTGACAGATACATTTGGTTTT
ATGATGCGGTGTAACAATCT

Downstream 100 bases:

>100_bases
GCACAATGATAGCATTTTGAAATAATGCTTTTATCATGAAGTTCAACATAAAAAAGACGTCTCATATCAAGGCGTCTTTT
TTATGTTTAAAATTTTATAT

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTVKRVKKQLVQLVVGVSISMGAVMASAAIQPPEMANTAYVLMDYNTGEILAQKNANQALPPASLTKMMTSYIIEQRLAS
GDLKETDQVLMSPSAWCRGSSSQSCMYVPVNKSASVIDMLRGIIIQSGNDASKAMAEHIAGSEASFAILMNEQAQKIGMK
NTHFVNSTGMPDEGHQASALDLAKLSRAIIKNSGDYYSIYSEKEFTYNGITQGNRNALLATDPTVDGLKTGHTDAAGYCL
AASSNREGMRLISVIMGTESQQARADQSRELLNWGFGHFTTVTQAPAGQFVSKVPVWFGEAKEIEVATGDNLQILTTKTQ
KNKITTVVDIPESLEAPIKKGQEIGKMMAVIDGKAVASVPVIATSDIEQSGFMSRIWQRFSRWTQNLF

Sequences:

>Translated_388_residues
MTVKRVKKQLVQLVVGVSISMGAVMASAAIQPPEMANTAYVLMDYNTGEILAQKNANQALPPASLTKMMTSYIIEQRLAS
GDLKETDQVLMSPSAWCRGSSSQSCMYVPVNKSASVIDMLRGIIIQSGNDASKAMAEHIAGSEASFAILMNEQAQKIGMK
NTHFVNSTGMPDEGHQASALDLAKLSRAIIKNSGDYYSIYSEKEFTYNGITQGNRNALLATDPTVDGLKTGHTDAAGYCL
AASSNREGMRLISVIMGTESQQARADQSRELLNWGFGHFTTVTQAPAGQFVSKVPVWFGEAKEIEVATGDNLQILTTKTQ
KNKITTVVDIPESLEAPIKKGQEIGKMMAVIDGKAVASVPVIATSDIEQSGFMSRIWQRFSRWTQNLF
>Mature_387_residues
TVKRVKKQLVQLVVGVSISMGAVMASAAIQPPEMANTAYVLMDYNTGEILAQKNANQALPPASLTKMMTSYIIEQRLASG
DLKETDQVLMSPSAWCRGSSSQSCMYVPVNKSASVIDMLRGIIIQSGNDASKAMAEHIAGSEASFAILMNEQAQKIGMKN
THFVNSTGMPDEGHQASALDLAKLSRAIIKNSGDYYSIYSEKEFTYNGITQGNRNALLATDPTVDGLKTGHTDAAGYCLA
ASSNREGMRLISVIMGTESQQARADQSRELLNWGFGHFTTVTQAPAGQFVSKVPVWFGEAKEIEVATGDNLQILTTKTQK
NKITTVVDIPESLEAPIKKGQEIGKMMAVIDGKAVASVPVIATSDIEQSGFMSRIWQRFSRWTQNLF

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=376, Percent_Identity=39.3617021276596, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1786851, Length=350, Percent_Identity=40.8571428571429, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87082022, Length=356, Percent_Identity=39.0449438202247, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082054, Length=254, Percent_Identity=29.5275590551181, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42022; Mature: 41890

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKRVKKQLVQLVVGVSISMGAVMASAAIQPPEMANTAYVLMDYNTGEILAQKNANQAL
CCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCCCCCC
PPASLTKMMTSYIIEQRLASGDLKETDQVLMSPSAWCRGSSSQSCMYVPVNKSASVIDML
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHCCCCCCCCEEEEECCCCHHHHHHH
RGIIIQSGNDASKAMAEHIAGSEASFAILMNEQAQKIGMKNTHFVNSTGMPDEGHQASAL
HHHEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCEEECCCCCCCCCCCCHHH
DLAKLSRAIIKNSGDYYSIYSEKEFTYNGITQGNRNALLATDPTVDGLKTGHTDAAGYCL
HHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
AASSNREGMRLISVIMGTESQQARADQSRELLNWGFGHFTTVTQAPAGQFVSKVPVWFGE
EECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHCCCEECC
AKEIEVATGDNLQILTTKTQKNKITTVVDIPESLEAPIKKGQEIGKMMAVIDGKAVASVP
CCEEEEECCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
VIATSDIEQSGFMSRIWQRFSRWTQNLF
EEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVKRVKKQLVQLVVGVSISMGAVMASAAIQPPEMANTAYVLMDYNTGEILAQKNANQAL
CHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCCCCCC
PPASLTKMMTSYIIEQRLASGDLKETDQVLMSPSAWCRGSSSQSCMYVPVNKSASVIDML
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHCCCCCCCCEEEEECCCCHHHHHHH
RGIIIQSGNDASKAMAEHIAGSEASFAILMNEQAQKIGMKNTHFVNSTGMPDEGHQASAL
HHHEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCEEECCCCCCCCCCCCHHH
DLAKLSRAIIKNSGDYYSIYSEKEFTYNGITQGNRNALLATDPTVDGLKTGHTDAAGYCL
HHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
AASSNREGMRLISVIMGTESQQARADQSRELLNWGFGHFTTVTQAPAGQFVSKVPVWFGE
EECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHCCCEECC
AKEIEVATGDNLQILTTKTQKNKITTVVDIPESLEAPIKKGQEIGKMMAVIDGKAVASVP
CCEEEEECCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
VIATSDIEQSGFMSRIWQRFSRWTQNLF
EEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]