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The map label for this gene is pth [H]

Identifier: 93005014

GI number: 93005014

Start: 213769

End: 214350

Strand: Reverse

Name: pth [H]

Synonym: Pcryo_0183

Alternate gene names: 93005014

Gene position: 214350-213769 (Counterclockwise)

Preceding gene: 93005015

Following gene: 93005013

Centisome position: 7.01

GC content: 45.7

Gene sequence:

>582_bases
ATGGCCATAAAGCTTATAGTCGGTCTTGGTAATCCGGGTCAGGAATATATGTTTACGCGCCATAATGCAGGATTTTGGTT
CGTCCTTCATTTGGCTCAGCAGTTTAATATCACTCTCGCCCCCGACAAAAAATTCCATGGAGTGACAGGACGCGGGCAGA
TTCATGGGCATGACGTGCGTCTATTGATGCCGCTGACTTTTATGAATAAATCAGGTCAGTCGGTCGTGCCCATGGTTAAA
TTTTATGGCATTGATAATGACGAGCTGTTAATCGCCCATGATGAGCTTGATATTCCTGCTGGTAGCATCAAACTCAAAAC
TGACGGTGGTCATGGCGGTCATAATGGTCTGCGTGACATAACCCCCCATATTGGTAACGACTTCCATCGTCTGCGTGTGG
GTATTGGTCATCCGGGTCACAAGTCTAAAGTCAGTGGTCATGTGCTTTCAAAAGCTGCGCCAGATGAGCAGATTGCTATT
GATAGTGCATTATCTGCTGCTTTTGACGCCCTGCCTTTGCTATTAGGCGGTGATGTCGAAAAAGCACGTTCGCAAATTAA
TGGTTTTAAATTACCTGAATGA

Upstream 100 bases:

>100_bases
AAAAAACGGCAGGTGATGAATATCTCCTGCTGTTTTTGTAAGTAAGGTTTGAGAAATCAGACCTTACCACTCATTTATTA
TAGTCAAGCAGGGTGTTTTT

Downstream 100 bases:

>100_bases
ATGGTGTTTCAATTATAATAGCCTTTTATTTTAGCAAGTTAATCCCCATTAACGTTTTGATTTGACTCATTTATATCCGT
TACACTAAGGAAGCAATCTA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MAIKLIVGLGNPGQEYMFTRHNAGFWFVLHLAQQFNITLAPDKKFHGVTGRGQIHGHDVRLLMPLTFMNKSGQSVVPMVK
FYGIDNDELLIAHDELDIPAGSIKLKTDGGHGGHNGLRDITPHIGNDFHRLRVGIGHPGHKSKVSGHVLSKAAPDEQIAI
DSALSAAFDALPLLLGGDVEKARSQINGFKLPE

Sequences:

>Translated_193_residues
MAIKLIVGLGNPGQEYMFTRHNAGFWFVLHLAQQFNITLAPDKKFHGVTGRGQIHGHDVRLLMPLTFMNKSGQSVVPMVK
FYGIDNDELLIAHDELDIPAGSIKLKTDGGHGGHNGLRDITPHIGNDFHRLRVGIGHPGHKSKVSGHVLSKAAPDEQIAI
DSALSAAFDALPLLLGGDVEKARSQINGFKLPE
>Mature_192_residues
AIKLIVGLGNPGQEYMFTRHNAGFWFVLHLAQQFNITLAPDKKFHGVTGRGQIHGHDVRLLMPLTFMNKSGQSVVPMVKF
YGIDNDELLIAHDELDIPAGSIKLKTDGGHGGHNGLRDITPHIGNDFHRLRVGIGHPGHKSKVSGHVLSKAAPDEQIAID
SALSAAFDALPLLLGGDVEKARSQINGFKLPE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=34.5238095238095, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=52.6041666666667, Blast_Score=176, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20930; Mature: 20799

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKLIVGLGNPGQEYMFTRHNAGFWFVLHLAQQFNITLAPDKKFHGVTGRGQIHGHDVR
CEEEEEEECCCCCHHEEEEECCCCEEEEEEEHHHCEEEECCCCCCCCCCCCCEECCCCEE
LLMPLTFMNKSGQSVVPMVKFYGIDNDELLIAHDELDIPAGSIKLKTDGGHGGHNGLRDI
EEEEEEEECCCCCEEECEEEEECCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCC
TPHIGNDFHRLRVGIGHPGHKSKVSGHVLSKAAPDEQIAIDSALSAAFDALPLLLGGDVE
CCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCHH
KARSQINGFKLPE
HHHHHHCCCCCCC
>Mature Secondary Structure 
AIKLIVGLGNPGQEYMFTRHNAGFWFVLHLAQQFNITLAPDKKFHGVTGRGQIHGHDVR
EEEEEEECCCCCHHEEEEECCCCEEEEEEEHHHCEEEECCCCCCCCCCCCCEECCCCEE
LLMPLTFMNKSGQSVVPMVKFYGIDNDELLIAHDELDIPAGSIKLKTDGGHGGHNGLRDI
EEEEEEEECCCCCEEECEEEEECCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCC
TPHIGNDFHRLRVGIGHPGHKSKVSGHVLSKAAPDEQIAIDSALSAAFDALPLLLGGDVE
CCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCHH
KARSQINGFKLPE
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA